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      • 김정은 시대 북한정치의 특징과 전망

        김일기(Kim, Il-Gi),이수석(Lee, Su-Suk) 북한학회 2013 북한학보 Vol.38 No.2

        이 글은 김정은 시대 북한 정치의 특징을 분석하고 향후 변화를 전망하고 있다. 북한 정치의 특정은 권력구조와 리더십 그리고 통치이념을 중심으로 분석하였다. 먼저, 북한의 권력구조는 수령체제라는 북한 정치체제의 특성에 주목하여 유일영도체계와 함께 권력엘리트의 재편에 초점을 두었다. 김정은 시대 유일영도체계는 김정일 시기에 비해 약해지고 있으며, 권력엘리트들은 당-정-군 모두에서 세대교체가 가속화되고 있다. 둘째, 김정은의 정치적 리더십은 인격적 리더십과 제도적 리더십을 통해 분석하였다. 김정은은 김정일 사망 직후 최고지도자의 지위에 기반한 제도적 리더십을 갖춘 이후, 현재까지 인격적 리더십 확립에 매진하고 있다. 셋째, 북한의 통치이념은 주체사상에서 김일성-김정일주의로 변경되었다. 그리고 북한은 김정은 시대의 실천담론으로서 김정일 애국주의를 확산시키고 있다. 결론적으로, 북한은 김정은 시대의 새로운 비전과 목표를 제시할 것이며, 이를 통해 김정일과의 차별성 및 변화를 모색할 가능성이 높다. This paper analyzes the characteristics of North Korean politics and predicts future changes under Kim Jong-Un era. It is analyzed power structure, political leadership and ruling ideology as the characteristics of North Korean politics. First, The power structure is consist of 'uilyongdochege (monolithic leadership)' and change of power elite. The 'uilyongdochege' has weakened and the replacement of power elite has accelerated compared to Kim Jong-Il era. Second, there were analyzed personal leadership and positional leadership as Kim Jong-un's political leadership. Kim Jong-Un established institutional leadership based on position of supreme leader soon after the death of Kim Jong-Il and has been trying to establish personal leadership. Third, The ruling ideology of North Korea changed from 'Juche Ideology' to 'Kimilsung-Kimjongilism'. And The 'KimJongil Patriotism' is spreading to the entire society as the discourse for practice 'Kimilsung-Kimjongilism'. Finally, North Korea will present a new vision and goals and try to differentiate Kim Jong-Un era from Kim Jong-Il era.

      • KCI등재

        한국인 전반적 급진성 치주염 환자에서 IL-6 유전자 다변성에 관한 연구

        방선정,김일,옥수,영준,정현주,Bang, Sun-Jung,Kim, Il-Shin,Kim, Ok-Su,Kim, Young-Jun,Chung, Hyun-Ju 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.4

        Purpose: The purpose of this study was to investigate the association of generalized aggressive periodontitis with IL-6 promoter gene single nucleotide polymorphisms(SNP). Material and Methods: The study population consisted of 52 generalized aggressive periodontitis patients(GAP) and 30 periodontally healthy control subjects, who were systemically healthy non-smokers. Genomic DNA was obtained from buccal swab. The IL-6 promotor SNP at the positions of -597, -572, and -174 were genotyped by amplifying the polymorphic region using polymerase chain reaction(PCR), restriction enzyme digestion and gel electrophoresis. Result: The genotype distributions for G/G, G/A and A/A genotypes of IL-6 -597 were 30.8%, 40.4%, and 28.8% in the GAP group and 53.3%, 40%, and 6.7% in the control group and were statistically different between 2 groups(p<0.05). Allele 2 frequency of IL-6 -597 were significantly higher in the GAP group than the control group(p<0.01). At the position of IL-6 -572, the distribution for C/C, C/G and G/G genotypes were 23.1%, 55.8% and 21.2% in the GAP group and 20%, 33.3%, and 46.7% in the control group. In female subjects, the genotype distribution were significantly different between 2 groups(p<0.01). In male subjects, allele 2 frequency of IL-6-572 was significantly lower in the GAP group than the control group(p<0.05). The genotype distribution of IL-6 -174 in the GAP group were 96.2%, 3.8% for G/G, G/C genotypes whereas only the G/G genotype was detected in the control group. Conclusion: In conclusion, significant associations were found in IL-6 gene promoter(-597, -572) polymorphisms and generalized aggressive periodontitis. Further cohort study will be necessary in larger population.

