Marsh와 Pond 형태의 인공 습지를 이용한 Parathion 농약의 처리에 관한 연구

김세경,최종규,오세희,강호정,조경덕,Kim, Se-Kyung,Choi , Jong-Kyu,Oh, Se-Hee,Kang, Ho-Jeong,Zoh, Kyung-Duk 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.3

The microcosm type wetland systems were constructed in order to treat wastewater contaminated with parathion. The microcosm reactor consisted of marsh and pond type. The experiment was carried out using batch (marsh or pond) and continuous (marsh-pond and pond-marsh type) systems. In the batch reactor, marsh-type wetland completely removed parathion in water within 8 days, while pond reactor removed 97% of parathion during the same period. During parathion degradation, the amount of 4-nitrophenol production, one of the metabolites from parathion degradation, was higher in marsh-type batch reactor. In the continuous systems, both marsh-pond and pond-marsh combination systems effectively removed parathion from water, and the production of 4-nitrophenol was also minimal. In the extraction experiment, the parathion and its metabolite were not found in the wetland soil and the plant. In order to achieve both aerobic and anaerobic conditions, the continuous wetland system combining marsh and pond type can be the alternative for the non-point source pollutants such as parathion pesticide.

라섹 수술 후 통증에 대한 비스테로이드성 항염증 점안액의 선행 진통 효과

김세경,홍진표,남상민,서경률.Se Kyung Kim. MD. Jin Pyo Hong. MD. Sang Min Nam. MD. Kyoung Yul Seo. MD. PhD 대한안과학회 2011 대한안과학회지 Vol.52 No.12

Purpose: To assess the preemptive analgesic effect of topical NSAIDs (0.5% ketorolac tromethamine, Acular) as postoperative pain relief in patients undergoing LASEK. Methods: A prospective, randomized, placebo-controlled, paired eye study was performed. Patients undergoing LASEK were randomized to receive 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at 30 minutes, 20 minutes, or ten minutes prior to LASEK. Pain was assessed using a visual analog scale of 0 to 10 in each eye 6, 12, 24, 36, 48 and 72 hours after surgery. Patients were also asked to assess the levels of glare, tearing and irritation using a visual analog scale from 0 to 10. Results: A total of 62 eyes from 31 patients were enrolled in the present study. The mean postoperative pain score in the NSAID group was significantly lower than that in the placebo group at postoperative hours 6 (2.35 versus 4.97), 12 (2.52 versus 5.16), and 24 (3.84 versus 4.94) (p < 0.05). The mean postoperative pain score after 36 and 48hours was also lower in the NSAID group than in the placebo group, but the differences were not statistically significant (p > 0.05). Patients reported significantly less tearing and irritation in the NSAID-administered eye compared to those in the placebo eye after LASEK (p < 0.05). Conclusions: Preemptive administration of topical NSAIDs before LASEK was effective in reducing acute postoperative pain. Preemptive analgesia with topical NSAIDs may be a valuable treatment option for controlling postoperative pain following ocular surgery. J Korean Ophthalmol Soc 2011;52(12):1414-1418

영산강,섬진강 수계 하천의 부착 조류 군집 동태

김세경 ( Se Kyung Kim ),황경섭 ( Kyung Sub Hwang ),임병진 ( Byung Jin Lim ),박종환 ( Jong Hwan Park ),김성원 ( Sung Won Kim ) 한국물환경학회(구 한국수질보전학회) 2011 공동 추계학술발표회 Vol.2011 No.-

Saccharomyces cerevisiae deletion mutant의 세라마이드 생합성

김세경(Se Kyung Kim),노용호(Yong Ho Noh),윤현식(Hyun Shik Yun) 한국생물공학회 2009 KSBB Journal Vol.24 No.1

