회원작품 - 안산어린이집

김성은,Kim, Sung-Eun 대한건축사협회 1998 建築士 Vol.1998 No.7

공정 개선에 따른 사고저항성 CrAl 코팅 피복관의 내마모성 향상

김성은,이영호,김대호,김현길,Kim, Sung Eun,Lee, Young-Ho,Kim, Dae Ho,Kim, Hyun-Gil 한국트라이볼로지학회 2022 한국트라이볼로지학회지 (Tribol. Lubr.) Vol.38 No.4

This paper investigates the enhanced wear performance of a CrAl coated accident tolerant fuel (ATF) cladding. In the wake of the Fukushima accident, extensive research on ATF with respect to improving the oxidation resistance of cladding materials is ongoing. Since coated Zr claddings can be applied without major changes to the criteria for reactor core design, many researchers are studying coatings for claddings. To improve the quality of the CrAl coating layer, optimization of the manufacturing process is imperative. This study employs arc ion plating to obtain improved CrAl coated claddings using CrAl binary alloy targets through an improved coating method. Surface roughness and adhesion are improved, and droplets are reduced. Furthermore, the coated layer has a dense and fine microstructure. In scratch tests, all the tested CrAl coated claddings exhibit a superior resistance compared to the Zr cladding. In a fretting wear test, the wear volume of the CrAl coated claddings is smaller compared to the Zr cladding. Furthermore, the coated cladding manufactured through the improved process exhibits better wear resistance than other CrAl coated claddings. Based on these results, we suggest that fine microstructure is attributed to a mechanically and microstructurally robust CrAl coating layer, which enhances wear resistance.

소엽 Ethyl acetate 분획의 세포독성 평가

김성은,천현자,김일광,한두석,이현옥,안종웅,이미희,백승화,Kim Sung-Eun,Chun Hyun-Ja,Kim Il-Kwang,Han Du-Seok,Lee Hyun-Ok,Ahn Jong-Woong,Lee Mee-Hee,Baek Seung-Hwa 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.2

The Cytotoxic activity of the ethyl acetate soluble fraction of Perilla frutescens on human oral epithelioid carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl-2H-tetrazalium bromide (MTT) colorimetric method. The light microscopic study was carried out to observe the morphological changes of cultured human oral epitheloid carcinoma cell lines (KB) These results were obtained as follows; 1. subfraction 1 of the ethyl acetate soluble fraction of perilla frutescens was shown significant cytotoxic activity (p<0.001) at 10-2 mg/ml concentration, this concentration was decreased the cytotoxic activity of 70.3% . 2. The comparison of IC50 values of various subfractions in human oral epithelioid carcinoma cell lines was exhibited that their susceptibility to these subfractions decreased in the following order ; subfraction 5 > subfraction 4 > subfraction 3 > subfraction 2 > subfraction 1 by MTT assay. In light microscopy, the subfraction 1 of the ethyl acetate soluble fraction of Perilla frutescens showed the highest cytotoxic activity. These findings suggest that subfraction 1 possessed the most cytotoxic constituents.

골격성 III급 부정교합자의 측두하악관절에 관한 방사선학적 연구

김성은,김재덕,Kim Sung-Eun,Kim Jae-Duk 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.2

Purpose : To investigate the differences between the position of the mandibular condyles in temporomandibular joints of patients presenting with normal occlusion and skeletal class III malocclusion. Materials and Methods: Forty-two subjects with normal occlusion and thirty-seven subjects exhibiting skeletal class III malocclusion prior to orthodontic treatment were included in the study. Transcranial radiographs of each subject were taken at centric occlusion and 1 inch mouth opening. The positional relationship between the mandibular condyles with articular fossae and articular eminences at two positional states were evaluated and analyzed statistically. Results: The mandibular condyles of the skeletal class III malocclusion group were found to be located more anteriorly from the center of the articular fossae compared to the normal occlusion group in centric occlusion. The mandibular condyles of the skeletal Class III malocclusion group were located more superiorly from the middle of articular height than those of the normal occlusion group in centric occlusion. However, these differences were not statistically significant. At 1 inch mouth opening, the mandibular condyles of the skeletal class III malocclusion group were placed more posteriorly from the articular eminences than those of the normal occlusion group. The mean angle of the articular eminence posterior slope were 56.51 ° ± 6.29° in the normal occlusion group and 60.37° ± 6.26° in the skeletal Class III malocclusion group. Conclusions: The mandibular condyles of the skeletal Class III malocclusion group were placed more anteriorly at centric occlusion and more posteriorly at 1 inch mouth opening when compared with those of the normal occlusion group.

