콜하스와 츄미의 라 빌레뜨 공원 계획안 비교 분석 - 드로잉에 나타난 점, 선, 면의 구성과 작동을 중심으로 -

김인성,Kim, In-Sung 한국건축역사학회 2011 건축역사연구 Vol.20 No.4

International Competition for Parc de la Villette has evoked the old architectural question that is about the conflict between unchanging architecture and ever changing time. Tschumi and Koolhaas suggested well-known solutions for it, both of which had started from the criticism of general urban design approach that ignored changing factors in time. However, this study argues that the approaches of Tschumi and Koolhaas are even opposite to each other in spite of their common aims. Influenced by deconstructivists' theories, Tschumi tries to generate the 'text' on the surface of la Villette so that the different users of the park can read it differently. The text is built by 'superimposing' different systems such as points, lines, and surfaces. This study criticizes such formalistic approach since such 'forms' do not generate any dialogue with the real users but just stay as a backdrop for irrelevant events. Meanwhile, Koolhaas concentrates on the 'ground-ness' of la Villette. What he deals with is the real ground which embraces all the potentials on it already. His 'bands' express nothing but the metamorphosis of the ground, and the ground generates the 'differences' out of itself by repeating itself ceaselessly. This study tries to clarify all those happenings and meanings by intimate investigation of various drawing works for the la Villette project by Tschumi and Koolhaas.

상자성 복합체의 분자량에 따른 T1 및 T2 자기이완시간에 관한 연구

김인성,이영주,김주현,김숙경,김태정,강덕식,장용민,Kim In-Sung,Lee Young-Ju,Kim Ju-Hyun,Sujit Dutta,Kim Suk-Kyung,Kim Tae-Jeong,Kang Duk-Sik,Chang Yong-Min 한국의학물리학회 2006 의학물리 Vol.17 No.2

상자성 복합체의 분자량에 따른 물분자의 T1 및 T2 자기이완 특성을 조사해 보고자 하였다. DMF (15 ml)와 DTPA-bis-anhydride (0.71 g, 2 mmol) 용액에 4-aminomethylcyclohexane carboxyilc acid를 넣어 리간드를 합성한 후 $Gd_2O_3$ (0.18g, 0.5 mmol)을 넣어 최종적인 Gd 착화물을 합성하였다. 상자성 복합체의 자기이완율을 측정하기 위해 상자성 복합체를 3차 증류수를 사용하여 1 mM로 희석시켰으며 1.5T(64 MHz)에서 자기이완 시간을 측정하였다. T1 자기이완시간을 측정하기 위하여 반전 회복(Inversion-recovery) 펄스열을 사용하였다. 반전 회복 펄스열의 경우 반전시간(Inversion time, T1)은 50 msec에서부터 최대 1,750 msec까지 총 35개의 반전시간에서 영상을 획득하였다. T2 자기이완시간은 CPMG(Carr-Purcell-Meiboon-Gill) 펄스열을 사용하였다. 자기이완 시간을 구하기 위해 각각의 샘플에 관심영역(region of Interest)을 설정하여 영상의 신호강도를 측정한 후 비선형 곡선 맞춤을 실행하여 T1 및 T2값을 얻어낸 후, 이를 통해서 R1 및 R2를 계산하였다. 분자량이 587 달톤인 Omniscan의 1.5T에서의 T1, T2값이($205.1{\pm}2.57$) msec, ($209.4{\pm}4.28$) msec 임에 비해 새로이 합성된 상자성 Gd 화합물의 경우 모두 T1, T2값이 T1의 경우 분자량에 따라 $(96.35{\pm}2.04)-(79.38{\pm}1.55)$ msec, T2의 경우 $(91.02{\pm}2.08)-(76.66{\pm}1.84)$ msec로 감소한 결과를 얻었다. 새로이 합성된 Gd 화합물 간에도 분자량에 따라 R1 및 R2값이 증가하는 경향을 나타내었다. 상자성 복합체의 분자량이 증가함에 따라 T1 및 T2 자기이완 시간이 단축되고 결과적으로 자기이완율 R1, R2가 분자량에 비례하여 증가하였다. To evaluate the T1, T2 magnetic relaxation properties of water molecule according to molecular weight of paramagnetic complex. 4-aminomethyicyclohexane carboxylic acid (0.63 g, 4 mmol) was mixed with the suspension solution of DMF (15 ml) and DTPA-bis-anhydride (0.71 g, 2 mmol) to synthesize the ligand. The ligand was then mixed with $Gd_2O_3$ (0.18 g, 0.5 mmol) to synthesize Gd-chelate. For the measurement of magnetic relaxivity of paramagnetic compounds, the compounds were diluted to 1 mM and then the relaxation times were measured at 1.57 (64 MHz). Inversion-recovery pulse sequence was employed for T1 relaxation measurement and CPMG (Carr-Purcell-Meiboon-Gill) pulse sequence was employed for T2 relaxation measurement. In case of inversion recovery sequence, total 35 images with different inversion time(T1)s ranging from 50 msec to 1,750 msec. To estimate the relaxation times, the signal intensity of each sample was measured using region of Interest (ROI) and then fitted by non-linear least square method to yield T1, T2 relaxation times and also R1 and R2. Compared to T1=($205.1{\pm}2.57$) msec and T2=($209.4{\pm}4.28$) msec of Omniscan (Gadodiamide), which is commercially available paramagnetic MR agent, T1 and T2 values of new paramagnetic complexes were reduced along with their molecular weight. That is, T1 value was ranged from $(96.35{\pm}2.04)\;to\;(79.38{\pm}1.55)$ msec and T2 value was ranged from $(91.02{\pm}2.08)\;to\;(76.66{\pm}1.84)$ msec. Among new paramagnetic complexes, there is a tendency that the R1 and R2 increase as the molecular weight is increases. As molecular weight of paramagnetic complex increases, T1 and T2 relaxation times reduce and thus the increase of relaxivity (R1 and R2) Is proportional to molecular weight.

