Glass dosimeter와 PCXMC Program을 이용한 소아피폭선량 측정 및 분석

김영은,이정화,홍선숙,이관섭,Kim, Young-Eun,Lee, Jeong-Hwa,Hong, Sun-Suk,Lee, Kwan-Seob 대한디지털의료영상학회 2012 대한디지털의료영상학회논문지 Vol.14 No.2

Exposed dose of young child should be managed necessarily. Young child is more sensitive than adult of a Radioactivity, especially, and lives longer than adult. Must reduce exposed dose which follows The ALARA(As Low As Reasonably Achievable)rule is recommended by ICRP(International Commission on Radiological Protection)within diagnostic useful range. Therefore, We have to prepare Pediatric DRL(Diagnostic Reference Level) in Korea as soon as possible. Consequently, in this study, wish to estimate organ dose and effective dose using PCXMC Program(a PC-Based Monte Carlo Program), and measure ESD(Entrance surface dose)and organ dose using Glass dosimeter, and then compare with DRL which follows EC(European Commission)and NRPB(National Radiological Protection Board). Using glass dosimeter and PCXMC programs conforming to the International Committee for Radioactivity Prevention(ICRP)-103 tissue weighting factor based on the item before the organs contained in the Chest, Skull, Pelvis, Abdomen in the organ doses and effective dose and dose measurements were evaluated convenience. In a straightforward way to RANDO phantom inserted glass dosimeter(GD352M)by using the hospital pediatric protocol, and in a indirect way was PCXMC the program through a virtual simulation of organ doses and effective dose were calculated. The ESD in Chest PA is 0.076mGy which is slightly higher than the DRL of NRPB(UK) is 0.07mGy, and is lower than the DRL of EC(Europe) which is 0.1mGy. The ESD in Chest Lateral is 0.130mGy which is lower than the DRL of EC(Europe) is 0.2mGy. The ESD in Skull PA is 0.423mGy which is 40 percent lower than the DRL of NRPB(UK) is 1.1mGy and is 28 percent lower than the DRL of EC(Europe) is 1.5mGy. The ESD in Skull Lateral is 0.478mGy which is half than the DRL of NRPB(UK) is 0.8mGy, is 40 percent lower than the DRL of EC(Europe) is 1mGy. The ESD in Pelvis AP is 0.293mGy which is half than the DRL of NRPB(UK) is 0.60mGy, is 30 percent lower than the DRL of EC(Europe)is 0.9mGy. Finally, the ESD in Abdomen AP is 0.223mGy which is half than the DRL of NRPB(UK) is 0.5mGy, and is 20 percent lower than the DRL of EC is 1.0mGy. The six kind of diagnostic radiological examination is generally lower than the DRL of NRPB(UK)and EC(Europe) except for Chest PA. Shouldn't overlook the age, body, other factors. Radiological technician must realize organ dose, effective dose, ESD when examining young child in hospital. That's why young child is more sensitive than adult of a Radioactivity.

문제 중심 학습(PBL)을 적용한 ?무기화학실험?수업의 효과

김영은,신예진,윤회정,우애자,Kim, Young-Eun,Shin, Ye-Jin,Yoon, Heo-Jeong,Woo, Ae-Ja 대한화학회 2010 대한화학회지 Vol.54 No.6

본 연구에서는 서울시 소재 대학의 "무기화학실험" 수강생을 대상으로 문제 중심 학습(Problem-based Learning; PBL) 전략을 적용한 실험 수업을 한 학기 동안 진행한 후, PBL 전략이 '자기 주도 학습 능력'과 '과학에 대한 태도'에 미치는 영향을 알아보았다. 이와 더불어 실험 수업에 적용한 PBL 문제와 PBL 실험 수업 과정에 대한 학생들의 인식을 조사하였다. 연구 결과는 다음과 같다. 첫째, PBL 전략을 적용한 "무기화학실험" 수업 후, 학생들의 '자기 주도 학습 능력'과 '과학에 대한 태도'가 통계적으로 유의미한 차이를 나타냈다(p < .05). 특히, '자기 주도 학습 능력'은 7개의 하위 영역 중 '학습자적 신념'을 제외한 6개의 영역에서, '과학에 대한 태도'는 5개의 하위 영역 중 '과학의 유용성'을 제외한 4개의 영역에서 유의미한 차이를 보였다(p < .05). 둘째, 학생들은 PBL 문제가 '자기 주도 학습'을 가능하게 하며 책임감을 가지고 학습할 수 있도록 하는 기회를 제공한다고 응답하였다. 하지만 스스로 문제를 정의하면서 학습 과제를 선정해 나가는 수업 과정에 대해서는 어렵다고 응답하였다. 셋째, 학생들은 PBL 실험 수업을 통해 효과적인 학습을 할 수 있었다고 생각하였으며, PBL이 실험 교과에 적합하고 자기 주도적으로 학습을 할 수 있도록 하는 수업 방식이라고 응답하였다. The purpose of this study is to examine the effects of PBL (Problem-based Learning) strategy applied to the "Inorganic Chemistry Laboratory" class. Especially, the changes in 'self-directed learning ability' and 'attitudes toward science' of undergraduate students were examined. In addition, perception on PBL problem and the PBL classes were investigated. The results of this study were as follows: First, after the course, 'self-directed learning ability' and 'attitude toward science' of students were significantly improved (p < .05). There were significant improvements in every sub-categories except 'self-confidence as a learner' for 'self directed learning ability' and every sub-categories except 'usefulness of science' for 'attitude toward science'. Second, the students expressed that PBL strategy provided opportunities to learn self-directively and responsibly, but the process of defining the problem was difficult. Finally on the survey toward PBL strategy, the students responded that PBL problems were authentic and helpful to learn problem solving ability. In conclusion, PBL laboratory course is effective for developing self-directed learning ability and positive attitude toward science.