      • KCI등재

        일반논문 : 김정은 체제의 대남정책과 남북관계

        김일기 ( Il Gi Kim ) 한국외국어대학교 글로벌정치연구소 2012 글로벌정치연구 Vol.5 No.1

        북한은 작년 김정일 사망 이후 권력승계의 속도를 빠르게 진행하여 올해 4월의 제4차 당대표자회와 제12기 제5차 최고인민회의를 통해 김정은 체제를 공식적으로 출범시켰다. 현재 김정은 체제의 대내외 정책 방향은 김정일의 유훈에 따라 진행되고 있으나, 구체적 내용들은 아직 공개되지 않고 있다. 이 연구는 이러한 점에 주목하여 김정은 체제의 대남정책 방향과 남북관계를 전망하였다. 김정은 체제는 북한의 전통적 대남전략 목표인 ``한반도 공산화``를 계승함과 동시에 강온 양면의 이중적 대남정책을 전개할 것이다. 북한의 대남 유화정책은 경제난 해결과 미북 관계 개선 및 6자회담 재개를 위해 전개될 가능성이 높다. 반면, 대남 강경정책은 미북 관계와 북핵 협상 미진, 체제위기 탈피, 남북관계 주도권 확보 차원에서 추진될 가능성이 높다. 김정은 시대의 남북관계는 북한의 이중적 대남정책에 따라 경색과 회복의 국면을 반복할 것이다. 북한의 대남정책에서 새로운 변화가 없는 한 당분간 남북관계는 경색국면을 벗어나기 어렵다. 그러나 장기적 측면에서 보면 남북관계는 김정은 체제의 안정화 속에서 제한적이지만 점진적으로 개선되는 방향으로 나아갈 가능성이 높다. 아마도 남북관계와 한국, 미국, 중국의 권력교체가 완료되고 새로운 정부가 출범하는 2013년 이후에 새로운 변화의 가능성을 기대할 것으로 예상된다. Kim Jong-un regime has been officially launched from the fourth Conference of the Workers` Party of North Korea, and the fifth session of the 12th Supreme People`s Assembly was held on April 2012. The policy of Kim Jong-un regime has been followed by the teachings left by Kim Jong-il, but the details of it have not been known. So, this article analyzes not only the North Korea`s Policy against South Korea, but also inter-Korea relations which could be expected in the Kim Jong-un Regime. While it maintains the past policy objective, "the communization of the entire Korean peninsula", North Korea will be continued to purse the dual strategy of hardline and moderate toward South Korea. Inter-Korea relations of Kim Jong-un Era will be swung back and forth such as pendulum in the wall clock. If there is no change in strict policy toward South Korea, inter-Korea relations will become progressively worse. Taking the long-term perspective, however, inter-Korea relations will be improved gradually.

      • SCIESCOPUSKCI등재

        괴화 추출물이 대식세포에서의 nitric oxide와 interleukin-6의 생성에 미치는 영향

        이지은,이주연,최점일,종관,성조,Lee, Ji-Eun,Lee, Ju-Youn,Choi, Jeom-Il,Kim, Chong-Kwan,Kim, Sung-Jo 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.1

        Both nitric oxide (NO) and interleukin-6 (IL-6) have been thought to have a role in the pathogenesis of inflammatory periodontal disease as it does in other inflammatory diseases, and the inhibitors of NO and IL-6 production have been considered as potential anti-inflammatory agents. In this study, we evaluated methanol extract of Sophorae Flos for inhibition of NO and IL-6 production in Prevotella intermedia LPS-induced mouse macrophages RAW264.7 cells. Dried Sopharae Flos was sliced, and extracted with 100% methanol. LPS from p. intermedia ATCC 25611 was prepared by the standard hot phenol-water method. NO production was assayed by measuring the accumulation of nitrite in culture supematants and IL-6 was measured using mouse IL-6 ELISA kit. Western blot analysis of iNOS and analysis of reverse transcription (RT)-PCR products were carried out. The methanol extract of Sophorae Flos concentration-dependently reduced the production of NO and the expression of iNOS protein and mRNA in RAw264.7 cells treated with P. intermedia LPS. Sophorae Flos also suppressed IL-6 production and the expression of IL-6 mRNA in RAw264.7 cells stimulated by P. intermedia LPS. The inhibition of NO and IL-6 production by Sophorae Flos may be useful in the therapy of inflammatory diseases such as periodontitis. This hypothesis, however, remains to be tested.

