과산화수소 제독 과정에서의 탄저균 전사체 분석

김상훈,김세계,정경화,윤성녀,김윤기,김민철,류삼곤,이해완,채영규,Kim, Sang Hoon,Kim, Se Kye,Jung, Kyoung Hwa,Yoon, Sung Nyo,Kim, Yun Ki,Kim, Min Cheol,Ryu, Sam Gon,Lee, Hae Wan,Chai, Young Gyu 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.4

Decontamination of biological agents utilizes hydrogen peroxide($H_2O_2$) for its effectiveness and safeness. Bacillus anthracis is a major target for $H_2O_2$ decontamination. To assess the effect of $H_2O_2$ on B. anthracis and identify biomarkers for decontamination, whole transcriptomic profiling of $H_2O_2$-treated B. anthracis was performed. Here we identified deregulation in stress response genes, transcription factors and cellular homeostasis genes. We also found that expression of antisense RNAs increased in B. anthracis during decontamination. We postulate that B. anthracis prioritizes survival and adaptation in response to $H_2O_2$ treatment by changing its gene expression pattern.

슬관절 전치환술에서 후방 안정 임플란트의 오정렬이 경골 기둥에 미치는 영향

김상훈,안옥균,배대경,김윤혁,김경수,이순걸,Kim, Sang-Hoon,Ahn, Ok-Kyun,Bae, Dae-Kyung,Kim, Yoon-Hyuk,Kim, Kyung-Soo,Lee, Soon-Gul 대한의용생체공학회 2007 의공학회지 Vol.28 No.1

Recently, it has been reported that the posterior stabilized implant, which is clinically used for the total knee replacement (TKR), may have failure risk such as wear or fracture by the contact pressure and stress on the tibial post. The purpose of this study is to investigate the influence of the mal alignment of the posterior stabilized implant on the tibial post by estimating the distributions of contact pressure and von-Mises stress on a tibial post and to analyze the failure risk of the tibial post. Finite element models of a knee joint and an implant were developed from 1mm slices of CT images and 3D CAD software, respectively. The contact pressure and the von-Mises stress applying on the implant were analyzed by the finite element analysis in the neutral alignment as well as the 8 malalignment cases (3 and 5 degrees of valgus and varus angulations, and 2 and 4 degrees of anterior and posterior tilts). Loading condition at the 40% of one whole gait cycle such as 2000N of compressive load, 25N of anterior-posterior load, and 6.5Nm of torque was applied to the TKR models. Both the maximum contact pressure and the maximum von-Mises stress were concentrated on the anterior-medial region of the tibial post regardless of the malalignment, and their magnitudes increased as the degree of the malalignment increased. From present result, it is shown that the malalignment of the implant can influence on the failure risk of the tibial post.

고등학교(高等學校) 재학생(在學生)들의 비합리적(非合理的) 신념(信念)과 정신병리(精神病理)

김상훈,최훈동,김학렬,Kim, Sang-Hoon,Choi, Hoon-Dong,Kim, Hack-Ryul 한국정신신체의학회 1995 정신신체의학 Vol.3 No.1

The purpose of this study is to investigate the relationship between irrational belief and psychopathology. The Korean version of Symptom Check List-90-R and Irrational Belief Test were administered to 621 high school students in group. The author used Pearson correlation coefficiency and multiple regression analysis to seek the regression patterns of the irrational belief. The results were as follows. 1) Most of the subscales of the SCL-90-R and Irrational Belief Test were correlated significantly. 2) In multiple regression analysis, the irrational belief associated with anxious overconcern was the most predictable variable for psychopathology.