갈대-상(床)을 이용한 쓰레기 매립지 침출수의 생물학적 연속흐름 처리

김인성,조용주,최홍근,이은주,Kim, In-Sung,Cho, Yong-Joo,Choi, Hong-Keun,Lee, Eun-Ju 한국생태학회 2004 Journal of Ecology and Environment Vol.27 No.6

본 연구는 수도권 매립지에서의 침출수 처리 방류수와 같은 특수한 수질 내에서 우수한 생장의 갈대(Phragmites australis)를 선별하여 침출수 처리 방류수의 자연정화 방법 및 처리 효율을 확인하기 위해 실시하였다. 침출수 처리 방류수에 대한 우수 갈대의 선발을 위해 13개의 갈대 서식지로부터 수집한 갈대를 침출수 처리 방류수에서 배양하며 영양염류 제거, 생태-생리학적인 반응 및 생장율 등을 조사하여 선별하였다. 본 실험에서는 침출수 처리 방류수 내에서 우수한 생장을 나타낸 갈대와 자연계에서 분리한 도우미 미생물(효모, 유산균 및 광합성 세균 등)을 조합한 갈대-상(床; reed-bed)에 침출수 처리 방류수를 연속적으로 공급하면서 체류 시간 및 식재 밀도 차이에 따른 침출수 처리 방류수의 수질 정화 효율을 확인하였다. 침출수 처리 방류수를 공급하며 약 5주 후에 갈대-상을 통과한 배출수 수질을 분석한 결과, 색도(chromaticity)는 약 $29.5{\sim}36.9\%$. 총질소(T-N)는 약 $49.4{\sim}67.2\%$, 총인(T-P)은 약 $42.1{\sim}94.6\%$, 생물화학적 산소요구량($BOD_5$)은 약 $74.5{\sim}88.8\%$, 화학적 산소요구량($COD_{Mn}$)은 약 $15.6{\sim}20.8\%$, 총 고형물질(TDS)은 약 $17.5{\sim}35.4\%$ 그리고 염도(salinity)는 약 $15.3{\sim}34.7\%$ 등으로 감소되었다. 또한 체류시간은 생물화학적 산소요구량을 감소시키고 질소 및 인의 제거에 영향을 주었고 식재밀도는 인의 제거에 영향을 주었다. 이러한 결과로 갈대-상을 통해 처리된 생물학적 처리 배출수의 수질이 침출수 처리 방류수의 수질에 비해 향상되었음을 확인하였다. We investigate the biological treatment of processed-leachate from SUDOKWON landfill site in Korea by the reed (Phragmites australis)-bed with a continuous flow system. The reed individuals showing superior growth in processed-leachate experiment were selected among the reeds of thirteen natural habitats by means of the comparisons between the removal rates of nutrient salts, eco-physiological responses and growth. The reed-beds (combination of the reed individuals showing superior growth with helper microorganisms) were continuously supplied with processed-leachate. We monitored the effluents that passing through the reed-beds during the experiment period. After five weeks, analysis results of effluent from each reed-bed were as follows; chromaticity, total nitrogen, total phosphorus, biological oxygen demand, chemical oxygen demand, total dissolved solid and salinity decreased $29.5{\sim}36.9\%,\;49.4{\sim}67.2\%,\;42.1{\sim}94.6\%,\;74.5{\sim}88.8\%,\;15.6{\sim}20.8\%,\;17.5{\sim}35.4\%\;and\;15.3{\sim}34.7\%$, respectively. These results represented the substantial improvement of water-quality after passing through reed-bed in a continuous flow system.