두 가지 유전적 변이가 동반된 선천성 적혈구조혈성 포르피린증 1예

김성은,이형근,Sung Eun Kim,Hyung Keun Lee 대한안과학회 2009 대한안과학회지 Vol.50 No.3

Purpose: Congenital erythropoietic porphyria (CEP) is a rare disorder inherited as an autosomal recessive trait, which is characterized by almost complete reduction of uroporphyrinogen III synthase (UROS) activity. The authors of the present study report a case of congenital erythropoietic porphyria with severe ocular involvement. Case summary: A 27-year-old male patient diagnosed with congenital erythropoietic porphyria was referred to our clinic with a history of ocular pain, and foreign body sensation in both eyes. Visual acuity was light perception in both eyes. Severe scarring of eyelids, corneal leukoma with neovascularization, total limbal deficiency and scleromalacia were observed in both eyes. Identification of the uroporphyrinogen III synthase (UROS) gene mutation revealed the patient had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10. Conclusions: CEP is clinically characterized by severe cutaneous photosensitivity, hemolytic anemia and porphyriuria. In addition to these manifestations, the authors report a severe ocular involvement in a patient with CEP who had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10.

위암 선별검사 현황

김성은,Sung Eun Kim 대한소화기암연구학회 2016 Journal of digestive cancer reports Vol.4 No.2

Gastric cancer is the fifth most common malignancy in the world and still remains the third and fifth leading cause of cancer death in male and female, respectively. In terms of the cancer survival, the survival of gastric cancer is low in the West with showed 5-year survival rates of 10-30%, whereas the survival rates in Asia is more than 50%. The reason of the higher survival rate from gastric cancer in Asia partially related with the availability of gastric cancer screening programs, however, the population-based screening for gastric cancer has been conducted just in Korea and Japan. Therefore, more effective method for detecting the gastric cancer is needed for countries without a population-based gastric cancer screening. Endoscopy is the most effective method for diagnosis of gastric cancer however, it requires a large infrastructure including a large number of endoscopic equipment and well-trained endoscopists. To overcome these problems, several noninvasive methods (such as serologic markers, biomarkers, cancer autoantibodies, and exhaled breath analysis) for diagnosis of gastric cancer screening are suggested. This review addresses the conventional methods and the emerging methods for gastric cancer screening.

대학생의 정보활용능력 교수학습모형 개발에 관한 기초연구

김성은,이명희,Kim, Sung-Eun,Lee, Myeong-Hee 한국비블리아학회 2006 한국비블리아학회지 Vol.17 No.2

This research has been done to develope a curricular model for the Information Literacy Course as one of liberal arts courses in Korean universities. This curricular model had resulted from investigating the standards and models for Information Literacy at the 4 standards(ACRL in USA, CAUL in Australia ANZILL in Australia and New Zealand, and SCONUL in the United Kingdom), 5 syllabi for Information Literacy used by 5 American universities and 33 syllabi by 23 Korean universities. On the basis of these educational results of the Information Literacy syllabi, a learning-instruction model has come into being for the Information Literacy Course that includes 7 core areas : information sources, information need, information access. information analysis, information management, information transfer and communication, and information ethics.

월경전 불쾌기분장애 환자에서 증상과 기질과의 관련성

김성은,이정현,김덕만,박진균,기선완,김지웅,Kim, Sung-Eun,Lee, Jung-Hyun,Kim, Deok-Man,Park, Jin-Kyun,Ki, Seon-Wan,Kim, Ji-Woong 한국정신신체의학회 2006 정신신체의학 Vol.14 No.1