알레르기 비염의 한의 진료 현황 설문조사

김영은,정의민,이동효,Kim, Young-Eun,Jeong, Ui-Min,Lee, Dong-Hyo 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.4

Objectives : The purpose of this study was to investigate the treatment trend for allergic rhinitis in Korean Medicine. Methods : We conducted an online survey for Korean Medicine Doctors who were registered in the association of Korean Medicine. The questionnaire was consisted of patient characteristics, diagnosis status, treatment status, and future research needs. Results : Data from total of 396 respondents were analyzed. More than 70% of the patient came to the Korean Medicine Clinic after visiting the Western Medicine Clinic in 43.9% of the respondents. 55.6% of the respondents performed combination therapy. History taking, nasal examination, x-ray, and Korean Medicine diagnostic test were used for diagnosis. The mean duration of treatment ranged from $4.9{\pm}2.91$ to $15.2{\pm}8.45$ for pediatric and early childhood patients and from $17.5{\pm}16.15$ to $5.3{\pm}3.85$ weeks for adolescents and adult patients. The mean number of treatment times was from $9.8{\pm}7.00$ to $33.5{\pm}24.45$ for pediatric and early childhood patients and from $10.8{\pm}11.55$ to $40.4{\pm}48.18$ times for adolescents and adult patients. 64.5%, 48.0%, and 91.2% of the respondents used herbal medication in national health insurance coverage, herbal medication uninsured in health insurance and herbal prescription filled at each medical institution, respectively for pediatric and early childhood patients and 67.6%, 42.8% and 86.1% for adolescents and adult patients. 36.9% and 36.4% of respondents answered that the study of acupuncture and herbal medicine are needed preferentially. Conclusions : The results of this survey will be used to develop clinical practice guideline that reflect actual clinical practice.

인공고관절의 설계인자들이 해리현상에 미치는 영향에 대한 해석

김영은,정정화,Kim, Young-Eun,Chung, Chung-Hwa 대한의용생체공학회 1993 의공학회지 Vol.14 No.2

The human's biomechanical structure keeps an optimal state by adapting the original biomechanical structure according to a change in the physical environment. This phenomenon is believed to be the main cause of loosening of the total hip replacement which is used widely in these days. In this study the bone density change due to artificial hip joint, which is generally believed as bone-remodeling, was investigated by the finite element method. For this, 2-D FEM models with 4 nodal point elements were constructed for intact and implanted cases. The density was calculated by comparing the relative amounts of effective stress for these two cases. In this way, calculated new density values were used in the next step as input values and this procedure repeated until convergence was obtained. Severe density change was detected at the femoral cortex of the proximal-medial side as expected. Moreover, following surprising result was found from this analysis. Titanium alloy prosthesis showed less density change compared to stainless steel prosthesis at earlier stage, however, almost same amount of the density change was detected at final stage. It was also found that other design parameters could not significantly affect its density change.

표준 요 시료 중 Oxalate의 측정을 위한 FT-NIR 분광기의 유용성 검정

김영은,홍수형,김정완,이종영,Kim, Yeong-Eun,Hong, Su-Hyung,Kim, Jung-Wan,Lee, Jong-Young 대한예방의학회 2006 예방의학회지 Vol.39 No.2

