마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과

김용준,이정치,김홍용,설광화,윤용갑,장선일,Kim Young Jun,Lee Jeong Chi,Kim Hong Yong,Xie Guanghua,Yun Yong Gab,Jang Seon Il 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3

In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6, IL-10 and $IFN-\gamma$ on DNFB-induced Th1 and Th2 cytokines in a concentration-dependent manner. Interestingly, this compound increased the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner The above results reveal that wogonin possesses anti-inflammatory, humoral and cellular immunomodulatory, and stress reducing activities on the DNFB-induced DTH in mice and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.

디지털 임플란트 시스템을 전용한 "All-on-4" 개념의 임플란트 보철 증례

김용준,정승미,김경희,방정환,김대환,최병호,Kim, Yong-Jun,Jeong, Seung-Mi,Kim, Kyeong-Hee,Fang, Jeong-Whan,Kim, Dae-Hwan,Choi, Byung-Ho 대한치과보철학회 2018 대한치과보철학회지 Vol.56 No.1

최근 치과치료의 영역에서 디지털 임플란트 시스템은 그 영역을 넓혀 나가고 있다. 디지털 장비들의 기술적 발전에 힘입어 한계점들이 하나 둘씩 극복되었다. 초기 단일치아 수복 정도에나 사용되었던 디지털 임플란트 시스템은 임플란트 수술에서부터 보철물 제작까지 무치악의 영역에서도 사용되고 있다. 본 증례에서는 50세의 하악 무치악 환자가 임플란트를 이용한 교합 재건을 원하였다. 하악의 임플란트 수복을 위해서 "All-on-4" 개념의 디지털 임플란트 시스템 사용을 계획하였고, 무절개 수술을 위한 가이드 장치를 제작하여 수술을 시행하였다. 수술 후, 전악 보철을 디지털 장비를 이용하여 제작하였다. 전체 치료 과정에서 기존의 아날로그 방식(인상채득, 납형 제작, 주조 등)을 가능한 배제하고 디지털 시스템을 이용하여 기공과정 및 임상과정을 최소화하기로 계획하였고 만족할만한 결과를 얻었기에 보고하는 바이다. Recently, digital implant systems are expanding its influence in dental area. Due to technical improvement, they jumped over their limits nowadays. We can use these newest systems to treat edentulous patient, from implant surgery to fabrication of prosthesis. In this case, The patient was a fifty years old female. She had a full edentulous ridge on mandible and wanted to reconstruct occlusion with using implants. We planned to use digital implant system with "all-on-4" concept on mandible and produced surgical guide for flapless implant surgery. After the surgery, we tried to fabricate full arch prosthesis just using a digital devices and confirmed satisfying result.

$CD4^+$ Jurkat T 세포주에서 Th1과 Th2 사이토가인 조절에 미치는 황금 유래 Baicalin, Baicalein 및 Wogonin의 효과

김용준,이정치,김홍용,설광화,윤용갑,장선일,Kim Young Jun,Lee Jeong Chi,Kim Hong Yong,Xie Guanghua,Yun Yong Gab,Jang Seon Il 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3

In the present study, baicalin, baicalein, and wogonin, a major flavone isolated from Scutellaria Radix were examined for their effects on PMA-induced Interlukin-6 (IL-6), $interferon-\gamma(IFN-\gamma)$, tumor necrosis factor $(TNF)-\alpha$, IL-4, IL-10, and IL-13 productions in the PMA-stimulated $CD4^+$ Jurkat T cells. These three compounds inhibited PMA-induced Th1 cytokine $(IL-6,\;IFN-\gamma,\;TNF-\alpha)$ and Th2 cytokine (IL-4 and IL-13) productions in a concentration-dependent manner. But wogonin, but not baicalin baicalein, increased PMA-induced IL-10 production. These results suggest that baicalin, baicalein, and wogonin, a major flavone modulate Th1 and Th2 cytokine productions in $CD4^+$ Jurkat T cells and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.