Saccharomyces cerevisiae의 deletion mutant를 이용하여 ydc1, ypc1, scs7, sur1, csg2, ipt1, lcb4, lcb5, dpl1의 deletion이 세라마이드의 생산에 미치는 영향을 고찰하였다. 세라마이드는 ELSD가 연결된 HPLC를 통하여 분석하였으며 △ydc1 mutant의 세라마이드 생산량이 6 mg ceramide/g cell로 최대량을 나타내었으며 △sur1 mutant, △lcb5 mutant, △dpl1 mutant의 경우 control로 사용한 BY4742와 비슷한 세라마이드 생산량을 나타내었고, 그 외 △ypc1 mutant, △scs7 mutant, △csg2 mutant, △ipt1 mutant, △lcb4 mutant는 BY4742보다 낮은 세라마이드 생산량을 나타내었다. Ceramide is important not only for the maintenance of the barrier function of the skin but also for the water-binding capacity of the stratum corneum. Though the effectiveness of ceramide is not understood fully, ceramide has become a widely used ingredient in cosmetic and pharmaceutical industries. However, ceramide production from Saccharomyces cerevisiae has not been widely studied and the quantity are very low. Gene deletion in the cell is used frequently to investigate the function of gene and verification research of drug target. Specially, deletion mutant library is useful for a large amount functional analysis of gene. In this study, deletion mutants of genes on the metabolic pathway of ceramide synthesis in S. cerevisiae were grown in a batch culture and the cellular content of ceramide was measured. The ceramide content was highest in Δydc1 mutant and 6 mg ceramide/g cell was obtained.

임신중 발현된 Crohn씨 병

김인철(In Chul Kim),김선무(Sun Moo Kim),오세정(Se Jong Oh),박조현(Cho Hyun Park),김세경(Se Kyung Kim),김병기(Byung Kee Kum) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2

Crohn's disease characterized by chronic relapsing, transmural inflammatory bowel disorder of unknown etiology is seldom experienced in Korea while it is one of the most common gastrointestinal tract disease in western countries. Because Crohns disease is characteristically a disease of young people, it may coexist with the reproductive years of many of the women who develop disease. Therefore relationship between Crohns disease and pregnancy has been studied but fertility rate, effect of Crohns disease on pregnancy and vice versa still remained controversy. A 28-year-old pregnant woman with Crohns disease complicated by intestinal perforation and newborn death resulting from premature labor was reported. And literatures especially on the effect of Crohns disease on pregnancy has been reviewed.

타액선 종양의 조직학적 빈도와 수술기의 문제점

김봉섭(Bong Sup Kim),김준기(Jun Gi Kim),김세경(Se Kyung Kim),김인철(In Chul Kim) 대한외과학회 1988 Annals of Surgical Treatment and Research Vol.34 No.6

The Study on Complex of Gallium Bromide with Ethyl Bromide in Aniline and in o-Chloroaniline under High Vacuum

김영철,김세경,구덕자,임종완,Young Cheul Kim,Se Kyung Kim,Deog Ja Koo,Jong Wan Lim Korean Chemical Society 1991 대한화학회지 Vol.35 No.5

아닐린 및 o-클로로아닐린 용액내에서 브롬화에탄의 용해도를 5, 1.5$^{\circ}$ 및 25$^{\circ}$C에서 브롬화칼륨이 존재할 때와 존재하지 않을 때의 두 경우에 대하여 각각 측정하여 보았다. 브롬화칼륨이 존재하지 않을 때에 o-클로로아닐린에서 브롬화에탄의 용해도가 아닐린에서 보다 크다. 이것은 브롬화에탄과 o-클로로아닐린의 상호작용이 아닐린보다 더 강하다는 것을 나타낸다. 그리고 브롬화칼륨이 존재할 경우에는 용액내에서 브롬화에탄과 브롬화칼륨이 불안정한 착물이 생성된다. 이 착물을 여러 경우로 가정하여 계산하여 본 결과 1:1 착물일 때, 불안정 상수 K값이 비교적 일정한 값을 나타내었다. 그러므로 1:1 착물 $C_2H_5Br[\cdot}GaBr_3$가 형성됨을 알았으며, 이 착물은 용액내에서 다음 평형식에 의해서 이루어진다고 본다. $C_2H_5Br{\cdot}GaBr_3\;{\rightleftharpoons}\;C_2H_5Br+1/2Ga_2Br_6$ 브롬화칼륨과 브롬화에탄의 착물의 불안정도를 이와 대응하는 브롬화메탄과 비교하여 보았다. 또한 이 착물의 해리에 대한 엔탈피, 자유에너지 및 엔트로피 변화도 산출하였다. The solubilities of ethyl bromide in aniline and o-chloroaniline have been measured at 5, 15$^{\circ}$ and 25$^{\circ}$C in the presence and the absence of gallium bromide. When gallium bromide does not exist in the system, the solubility of ethyl bromide in o-chloroaniline is greater than in aniline, indicating a stronger interaction of ethyl bromide with o-chloroaniline than that with aniline. It could be thought that ethyl bromide forms unstable complex with gallium bromide in the presence of gallium bromide in the system. This complex has been assumed in various ways and evaluated, that instability constant (K value) is relatively constancy under the assumption of 1 : 1 complex, $C_2H_5Br{\cdot}GaBr_3$. Therefore, the complex forms the following equilibrium in the solution: $C_2H_5Br{\cdot}GaBr_3\;{\rightleftharpoons}\;C_2H_5Br +1/2Ga_2Br_6$ The instability of the complex of ethyl bromide with gallium bromide is compared with similar complexes of gallium bromide with methyl bromide. The changes of enthalpy, free energy and entropy fcor the dissociation of the complex are also calculated.

