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임상연구 : 서혜부 탈장 환아에서 Sevoflurane 마취 후 각성 흥분: Thiopental Sodium, Propofol과 Ketamine 마취 유도의 비교
김욱종 ( Wook Jong Kim ),길현주 ( Hyun Jue Gill ),김용찬 ( Yong Chan Kim ),이종연 ( Jong Youn Lee ),정금희 ( Kum Hee Chung ),이상우 ( Sang Woo Lee ),손석우 ( Suk Woo Son ),신용섭 ( Yong Sup Shin ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.6
Background: This study compared the incidence of emergence agitation and the recovery profile from sevoflurane anesthesia after thiopental sodium, propofol or ketamine induction in pediatric inguinal herniorrhaphy. Methods: Forty eight children aged 1-7 years undergoing high ligation due to an inguinal hernia were examined. All patients received a 0.004 mg/kg glycopyrrolate injection for premedication prior to induction and were randomly assigned to receive thiopental sodium 5 mg/kg (Group T, n = 16), propofol 2 mg/kg (Group P, n = 16) or ketamine 1 mg/kg (Group K, n = 16) for induction. The side effects during the induction time were checked. All patients received sevoflurane (2-2.5 vol%)-N2O (2 L/min)-O2 (2 L/min) for the maintenance of anesthesia. Ventilation was given to assist spontaneous ventilation using a facial mask. The agitation score, pain score, discharge score, incidence of emergence agitation and postoperative side effects in the three groups were assessed at the recovery room and compared. Results: The emergence time in Group T (7.5 ± 1.8 min) was significantly rapid. The agitation and pain scores were significantly low in Group P. The discharge score was more rapid in Groups P and K than in Group T. The incidence of emergence agitation was similar in all three groups. Conclusions: Although recovery was faster and emergence agitation was low in the propofol group, propofol induction was not smooth compared with thiopental or ketamine induction. The incidence of emergence agitation after sevoflurane anesthesia in pediatric inguinal herniorrhaphy was similar in the thiopental sodium, propofol or ketamine induction groups. (Korean J Anesthesiol 2006; 50: 616~22)