갈색세포종과 복부 부신경절종의 임상적 특성 분석

김상훈,정승필,이정희,김지영,최민영,이세경,최준호,이정언,김지수,남석진,양정현<SUP>1<.SUP>,김정한,Sang-Hoon Kim,Seung-Pil Jung,Jeong-Hee Lee,Ji-Yeong Kim,Min-Yeong Choi,Se-Kyung Lee,Jun-Ho Choe,Jeong-Eon Lee,Jee Soo Kim,Seok-Jin Nam,Jung- 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.4

신약 헬라어 본문 분석 방식의 새로운 연구

김상훈(Sang Hoon Kim) 한국복음주의신약학회 2007 신약연구 Vol.6 No.1

The New Testament Greek is often a compulsory pre-requisite course in theological seminary education. Although it becomes heavy burden to most students who take the course, spending much time to learn to read the NT in Greek, most of them fail to maintain their Greek after graduation. I think we need to advance some useful tool for Greek study, particularly from the pedagogical point of view, such as a syntactic-semantic arranged method contributed by Johannes Louw, Douglas Stuart, Walter Kaiser, Gordon Fee, William Mounce, and others. These sorts of methods differ from the traditional way of interpretation, the grammatical-historical method, in terms of how to approach the text. The texts arranged for the purpose of visualization, letting the reader to see the text with much clarity in terms of grammatical function of each phrase and their connections between them. The visualized arrangement itself is applied from the area of syntax and semantics in modern linguistics. There are various types of syntactic arrangements of the Greek text. Each pattern has its own principles and rules to be arranged in certain ways. I have compared, in this paper, those models of syntactic arrangements to my model, the Kim's diagram. For the purposes of this paper, I have posed several questions to my students in my classes, regarding their experiences on the syntactic-analytic arrangement of the Greek Bible (SAGB) and their practical uses of both the method and its materials, analyzing their questions in order to show up how much this type of study to be needed for the student

과산화수소 증기를 이용한 다양한 쿠폰 표면의 Geobacillus Stearothermophilus 아포 제독조건

김상훈,정경화,김세계,채영규,김윤기,황현철,김민철,박명규,류삼곤,Kim, Sang Hoon,Jung, Kyoung Hwa,Kim, Se Kye,Chai, Young Gyu,Kim, Yun Ki,Hwang, Hyun Chul,Kim, Min Cheol,Park, Myung Kyu,Ryu, Sam Gon 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.4

Biological decontamination means the removal of microorganisms from the inanimate object such as building or equipment. In this study, hydrogen peroxide vapor efficacy test using VHP 1000ED system(Steris LifeSciences) were conducted for G. stearothermophilus spore with agent materials(aluminum, stainless steel, poly-carbonate, viton, silicone, kapton and glass). Total recovered spores exposed to hydrogen peroxide vapor(1.0 g/min) during 7, 15, 30, 60 min were calculated. As a result, all agent materials were totally decontaminated within 60 min at 1.0 g/min concentration with 35% hydrogen peroxide vapor. Finally, we could confirmed that hydrogen peroxide vapor possess sporicidal capacity of G. stearothermophilus and found the optimum decontamination conditions with VHP1000ED system.

정상 반월상 연골의 혈관 분포

김상훈,조홍식,이한영,이기범,민병현,Kim Sang Hoon,Cho Hong Sik,Lee Han Young,Lee Ki-Bum,Min Byung-Hyun 대한관절경학회 2003 대한관절경학회지 Vol.7 No.1