근무력증과 왜소증을 동반한 Bartter syndrome 1례

김인성,강주형,신윤혜,이동국,김순남,배기수,Kim In-Sung,Kang Ju-Hyung,Shin Yun-Hei,Lee Dong-Kuk,Kim Soon-Nam,Pai Ki-Soo 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

저자들은 본원 소아과에 입원한 9년 3개월된 남아에서 만성병색소견, 심한 근무력증, 왜소증, 저칼륨성 대사성 알칼리혈증 및 신석회증과 좌측 요관의 확장을 보이는 영아기 이후 발병한 Bartter 증후군 1례를 경험하였기에 치료반응 및 임상경과를 문헌 고찰과 함께 보고하는 바이다. Bartter syndrome is a rare disorder characterized by the association of hypokalemic hypochloremic metabolic alkalosis, hyperreninemia, hyperaldosteronemia, short stature and nephrocalcinosis. This disorder presents with hyperplasia of juxtaglomerular apparatus on renal biopsy. We experienced a case of late-onset Bartter syndrome with nephrocalcinosis in a 9-year-old boy, whose chief pictures were muscle weakness, short stature, persistent sterile pyuria and microscopic hematuria. We report this case with a brief review of related literatures.

경기도 대부도 모래해변에 잔류하는 미세플라스틱의 계절별 분포특성

김인성 ( In Sung Kim ),김승규 ( Seung Kyu Kim ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.4

Seasonal variation in the abundance and distribution of microplastics (MPs) in beach sediments was investigated for the Daebu island, Gyeonggi-do, South Korea. Beach surface sediments were sampled at five stations along the high strandline of the island beach in July and November 2013 and March 2014 to represent the summer, winter, and spring seasons, respectively. Six sizes ranging from 0.3 to 5 mm were classified and seven types of polymers were determined using FT-IR. The abundances of microplastics were 8,776-891,844 particles/ m2 in summer, 4,628-17,724 particles/m2 in winter, and 13,784-100,196 particles/m2 in spring with a predominant contribution of expanded polystyrene (EPS) of >95% in all seasons. Distinct seasonal differences were exhibited in the MPs abundance (i.e., 6-26 times higher in summer) and spatial distribution pattern (i.e., higher at northern stations in summer with southerly winds but southern stations in winter with northerly winds). On the other hand, similarities in size distribution as well as polymer composition were observed among seasons and stations. Particularly, there were good correlations between EPS of fishery-activity origin and non-EPS of inland origin. In conclusion, well-mixed currents seem to cause spatial and temporal homogeneity in size and polymer distribution, while different wind directions with seasons were likely to generate differences in the MPs abundance with time and space in the beach. However, whether the distribution characteristics of MPs on the beach sediments were determined by the direct reflection of those in flooding seawaters or by the redistribution of deposited MPs is unclear. Further study is required to identify the major mechanism.

