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유방 종괴의 세침흡인 세포학적 소견 - Masood 등급에 따른 분류 -
김애리,김혜선,김한겸,원남희,박미자,구범환,Kim, Ae-Lee,Kim, Hye-Sun,Kim, Han-Kyeom,Won, Nam-Hee,Park, Mee-Ja,Koo, Bum-Hwan 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1
Fine needle aspiration cytology is considered as a useful diagnostic procedure in management of patients with breast lesions. This study was undertaken to evaluate the scoring system of Masood in the interpretation of breast aspirates, to establish the most useful cytologic criteria for the diagnosis of breast lesions, and to subclassify the benign breast diseases. To assess the feasibility of a cytologic grading system, 57 cases of benign breast disease, 61 cases of malignant breast disease were studied, respectively. The aspirates were evaluated for the cellular arrangement, the degree of cellular pleomorphism and anisonucleosis, and the presence of myoepithelial cells and nuceoli. Values ranging from 1 to 4 were assigned to each criterion and the sum of the individual values was made for each case. The presence of stroma, apocrine metaplasia, foamy histiocytes and inflammatory cells, background of the smear, and cellularity were also evaluated. Cut-off value of the scoring system of Masood between benign and malignant lesion was 15. Among the cytologic criteria, cellular arrangement, presence of myoepithelial cells, nucleoli, and stroma, status of chromatin pattern, and background of smear were useful criteria in the differentiation between benign and malignant lesions. Application of the scoring system of Masood does not always make the accurate diagnosis and the subclassification of benign breast disease.
1p36 Deletion syndrome Presenting with Various Epileptic Semiologies
김애리(Ae ree Kim),이지원(Ji own Lee),이문향(Mun hyang Lee),이지훈(Jee hun Lee) 대한소아신경학회 2015 대한소아신경학회지 Vol.23 No.4
본 저자들은 생후 1개월부터 발생한 여러 유형의 발작, 삼킴장애, 발달지연, 소두증 및 형태학적 이상을 보인 남아에서 비교유전체 보합법(array comparative genomic hybridization)을 통하여 1p36 결실증후군을 진단한 예를 경험하였기에 보고하는 바이다. 1p36 deletion syndrome is the most common telomeric microdeletion syndrome. It is related to various clinical features including neurodevelopmental impairment, seizure, growth retardation, and heart defects. It is also known to have several morphologic features, including deep-set eyes, flat nasal bridge, straight eyebrows and pointed chin. Seizure is common in 1p36 deletion syndrome and its type and natural course is variable. Control of seizure with antiepileptic drugs is variable; however, seizure improves with time in majority of cases. We report a patient presenting with various types of seizure, developmental delay, and morphological abnormality. The patient developed complex partial seizure, infantile spasm, and myoclonic seizure, at the age of 1, 4, and 12 months, respectively. The patient was diagnosed as 1p36 deletion syndrome using array comparative genomic hybridization. At the age of 15 months, seizure disappeared and development began to progress.
알콜이 단백질 급원이 다른 식이를 섭취한 흰주의 지질 대사에 미치는 영향
김애리(Ae Lee Kim),김화영(Hwa Young Kim) 가톨릭대학교 생활과학연구소 1981 생활과학연구논집 Vol.2 No.1
This study was designed to observe the effects of alcohol on the lipid metabolism in adult male rats fed diets containing two different kinds of protein (casein and gluten), and cholesterol. The body weight gain was greater in the rats of casein diet groups than in those of gluten diet groups. Serum cholesterol and triglycerides levels were also higher in the casein diet groups. Rats fed cholesterol containing diets showed higher serum and liver cholesterol and triglycerides concentrations compared to those fed cholesterol free diets. And this effects of cholesterol was more notable in gluten fed rats. Liver cholesterol and triglycerides levels were increased in the rats fed alcohol-contaning diets. And the live lipid levels were higher in the rats fed diets containing both cholesterol and alcohol compared to those fed diets containing either cholesterol or alcohol alone.
