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김인수,이원,김성훈,최봄,Kim, In-Soo,Lee, Won,Kim, Seong-Hun,Choi, Bohm Korean Association of Maxillofacial Plastic and Re 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.4
In the present study, I investigated the effects of N-methyl-D-aspartate (NMDA), arachidonic acid (AA), and Nitric Oxide Synthase Inhibitor (NOS-I), alone or in combination, on the viability of cultured primary normal human oral keratinocytes (NHOK). Specifically, we examined whether AA and NOS-I could protect primary NHOK from glutamate cytotoxicity. The purpose of this study was therefore the preliminary study for the examination of the interaction between these agents and NHOK in order to elucidate the mechanisms by which epithelial growth and regeneration are regulated. NHOK were obtained from gingival tissue of 20 individuals aged 20 to 29, and third passage (P3) cells were used for this study. Cell viability was measured by the MTT assay. NMDA and NNA, a calcium dependent NOS inhibitor, induced an initial increase in cell number, which subsequently decreased by the $7^{th}$ day. Low concentration of AA ($0.5\;{\mu}M$ & $1\;{\mu}M$) induced an increase in cell number while high concentrations of AA ($5\;{\mu}M$ & $10\;{\mu}M$) induced a decrease in cell number. The decrease in cell number induced by NMDA at the $7^{th}$ day was abolished by the addition of low concentrations of AA ($0.5\;{\mu}M$ & $1\;{\mu}M$) or NOS inhibitors. Low concentrations of AA ($0.5\;{\mu}M$ & $1\;{\mu}M$) or NOS inhibitors may protect the NHOK from NMDA induced cytotoxicity. These reactions might be related to the NMDA receptor in the cell and the change of the intracellular calcium ion concentration.
김인수,서진종,김광곤,하동룡,신민구,김의수,전상윤,Kim, In-Soo,Seo, Jin-Jong,Kim, Kwang-Gon,Ha, Dong-Ryong,Shin, Min-Koo,Kim, Eui-Su,Jeon, Sang-Yun 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.3
Objectives: The goal of this project was to measure the antibacterial effectiveness of Hwangryunhaedok-tang (barberry root decoction for detoxification) and its constituents. All of the active ingredients including the final product were prepared using high-pressure sterilization for use as medicinal eye drops. The varying forms of Hwangryunhaedok-tang (barberry root decoction for detoxification) were used to treat Staphylococcus epidermidis and Enterococcus faecalis which are found in keratitis. Methods: The antibacterial effect was measured by observing the presence or absence of antimicrobial activity when treated with varying concentrations of Hwangryunhaedok-tang extract. The tests were performed using a dosage of $70{\mu}l$ dosages of 100%, 50%, 10% and 1% the extracted solution by the minimum growth inhibitory concentration measurement. Antimicrobial activity was measured by examining the correlation between dosage strength and bacterial activity from $70{\mu}l$ to $10{\mu}l$ at the same concentration. Results: 1. Hwangryunhaedok-tang (barberry root decoction for detoxification), Phellodendri Cortex, and gardenia didn't show any antimicrobial effects against S. aureus, S. epidermidis, or E. faecalis. 2. Barberry root showed antimicrobial effects against S. aureus and S. epidermidis depending on the levels of concentration but didn't show any antimicrobial effects against E. faecalis. 3. Skullcap showed antimicrobial effects against S. aureus and S. epidermidis when a dosage of 100% extract $70{\mu}l$ was used. However, did not show any antimicrobial effects at all against E. faecalis. Conclusions: Hwangryunhaedok-tang (barberry root decoction for detoxification) and its constituents such as barberry root, phellodendri cortex, skullcap, and gardenia, can be used as an alternative to antibiotic medicinal eye drops to treat keratitis. However, further research on effective uses of and efficient extraction methods are needed.
