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김선길 ( Sun-gil Kim ),정지원 ( Ji-won Jeong ),임용하 ( Young-ha Lim ),김지훈 ( Ji-hoon Kim ),나창수 ( Chang-su Na ),김선종 ( Seon-jong Kim ) 대한한의학회 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.2
Objectives The objective of this study was to investigate the effect of Anti-condensing on the composition of ChondroT Methods Specimens are divided in 7 groups (Control, ChondroT, Lonicerae Folium (Gumenhwa, GEH), Angelicae Gigantis Radix(Danggui, DG), Phellodendri Cortex(HwangBaek, HB), Osterici Radix(Kanghwal, KH), Clematidis Radix(Weeryungsun, WRS)) Each specimen is subjected to a concentration of 20 %, 10 %, and 5 %, and is administered to collagen and thrombin-stimulated platelets. Results In the anticoagulance effect test, Lonicerae Folium and ChondroT very well. The effect was high in order of Lonicerae Folium-Angelicae Gigantis-Phellodendri Cortex-Osterici Radix and Clematidis Radix. Conclusions ChondroT has anti-condensing effects on blood platelet. (J Korean Med Rehabil 2018;28(2):47-60)
시뮬레이션과 순차 패턴을 이용한 FMC 로봇의 효율적 작업 순서 설계 및 분석
김선길(Kim, Sun-Gil),김연진(Kim, Youn-Jin),이홍철(Lee, Hong-Chul) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.6
본 논문에서는 FMC 로봇의 생산성 향상을 위해 시뮬레이션과 순차 패턴 기법을 이용해 로봇의 패턴을 분 석하고 최적의 로봇 작업 우선순위규칙(Dispatching Rule)을 설계하는 방법을 제시하였다. 이를 위해, 먼저 FMC를 시 뮬레이션으로 설계하고 각 설비가 로봇에게 요청하는 신호를 추출 해 이를 로그(Log) 형태로 생성, 저장하였다. 그 후, 이 로그를 데이터 마이닝 기법 중 하나인 순차 패턴 분석을 이용해 설비의 신호와 로봇간의 연관된 순서를 분석 하여 로봇의 최적 이동 경로를 도출하는 방법을 제시하였다. 또한, 사례연구를 통하여 FMC의 적용성에 대한 효율성 을 입증하였다. 도출된 최적의 패턴을 국내 A사 생산라인에 적용한 결과 작업물 대기시간(Loss Time)의 감소와 로봇 이용률의 향상, 작업물의 총 처리량의 증가와 평균 처리시간 감소를 가져왔다. 또한, 이러한 신호의 패턴을 이용한 분석 방법은 신호와 동작간의 로그를 저장, 데이터베이스화하여 시스템 상에서 로봇의 작업 우선순위규칙을 도출할 수 있게 하므로, 작업자의 오랜 노하우(Know-How) 없이도 로봇 운영의 문제점을 파악하고 그 개선안을 제시할 수 있다. 이러한 방법을 통해 FMC 뿐만이 아닌 로봇을 사용하는 모든 분야에 설비의 신호와 로봇 동작간의 그 연관관 계를 분석하고 최적의 운영법칙을 설계, 운영하여 생산성 향상에 크게 기여할 것으로 기대된다. This paper suggested the method to design and analyze FMC robot's dispatching rule using the Simulation and Sequential Patterns. To do this, first of all, we built FMC using simulation and then, extracted signals that facilities call a robot, saved it as the log type. Secondly, we built robot's optimal path using the Sequential Pattern Mining with the results of analyzing the log and relationship between machine and robot actions. Lastly, we adapted it to the A corp.'s manufacturing line for verifying its performance. As a result of applying the new dispatching rule in FMC, total throughput and total flow time decrease because of decreasing material loss time and increasing robot utility. Futhermore, because this method can be applied for every manufacturing plant using simulation, it can contribute to advance total FMC efficiency as well.