목적 : 정상 반월상 연골을 형태학적으로 계측하고 혈관 분포를 조사하여 연령과 해부학적 위치에 따른 차이를 비교하였다. 대상 및 방법 : 21구의 사체에서 반월상 연골을 채취하여 이를 연령별로 3군으로 나누고 각각을 10개의 절편으로 나누어 반월상 연골의 폭(width)과 혈관의 분포를 측정하였다. 결과 : 반월상 연골의 평균 폭은 내측이 $10.4{\pm}2.92mm$, 외측이 $10.55{\pm}2.05mm$로 측정 되었다. 혈관 분포 범위는 내측이 $20.29{\pm}8.44\%$, 외측이 $18.99{\pm}7.03\%$이었다. 해부학적 위치에 따른 혈관 분포는 내측의 경우 전각의 혈관 분포가 가장 풍부하였고(p<0.05), 외측의 경우 후각의 혈관 분포가 가장 풍부하였으며(p<.0.05) 슬와근부에서도 혈관 주행을 관찰할 수 있었다. 연령이 증가할수록 내측은 전각, 체부, 후각 모두 혈관 분포가 감소하며 외측은 체부와 후각에서 혈관 분포가 감소하는 것으로 나타났다(p<.0.05). 결론 : 내측 및 외측 반월상 연골의 혈관 분포는 해부학적 위치에 따라 달랐으며 연령이 증가함에 따라 내측과 외측에서 모두 전체적인 혈관 분포가 감소함을 알 수 있었다. Purpose : To evaluate the morphologic measurement and microvasculature of the normal human meniscus in Korean and to compare the difference of microvasculature according to the age and anatomical location. Materials and methods : Menisci of 21 cadavers divided into 3 groups according to the age. Each meniscus was divided into 10 parts of which the width and area of microvasculature were measured. Results : The average width of the medial and lateral menisci were $10.49{\pm}02.92mm$ and $10.55{\pm}2.05mm$, respectively. The average area of the microvasculature measured $20.29{\pm}8.44\%$ in the medial meniscus and $18.99{\pm}7.03\%$ in the lateral meniscus. The microvasculature of the medial meniscus was most abundant in the anterior horn and least abundant in the posterior horn (p<0.05). The lateral meniscus showed the most vessels in the posterior horn (p<0.05). The microvasculature of popliteal hiatus was not avascular but hypovascular. The area of microvasculature decreased with increasing age in all parts of the medial meniscus and body and posterior horn of the lateral meniscus (p<0.05). Conclusion : Differences in the anatomical distribution of the vessels were noted of both the medial and lateral menisci. The area of microvasculature generally decreased proportionally with increasing age in both medial and lateral meniscus.

소실점을 이용한 3차원 재구성

김상훈,김태은,최종수,Kim, Sang-Hoon,Choi, Jong-Soo,Kim, Tae-Eun 한국정보처리학회 2003 정보처리학회논문지B Vol.10 No.5

본 논문에서는 2장의 영상으로부터 카메라 내부 파라미터를 추출하는 교정 방법을 제시한다. 카메라 교정은 2차원 영상으로부터 3차원 정보를 얻기 위해서는 필수 불가결한 기술이다. 기존의 많은 연구들이 수행되어 왔는데, 영상내에 체크 패턴을 포함한 3장의 영상을 이용하는 방법과 연속된 3장의 영상으로부터 Kruppa 방정식을 풀어 카메라 교정하는 방법이 대표적인 예가 되겠다. 본 논문에서는 인간이 만든 조형물에서 쉽게 발견할 수 있는 기하학적인 정보를 이용하여 보다 쉽고 빠르게 내부 파라미터를 추출한다. 이러한 내부 파라미터는 소실점들로부터 추정되며 대응되는 2장의 영상에서 대응점들로부터 외부 파라미터를 추출할 수 있다. 이렇게 교정된 내부, 외부 파라미터를 이용하여 사영 행렬을 유도하고, 유도된 사영행렬로 3차원 정보를 얻게 되고 3차원 재구성을 구현하게 된다. This paper proposes a calibration method from two images. Camera calibration is necessarily required to obtain 3D Information from 2D images. Previous works to accomplish the camera calibration needed the calibration object or required more than three images to calculate the Kruppa equation, however, we use the geometric constraints of parallelism and orthogonality can be easily presented in man-made scenes. The task of it is to obtain intrinsic and extrinsic camera parameters. The intrinsic parameters are evaluated from vanishing points and then the extrinsic parameters which are consisted of rotation matrix and translation vector of the camera are estimated from corresponding points of two views. From the calibrated parameters, we can recover the projection matrices for each view point. These projection matrices are used to recover 3D information of the scene and can be used to visualize new viewpoints.