Objectives : The determination of oxalate in urine is required for the diagnosis and treatment of primary hyperoxaluria, idiopathic stone disease and various intestinal diseases. We examined the possibility of using Fourier transform near-infrared (FT-NIR) spectroscopy analysis to quantitate urinary oxalate. The practical advantages of this method include ease of the sample preparation and operation technique, the absence of sample pre-treatments, rapid determination and noninvasiveness. Methods : The range of oxalate concentration in standard urine solutions was $0-221mg/{\ell}$. These 80 different samples were scanned in the region of 780-1,300 nm with a 0.5 nm data interval by a Spectrum One NTS FT-NIR spectrometer. PCR, PLSR and MLR regression models were used to calculate and evaluate the calibration equation. Results : The PCR and PLSR calibration models were obtained from the spectral data and they are exactly same. The standard error of estimation (SEE) and the % variance were $10.34mg/{\ell}$ and 97.86%, respectively. After full cross validation of this model, the standard error of estimation was $5,287mg/{\ell}$, which was much smaller than that of the pre-validation. Furthermore, the MCC (multiple correlation coefficient) was 0.998, which was compatible with the 0.923 or 0.999 obtained from the previous enzymatic methods. Conclusions : These results showed that FT-NIR spectroscopy can be used for rapid determination of the concentration of oxalate in human urine samples.

동물 경조직 단백성분의 조성과 생리기능에 관한 연구 녹각의 경단백질에 대하여

김영은,이승기,윤웅찬 ( Young Eun Kim,Seung Ki Lee,Ung Chan Yoon ) 생화학분자생물학회 1973 BMB Reports Vol.6 No.1

With an attempt to elucidate the biologically functioning groups of deer horn, we obtained, in this investigation, a protein fraction after extraction of the pulverized deer horn with 5M-urea followed by decalcification with acetic acid. The amino acid composition of deer horn extracted came up to 16 kinds. And analysis of the protein extracted with 5M-urea gave values, as per cent, glycine, 24.51 % ; proline, 11.09% ; glutamic acid, 10.26%, which come up to 46. 86% of the; total amino acids initially present. The existence of glucose and galactose is confirmed with the results of thin-layer chromatography being carried out many times. And the total amounts o_f hexose and hexosamine are accounting for 0.74% and 0.87% for each. The present communication described as above has affirmed the protein from deer horn to be a sort of collagen. However, it can be focused on the significance of the existence of cystine and the absence of valine in deer horn. The contents of inorganic elements detected with emission spectroscophy are listed as following: total inorganic elements are detected to be 13 kinds. And the ash-contents of deer horns are 55.6% (w/w). The quantitative analysis for the ash shows that it contains 36.79 of Ca and 1.42% of Mg against ash contents by weight per weight.

녹용의 약효 성분에 관한 연구 ( Ⅴ ) 녹용 및 판토크린의 당지질과 인지질의 조성에 관하여

김영은,임동구,신승언 ( Young Eun Kim,Dong Koo Lim,Seung Uon Shin ) 생화학분자생물학회 1977 BMB Reports Vol.10 No.3

The lipid soluble fraction of Antler velvet layer (cervus nippon taiouanous) was extracted and compared to that of pantocrin (ethanol preparation of Antler, commercially available). Lipid soluble components (801㎎/24.5g from Antler velvet ayer and 979.1㎎/143㎖ from pantocrin) were fractionated by gel filteration using a sephadex CT-25 into neutral lipids, sulfatides, cerebrosides, phospholipids and non-lipid components (lipoprotein and peptide). A silicic acid and a DEAE-sephadex A-25 column chromatography were followed from refractionation and purification. Each fraction was identified by thin layer chromatography using standard materials. Typical lipid soluble fraction of Antler contained 65.3% neutral lipid, 5.2% glycolipid, 12.9% phospholipid, 6.1% ganglioside and 2.9% non-lipid components. The glycolipid was composed of 63.5% cerebroside and 36.5% sulfatide. The cerebroside fraction of the Antler velvet layer showed four spots while pantocrin gave only one spot on a thin layer chromatogram. Among the four spots of Antler cerebroside two had almost same migration with standard but two had quite different mobility compared to the standard. The latter fractions were hydrolyzed by 0.025M methanolic HCl in order to desulfate. The two unknown materials were identified as sulfatides by the method of IR spectroscopy and thin layer chromatography. By two dimensional thin layer chroma tography, it was found that phospholipid of thr. Antler velvet layer were composed of phosphatidylethanolamine, sphingomyelin, phosphatidylcholine, lysophospahtidylethanolamine, and lysophosphatidylcholine and phosphatidic acid. On the other hand pantocrin contained phosphatidylcholine and sphingomyelin as phospholipids.

