http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
난소의 난황낭종양을 가진 환자에서 bleomycin, etoposide 및 cisplatin의 병합 항암화학요법 후 결과 분석
김지영 ( Ji Young Kim ),신유정 ( Yu Jung Shin ),문제원 ( Jei Won Moon ),박정열 ( Jeong Yeol Park ),김대연 ( Dae Yeon Kim ),이주학 ( Joo Hak Lee ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),남주현 ( 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.11
목적: 난소의 난황낭종양에서 시행하는 bleomycin, etopside, cisplatin (BEP)의 항암화학요법 후의 치료 결과 및 부작용에 대해 연구하고자 한다. 연구 방법: 1994년 10월부터 2008년 12월까지 서울아산병원에 내원하여 난소의 난황낭종양으로 진단받고 BEP 병합화학요법을 시행한 43명의 환자를 대상으로 의무기록을 후향적으로 분석하였다. 결과: 전체 43명 중 39명(90.7%)이 완전관해를 보였다. 1명(2.3%)이 부분관해를 보였고 3명이 암의 진행을 보였다. 43명의 환자들이 총 179 주기의 BEP 병합 항암화학 요법을 받았다. 혈액학적 독성 중 호중구 감소증은 21명의 환자에서 총 46주기에서 나타났으며, 빈혈은 40명의 환자에서 총 138주기에서 나타났다. 혈소판 감소증은 6명의 환자에서 총 8주기에서 나타났다. 간독성은 16명의 환자에서 총 27주기, 호흡기 독성은 1주기, 신독성은 보이지 않았다. 근치적 수술을 받은 환자 8명과 사망환자 4명을 제외한 31명의 환자 중에서 규칙적 생리를 보이는 환자는 29명(93.5%)이고, 불규칙 생리를 보이는 환자는 1명(3.2%)이었다. 치료 후 임신을 시도한 경우는 5명이며 임신을 한 경우는 3명이고, 이 중 2명은 정상만삭 질식분만, 1명은 현재 임신 중이다. 결론: BEP 항암화학요법은 난소의 난황낭종양을 가진 환자들에서 매우 효과적이며 안전한 치료이고, 치료 후 월경 및 생식기능은 대부분의 환자에서 보존되었고, 임신결과 또한 좋은 것으로 생각된다. Objective: The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery. Methods: Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed. Results: The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy. Conclusion: BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy.
자궁경부 편평상피암에서 in vitro , ex vivo 및 in vivo 수소 핵 자기공명분광상의 특성 분석
김상태 ( Sang Tae Kim ),이동헌 ( Dong Heon Lee ),남주현 ( Joo Hyun Nam ),이정희 ( Jung Hee Lee ),김용만 ( Yong Man Kim ),김종혁 ( Jong Hyeok Kim ),목정은 ( Jung Eun Mok ),김영탁 ( Young Tak Kim ),조경식 ( Kyoung Sik Cho ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: To evaluate the potential value of in vitro, ex vivo, and localized in vivo 'H Magnetic resonance spectroscopy(MRS) for detecting and characterizing squamous cell carcinoma of uterine cervix. Materials and Methods: Eleven cases of squamous cell carcinoma and 6 cases of normal cervical tissue underwent in vitro and ex vivo 'H MRS. In vitro analysis was carried out after processing the specimen with dual phase extraction method. In ex vivo test, at least 500 p 1 of tissue specimen was directly analyzed by 100.14 MHz NMR spectrometer (Bruker 11.7T AMX, Germany) without any processing procedure. In addition, 29 patients with squamous cell carcinoma of uterine cervix and 6 normal women were examined by in vivo 'H MRS. Localized in vivo 'H MR spectra of the human uterine cervix were obtained using PRESS sequence with homebuilt endovaginal surface coil. Surface coil T2 weighted images were used as the localizer images where voxel (1-3 mm3) was located to contain the cancer area only. The following spectral acquisition parameters were used: SW=2500 Hz, SI=2048, TR=3.0 sec, TE=20/135 msec, NEX=2, and NS=36. HO signal suppressed down to 96-99% by 3-pulse CHESS technique. The spectra were processed with 0.5 Hz of exponential line broadening, zerofilling of 8K followed by linear phasing. Results: The intense resonance signal at 0.9 ppm and 1.3 ppm by lipid component of triglyceride was visible in all cases (11/11) of squamous cell cancer of cervix both in vitro and ex vivo test. But in 6 normal cervical tissues, such peaks were not detected at all. The in vivo spectrum of the cervical cancer was comparable with that in in vitro and ex vivo spectrum. In the in vivo spectra of the cervical cancer, the resonance peaks at 0.9 ppm, 1.3 ppm, 3.0 ppm, and 3.2 ppm from CH3 and CH2 groups of neutral mobile lipid (triglyceride), creatine, and choline containing residues respectively, were consistent with results reported earlier. The resonance peak at 1.3 ppm which is from acyl chains of triglyceride was characteristically intense and seen in 25 of 29 cancer patients. But triglyceride peak at 1.3 ppm was not detected in normal cervix (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). Conclusion: The study shows that H MRS can effectively discriminate squamous cell cancer from normal cervix in most cases. It also demonstrates the feasibility of localized in vivo 'H MRS technique as a new diagnostic modality in the detection of squamous carcinoma of uterine cervix.
난소의 악성 배세포종양에서 림프절 절제술의 필요성 및 보존적 수술 후 난소기능 및 가임력 유지에 대한 연구
김대연 ( Dae Yeon Kim ),남주현 ( Joo Hyun Nam ),유항조 ( Hang Jo Yoo ),김미경 ( Mi Kyung Kim ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),목정은 ( Jung Eun Mok ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 난소의 악성 배세포종양 환자에서 보존적 수술 후 장기적인 가임력 및 출산력을 평가하고 재발 양상을 확인하며, 보존적 수술 시 후복막 림프절 평가의 중요성을 알아보고자 하였다. 연구 방법: 1991년부터 2001년까지 서울아산병원 산부인과에 내원하여 난소의 악성 배세포종양으로 진단 받고 치료 받은 50명의 환자들의 의무기록을 후향적으로 고찰하고 전화 인터뷰를 통하여 월경력 및 출산력을 확인하였다. 결과: 54개월의 평균 추적 관찰기간 동안 6명 ( Objective: To evaluate the long-term fertility and reproductive outcomes after conservative surgery, to observe the recurrence pattern and to elucidate the significance of retroperitoneal lymph node evaluation in patients with malignant ovarian germ cell