이영호(Young Ho Lee),김난희(Nam Hee Kim),윤종우(Jong Woo Yoon),이영기(Young Ki Lee),조상경(Sang Kyung Jo),김용섭(Yong Sup Kim),차대룡(Dae Ryong Cha),조원용(Won Yong Cho),김애리(Ae Ree Kim),원남희(Nam Hee Won),구자룡(Ja Ryong Ku),김형규( 대한내과학회 1997 대한내과학회지 Vol.52 No.6
N/A Objectives: Apoptosis is a physiologic or programmed cell death in contrast with necrotic cell death. Recently it has been known that apoptosis are concerned in the effects of chemotherapeutic agents or radiation therapy on tumor cells. Cyclosporine a(CsA), a potent immunosuppressant, has been effectively used in organ transplantaion, but it also has a significant toxicity in the kidneys. However the exact mechanism of CsA nephrotoxicity has not been ellucidated yet. This study was performed to investigate whether apoptosis particiates in CsA nephrotoxicity or not. Methods: Twenty seven Sprague-Dawley rats were divided into 5 groups. 1) Vehicle group(n=7) as a control: Cremopbor 50mg/kg/day/subcutaneously (sc) for 7 days, 2) CsA4 groupin=5): CsA 50mg/kg/ day/sc for 4 days, 3) CsA7 group(n=5): CsA 50mg/ kg/day/sc for 7 days, 4) R4 group(n=5): 4 days after CsA 50mg/kg/day/se for 7 days, and 5) R8 group (n=5): 8 days after CsA 50mg/kg/day/sc for 6 days, Biochemical parameters including blood pressure were measured in each group and the cell count of apoptosis in rat kidney was evaluated by in situ end labelling(ISEL) method. Results: 1) The increase of serum creatinine, blood pressure and decrease of creatinine clearance appeared in CsA4 and CsA7 groups. 2) The ce11 counts of apoptosis on tubular cells in CsA4 and CsA7 groups were significantly increased more than in control group(79.0±16.9, 98.4±11.4 vs 35.4±8.8, p<0.05), and the cell counts of apoptosis on tubular cells in R4 and R8 groups were not significantly different from that in control group(53.8±12.5, 65.2±7.1 vs 35.4±8.8, p>0.05), 3) The cell count of apoptosis on the interstitium in each group was not significantly different from that in control group(p>0.05). 4) The cell count of apaptosis on tubular cells was increased more than that on the interstitium in all groups. 5) The cell count of apoptosis on cortex only in CsA7 group was significantly increased more than that io control group(57.8±11.5 vs 21.8±2.6, p<0.05), 6) The cell count of apoptosis on medulla only in CsA4 group was significantly increased more than that in control group(636. ±17.9 vs 22.6±9.7, p<0.05). 7) Total cell counts of apoptosis only in CsA4 and CsA7 groups were significantly increased more than in contral group(96.0±21.1, 99.8±11.8 vs 46.6±11.4, p<0.05). Conclusion: CsA caused apoptosis mainly on tubular cells rather than the interstitial cells and apoptotic cells in CsA nephrotoxicity were not in- creased during the recovery phase. With the results apoptosis may play an important role in CsA nephrotoxicity.
문정석,오화은,이주한,김애리,김철환,김한겸,박미자,원남희,Moon, Jeong-Seok,Oh, Hwa-Eun,Lee, Ju-Han,Kim, Ae-Ree,Kim, Chul-Hwan,Kim, Han-Kyeom,Park, Mee-Ja,Won, Nam-Hee 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
Mucoepidermoid carcinoma is the most common malignant neoplasm of the salivary gland, compring between 30 and 40%. Fine needle apsiration cytology was performed in five patients with mucoepidermoid carcinoma. The patients consisted of three males aged of 42, 48, and 60 years, and two females aged 36, and 56 years. The primary tumor sites were the parotid gland in four patients and the submandibular gland in the rest one. The histologic grades were low in one patient, intermediate in two patients and high in other two. In our experience, the common cytologic findings of low grade subtype were predominent mucous cells with some intermediate cells in an abundant mucinous background. The cytologic findings of intermediate grade subtype were predominant clusters of intermediate cells with or without mucous cells in an abundant mucinous background. And the cytologic findings of high grade subtype were predominant clusters of epidermoid cells with intermediate cells in a bloody background. Cytologic pleomorphism and atypia were more severe in high grade than low and intermediate grade, and nucleoli were more frequently noted in epidermoid cells. In low grade, it is very difficult to decide the benignancy or malignancy of the tumor. In fact, the presence of mucous cells in a mucinous background should rule out any other type of well differentiated carcinoma.