경상분지(慶尙盆地) 언양단층(彦陽斷層) 지역(地域)에 대(對)한 전기비저항(電氣比抵抗) 탐사연구(探査硏究)
김인수,김종열,Kim, In-Soo,Kim, Jong-Yeol 대한자원환경지질학회 1983 자원환경지질 Vol.16 No.1
Gyeongsang Basin in the southeastern part of the Korean peninsular is characterized by many fault systems. To decipher the geotectonical evolution of the Korean peninsular and marginal basins in her adjacent areas it is prerequisite to understand the spatial distribution pattern and mutual relationships of these fault systems. Because of difficulties in finding any criterion to recognize the faults in field, their extension and mutual relationships in ages are not very clear yet. As an attempt to find geophysical criteria to recognize the fault, geoelectrical resistivity survey was carried out in this study. With the Wenner configuration four resistivity soundings and twenty seven resistivity profilings were done. The electrode distance used was up to 50m. From the results of the resistivity soundings and boring data of earlier groundwater investigations the depth of alluvial and weathered zone was established to be at most 20m in the study area. In the resistivity profiling low resistivity anomaly zones are detected on every traverse, which are interpreted as caused by fractures, fault clays and mylonites in the fault zone. The width of the fault zone amounts to 0.3-1km. By correlating and connecting the negative anomaly zones from traverse to traverse one can determine the trend of th of the faultzone and therefore that of fault itself. The recognized fault trend in this way was $N15^{\circ}-20^{\circ}E$ and this coincides with the direction of the inferred fault line from earlier geological surface mapping. With the help of this characteristical negative anomaly the existance of another $N80^{\circ}W$ trending fault was estabished. This study has shown that geoelectrical resistivity survey can be applied successfully to the problem of tracing fault line insofar as a fault zone has been developed along fault line.
김인수,심재홍,최경희,정기현,문경덕,김태근,Kim, In-Soo,Shim, Jae-Hong,Choi, Kyung-Hee,Jung, Gi-Hyun,Moon, Kyeong-Deok,Kim, Tae-Geun 한국정보처리학회 2000 정보처리논문지 Vol.7 No.1
본 논문에서는 초고속 통신망인 Myrinet을 기반으로 하는 워크스테이션 연동(network of workstations) 환경하에서 병렬 프로그래밍 모델을 지원하는 PVM (parallel virtual machine)의 통신 성능 개선 방안을 제시한다. PVM을 위해 새로이 제안하는 Myrinet 기반 통신 모델은 커널을 경유하는 기존의 UDP/IP 프로토콜을 이용하는 통신 모델과 Myrinet API를 직접 이용하는 통신 모델을 혼합한 복합 통신 모델이다. 제안된 복합 통신 모델은 사용자 영역(커널)에서 커널(사용자) 버퍼로의 메시지 복사 부하를 제거하고 커널내의 프로토콜 스택 처리를 위한 통신 지연 요인을 감소시키므로, Myrinet상에서 보다 빠른 PVM 테스크간의 데이터 전송 속도를 보장한다. 또한, UDP/IP를 사용하는 기존 PVM에 본 논문에서 제안된 Myrinet 기반 복합 통신 모델을 적용시킨 EPVM (Enhanced PVM)을 구현하고, 이의 성능을 측정하였다. 실험 결과 EPVM의 통신 성능이 기존 PVM 보다 평균 1.5배 정보 우수하다는 것을 확인하였다. PVM (parallel virtual machine) provides a programming environment that allows a collection of networked workstations to appear as a single parallel computational resource. The performance of parallel applications in this environment depends on the performance of data transfers between tasks. In this paper, we present a new Myrinet-based communication model of PVM that improves PVM communication performance over a high-speed Myrinet LAN. The proposed PVM communication model adopts a communication mechanism that allows any user-level process to directly access the network interface board without going through UDP/IP protocol stacks in the kernel. This mechanism provides faster data transfers between PVM tasks over the Myrinet since it avoids data copy overhead from kernel (user space) to user space (kernel) and reduces communication latency due to network protocol software layers. We implemented EPVM (Enhanced PVM), our updated version of the traditional PVM using UDP/IP, that is based on the proposed communication model over the Myrinet. Performance results show EPVM achieves communication speed-up of one to two over the traditional PVM.
경주-울산일원에 대한 지역지질 특성연구 : 울산단층주변 화강암류의 잔류자기와 대자율
김인수,손문,정현정,이준동,김정진,백인성,Kim, In-Soo,Son, Moon,Jung, Hyun-Jung,Lee, Joon-Dong,Kim, Jeong-Jin,Paik, In Sung 대한자원환경지질학회 1998 자원환경지질 Vol.31 No.1
A total of 469 granitic samples were collected from 44 sites in the Ulsan fault area, southeast Korea. According to the previous petrographic studies, the granitic rocks have been divided into four groups (Hornblende biotite granodiorite, Hornblende granite, Biotite granite and Alkali-feldspar granite). NRM intensities, values of low field magnetic susceptibility, and magnetic behaviors during stepwise demagnetization experiments suggest rather a three-fold classification: In this scheme, Hornblende granite and Biotite granite are grouped together, as they did not show any significant differences in magnetic characteristics. Based on the Ishihara (1979)'s criterion, Alkali-feldspar granite is classified as ilmenite-series granite, whereas others are classified as magnetite-series granite. In the eastern part of the study area including the Tertiary basin area, declinations of site-mean characteristic remanent magnetizations (ChRMs) show clockwise deflection of more than 30 from the reference direction of east Asia. Both along and in the adjacent region of the Ulsan fault-line, however, no deflection of remanent direction was observed. A boundary line between the deflected and undeflected site-mean ChRMs is defined in this study, which runs roughly parallel to the Ulsan fault-line at the distance of about 6km eastward from the fault-line. We suggest that this newly found boundary line, which we call Yonil tectonic line, released dextral simple shear stress acted in the southeastern part of the Korean peninsula during the opening stage of the East Sea in the Early Cenozoic.
