대학생의 정보활용능력 교수학습모형 개발에 관한 기초연구

김성은,이명희,Kim, Sung-Eun,Lee, Myeong-Hee 한국비블리아학회 2006 한국비블리아학회지 Vol.17 No.2

This research has been done to develope a curricular model for the Information Literacy Course as one of liberal arts courses in Korean universities. This curricular model had resulted from investigating the standards and models for Information Literacy at the 4 standards(ACRL in USA, CAUL in Australia ANZILL in Australia and New Zealand, and SCONUL in the United Kingdom), 5 syllabi for Information Literacy used by 5 American universities and 33 syllabi by 23 Korean universities. On the basis of these educational results of the Information Literacy syllabi, a learning-instruction model has come into being for the Information Literacy Course that includes 7 core areas : information sources, information need, information access. information analysis, information management, information transfer and communication, and information ethics.

피부 찰과상을 통한 파라쿼트 중독에 의한 사망 1례

김성은,조준휘,천승환,이승용,최기훈,배지훈,서정열,안희철,안무업,옥택근,박찬우,Kim, Sung-Eun,Cho, Jun-Hwi,Cheon, Seung-Whan,Lee, Seung-Young,Choi, Ki-Hoon,Bae, Ji-Hoon,Seo, Jeong-Yeul,Ahn, Hee-Cheol,Ahn, Moo-Eob,Ok, Taek-Gun,Park, Chan 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Paraquat, is a widely used for its great effect as a herbicide. But the mortality rate by paraquat intoxication is known to be very high. It is thought to act by changing form to superoxide and peroxide free radical. Almost paraquat intoxication is through ingestion. A few intoxication of paraquat is through skin absorption. But there was no known death case through skin absorption. We experienced a case of a expired patient by paraquat intoxication through skin abrasion and scratching wound. A 75-year-old man was visited emergency room after motorcycle accident during transporting paraquat. He has multiple abrasion and scratching wound on extremities, and pelvic bone fracture. There was no evidence of ingestion of paraquat. But serum/urine gramoxone level was all positive. In spite of wound irrigation and hemoperfusion, his condition was been gone form bed to worse. 2 days after, multiple organ failure and the respiratory arrest were developed and he was expired. Paraquat intoxication through skin wound is extremely dangerous and death by that could possibly happen

소엽 Ethyl acetate 분획의 세포독성 평가

김성은,천현자,김일광,한두석,이현옥,안종웅,이미희,백승화,Kim Sung-Eun,Chun Hyun-Ja,Kim Il-Kwang,Han Du-Seok,Lee Hyun-Ok,Ahn Jong-Woong,Lee Mee-Hee,Baek Seung-Hwa 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.2

The Cytotoxic activity of the ethyl acetate soluble fraction of Perilla frutescens on human oral epithelioid carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl-2H-tetrazalium bromide (MTT) colorimetric method. The light microscopic study was carried out to observe the morphological changes of cultured human oral epitheloid carcinoma cell lines (KB) These results were obtained as follows; 1. subfraction 1 of the ethyl acetate soluble fraction of perilla frutescens was shown significant cytotoxic activity (p<0.001) at 10-2 mg/ml concentration, this concentration was decreased the cytotoxic activity of 70.3% . 2. The comparison of IC50 values of various subfractions in human oral epithelioid carcinoma cell lines was exhibited that their susceptibility to these subfractions decreased in the following order ; subfraction 5 > subfraction 4 > subfraction 3 > subfraction 2 > subfraction 1 by MTT assay. In light microscopy, the subfraction 1 of the ethyl acetate soluble fraction of Perilla frutescens showed the highest cytotoxic activity. These findings suggest that subfraction 1 possessed the most cytotoxic constituents.

고지방식이(HFD)/stereptozotocin(STZ) 유도 당뇨모델에서 여주가 글루카곤 분비에 미치는 영향

김성은,김상백,김슬기,김현규,박병준,이학성,Kim, Seong-Eun,Kim, Sang-Back,Kim, Seul Ki,Kim, Hyun-Kyu,Park, Byoungjun,Lee, Hak Sung 한국환경과학회 2020 한국환경과학회지 Vol.29 No.8

In present study, we investigated the antidiabetic effect of Momordica charantia(as well known "bitter melon"). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ± 20.22 mg/dL) and 250 mg/kg(124.17 ± 22.17 mg/dL) groups than in the vehicle group(188.83 ± 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.