김선길 ( Sun-gil Kim ),김주일 ( Joo Il Kim ),김지훈 ( Ji-hoon Kim ),윤찬석 ( Chan Suk Yoon ),정지원 ( Ji-won Jeong ),나창수 ( Chang-su Na ),김선종 ( Seon-jong Kim ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.1
Objectives This study was performed to observe the genotoxic effect of the ChondroT. Methods To evaluate the genotoxicity of ChondroT, an experiment of bacterial reverse mutation test, in vitro mammalian chromosomal aberration test and mammalian erythrocyte micronucleus test in mouse was conducted. Results TA98, TA100 and TA1537 strains in the absence of metabolic activation system (S9 mix), the number of revertant colonies being greater than 2-fold of the respective negative control value. Both in -S9 mix and +S9 mix, the frequencies of aberration cells with structural aberration and numerical aberrations of chromosome were less than 5%. There was no increase of polychromatic erythrocyte with one or more micronuclei at any dose of test substance compared to the negative control group (p<0.05). Conclusions In TA98, TA100 and TA1537 strains in the absence of metabolic activation system (S9 mix), the number of revertant colonies was greater than 2-fold of the respective negative control value, showing positive results. ChondroT was considered to be non-clastogenic to Chinese hamster lung (CHL/IU) cells under the present experimental condition. and ChondroT was determined not to induce an increased frequency of micronuclei in the bone marrow cells of male ICR mice under the present experimental condition. (J Korean Med Rehabil 2021;31(1):59-79)
ChondroT 투여가 FeCl<sub>3</sub>로 유발된 혈전에 미치는 영향
김지훈 ( Ji Hoon Kim ),김선길 ( Sun Gil Kim ),김주일 ( Joo Il Kim ),윤창석 ( Chang Suk Yoon ),최지민 ( Ji Min Choi ),나창수 ( Chang Su Na ),김선종 ( Seon Jong Kim ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3
Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl<sub>3</sub>-induced rats. Methods We exposed FeCl3 to rat’s carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl<sub>3</sub>-induced rats, and further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):45-56)
Indomethacin으로 유발된 흰쥐의 위장장애에 ChondroT가 미치는 영향
김주일 ( Joo-il Kim ),김선길 ( Sun-gil Kim ),김지훈 ( Ji-hoon Kim ),윤찬석 ( Chan-suk Yoon ),최지민 ( Ji-min Choi ),최찬헌 ( Chan-hun Choi ),김선종 ( Seon-jong Kim ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3
Objectives The aim of this study was to investigate the inhibitory effect of ChondroT in indomethacin-induced gastric mucosal injury rat model. Methods Sprague-Dawley rats were randomly assigned to intact, control Joins, Celebrex, ChondroT50 and ChondroT200. Indomethacin (25 mg/kg) was used to induce damage to the gastric mucosal injury. ChondroT was administered by orally to inhibit the indomethacin-induced gastric mucosal injury. At the end of the experiment, pH level in stomach, stomach contents volume, tumor necrosis factor-α (TNF- α) level, interleukin-1β (IL-1β) level, prostaglandin E2 (PGE2) level, myeloperoxidase (MPO) activity, erythrocytes, and thrombocytes were measured. Ophthalmologic and histopathological examination was also analyzed. Results pH level in stomach and Stomach contents volume had no difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. TNF-α level was decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group and there were no significant difference. IL-1β level was decreased in PC-Joins group and ChondroT200 group compared to control group. PGE2 level had no significant difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. MPO level and complete blood count level were decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200. Symptom score of ophthalmologic examination was decreased in ChondroT50 and ChondroT200 group compared to control group. Conclusion Based on these results, It could be suggested that ChondroT was effective in reducing damage to the gastric mucosal injury. And further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):57-69)
저발열 콘크리트를 사용한 교각 기초-기둥의 수화열 해석에 관한 연구
전중규,김선길,전찬기,김기형,Jeon, Joong-Kyu,Kim, Sun-Gil,Jeon, Chan-Ki,Kim, Ki-Hyung 한국건설순환자원학회 2014 한국건설순환자원학회 논문집 Vol.2 No.3
본 연구에서는 Premixed 혼합시멘트를 사용한 저발열 콘크리트에 대하여 기초물성 평가로 공기량, 슬럼프 및 압축강도 시험을 수행하고, 수화열 해석을 수행하여 Premixed 혼합시멘트를 사용한 콘크리트의 현장 적용성을 검토하였다. 검토 결과 Premixed 혼합시멘트를 사용한 저발열 콘크리트는 목표 작업성 및 설계기준 압축강도를 충분히 만족하였다. 또한, 수화열 해석 결과 Premixed 혼합시멘트를 사용한 저발열 콘크리트는 목표 온도균열지수를 충분히 확보할 수 있었다. 따라서, 현장 교량구조물의 교각 기초-기둥의 시공에 있어 Premixed 혼합시멘트를 사용한 저발열 콘크리트의 적용은 바람직한 것으로 판단된다. This study carried out to evaluate the hydration heat analysis and fundamental characteristics such as air content, slump and compressive strength for field application of low heat concrete with premixed cement. The results of experiment show that low heat concrete with premixed cement have sufficient performances on the workability and compressive strength. In addition, hydration heat analysis shows that low heat concrete with premixed cement make sure of target thermal cracking index. Therefore, it is desirable to apply the low heat concrete with premixed cement on pier foundation-column.