포항이남 제3기분지암석의 자기 비등방성과 지구조적 응력장
김인수,Kim, In-Soo 대한자원환경지질학회 1990 자원환경지질 Vol.23 No.1
Magnetic anisotropy of a total of 213 independently oriented Tertiary rock samples from Pohang-Ulsan area has been studied. The sampled strata comprise basalts, tuffs and black shale, and range in age from Eocene to Miocene. The previous palaeomagnetic studies indicate that their magnetic carrier minerals are titanomagnetites. Among 23 sampled sites, 11 sites were found to preserve magnetic load foliation parallel to the bedding plane caused by the Iithostatic load of the overlying strata. Other 4 sites showed magnetic lineation indicating the flow direction of lava and tuffs. The remaining 8 sites revealed the magnetic tectonic foliation nearly vertical to the bedding plane. This magnetic foliation is interpreted to be generated by tectonic compression which acted nearly horizontally during the solidification stage of the strata. The compression directions deduced from the tectonic foliation of the 8 sites can be grouped into internally very consistent two group: a N-S trending one and the other WNW-ESE trending one. It is interpreted that the former N-S compression was associated with the N-S spreading of the East Sea(Sea of Japan) and the dextral strike-slip movement of the Yangsan-Ulsan fault system. The latter WNW-ESE compression is interpreted to represent the folding and reverse faulting activity in the Korean and Tsushima straits during middle/late Miocene times.
김인수,이현구,윤혜수,강희철,Kim, In-Soo,Lee, Hyun Koo,Yun, Hyesu,Kang, Hee-Cheol 대한자원환경지질학회 1993 자원환경지질 Vol.26 No.3
The Cretaceous Kyongsang Basin is known to be composed of several tectonic blocks (or subbasins) with each distinct stratigraphic succession. The study area represents a major part of one of these blocks, i. e. the $\check{U}is\check{o}ng$ block. The area is charaterized by a suite of WNW-trending sinistral strike-slip faults as well as a number of ring faults. A total of 292 independently oriented core samples were drilled from 23 sites, covering virtually all the formations of the Cretaceous $Ky\check{o}ngsang$ Supergroup. Alternating field and thermal demagnetization experiments were conducted to reveal the primary magnetization. Due to the homoclinal nature of the strata in the area, it was not possible to make use of the conventional fold test It is, however, believed that the primary remanent components have been obtained from the majority of the formations, considering the similarity of the palaeomagnetic pole positions with those of contemporary strata of other blocks and the existence of antiparallel reversed remanence. It was found neither any significant difference in magnetic declination on each side of the strike-slip faults nor systematic change of magnetic declination with distance from the fault-line. This does not support such a block rotation hypothesis associated with the strike-slip faulting in the area as alleged by some authors. The samples from the outcrops on or near the fault-lines were severely overprinted by the recent magnetic fields regardless of age and lithology. Epithermal Au-Ag-Cu-Pb-Zn mineralizations are known along some fault lines in the area. It is interpreted that these two facts are closely related with fluid circulations along the fracture zones caused by fault activities. In regard to the age of the strata as deduced from the magnetostratigraphic consideration, the $Ch\check{o}mgok$ formation and the lower strata should be older than Barremian or 124 Ma. The age of volcanics of the $Yuch^{\prime}\check{o}n$ Group sampled in this study should be younger than Campanian or 83 Ma.
