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마이크로어레이 기술을 활용한 자외선 차단제의 주름생성 억제 연구
주정흔 ( Jung Hun Ju ),이종권 ( Jong Kwon Lee ),손경희 ( Kyung Hee Sohn ),임채형 ( Chae Hyung Lim ),홍순근 ( Soon Keun Hong ),김정래 ( Jung Rae Kim ),옥소원 ( So Won Ock ),김진호 ( Jin Ho Kim ),김인영 ( In Young Kim ),김승희 ( Seu 한국동물실험대체법학회 2008 동물실험대체법학회지 Vol.2 No.1
Ultraviolet(UV) irradiation damages skin and causes premature skin aging (photoaging) characterized by thickening, rough texture, coarse wrinkles and mottled pigmentation. A number of genes have been reported to be involved in the response to UV irradiation. However, these data are concentrated on a limited number of well-known genes and consequently limited in scope. Microarray technology has greatly facilitated the study of differential gene expression and allowed large-scale determination of gene expression changes associated with tissue changes and tumor formation. In the skin, microarrays have previously been used to study the basal gene expression that are sensitive or resistant to skin aging, and to examine differential gene expressions associated with the effects of UV irradiation. Many investigations have attempted to clarify the mechanisms induced by chronic UV irradiation, but the cellular and molecular events are not fully understood. To identify differential gene expressions associated with the effects of UV and sunscreen agent, we performed cDNA microarray analysis. We evaluated the differentially expressed gene profiles in UV-induced wrinkle and inhibitory effect of topical application of sunscreen agent on the formation of UVB-induced wrinkle. We identified functional gene sets including those involved in extracellular matrix, signaling, immunity and defense. There were significant changes of the gene expression in the mmp-13, laminin(beta), procollagen, ccl3, ccl4, cxcl10, ccl9, p16, caspase 9 etc. in the skin irradiation with UV.