비접촉 안압계, 리바운드 안압계, 토노펜, 골드만 압평안압계의 안압 비교

이경식,김세경,김응권,김태임,Kyung Sik Lee,Se Kyung Kim,Eung Kweon Kim,Tae Im Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.1

Purpose: To compare the level of accuracy of intraocular pressure (IOP) measurements attained by non-contact tonometer (NCT), rebound tonometer (RT) Icare<sup>®, and Tono-Pen (TONO-PEN AVIA<sup>®), using Goldmann Applanation tonometer (GAT) as a reference value and to explore their clinical usefulness. Methods: In a prospective study of 71 normal eyes, IOP was measured with NCT, RT, Tono-Pen and GAT. The IOP values of were then compared between the eyes. Results: RT showed statistically most significant agreement with the GAT [ICC 0.811, 95%CI 0.712-0.878]. In analysis of Bland-Altman plots, NCT showed the smallest mean bias (+0.2 mm Hg) and widest CI (95%CI; ±5.05 mm Hg), RT showed relatively small mean bias (-0.7 mm Hg) and narrowest CI (95%CI; ±3.75 mm Hg). Conclusions: There was a significant agreement between the RT and the GAT measurements. We expect RT to be considered as a reliable alternative when IOP measurement with GAT is not feasible. J Korean Ophthalmol Soc 2014;55(1):47-53

고압하의 전하이동착물에 대한 물성론적 연구-사염화탄소 용액내에서 헥사메틸벤젠과 여러 전자받게들간의 전하이동착물 생성에 대한 압력과 온도의 영향

권오천,김명자,김세경,Kwun Oh Cheun,Kim Myong Ja,Kim Se Kyung 대한화학회 1991 대한화학회지 Vol.35 No.4

헥사메틸벤젠과 1,3,5-트리니트로벤젠, 테트라클로로 파라벤조퀴논 및 테트라시아노 에틸렌간에 형성되는 전하이동착물의 안정도에 미치는 압력과 온도의 영향을 사염화탄소 용액내에서 분광광도법으로 연구하였다. 압력 및 온도증가에 따른 각계 착물들의 평형상수를 구하고 이 값으로부터 착물형성에 대한 열역학적 파라미터를 산출한 결과 헥사메틸벤젠과 각계의 전하이동착물의 상대적 안정도가 1,3,5-트리니트로벤젠 < 테트라클로로 파라벤조퀴논 < 테트라시아노 에틸렌 순으로 나타났다. 이러한 사실은 헥사메틸벤젠에 대한 그들의 상대적 산성도를 의미하며, 이 현상은 전자받게들의 음유도 효과와 입체장애 효과로 설명할 수 있다. 또 각 착물들의 압력 증가에 의한 적색이동, 온도 증가에 의한 청색이동 현상 및 압력 변화에 의한 진동자세기의 관계를 열역학 함수와 관계지워 설명하였다. The effect of pressure and temperature on the stabilities of the charge transfer complexes of 1,3,5-trinitrobenzene, tetrachloro-p-benzoquinone and tetracyanoethylene with hexamethylbenzene in carbon tetrachloride has been investigated by spectrophotometric measurements. The equilibrium constants for the formation of the complexes were obtained at various temperature and pressure, and thermodynamic parameters for the formation of the charge transfer complexes are calculated from these values. The relative stabilities of charge transfer complexes with hexamethylbenzene increase in the order; 1,3,5-trinitrobenzene < tetrachloro-p-benzoquinone < tetracyanoethylene. This may be regarded as an order of relative acidity of these compounds in complexation with hexamethylbenzene and is explained in terms of the negative inductive effect of the ${\pi}$ acceptors. The red-shift at higher pressure, the blue-shift at higher temperature and the relation between pressure and oscillator strength are discussed on the basis of thermodynamic functions.

직장 및 대장암 167예에 대한 임상 분석

최흥식(Heung Sik Choi),김세경(Se Kyung Kim),김인철(In Chul Kim) 대한외과학회 1988 Annals of Surgical Treatment and Research Vol.34 No.6