경상분지 남서부 진교-사천 지역 전기백악기 퇴적암에 대한 고자기 연구
김인수,강희철,이현구,Kim, In-Soo,Kang, Hee-Cheol,Lee, Hyun Koo 대한자원환경지질학회 1993 자원환경지질 Vol.26 No.4
A total of 264 independently oriented core samples were collected from 26 sites in the southwestern part (the Naktong Trough) of the Cretaceous $Ky{\check{o}}ngsang$ Basin in south Korea. The sampled formations comprise the sedimentary Shindong and the Hayang Groups of the Lower Cretaceous age. Alternating field and thermal demagnetizations were conducted. Characteristic remanent magnetization (ChRM) was relatively easily isolated in each formation except in the Chinju formation, from which only remagnetization circles were observed. Even though an extensive use of the fold test was not possible due to the nearly homoclinal nature of the strata in the area, we believe that the ChRM of each formation is of primary origin based on the following grounds: The in-situ ChRM direction of each formation is different from the present geomagnetic field direction. Fisherian precision parameter becomes enhanced through the tilt correction in all formations, closely to the values required for a positive fold test. Three out of the five studied formations pass the reversal test. The mean palaeomagnetic pole position from the studied area is found to be statistically different from the contemporary pole from the Chinese block exclusive of the Shandong area. The difference in magnetic declination suggests a $14.5^{\circ}$ (${\pm}10.5^{\circ}$) clockwise rotation of the studied area relative to the Chinese block comprising the west of the Tan-Lu fault. On the other hand, any significant difference in magnetic inclination and concurrent palaeolatitude is not observed between the studied area and China as well as the other area (Taegu-Andong area) in the $Ky{\check{o}}ngsang$ Basin. The dual nature of the magnetic polarity confirmed in all formations suggests an older than 124 Ma (Neocomian or older) age of the studied sedimentary strata.
대두(大豆)(Glycine max)의 ${\gamma}-Conglycinin$의 정제(精製)와 특성(特性)에 관(關)하여
김인수,이춘영,Kim, In-Soo,Lee, Chun-Yung 한국응용생명화학회 1979 Applied Biological Chemistry (Appl Biol Chem) Vol.22 No.1
대두(大豆)의 ${\gamma}-conglycinin$을 정제(精製)하고 그의 물리일(物理一) 화학적(化學的) 성질(性質)을 연구(硏究)하여 다음의 결과(結果)를 얻었다. Gamma-conglycinin은 대두(大豆)의 pH 4.5, 0.2M Nacl 추출액을 Sephadex G-150으로 분리하여 얻은 7S globulin을 DEAE-Sephadex A-50으로 column chromatography하여 정제(精製)하였다. 정제된 ${\gamma}-conglycinin$은 면역전기영동(免疫電氣泳動), polyacrylamide gel 전기영동(電氣泳動)과 gel isoelectric focusing 상으로 순수(純粹)하였다. 등전점(等電點)은 pH 5.4이었으며 질소(窒素) 16.21%, mannose 4.18, glucosamine 1.21%의 함량(含量)이었다. 아미노산 조성(組成)은 일반적(一般的)으로 lysine, dicarboxylic acid와 암모니아태(態) 질소(窒素)의 함량(含量)이 높았고 함황(含黃)아미노산과 tryptophane의 함량(含量)은 낮은 편이었다. Subunit의 등전점(等電點)은 pH $4.5{\sim}5.5$에 분희(分希)하였는데 그중 pH $4.6{\sim}5.0$에 위치(位置)한 것은 분자량(分子量) 38,000의 당(糖) peptide이었으며 pH $5.0{\sim}5.5$의 것은 분자량(分子量) 32,000의 단순(單純) peptide이었다. The physical and chemical properties of ${\gamma}-conglycinin$ of soybean (Glycine max) were investigated. The soybean protein extracted from soybean meal using 0.2M NaCl solution at pH 4.5 was passed through a Sephadex G-150 column to isolate 7S globulin. ${\gamma}$-Conglycinin was isolated and purified from the 7S globulin with a DEAE Sephadex A-50 column chromatography. The protein preparation was pure on immunoelectrophoresis, polyacrylamide gel electrophoresis and gel isoelectric fouling. It had an isoelectric point at pH 5.4 and contained 16.12% nitrogen, 4.18% mannose and 1.21% glucosamine. Amino acid composition, in general, shaved that ${\gamma}-conglycinin$ contained higher contents of lysine, dicarboxylic acids and ammonia nitrogen, and lower contents of sulfur-containing amino acids and tryptophan. The subunits of ${\gamma}-conglycinin$ were distributed in the range of pH 4.6-5.5. The subunits located in the pH region of 4.6-5.0 and 5.0-5.5 were glycopeptides (molecular weight of 38,000) and simple peptide (MW of 32,000), respectively.