골격성 III급 부정교합자의 측두하악관절에 관한 방사선학적 연구

김성은,김재덕,Kim Sung-Eun,Kim Jae-Duk 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.2

Purpose : To investigate the differences between the position of the mandibular condyles in temporomandibular joints of patients presenting with normal occlusion and skeletal class III malocclusion. Materials and Methods: Forty-two subjects with normal occlusion and thirty-seven subjects exhibiting skeletal class III malocclusion prior to orthodontic treatment were included in the study. Transcranial radiographs of each subject were taken at centric occlusion and 1 inch mouth opening. The positional relationship between the mandibular condyles with articular fossae and articular eminences at two positional states were evaluated and analyzed statistically. Results: The mandibular condyles of the skeletal class III malocclusion group were found to be located more anteriorly from the center of the articular fossae compared to the normal occlusion group in centric occlusion. The mandibular condyles of the skeletal Class III malocclusion group were located more superiorly from the middle of articular height than those of the normal occlusion group in centric occlusion. However, these differences were not statistically significant. At 1 inch mouth opening, the mandibular condyles of the skeletal class III malocclusion group were placed more posteriorly from the articular eminences than those of the normal occlusion group. The mean angle of the articular eminence posterior slope were 56.51 ° ± 6.29° in the normal occlusion group and 60.37° ± 6.26° in the skeletal Class III malocclusion group. Conclusions: The mandibular condyles of the skeletal Class III malocclusion group were placed more anteriorly at centric occlusion and more posteriorly at 1 inch mouth opening when compared with those of the normal occlusion group.

위암 선별검사 현황

김성은,Sung Eun Kim 대한소화기암연구학회 2016 Journal of digestive cancer reports Vol.4 No.2

Gastric cancer is the fifth most common malignancy in the world and still remains the third and fifth leading cause of cancer death in male and female, respectively. In terms of the cancer survival, the survival of gastric cancer is low in the West with showed 5-year survival rates of 10-30%, whereas the survival rates in Asia is more than 50%. The reason of the higher survival rate from gastric cancer in Asia partially related with the availability of gastric cancer screening programs, however, the population-based screening for gastric cancer has been conducted just in Korea and Japan. Therefore, more effective method for detecting the gastric cancer is needed for countries without a population-based gastric cancer screening. Endoscopy is the most effective method for diagnosis of gastric cancer however, it requires a large infrastructure including a large number of endoscopic equipment and well-trained endoscopists. To overcome these problems, several noninvasive methods (such as serologic markers, biomarkers, cancer autoantibodies, and exhaled breath analysis) for diagnosis of gastric cancer screening are suggested. This review addresses the conventional methods and the emerging methods for gastric cancer screening.

두 가지 유전적 변이가 동반된 선천성 적혈구조혈성 포르피린증 1예

김성은,이형근,Sung Eun Kim,Hyung Keun Lee 대한안과학회 2009 대한안과학회지 Vol.50 No.3

Purpose: Congenital erythropoietic porphyria (CEP) is a rare disorder inherited as an autosomal recessive trait, which is characterized by almost complete reduction of uroporphyrinogen III synthase (UROS) activity. The authors of the present study report a case of congenital erythropoietic porphyria with severe ocular involvement. Case summary: A 27-year-old male patient diagnosed with congenital erythropoietic porphyria was referred to our clinic with a history of ocular pain, and foreign body sensation in both eyes. Visual acuity was light perception in both eyes. Severe scarring of eyelids, corneal leukoma with neovascularization, total limbal deficiency and scleromalacia were observed in both eyes. Identification of the uroporphyrinogen III synthase (UROS) gene mutation revealed the patient had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10. Conclusions: CEP is clinically characterized by severe cutaneous photosensitivity, hemolytic anemia and porphyriuria. In addition to these manifestations, the authors report a severe ocular involvement in a patient with CEP who had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10.

