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RISS 인기검색어
- 검색키워드
- 저자 : 김복희(B. H. Kim) (검색결과 3 건)
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김복희,홍영숙,성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1981 EMJ (Ewha medical journal) Vol.4 No.3
In cholestatic rats, effects of phenobarbital or cholic acid on hepatic microsomal cytochrome p-450 and b_5 were investigated. The total contents of both cytochrome p-450 and cytochrome b_5 were decreased after bile duct ligation and the administration of estradiol. When cholic acid or phenobarbital was adminstrated in cholestatic rats, the decrease of cytochrome p-450 was prevented. The effects of cholic acid or phenobarbital on both ring-hydroxylation and N-hydroxylation of AAF in cholestatic rat hepatic microsomal fraction were studied. N-hydroxylation of AAF in bile duct ligated rat liver microsomes was reduced by 34%, but ring-hydroxylation was increased by 51%. In estradiol administrated rat, both ring-hydroxylation and N-hydroxylation of AAD was increased by 20 to 25%. In cholic acid administration, both ring-hydroxylation and N-hydroxylation was increased by about 10%. N-hydroxylation of AAF in phenobarbital treated rats was reduced more than ring-hydroxylation was reduced compared to the bile duct ligated group. Estradiol treated group which administrated with cholic acid or phenobarbital exhibited inhibited effects of N-hydroxylation.
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白鼠에 있어서 Hepatic Microsomal Cytochrome P-450에 대한 Diazepam, Cimetidine 및 Sulpiride의 영향
김복희,함윤애,홍영숙,성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1979 EMJ (Ewha medical journal) Vol.2 No.3
Cytochrome P-450 is a terminal oxidase of the hepatic microsomal monooxygenase system associated with the oxidative biotransformation of a varity of lipophilic endogenous and exogenous compounds, and generally is assayed by CO-binding spectro-photometry of dithionite-reduced samples. In well fed normal male rats with or without stress condition, the dffect of antiulcer drug; cimetidine, sulpiride and diazepam on the level of microsomal cytochrome P-450 were determined. Only stress condition produced on significant effect in cytochrome P-450 contents. Administration of cimetidine, sulpiride and diazepam in this condition caused a 44.1%~87.5% increment in cytochrome P-450, diazepam produced the most increase. After diazepam treatment of rats, the peak position of cytochrome P-450 shifted to a longer wave length of 452 nm.
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개회충(Toxocara canis) 유충의 마우스 중추신경내 미입 분포에 관한 실험적 연구
김복희,송선옥,장은덕 이화여자대학교 의과대학 1977 梨花醫學誌 Vol.- No.9
The present study was carried out to get further information on the migratory behavior and distribution rate of T. canis larvae in the central nervous system of mice infected experimentally. For the purpose, thirty albino-mice were infected orally with approximately 500 embryonated eggs of T. canis which were incubated at room temperature for 5 weeks. All the mice were sacrificed according to various intervals and the brains were divided into six parts; cerebrum, cerebellum, medulla, olfactory bulb, pituitary and spinal cord. The number of larvae in each part of the brain was counted by means of the pressure method. The results are summarized as follows; 1. Average total number of larvae in the central nervous system increased by 4 weeks after infection, since then it decreased. 2. A tendency of higher distribution rates was recognized in female mice than in male. 3. The ranges of distribution rates of larvae throughout the observation were 52.6%-65.6% in the cerebrum, 12.5-36.8% in the cerrebellum, 5.3-15.6% in the medulla, 0-9.4% in the olfactory bulb, 0-6.6% in the spinal cord and 0-3.4% in the pituitary.
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