아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과

김인성(In Sung Kim),김성학(Sung Hak Kim),김정아(Jeong A Kim),유다윤(Da Yoon Yu),김광일(Gwang Il Kim),박동찬(Dong-Chan Park),임종민(Jong Min Lim),이상석(Sang Suk Lee),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.1

본 연구에서는 아토피 피부염 동물 모델에 대한 β-1,3/1,6-glucan과 L. plantarum LM1004의 면역조절 효과를 확인하고자 하였다. 가려움증의 횟수와 유출된 evans blue, 그리고 혈청 IgE와 histamine의 농도는 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹에서 아토피 피부염 유발그룹에 비해 유의적으로 감소하는 결과를 나타내었다. 아토피 피부염이 유발되면 전사 수준에서 Th2 및 Th17 세포의 전사인자 및 cytokine은 과발현되며, β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취하였을 때 이를 유의적으로 감소되었다. 또한 β-1,3/1,6-glucan과 L. plantarum LM1004는 Th1 및 Treg 세포의 전사인자(T-bet, GATA-3, RORγT, Foxp3) 및 cytokine (INF-γ, IL-4, IL-17, TGF-β)의 발현을 증가시킴으로써 면역 균형을 조절하는 것으로 나타났다. Galectin-9과 filaggrin은 아토피 피부염 유발 처리군에서 유의적으로 가장 낮았으며, β-1,3/1,6-glucan 처리군에서 유의적으로 가장 높게 나타났다. 이와 반대로 TSLP는 아토피 피부염 유발그룹에서 유의적으로 가장 높았으며 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹은 대조군과 유사한 수준이었다. 이러한 결과를 통해 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염 동물 모델에서 면역조절 작용 및 아토피 피부염의 개선 효과를 가짐을 알 수 있었다. 따라서 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염에 유용한 천연소재로서 사용될 것으로 기대된다. In this study, we examined the efficacy of the immune regulation of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of β-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis–induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor γ T [RORγT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of β-1,3/1,6-glucan and L. plantarum LM1004. In addition, β-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-γ [IFN-γ], transforming growth factor-β [TGF-β]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis–induced group and significantly higher in the β-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis–induced group, while mice that were orally administered β-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that β-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that β-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.

고마리 내에서 Cu 의 흡수량과 Phytochelatin 의 관계

강경홍,김인성 ( Kyung Hong Kang,In Sung Kim ) 한국환경생물학회 1997 환경생물 : 환경생물학회지 Vol.15 No.2

When Persicaria thunbergii was treated with Cu(NO_3)_2 of 5mM and 10 mM for 48hr in laboratory, the biolmagnification of copper in the leaf and root of plants and the rate of increase of phytochelatin were examined. The concentration of Cu in the root was greater than in the leaf and the Cu concentration in Cu(NO_3)_2 treated plants was higher than in Cu(NO_3)_2 5mM treated plants as follows; in the case of Cu 5mM treated plants, the leaf was 5.04㎍/g and the root was 11.25㎍/g and in 10 mM treated plants, the leaf was 6.96㎍/g and the root was 13.91㎍/g. But, in the extract of the soluble protein of the leaf and root tissue of plants with extraction buffer (20mM Tris-HCl, pH 8.0 and 10mM β-mercaptoethanol), the contcentration of Cu in the leaf was higher than in the root of plants. The phytochelatin (Cu-binding protein) was isolated from the tissue of leaf and root and chromatographed on the gel filtration resin Sephadex G100. The rate of increase of Cu-binding protein increased with increasing heavy-metal addition in nutrient solution as follows: Compared with that of the control, in the case of leaf, Cu 5mM treated extract was 202% and 10 mM treated extract was 222% and in root, Cu 5mM treated extract was 120% and 10 mM treated extract was 182%. And, it had a high UV absorption at 254 ㎚ and a low absorption at 280㎚.