일제시기 김활란의 여권의식과 여성교육론

김성은(Kim Sung-Eun) 부산경남사학회 2011 역사와 경계 Vol.79 No.-

김활란은 여권문제의 원인을 여성의 교육권과 재산권 부재에서 그원인을 찾았다. 여권향상을 위해 김활란이 할 수 있는 일은 여성교육이었다. 김활란의 남녀관은 가정과 사회에서 여성과 남성이 동반자이자 동업자, 동등한 협력관계라고 보았다. 김활란은 가정에서 남녀동등은 주부의 역할과 기여를 인정하고 여성이 직업과 경제력을 가지고 결혼비용을 분담하는데서 시작된다고 보았다. 이러한 의미에서 여성의 직업은 남녀동등한 가정을 준비하는 단계였다. 나아가 김활란은 여성들에게 결혼을 얽매이지 말고 사회에 진출하여 이제까지 남성의 영역으로 간주되었던 직업들에 과감히 도전할 것을 촉구했다. 한편 사회가 여성에게 남성과 동등한 교육과 취업의 기회를 줌으로써 여성이 능력을 발휘할 수 있도록 해야 한다고 촉구했다. 김활란은 특히 가정부인이 소비자가 아니라 생산자라는 점을 강조했다. 따라서 가사, 직업, 부업을 하는 생산자로서 여성의 위상 정립이 중요하다고 보았다. 또한 주부가 사회의식을 가지고 가사의 합리화를 통해 확보한 시간과 노력을 활용하여 사회봉사에 나설 것을 촉구했다. 김활란은 여권운동의 첫걸음이 문맹퇴치운동이며 여성일반의 지위향상을 위해서는 여성의 고등교육뿐 아니라 보통교육이 확산되어야 한다고 생각했다 따라서 교육을 받은 신여성이 여성의 지위 향상을 위해 여성의 문맹타파에 나서야 한다고 촉구했다. 특히 신여성 주부가 사회봉사로써 농촌계봉과 문맹퇴치에 나서야 한다고 촉구했다. 문맹퇴치는 단순히 한글보급뿐 아니라 상식과 지식계발, 사회의식의 고취를 포함한 것이었다. 김활란은 신여성들이 지도자의식을 가지고 여성의 문맹퇴치에 힘써야 한다고 강조했다. 여성교육담당자로서 김활란은 여성고등교육의 유용성에 대한 회의, 현모양처 교육 논란, 실생활과 괴리된 교육내용 학생풍기문제와 사치문제에 대한 비판여론에 대응하며 여성교육의 문제점을 점검하고 방향을 모색해야 했다. 미국유학에도 불구하고 김활란은 한국인으로서 조선적인 실생활교육을 지향하며 조선화된 이화, 조선의 이화를 만들고자 했다. 이를 위해 한국인의 힘으로 재단법인 설립, 재정 자립, 학교 경영을 하길 원했다. 또한 여자종합대학교 설립을 목표로 기존의 문과, 음악과, 가사과, 보육과 이외에 상과, 농촌사업과, 사회사업과, 의과, 체육과의 학과 증설을 계획했다. 이 학과들은 당시 우리 민족에게 절실히 필요했던 분야인 동시에 여성의 직업과 사회활동, 봉사활동에 도움이 되는 분야였다. 김활란은 여성고등교육만 강조한 것이 아니라 문맹퇴치와 농촌계몽, 보통교육의 대중화 역시 강조했다. 여성고등교육에 있어서도 조선의 사회현실과 실생활을 고려하여 실제 가정생활과 사회운동에 필요한 교육이 되도록 끊임없이 노력했다. This is about Hellen Kim’s consciousness of women’s rights and view of Korean women’s education. Hellen Kim was one of the greatest educator in modern Korea. She had dedicated herself to Korean women’s education and elevation. She had maintained equal rights for both sexes and equality of both sexes. So She had thought Korean women of being have rights for education and profession. She had encouraged Korean women to have profession and had revaluated housewives’ housework. She had thought elementary education need to spread and higher education need to grow for elevating Korean women’s status. So she maintained educated Korean women have to sense of duty to serve her sisterhood to teach Korean literacy and common sense. She had tried to solve probloms of women’s education like good wife and wise mother education or Korean practical life education.