      • SCOPUSKCI등재

        주조직적합항원이 불일치하는 마우스 동종 조혈모세포이식에서 IL-2로 유도된 CD4+CD25+ T세포를 이용한 이식편대숙주병의 억제

        현재호,정대철,정낙균,박수정,민우성,태규,최병옥,원일,한치화,학기,Hyun, Jae Ho,Jeong, Dae Chul,Chung, Nak Gyun,Park, Soo Jeong,Min, Woo Sung,Kim, Tai Gyu,Choi, Byung Ock,Kim, Won Il,Han, Chi Wha,Kim, Hack Ki 대한면역학회 2003 Immune Network Vol.3 No.4

        Background: In kidney transplantation, donor specific transfusion may induce tolerance as a result of some immune regulatory cells against the graft. In organ transplantation, the immune state arises from a relationship between the immunocompromised graft and the immunocompetent host. However, a reverse immunological situation exists between the graft and the host in hematopoietic stem cell transplantation (HSCT). In addition, early IL-2 injections after an allogeneic murine HSCT have been shown to prevent lethal graft versus host disease (GVHD) due to CD4+ cells. We investigated the induction of the regulatory CD4+CD25+ cells after a transfusion of irradiated recipient cells with IL-2 into a donor. Methods: The splenocytes (SP) were obtained from 6 week-old BALB/c mice ($H-2^d$) and irradiated as a single cell suspension. The donor mice (C3H/He, $H-2^k$) received $5{\times}10^6$ irradiated SP, and 5,000 IU IL-2 injected intraperitoneally on the day prior to HSCT. The CD4+CD25+ cell populations in SP treated C3H/He were analyzed. In order to determine the in vivo effect of CD4+CD25+ cells, the lethally irradiated BALB/c were transplanted with $1{\times}10^7$ donor BM and $5{\times}10^6$ CD4+CD25+ cells. The other recipient mice received either $1{\times}10^7$ donor BM with $5{\times}10^6$ CD4+ CD25- cells or the untreated SP. The survival and GVHD was assessed daily by a clinical scoring system. Results: In the MLR assay, BALB/c SP was used as a stimulator with C3H/He SP, as a responder, with or without treatment. The inhibition of proliferation was $30.0{\pm}13%$ compared to the control. In addition, the MLR with either the CD4+CD25+ or CD4+CD25- cells, which were isolated by MidiMacs, from the C3H/He SP treated with the recipient SP and IL-2 was evaluated. The donor SP treated with the recipient cells and IL-2 contained more CD4+CD25+ cells ($5.4{\pm}1.5%$) than the untreated mice SP ($1.4{\pm}0.3%$)(P<0.01). There was a profound inhibition in the CD4+CD25+ cells ($61.1{\pm}6.1%$), but a marked proliferation in the CD4+CD25- cells ($129.8{\pm}65.2%$). Mice in the CD4+CD25+ group showed low GVHD scores and a slow progression from the post-HSCT day 4 to day 9, but those in the control and CD4+CD25- groups had a high score and rapid progression (P<0.001). The probability of survival was 83.3% in the CD4+CD25+ group until post-HSC day 35 and all mice in the control and CD4+CD25- groups died on post-HSCT day 8 or 9 (P=0.0105). Conclusion: Donor graft engineering with irradiated recipient SP and IL-2 (recipient specific transfusion) can induce abundant regulatory CD4+CD25+ cells to prevent GVHD.