하천유역의 관속식물에 의한 중금속의 생물학적농축 및 중금속 오염도 평가에 관한 연구 3. 고마리 ( Persicaria thunbergii ) 에 의한 서식처 토양의 Pb , Cu 및 Zn 의 제거

박기남,강경홍,김인성 ( Ki Nam Park,Kyung Hong Kang,In Sung Kim ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.2

The biological magnification and the uptake patterns of lead, copper and zinc in Persicaria thunbergii naturally grown at the areas of the rivers were investigated. The biological magnification values of lead, copper and zinc in the plant were 82.4∼254.6㎍g^1, 284.6∼688.4㎍g^1 and 635.5∼1979.4㎍g^1 individually. The tendency of the biological magnification in the each organ of the plant was as follows : Pb an Zn were increased of stem<leaf<root but Cu was leaf<stem<root. The amount of heavy metals in the plant were in the order of Pb<Cu<Zn. The magnification force of heavy metals in the plant were 13.2 times in Pb, 73.2 times in Cu and 58.7 times in Zn to compare with the content of heavy metals in the habitat soil and have a tendency to follow the content of those in the habitat soil but not proportional. In the mixture medium applied heavy metals, Cu induced the Zn depiciency in the plant. Concludly, the P. thunbergii was the excellent plant which removed the heavy metals from the soil and water of the habitat.

간헐적 운동부하에서 흑마늘과 생약재의 복합처방이 흰쥐의 체내 지질 성분 및 항산화에 미치는 영향

이수정(Soo Jung Lee),김인성(In Sung Kim),이혜진(Hye Jin Lee),오수정(Soo Jeong Oh),신정혜(Jung Hye Shin),김정균(Jeong Gyun Kim),성낙주(Nak Ju Sung) 한국생명과학회 2013 생명과학회지 Vol.23 No.12

항산화 활성과 피로회복 기능성이 강화된 흑마늘 함유 음료를 개발하기 위하여 5% 흑마늘 추출물과 1%의 생약재 5종 혼합추출물(상황버섯, 황금, 단삼, 뽕잎, 작약)을 70:30(v/v)의 비로 혼합한 흑마늘 복합물(BHF)을 제조하였다. 흑마늘 복합물은 성인의 1일 섭취량을 고려하여 1일 100 ml 섭취 시(BHF1)와 300 ml 섭취 시(BHF2)를 기준으로 실험쥐의 식이에 5주간 혼합 급이하면서 간헐적 강제운동에 따른 체내 지질 성분 및 항산화 효소 활성을 분석하였다. 흑마늘 복합물의 총 페놀화합물 함량은 BHF2가 BHF1에 비해 유의적으로 높았으며, 항산화 활성은 총 페놀 함량에 의존적이었다. 혈중 총 단백질 함량은 운동대조군과 흑마늘 복합물 급이군 간에 유의차가 없었으나, 알부민 함량은 Ex-BHF2군이 유의적으로 높았다. AST 및 ALT 활성은 흑마늘 복합물 급이군이 운동대조군에 비해 유의적으로 감소되었다. 혈청 중성지방, 총 콜레스테롤, LDL-콜레스테롤 및 HTR 수준은 Ex-BHF2군에서 운동대조군에 비해 유의적으로 감소되었다. 간 조직의 총 지질 함량은 흑마늘 복합물 급이군과 운동 대조군간에 유의차가 없었다. 반면에 중성지방과 총 콜레스테롤 함량은 Ex-BHF2군이 타 실험군에 비해 유의적으로 낮았다. 흑마늘 복합물 급이에 따른 간 조직에서 catalase 활성은 Ex-BHF2군만 유의적으로 증가하였으나, SOD와 GSH-px 활성은 흑마늘 복합물의 농도가 많아짐에 따라 유의적으로 증가되었다. 간헐적인 강제운동을 한 흰쥐에서 흑마늘과 생약재 복합물의 급이는 체내 중성지방과 콜레스테롤 함량을 낮추고, 항산화 효소 활성을 증가시킴으로써 산화적 스트레스에 대한 생체 보호가 가능할 것으로 판단된다. To improve the functionality of black garlic drinks, black garlic extract (5%) and five herb extracts (1%) were mixed in 70:30 (v/v) ratios as BHF1, and BHF2 was prepared using a 3X concentration of BHF1. After the black garlic and herb formulas (BHFs) were administered over the course of five weeks in rats by interval running training, the lipid profiles and the antioxidant enzyme activities were tested. The total phenolic content of the BHFs were significantly higher in BHF2 than they were in BHF1, and their antioxidant activities were dependent upon the total phenolic content. No significant difference was found in the total serum protein levels among the rats in the Ex-con group by interval running training and the rats in the BHFs-fed groups. However, the albumin level was significantly higher in the Ex-BHF2 to Ex-con group. AST and ALT activities significantly decreased in the BHFs-fed groups compared to the Ex-con group. In terms of changes in the serum lipid profiles, no significant difference was found between the specimens that underwent interval running training and those that did not undergo interval running training. Triglyceride levels, total cholesterol, LDL-C, and HTR levels in the serum were significantly decreased in the Ex-BHF2 to Ex-con group. No significant difference was found in the total lipid levels in the livers of the BHFs-fed groups and the Ex-con group. The triglyceride levels and total cholesterol levels in the Ex-BHF2 group were significantly lower compared to another group. Hepatic catalase activity was significantly increased in the Ex-BHF2 group, but SOD and GSH-px activities were significantly increased as the concentration of the BHF . The antioxidant enzyme activities by supplementation of BHFs increased; thus, three intakes of BHF each day could improve antioxidant status against different types of oxidative stress.