월경전 불쾌기분장애 환자에서 증상과 기질과의 관련성

김성은,이정현,김덕만,박진균,기선완,김지웅,Kim, Sung-Eun,Lee, Jung-Hyun,Kim, Deok-Man,Park, Jin-Kyun,Ki, Seon-Wan,Kim, Ji-Woong 한국정신신체의학회 2006 정신신체의학 Vol.14 No.1

연구목적 : 본 연구는 월경전 불쾌기분장애와 기질 특성과의 관련성을 알아봄으로써 월경전 불쾌기분장애의 병태생리 및 관련된 성격 경향을 이해하며 치료 응용의 가능성을 제시해 보고자 하였다. 방법 : DSM-IV 진단기준에 의해 월경전 불쾌기분장애로 진단된 28명을 대상으로 한국어판 TPQ, 축약형 월경전기평가서 등을 작성케 한 후, 이들 사이의 상관관계를 구하였다. 결과 : 기질의 4가지 차원에 해당하는 점수를 독립 변인으로 하고, 축약형 월경전기평가서 점수를 종속 변인으로 하여 표준 중다회귀분석을 시행하였을 때 월경전 불쾌기분장애 증상은 Cloninger가 제시한 성격의 기질을 구성하는 4가지 요인 중 손해 회피(HA) 요인과 보상 의존(RD) 요인에 대하여 유의하였으며, 특히 손해 회피(HA) 요인에 의해 가장 많이 설명될 수 있는 것으로 나타났다. 결론: 월경전 불쾌기분장애의 증상은 높은 손해 회피(HA) 요인과 낮은 보상 의존(RD) 요인에 의해 잘 설명되었다. 월경전기증상 중 특히 정동 증상이 손해 회피(HA) 요인과 상관관계를 갖고 있는데, 이는 월경전 불쾌기분장애가 기질의 특성에 영향을 받음을 의미한다. 이는 향후 월경전 불쾌기분장애의 병태생리의 이해에 도움이 될 것으로 생각한다. Objectives: The study was intended to explore the relationships between temperament and premenstrual dysphoric disorder, to understand symptomatology of premenstrual dysphoric disorder and associated personality trait and to suggest therapeutic availability. Method : Twenty eight women, diagnosed as premenstrual dysphoric disorder by DSM-IV, were asked to complete the Korean version of Tridimensional Personality Questionnaire, and Shortened Premenstrual Assessment Form. The correlations between the severity of premenstrual symptoms and the scores of Tridimensional Personality Questionnaire were calculated. Results : The severity of symptoms of premenstrual dysphoric disorder was best explained by the harm-avoidance factor of the four dimensions of temperament. Conclusion : The symptoms of premenstrual dysphoric disorder are well explained by the harmavoidance factor and the reward-dependence factor of four dimensions of the temperament.

신생아 로타바이러스 감염 진단에서 효소면역법과 중합효소연쇄반응과의 비교

김성은,김미옥,박선영,정원조,마상혁,김윤정,김선주,Kim, Sung Eun,Kim, Mi Ok,Park, Sun Young,Jung, Won Jo,Ma, Sang Hyeok,Kim, Yun Jung,Kim, Sun Ju 대한소아감염학회 2000 Pediatric Infection and Vaccine Vol.7 No.1

Purpose : Rotavirus is a most common etiologic agent of pediatric gastroenteritis. The standard method to diagnose rotavirus infection was the detection of viral particles in specimens through electron microscopy. But it was complex. Enzyme immunoassay and latex agglutinin are preferred because they are relatively handy, inexpensive and take a short time, in comparison with electron microscopy. However, several reports have shown that the use of ELISA to diagnose rotavirus infection in neonates can result in false positive reactions. The main purpose of this study is to compare ELISA and RT-PCR in the diagnosis of neonatal rotavirus infection. Methods : Data presented in this study were obtained form 123 newborn babies in the nursery of the Fatima Hospital, Masan, Korea, form Jury to December, 1997. We obtained two samples of stool from each of the newborn babies and then performed the Rotazyme test and the RT-PCR. In the Rotazyme test, the results were interpreted according to visual findings. The samples were used for the RT-PCR test after at stock $-30^{\circ}C$ to identify rotavirus group A. The result of the two tests were compared. Results : The informations are divided into 73 males and females. Out of the total informations 15 were transferred from other hospitals. Their average gestational age was $38.5{\pm}1.6$ weeks. The average birth weight was $3134.8{\pm}539gm$. In the Rotazyme test, 75 samples turned out to be positive. Out of them, 55 samples(75.3%) were positive and 18 samples(24.7%) were negative in the RT-PCR. On the other hand, in the Rotazyme test, 50 samples turned out be negative. Out of them, 27 samples(54%) were positive and 23 samples(46%) were negative in the RT-PCR. Conclusion : Rotavirus infection in uncommon in neonates. The diagnosis based on visual findings using Rotazyme test has a disadvantage in the sense that it can result in false positive reactions and false negative reactions in the diagnosis of neonatal rotavirus infection.