옥천지향사대(沃川地向斜帶) 동남대(東南帶)에서의 화성활동(火成活動)(I): 남원(南原)-거창(居昌)-상주(尙州) 지역(地域)을 중심(中心)으로

김용준,박영석,주승환,오민수,Kim, Yong Jun,Park, Yong Seog,Choo, Seung Hwan,Oh, Mihn Soo 대한자원환경지질학회 1989 자원환경지질 Vol.22 No.4

Igneous rocks of study area consist of Pre-Cambrian orthogneiss, Devonian granite, Triassic foliated granites and Jurassic granites distributed along the southeast margin of Ogcheon Geosynclinal belt(SE-zone), and irregular shaped granitic stocks in the central part of the belt(C-zone). Anorthosite and gaabbro are also present in southern part of the SE-zone in the belt and intruded into gneiss complex of Ryongnam massif. Distribuition of foliated granites shows three linear arrangements which are composed of hornblende-biotite foliated granodiorite, porphyritic foliated granodiorite, biotite foliated granodiorite, leuco foliated granite and two mica foliated granite. Foliated granites generated by dextral strike slip movement at deep level. Jurassic granites composed of several rock facies are considered to be formed by differentiation of magma during Daebo Orogeny. A general trend of the chemical composition of these igneous rocks in study area suggests that most of them corresponding to calc-alkaline rock series was affected under orogeny and I-type granite except for two mica foliated granite. In chondrite normalised REE pattern of these igneous rocks, LREE shows more variable range and strong (-)Eu anomaly than HREE. Geochronological episodes of igneous activity from early Proterozoic to Cretaceous in SE-zone of Ogcheon Geosynclinal belt are two more Pre-Cambrian Orogeny, Devonian Orogeny(Variscan), Songrim Disturbance, Daebo Orogeny and Bulkuksa Disturbance.

유학정신

김용준,Kim, Yong-Jun 한국대학교육협의회 1993 大學敎育 Vol.61 No.-

영남육괴(嶺南陸塊)에 분포(分布)하는 고기화강암질암(古期花崗巖質岩)의 지질연대(地質年代)와 성인(成因)에 대(對)한 연구(硏究)

김용준,Kim, Yong Jun 대한자원환경지질학회 1986 자원환경지질 Vol.19 No.no.spc

The older granitic rocks of the study area are composed of mainly orthogneiss and foliated granite. These rocks shows mostly mortar or fiaser structure by strong mylonitization and thermal metamorphism during several orogenies. $^{40}Ar-^{39}Ar$ incremental·release ages of these rocks have been determined for 6 hornblende. 7 muscovite and 4 biotite concentrates separated from rocks collected across the Ryeongnam massif. Most $^{40}Ar-^{39}Ar$ age are discordant with Rb-Sr whole rock age of the same area. These ages range from 1998 to 172Ma. This discordant age is interpreted to indicate that samples were in contact with Daebo granite body that was characterized by large and variable $^{40}Ar-^{39}Ar$ ratios. Such ratios most likely resulted from widespread diffusion of the argon liberated from older granitic rocks during several metamorphic overprint. The general trend of the chemical composition of these rocks suggest that most of them are some series of differentiated products by fractional crystallization.

운봉(雲峰)-아영(阿英) 지역(地域)에서 나타나는 압쇄상화강암(壓碎狀花崗岩)에 대(對)한 암석기재학적(岩石記載學的) 연구(硏究)

김용준,김정빈,Kim, Yong Jun,Kim, Jeong Bin,Dallmeyer, R.D. 대한자원환경지질학회 1987 자원환경지질 Vol.20 No.2

The characteristic features of mylonitic granite in the Unbong-Ayoung area is as follow; (1) Mylonitic granite is a shearing product from porphyritic granite of Namweon Granites. (2) This rock megascopically shows foliated texture, and their modal compositions according to classification of dynamically metamorphosed rock are correspond to blastomylonite. (3) This rock generated by dextral strike slip movement at deep level. (4) The geochronological data of hornblendes from this rock undertaken by $^{40}Ar/^{89}Ar$ method are 191Ma to 195Ma. (5) The geochronological data of this rock suggests that Namweon Granites might be a product of intrusion and crystallization at the late Triassic or the Jurassic.

삼척지역(三陟地域)에 분포(分布)하는 우백질화강암류(優白質花崗巖類)의 Rb/Sr 연령(年齡)에 관(關)한 연구(硏究)

김용준,주승환,조등룡,Kim, Yong Jun,Joo, Seung Hwan,Jo, Deung Ryong 대한자원환경지질학회 1984 자원환경지질 Vol.17 No.4

The purpose of this study is to clarify geological age of leucogranitic rocks in the Samcheog area. Petrographical and geochronological features of leucogranitic rock are as follows; (1) These rocks in the area can be classified into two rock types: Moogho leucogranite gneiss and Yimwon leucogranite. (2) These rocks intruded into Precambrian metasediments and are overlain by Paleozoic sedimentary rocks. (3) These rocks are distinctly showing slight foliation and containing garnet and sillimanite which produced by assimilation and contamination. (4) Rb/Sr whole rock age of these rocks indicates an isochron of $2088{\pm}8.5$ m.y. with the initial $^{87}Sr/^{86}Sr$ ratio of $0.7108{\pm}0.0007$.