      • KCI등재
      • KCI등재

        Ad-hoc 네트워크에서 악의적 노드 관리기법에 관한 연구

        김일,동천,Kim, Il-Do,Kim, Dong-Cheon 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.12

        Ad-hoc 네트워크가 정상적으로 동작하기 위해서는 각 노드가 동등한 권한을 갖고 상호 협조할 때 원활한 통신이 가능하다. 신뢰성을 확보하기 위해 인증된 노드로만 네트워크가 구성이 가능하지만 인증만으로 악의적 행위를 하는 노드를 완전히 배제할 수 없으므로 이들의 행위가 네트워크 전체를 위험에 빠뜨릴 수 있다. 이를 탐지 및 배제해야만 더욱 안전하고 신뢰할 수 있는 네트워크를 유지할 수 있으나 이에 대한 연구는 상대적으로 미흡한 수준이다. 따라서 신뢰 관계에 있는 노드로 구성된 네트워크에서 이기적이거나 악의적인 노드를 탐지하고 배제시켜 결과적으로 네트워크의 안전성과 신뢰성을 유지하고 처리율을 향상시킬 수 있는 방법을 제안한다. An Ad-hoc network will operate properly and provide smooth communication when nodes cooperate mutually with each of them having equal authority. Although it is possible to form a network consisting only of authenticated nodes in order to ensure reliability, authentication by itself is not sufficient to remove malicious nodes and their activities jeopardizing the whole network. Detection and prevention of such activities are vital for maintaining a safe and reliable network, but research on this matter is relatively lacking. Hence a suggestion is made on how to detect and prevent malicious or uncooperative ones among the nodes forming a network by a relationship of mutual trust, thereby maintaining safety and stability of the network and improving its processing abilities

      • SCOPUSKCI등재

        대장암의 병리학적 특성 - 절제 대장암 872예에 대한 분석 -

        우호(Woo Ho Kim),용일(Yong Il Kim),장미수(Mee Soo Chang) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

        This study was undertaken to characterize the pathologic features of the carcinomas of the large intestine among Koreans. A total of 872 consecutive cases of surgically resected large intestine carcinomas operated at Seoul National University Hospital during a perioid of 8 and 8/12 years from 1981 to 1989 were investigated according to the Korean Guideline for Colo-Rectal Cancer Study. The results were summarized as follow: 1) The male to female ratio was 1.3:1(498 males and 374 females). The age at the time of resection ranged from 17 to 86 years, and the highest peak was in the 6th decade. 2) The topographic incidence order of the carcinomas were 256 cases(30%) in the upper rectum; 229(27%) in the lower rectum; 103(12%) in the ascending colon; 102(12%) in the sigmoid colon. 3) Moderately differentiated adenocarcinoma was found in 56%, well differentiated adenocar- cinoma in 24%, and poorly differentiated adenocarcinoma in 6%. Mucinous carcinoma and signet-ring cell carcinoma comprised 8.3% and 1.5%, respectively. 4) The average size of the tumors was 5.2 +- 2.9 cm. Applying the Borrmann classification to the colo-rectal carcinomas, the order of the frequency was type II(366 cases), type lll(298 cases) and type I (144 cases). 5) Early colon cancer was found in 15 cases(1.8%). The stage of the colo-rectal cancer showed a preponderance of Dukes Astler-Coller C2 lesions; 375(44%) were in C2, 319(37%) in B2, 95(11%) in Bl, 40(5%) in D, 17(2%) in Cl, and 6(1%) in A. In 20 cases of anal cancer, 11 were Boman stage B2 and the remaining 9 were stage C. 6) There were 16(1.8%) cases with multiple primary carcinornas, of which 12(1.4%) were synchro- nous and 4(0.46%) metachronous. 7) In 83 cases(9.5%), the colo-rectal polyps including 73 cases(8.4%) of neoplastic polyps were associated. The majority of them were tobular adenomas(59 cases). 8) Familial polyposis with cancer was found in 7 cases(0.8%) and their age ranged from 29 to 58 years. Of them, 4 cases were multiple carcinomas, and all of 7 cases showed one or more cancers in the rectum. 9) Adenoma-carcinoma sequence was histologically confirmed in 32 of 872 carcinomas(3.7%). The above data were compared and discussed with those from domestic and western literatures.

      • KCI등재

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