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한국 공업교육 방향 정립을 위한 연구 - 공업고등학교를 중심으로 -
김영전(Young Jeon Kim),박만식(Man Sik Park),조통래(Tong Rae Cho),유승곤(Seung Gon Ryu),성세진(Sei Jin Seong),장석명(Suk Myung Chang) 대한공업교육학회 1979 대한공업교육학회지 Vol.4 No.1
To get the best educational policy of technical high school in korea many problems were surveyed by questionaire and concerned materials were gathered. Through careful analysis of those matters we get the following results 1. Technical high school education should be closely linked with industry 2. There is much need of innovation of the teaching methods, measurements and evaluation of education, developmeat of teaching materials and resources, organizing and writing objectives etc. in the technical high school. 3. To meet the above needs, industry-school cooperation and teacher and in-service teacher training must be strengthened, and gorverment investmeat on the development of teacher, research on the educational methods and resources, and vocational guidance should be raised.
전우택,정한나,김영전,김찬웅,윤소정,이건호,임선주,이선우,Jeon, Woo-Taek,Jung, Hanna,Kim, Young-Jon,Kim, Chanwoong,Yune, Sojung,Lee, Geon Ho,Im, Sunju,Lee, Sun-Woo 연세대학교 의과대학 2022 의학교육논단 Vol.24 No.2
With increasing demands for medical care by society, the medical system, and general citizens and rapid changes in doctor's awareness, the competencies required of doctors are also changing. The goal of this study was to develop a doctor's competency framework from the patient's perspective, and to make it the basis for the development of milestones and entrustable professional activities for each period of medical student education and resident training. To this end, a big data analysis using topic modeling was performed on domestic and international research papers (2011-2020), domestic newspaper articles (2016-2020), and domestic social networking service data (2016-2020) related to doctor's competencies. Delphi surveys were conducted twice with 28 medical education experts. In addition, a survey was conducted on doctor's competencies among 1,000 citizens, 407 nurses, 237 medical students, 361 majors, and 200 specialists. Through the above process, six core competencies, 16 sub-competencies, and 47 competencies were derived as subject-oriented doctor's competencies. The core competencies were: (1) competency related to disease and health as an expert; (2) competency related to patients as a communicator; (3) competency related to colleagues as a collaborator; (4) competency related to society as a health care leader (5) competency related to oneself as a professional, and (6) competency related to academics as a scholar who contributes to the development of medicine.
한국에서 분리된 Helicobacter pylori 균주에서의 병리 인자 분포 및 이에 대한 숙주 방어 기전의 분자생물학적 연구
김정목(Jung Mogg Kim),정현채(Hyun Chae Jung),이주영(Joo Young Lee),이경미(Kyung Mee Lee),진영주(Young Joo Chin),김영전(Young Jeon Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.1
N/A Objectives: CagA or cytotoxin-positive H. pylori may be associated with gastroduodenal diseases. However, controversies about this association also exist. Moreover, there could be geographic differences in the prevalence of virulence factors such as cagA or cytotoxin. In H. pylori infection, the gastric mucosa shows acute and chronic inflammation. However, the pathogenesis of such as an inflammation by H. pylori is not well elucidated. We performed this study 1) to determine prevalence of the genes of virulence factor such as cagA and cytotoxin in H. pylori, 2) to assess the correlation of their presence with clinical findings, and 3) to test whether the vacuolating cytotoxin of H. pylori could evoke proinflammatory cytokine gene expression in gastric epithelial cells. Methods: 1) The prevalence of the cagA, vacA and adhesin genes in H. pylori strains isolated from Koreans was determined by PCR analysis. 2) H. pylori was cultured in Brucella broth containing 10% fetal bovine serum for 3 days using a shaker in a microaerophilic condition. Cytotoxin assay was performed by determining whether addition of the concentrated culture supernatants is able to cause vacuolization of HeLa cells. 3) After human gastric epithelial cells, Hs746T and AGS were incubated with the culture supernatants containing vacuolating cytotoxin, each RNAs were extracted from the gastric epithelial cells. And then various cytokine gene expression were assessed using RT-PCR. The expressed cytokine transcripts were quantified by RT-PCR and standard synthetic RNA. Among cytokines, IL-8 proteins were also measured by ELISA. Results: 1) More than 95% of H. pylori isolates from Korean adults possessed cagA, vacA and adhesin genes. And 80.6% of H. pylori strains have expressed vacuolating cytotoxicity against HeLa cells within 24 hours. 2) There was no correlation between the virulence factors of H. pylori strains and clinical findings. 3) Cytotoxin-positive culture supernatants also caused vacuolization in gastric epithelial cells, both Hs746T and AGS. 4) Expression of mRNA for proinflammatory cytokines such as IL-1 α, IL-8, MCP-1 and GM-CSF was much more upregulated by vacuolating cytotoxin-positive culture supernatants than cytotoxin-negative ones in both Hs746T and AGS cells. Number of molecules of the expressed IL-8 transcripts was parallel to the amounts of IL-8 protein secreted from gastric epithelial cells. Conclusion : These results suggest that virulence factors of H. pylori may not be factors determining disease entitiy in Korean patients infected with H. pylori. In addition, vacuolating cytotoxin secreted from H. pylori could give rise to vacuolization in gastric epithelial cells as well as induce proinflammatory cytokines from the cells.
Helicobacter pylori에서 생성되는 Vacuolating Cytotoxin이 위상피세포에서 Eotaxin 발현에 미치는 영향
박효간(Hyokhan Park),김남인(Nam In Kim),김정목(Jung Mogg Kim),김주성(Joo Sung Kim),오유경(Yu-Kyoung Oh),김영전(Young-Jeon Kim),김나영(Nayoung Kim),정현채(Hyun Chae Jung),송인성(In Sung Song) 대한미생물학회 2006 Journal of Bacteriology and Virology Vol.36 No.1