치매에서 산화 스트레스의 혈액지표

전진숙(Jin Sook Cheon),정흥채(Heung Chae Chung),김인성(In Sung Kim),오병훈(Byoung Hoon Oh) 대한노인정신의학회 2003 노인정신의학 Vol.7 No.1

Objectives:To identify changes in blood markers of oxidative stress among dementic and healthy aged persons, and to compare levels of peripheral markers of oxidative stress between dementia of the Alzheimer's type (DAT) and vascular dementia (VD), and finally to analyze factors affecting those. Design:Some antioxidants had been known to reduce the risk of dementia, while increase of 4-hydroxy-nonenal and decrease of heme oxygenase in DAT had been reported. Recently increased free radical activities were also found in VD. Therefore, this study was tried to search for a blood markers to discriminate DAT and VD. Materials and Methods:The blood levels of total antioxidant capacity (TAC) and catalase activity of 50 patients with DAT and 50 patients with VD were compared with those of 56 healthy aged controls. In addition, variables including risk factors of dementia, degree of dementia measured by MMSE, Hasegawa Dementia Scale, GDS and CDR, and activities of daily living were also assessed. Results:1) The levels of TAC were significantly (p<0.01) lower in dementia than normal aged controls (1.47±0.08 mmol/L), while the catalase activities were significantly (p<0.01) higher in dementia than normal aged controls (45.61±11.67 kU/L). 2) The TAC levels were significantly (p<0.01) lower while the catalase significantly (p<0.01) higher in DAT (1.24±0.09 mmol/L, 133.42±58.45 kU/L respectively) than VD (1.31±0.08mmol/L, 81.33±24.65 kU/L respectively). 3) The TAC and catalase activities were significantly (p<0.01) correlated with duration of dementia, behavior symptoms, activities of daily living, and the severity of dementia. Conclusions:Peripheral blood markers of oxidative stress were significantly different in dementia from normal aged controls. Furthermore, the difference was more severe in DAT than VD, which means the effect of oxidative stress is more in DAT than in VD. Therefore, they might be clinically useful to assess and discriminate dementia.