연구목적 : 본 연구는 월경전 불쾌기분장애와 기질 특성과의 관련성을 알아봄으로써 월경전 불쾌기분장애의 병태생리 및 관련된 성격 경향을 이해하며 치료 응용의 가능성을 제시해 보고자 하였다. 방법 : DSM-IV 진단기준에 의해 월경전 불쾌기분장애로 진단된 28명을 대상으로 한국어판 TPQ, 축약형 월경전기평가서 등을 작성케 한 후, 이들 사이의 상관관계를 구하였다. 결과 : 기질의 4가지 차원에 해당하는 점수를 독립 변인으로 하고, 축약형 월경전기평가서 점수를 종속 변인으로 하여 표준 중다회귀분석을 시행하였을 때 월경전 불쾌기분장애 증상은 Cloninger가 제시한 성격의 기질을 구성하는 4가지 요인 중 손해 회피(HA) 요인과 보상 의존(RD) 요인에 대하여 유의하였으며, 특히 손해 회피(HA) 요인에 의해 가장 많이 설명될 수 있는 것으로 나타났다. 결론: 월경전 불쾌기분장애의 증상은 높은 손해 회피(HA) 요인과 낮은 보상 의존(RD) 요인에 의해 잘 설명되었다. 월경전기증상 중 특히 정동 증상이 손해 회피(HA) 요인과 상관관계를 갖고 있는데, 이는 월경전 불쾌기분장애가 기질의 특성에 영향을 받음을 의미한다. 이는 향후 월경전 불쾌기분장애의 병태생리의 이해에 도움이 될 것으로 생각한다. Objectives: The study was intended to explore the relationships between temperament and premenstrual dysphoric disorder, to understand symptomatology of premenstrual dysphoric disorder and associated personality trait and to suggest therapeutic availability. Method : Twenty eight women, diagnosed as premenstrual dysphoric disorder by DSM-IV, were asked to complete the Korean version of Tridimensional Personality Questionnaire, and Shortened Premenstrual Assessment Form. The correlations between the severity of premenstrual symptoms and the scores of Tridimensional Personality Questionnaire were calculated. Results : The severity of symptoms of premenstrual dysphoric disorder was best explained by the harm-avoidance factor of the four dimensions of temperament. Conclusion : The symptoms of premenstrual dysphoric disorder are well explained by the harmavoidance factor and the reward-dependence factor of four dimensions of the temperament.

Stage 3 플러스 징후를 동반한 미숙아 망막병증에서 일차 유리체강내 베바시주맙 주입술의 효과

김성은,임형택,이승규,Sung Eun Kim,Tyler Hyung Taek Rim,Christopher Seungkyu Lee 대한안과학회 2015 대한안과학회지 Vol.56 No.1

Purpose: To evaluate the efficacy and safety of primary intravitreal bevacizumab injection in stage 3 retinopathy of prematurity with plus signs. Methods: We reviewed retrospectively the medical records of 30 eyes of 16 patients diagnosed with stage 3 retinopathy of prematurity with plus signs treated with primary intravitreal bevacizumab injection between March 1, 2011 and February 28, 2013 and followed up for at least 9 months. Results: Mean gestational age was 26 + 4 weeks ± 11 days and mean birth weight was 822 ± 251.4 g. The locations of disease were zone II in 24 eyes and zone III in 6 eyes. Intravitreal bevacizumab injection was performed after the mean 1.3 ± 1 day after plus signs were detected. Mean postconceptional age at treatment was 38 + 2 weeks ± 16 days. Mean follow-up period was 16.6 ± 6.9 months. Plus signs started to regress after the mean 4.6 ± 2.3 days after injection and completely regressed after the mean 24.3 ± 12.4 days. Cataract extraction was performed in 1 eye due to a cataract that appeared not associated with the injection procedure, but was regarded as a treatment failure. There were no local or systemic complications. Conclusions: Primary intravitreal bevacizumab injection in stage 3 retinopathy of prematurity with plus signs demonstrated excellent short-term efficacy and safety. J Korean Ophthalmol Soc 2015;56(1):62-69

고지방식이(HFD)/stereptozotocin(STZ) 유도 당뇨모델에서 여주가 글루카곤 분비에 미치는 영향

김성은,김상백,김슬기,김현규,박병준,이학성,Kim, Seong-Eun,Kim, Sang-Back,Kim, Seul Ki,Kim, Hyun-Kyu,Park, Byoungjun,Lee, Hak Sung 한국환경과학회 2020 한국환경과학회지 Vol.29 No.8

In present study, we investigated the antidiabetic effect of Momordica charantia(as well known "bitter melon"). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ± 20.22 mg/dL) and 250 mg/kg(124.17 ± 22.17 mg/dL) groups than in the vehicle group(188.83 ± 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.