동물 경조직 단백성분의 조성과 생리기능에 관한 연구 녹각의 경단백질에 대하여

김영은,이승기,윤웅찬,Kim, Young-Eun,Lee, Seung-Ki,Yoon, Ung-Chan 생화학분자생물학회 1973 한국생화학회지 Vol.6 No.1

동물 경조직 단백성분의 연구의 일환으로 녹각 및 녹용의 생화학적 기능을 나타내는 성분을 밝히기 위하여 녹각 분말을 0.5M 초산으로 탈칼슘을 한 후 5M 요소로 단백질부분을 추출하였다. 추출한 녹각단액의 아미노산 구성은 16종류에 달했으며 이중 glycine은 24.51%; proline 11.09%; glutamic acid는 10.26%가 되어 검출된 전 아미노산의 45.86%를 차지하고 있음이 밝혀졌다. 박충크로마토그라피로 glucose와 galactose 및 hexoamine의 존재를 확인하였고 정량분석 결과 총 hexose의 양은 추출단백의 0.74%이고, 총 hexoamine의 양은 0.87%였다. 본보에서 보고한 바와 같은 아미노산의 구성비율로 미루어 녹각단백은 일종의 collagen으로 추정하였다. 그러나 녹각단백중에 존재하는 아미노산 구성중 특기할 점은 cystine이 존재하는 반면 valine이 검출되지 않았다는 점이다. emission spectroscopy로 검출된 무기원소의 종류는 13종이며 회화잔사의 함량은 녹각무게의 55.6% (w/w)이며 이 회화잔사중 Ca은 회화잔사의 36.79%이고 Mg은 1.42%를 차지하고 있음을 청량분석의 결과 규명하였다. With an attempt to elucidate the biologically functioning groups of deer horn, we obtained, in this investigation, a protein fraction after extraction of the pulverized deer horn with 5M-urea followed by decalcification with acetic acid. The amino acid composition of deer horn extracted came up to 16 kinds. And analysis of the protein extracted with 5M-urea gave values, as per cent, glycine, 24.51%; proline, 11.09%; glutamic acid, 10.26%, which come up to 46.86% of the total amino acids initially present. The existence of glucose and galactose is confirmed with the results of thin-layer chromatography being carried out many times. And the total amounts of hexose and hexosamine are accounting for 0.74% and 0.87% for each. The present communication described as above has affirmed the protein from deer horn to be a sort of collagen. However, it can be focused on the significance of the existence of cystine and the absence of valine in deer horn. The contents of inorganic elements detected with emission spectroscophy are listed as following: total inorganic elements are detected to be 13 kinds. And the ash-contents of deer horns are 55.6% (w/w). The quantitative analysis for the ash shows that it contains 36.79% of Ca and 1.42% of Mg against ash contents by weight per weight.

아토피피부염 개인건강기록 어플리케이션 개발을 위한 전문가 집단 설문조사 연구

김영은,김안나,이동효,박민철,손미주,장현철,Kim, Young-Eun,Kim, An-Na,Lee, Dong-Hyo,Park, Min-Cheol,Son, Mi Ju,Jang, Hyun-Chul 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.3

Objectives : We conducted a survey aimed at developing a personal health record application for the treatment of atopic dermatitis in Korean medicine .Methods : We conducted a survey on Korean medicine doctors who attended the Korean Medicine Ophthalmology and Otolaryngology and Dermatology conference 2016. The questionnaire was based on priority of usage of the diagnostic indices and tools, and intention to use the personal health record application for treatment of atopic dermatitis in the clinic.Results : Data were collected from 50 Korean medicine doctors. Ninety-six per cent of respondents replied that they were willing to use the personal health record application for treating atopic dermatitis. Among the diagnostic indices related to atopic dermatitis, Korean medicine doctors regarded the following as important in the order of priority, i.e., condition of skin, lifestyle, risk factors, symptoms other than those of skin, past history, family history and medical history, results of tongue, pulse, and abdomen investigation, and constitution. These results did not vary with the purpose of diagnosis, and the results were consistent with those obtained with the intention to use diagnostic. Over 50% of respondents replied that they use immunoglobulin E, scoring atopic dermatitis, and visual analogue scale among the diagnostic tools.Conclusions : Our survey was conducted on clinicians who are the intended users of the personal health record application for the treatment of atopic dermatitis; hence, the results of this study can be helpful for developing a useful personal health record application for atopic dermatitis in the clinic.

녹용의 약효 성분에 관한 연구 ( Ⅳ ) 녹용 벨벳층의 프로스타그란딘의 검출

김영은,이승기,이명희 ( Young Eun Kim,Seung Ki Lee,Myoung Hee Lee ) 생화학분자생물학회 1977 BMB Reports Vol.10 No.1

The fresh antler was cut, frozen and mechanically separated into spongy bone layer and velvet layer. The prostaglandin-like components were extracted from antler velvet layer and qualitatively analyzed by three different methods: thin layer chromatography, ultra-violet spectroscopy after conversion to PGB series by alkaline treatment, and gas liquid chromatography. The prostaglandins detected were PGE₂, 15-epi-PGE₁, PGF_(1α), PGF_(1β). The experiments indicated that the petroleum ether fraction contained mostly PGE series and that the ethylether fraction contained PGF series. One major prostaglandin-like components of antler velvet layer was found to be the main compound in the petroleum ether extract. The structure of this compound is still unknown but the gas liquid chromatography data suggest that it is a hydroxy fatty acid.