사실적인 3D 얼굴 모델링 시스템

김상훈,Kim, Sang-Hoon 한국전자통신학회 2013 한국전자통신학회 논문지 Vol.8 No.8

본 논문은 사실적인 3D 얼굴 모델링과 얼굴 표정 생성 시스템을 제안한다. 사실적인 3D 얼굴 모델링 기법에서 개별적인 3D 얼굴 모양과 텍스쳐 맵을 만들기 위해 Generic Model Fitting 기법을 적용하였다. Generic Model Fitting에서 Deformation Function을 계산하기 위해 개별적인 얼굴과 Generic Model 사이의 대응점을 결정하였다. 그 후, Calibrated Stereo Camera로부터 캡쳐 된 영상들로부터 특징점을 3D로 복원하였다. 텍스쳐 매핑을 위해 Fitted된 Generic Model을 영상으로 Projection하였고 사전에 정의된 Triangle Mesh에서 텍스쳐를 Generic Model에 매핑 하였다. 잘못된 텍스쳐 매핑을 방지하기 위해, Modified Interpolation Function을 사용한 간단한 방법을 제안하였다. 3D 얼굴 표정을 생성하기 위해 Vector Muscle기반 알고리즘을 사용하고, 보다 사실적인 표정 생성을 위해 Deformation 과 vector muscle 기반의 턱 rotation을 적용하였다. In this paper, we present realistic 3D head modeling and facial expression systems. For 3D head modeling, we perform generic model fitting to make individual head shape and texture mapping. To calculate the deformation function in the generic model fitting, we determine correspondence between individual heads and the generic model. Then, we reconstruct the feature points to 3D with simultaneously captured images from calibrated stereo camera. For texture mapping, we project the fitted generic model to image and map the texture in the predefined triangle mesh to generic model. To prevent extracting the wrong texture, we propose a simple method using a modified interpolation function. For generating 3D facial expression, we use the vector muscle based algorithm. For more realistic facial expression, we add the deformation of the skin according to the jaw rotation to basic vector muscle model and apply mass spring model. Finally, several 3D facial expression results are shown at the end of the paper.

2급 치근이개부 치료 시 흡수성 차폐막, 동종골 이식 및 혈소판 농축 혈장의 골 재생 효과에 대한 디지털 공제술의 정량적 분석

김상훈,임성빈,정진형,Kim, Sang-Hoon,Lim, Sung-Bin,Chung, Chin-Hyung 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.1

The purpose of this study was to evaluate effect of platelet rich plasma on the treatment of Grade II furcation involvement, with Demineralized Freeze-Dried Bone(Dembone(R)) and bioabsorable membrane(BioMesh(R)) in humans by digital subtraction radiography. 12 teeth(control group) were treated with Demineralized Freeze-Dried Bone(Dembone(R)) and bioabsorable membrane(BioMesh(R)), and 12 teeth(test group) were treated with Demineralized Freeze-Dried Bone(Dembone(R)), bioabsorable membrane(BioMesh(R)) and Platelet Rich Plasma. The change of bone density was assessed by digital subtraction radiography in this study. The change of mineral content by as much as 5%(vol) could be perceived in the subtracted images. The change of mineral content was assessed in the method that two radiographs are put into computer program to be overlapped and the previous image is subtracted by the later one. Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-whitney Test using SPSS program (5% significance level). The results were as follows: 1. In test group, the radiopacity in 3 months after surgery were significantly increased than 1 month after surgery(p<0.05). However. there were no significant difference between 1 month after surgery and 3 months after surgery in control group(p>0.05). 2. In test and control group, the radiopacity in 6 months after surgery were significantly increased than 1 month after surgery(p<0.05) 3. In test and control group, the radiopacity in 6 months after surgery were significantly increased than 3 months after surgery(p<0.05). 4. There were no significant difference between test group and control group at 1 month, 3 months after surgery, but radiopacity in test group were significantly increased than control group at 6 months after surgery(p<0.05). In conclusion, Platelet Rich Plasma can enhance bone density.