제천(提川) 화강암체(花崗岩體)에 대(對)한 암석학적(岩石學的) 연구(硏究)

김용준,Kim, Yong Jun 대한자원환경지질학회 1979 자원환경지질 Vol.12 No.3

The Jecheon granite mass has turtle-shape exposure of about $190km^2$ at vicinity of Jecheon-eup, and is elongated in the direction of NEE-SWW. It discordantly intrudes the Bakdalryong metamorphic rocks and the great limestone series(Samtaesan and Hungwolri formation) which belong to the pre-Cambrian and Ordovician, respectively. The mass is composed of five facies of different grain size; texture and charecteristic minerals. The five facies are (1) coarse grained biotite granodiorite, (2) fine grained hornblende biotite granodiorite, (3) coarse grained pink feldspar granodiorite (4) leucogranite, and (5) porphyritic biotite granite. The mutual relationship between each facies is intrusion in (1)-(2) and (2)-(3), but unknown in (3)-(4) and (4)-(5). 22 modal analyses and and 10 chemical analyses on more than a hundred of representative samples taken from the mass are listed as tables. Triangular plot of modal and normative Q-Kf-Pl of this mass show a continuous differentiation products from certain common magma by change of chemical composition and anorthite contents in plagioclase. The metamorphic facies of contact aureole in surrounding rocks adjacent to the granite body are corresponded to hornblende hornfels facies with mineral assemblages of wollastonite-diopside-calcite in calcareous rocks, and of quartz-biotite-muscovite-cordierite in argillaceous rocks. Variation of silica versus oxides of major elements shows that the mass is similar to the trend of Daly's average basalt-andesite-dacite-rhyolite which shows the trend of the fractional crystallization of magma, and is equivalent to the calc-alkali rock series by Peacock. AMF diagram shows that Jecheon granite mass is equivalent to normal diffentiation products such as skaergaard intrusion. The above evidences suggest that the Jecohon granite mass is normal differentiation products formed by fractional crystallization under relatively slow cooling condition.

강화도(江華島) 동남부(東南部)에 분포(分布)하는 소위(所謂) 강화섬장암질암(江華閃長岩質岩)에 대(對)하여

김용준,오민수,Kim, Yong-Jun,OH, Mihn-Soo 대한자원환경지질학회 1978 자원환경지질 Vol.11 No.2

The study focused on the petrology and petrochemistry of the so called "Ganghwa syenitic rocks" which intruded into metasediment of basement in southeastern part of Ganghwa Island. The geologic sequence of the mapped area was shown in table 1, 10 model analyses and 7 chemical analyses on the rock samples taken from the Ganghwa syenitic rocks and Manisan granite have been used to discuss the nomenclature of the rocks and petrological relationship between rock types. The petrograpical and petrochemical features based on, the analyses are as follows: 1) Ganghwa syenitic rocks consist of Ganghwa alkali syenite and Ganghwa diorite porphyry which based on the classification of the subcommision on systematics of igneous of IGUS. Ganghwa diorite porphyry which occured as dike forms are intruded into Ganghwa alkali syenite. The rock forming minerals of Ganghwa alkali syenite are composed of perthite, plagioclase, quartz, hornblend and chlorite in major, and zircon, apatite, sericite and magnetite in minor. Ganghwa diorite porphyries consist of plagioclase, biotite, hornblend, orthoclase and chlorite, with, porphyritic texture. 2) In silica-oxides variation (Fig. 2) and AMF diagram (Fig_ 3), the Ganghwa alkali syenite is similar to the trend of Daly's average basalt-andesite-dacite-rhyolite than Skaergaard which shows the trend of the fractional crystallization of magma, and equivalent to the alkali rock series by Peacock. 3) The general trend of data points shift to plagioclase, and are superimposed on the alkali rich terminal part of the granodiorite province of SW Finland in normative Q-Kf-Pl(Fig. 4) and Or-Ab-An diagram respectively. The above-mentioned evidences suggested that the Ganghwa syenitic rocks are the differential products resulted by assimilation of intermediated magma and metasedment rock under relatively rapid cooling condition.