신경외과 중환자실 환자의 경장영양 지침서 적용에 따른 영양적 중재 효과
한정희,김영란,이영민,김애리,김호진,정영균,유정하,Han, Jung-Hee,Kim, Young Ran,Lee, Young Min,Kim, Ae Lee,Kim, Ho Jin,Jeong, Young-Gyun,Ryu, Jeong Ha 한국의료질향상학회 2011 한국의료질향상학회지 Vol.17 No.1
Background : Evidence-based guidelines are now used for enteral nutrition(EN) in neurosurgical intensive care unit patients who mostly depend on EN. This study compared and analyzed the nutritive conditions of patients before and after they underwent guideline based nutritional interventions in order to determine whether using these guidelines improved their calorie supply. Methods : Data on the patients' nutritional requirements, maximum calorie supply through EN, serum albumin level, and total lymphocyte count were collected and analyzed using SAS version 9.1.3. All the statistical analyses were performed at a significance level of P<0.05. Result : The maximum calorie supply through EN was $923.1{\pm}359.7$ kcal before the intervention and $1254.4{\pm}196.3$ kcal after the intervention; this difference was statistically significant(P<0.05). The ratio of nutritional requirements to maximum calorie supply through EN was $55.5{\pm}22.4%$ and $74.2{\pm}13.9%$ before and after the intervention, respectively; this difference was statistically significant(P<0.05). This indicates a 19% increase in the ratio after the nutritional intervention. The serum albumin level also significantly increased from $2.7{\pm}0.6g/dL$ before the intervention to $3.2{\pm}0.4g/dL$ after the intervention(P<0.05). The total lymphocyte count slightly increased from $1267.7{\pm}728.2cells/mm^3$ before the intervention to $1801.9{\pm}1211.5cells/mm^3$ after the intervention; this difference was not statistically significant. Conclusion : The results showed that using the evidence-based feeding guidelines for interventions increased the calorie supply and improved the patients' nutritive conditions from moderate malnutrition to mild malnutrition.
류마티스 관절염 활액막에서 Cyclooxygenase-1, 2의 발현 양상
이영호 ( Young Ho Lee ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),김애리 ( Ae Ree Kim ),김철환 ( Chul Hwan Kim ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.2
목적: 류마티스 관절염 환자의 활액막에서 COX-1과 COX-2의 발현양상을 알아보고자 하였다. 방법: 류마티스 관절염 환자 9명의 활액막과 대조군으로 골관절염 환자 5명의 활액막 조직을 COX-1과 COX-2 특이항체를 이용하여 면역조직화학법으로 염색하여 관찰하였고 H&E 염색상 조직학적 소견 조사하였다. 결과: 1. COX-1은 류마티스 관절염 활액막조직에서 기질 유섬유아세포에서 강하게 염색되었고, 활액내막세포, 염증성 단핵세포와 혈관내피세포에서도 발현되었으며, 골관절염 활액막조직의 COX-1 염색소견과 유사하였다. 2. COX-2는 류마티스 관절염 활액막조직에서 염증성 단핵세포에서 강하게 염색되었고, 기질 유섬유아세포, 혈관내피세포와 활액내막세포에서 발현되었으며, 골관절염 활액막조직의 COX-2 발현소견과 의의 있는 차이를 보이지 않았다. 3. 류마티스 관절염 활액막에서 COX-1과 COX-2의 발현양상간에 있어서 의의 있는 차이는 관찰되지 않았다. 결론: COX-1도 COX-2처럼 류마티스 관절염 활액막에서 증가되어 있고 COX-1도 COX-2처럼 류마티스 관절염 활액막의 염증반응에 기여할 가능성이 있다. Objective: To investigate expression and localization of cyclooxygenase-1(COX-1) and cyclooxygenase-1(COX-2) in synovial tissues from patients with rheumatoid arthritis(RA). Methods: We examined expression and localization of COX-1 and COX-2 staining in synovial tissues from patients with RA, compared with osteoarthritis(OA) as control by immunohistochemical staining using polyclonal COX-1 and COX-2 antibodies and also scored histologic features of inflammation. Results: COX-1 in synovial tissues from RA was stained most strongly in stromal fibroblast-like cells and expressed in synovial lining cells, inflammatory mononuclear cells and vascular endothelial cells. COX-1 expression in RA synovial tissues was comparable to that in OA synovial tissues. COX-2 in synovial tissues from RA was stained most strongly in inflammatory mononuclear cells and expressed in stromal fibroblast-like cells, vascular endothelial cells and synovial lining cells. COX-2 expression in RA synovial tissues was not significantly different from that in OA synovial tissues. In addition, no significant difference between COX-1 and COX-2 stainings in synovial tissues from RA was observed. Conclusions: Our data suggest that COX-1 expression may be up regulated like COX-2 expression in chronic RA and COX-1, like COX-2, might contribute to synovial inflammation in RA.