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수종의 한약재 열수추출물이 멜라토닌 수용체 발현에 미치는 영향
김보라미 ( Bo Ra Mi Kim ),양동호 ( Dong Ho Yang ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.1
Objective : This study was to investigate the effects of several herbs on the levels of MT1 and MT2 melatonin receptorsMethods : For this study, we carried out dementia assessment examination of 34 patients with memory disturbance who have come to Cheongju oriental hospital of Daejeon university from April 2005 to February 2006. This study classified the patients as none-dementia(ND), questionable dementia(QD), and dementia(DA) groups and analyzed the result of examination. Results : 1. The water extracts of Dimocarpus long (WEDL) induced the levels of MT2 melatonin receptor expression in a concentration-dependent manner without altering the levels of MT1 melatonin receptor expression. 2. The treatment with the water extract of Zizyphus vulgaris (WEZV) induced the levels of MT1 melatonin receptor expression and the levels of MT2 melatonin receptor expression was not affected. 3. The levels of MT1 as well as MT2 melatonin receptor expression were markedly up-regulated in the water extract of Fossilia ossis (WEFO) and the water extract of Ostreae caro (WEOC)-treated C6 cells. 4. The combination treatment with WEDL and WEZV induced not only the levels of MT1 melatonin receptor expression but also MT2 melatonin receptor expression, but the synergic effects of the combination treatment with WEFO and WEOC were not detected in C6 cells. Conclusion : The study provides important new insights into the possible mechanisms on the regulation of melatonin receptor synthesis by WEDL, WEZV, WEFO and WEOC.
디지털 방사선에서 조사선량과 관전압조절에 의한 원본영상과 처리영상 분석
김보라,류신영,석진영,최준구,Kim, Bo-Ra,Ryu, Sin-Young,Seok, Jin-Young,Choi, Jun-Gu 대한디지털의료영상학회 2011 대한디지털의료영상학회논문지 Vol.13 No.1
Dynamic range on the digital detector can be a representation to the ratio of maximum and minimum of pixel value. Wide dynamic range and post processing ability of the digital detector made difficult to recognize visually to high or low dose images. We were evaluated a change of mean pixel value on the original and processed image, when we controlled the kVp, mA, exposure time on the digital detector. On the kVp of a constant condition, we were acquired an original and processed image by changes of mA, exposure time. According to the thickness of the subject under the same conditions, to determine a relation of pixel value and X-ray intensity, we used an aluminum step wedge. When mA and exposure times were changed under the kVp of a constant condition, the X-ray intensity was decreased by the reduction of the mean pixel value. In addition when kVp was increased in a constant condition of mAs, the mean pixel value was increased according to the increment of the X-ray intensity. Therefore, low kVp, high mA and short exposure time were a way to reduce a patient dose.
코팅 피치의 물성제어를 통한 흑연 음극재의 전기화학 성능 향상 연구
김보라,김지홍,강석창,임지선,Kim, Bo Ra,Kim, Ji Hong,Kang, Seok Chang,Im, Ji Sun 한국공업화학회 2022 공업화학 Vol.33 No.5
A pitch coating method was proposed for the purpose of improving the electrochemical properties of natural graphite. The synthesis conditions of pitch coating were optimized via measuring electrochemical properties of pitch-coated graphite anodes. As the synthesis temperature increased, the thermal stability was improved in addition to an increase in the softening point and residual carbon weight. However, the synthesis temperature of 430 ℃ resulted in the synthesis of a large amount of NI (NMP Insoluble) due to excessive condensation reaction. As the surface uniformity and coating thickness increased due to high thermal stability, the initial coulombic efficiency and rate capability of the pitch-coated graphite were improved. However, the graphite coated with the pitch containing excessive NI showed lower electrochemical properties than the uncoated graphite. NI had low dispersibility and formed spheres after heat treatment, so it formed the heterogeneous and thicker SEI layer. The optimum conditions for forming a uniform surface and an appropriate coating layer were investigated.
해초 Biochar를 이용한 Cr<sup>6+</sup>과 As<sup>3+</sup> 흡착 특성
김보라,신우석,김영기,Kim, Bo-Ra,Shin, Woo-Seok,Kim, Young-Kee 한국공업화학회 2015 공업화학 Vol.26 No.4
본 연구에서는 제주도에서 채집한 Hizikia fusiformis biochar를 이용하여 수용액 상에서 $Cr^{6+}$과 $As^{3+}$ 중금속의 흡착 특성을 평가하였다. $Cr^{6+}$과 $As^{3+}$ 흡착에 있어서 최적 pH는 각각 pH 2와 pH 6이었다. 동역학적 실험 결과, 대부분의 중금속이 처음 100 min 동안 흡착이 되었으며, 300 min 이후 평형에 도달하였다. 또한, 해초 biochar의 $Cr^{6+}$과 $As^{3+}$ 중금속 흡착은 유사 1차 모델과 2차 모델에서 모두 잘 부합하고 있는 것으로 나타났다. 평형 흡착 실험 결과는 Langmuir 모델에 잘 부합했고, $Cr^{6+}$ (25.91 mg/g)이 $As^{3+}$ (16.54 mg/g)보다 흡착량이 높았다. 본 연구 결과를 통해, 오염된 환경에서 해초 biochar는 $Cr^{6+}$ 및 $As^{3+}$ 중금속의 효과적인 흡착제임을 보였다. This study examined the adsorption characteristics of $Cr^{6+}$ and $As^{3+}$ in the aqueous solution by Hizikia susiformis biochar which was collected from Jeju Island. The optimal pH for $Cr^{6+}$ and $As^{3+}$ adsorption were 2 and pH 6, respectively. Kinetic data showed that the adsorption occurred during the first 100 min, and the most of heavy metals were bound to biochars within 300 min. Moreover, the kinetic data presented that the course of adsorption follows the Pseudo first and second order models. The equilibrium data were well fitted by the Langmuir model and the $Cr^{6+}$ adsorption capacity (25.91 mg/g) was higher than that of $As^{3+}$ (16.54 mg/g). From these results, the seaweed biochar was shown to be a efficient adsorbent for $Cr^{6+}$ and $As^{3+}$ metals in a contaminated environment.
기혼 중년 남성의 갱년기 증상이 자살 사고에 미치는 영향에서 주관적 행복감의 매개효과
김보라,성경미,Kim, Bo Ra,Sung, Kyung Mi 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.4
본 연구는 기혼 중년 남성의 갱년기 증상이 자살 사고에 미치는 영향에서 주관적 행복감의 매개효과를 파악한 연구이다. 자료수집은 2020년 12월부터 2021년 1월까지 실시하였으며 인터넷 커뮤니티를 통해서 설문 응답에 자발적으로 참여한 기혼 중년 남성을 대상으로 하였다. 최종 연구 대상자는 갱년기 증상이 있는 199명의 기혼 중년 남성이었다. 기혼 중년 남성의 갱년기 증상, 자살 사고 및 주관적 행복감은 유의한 상관관계가 있었으며, 갱년기 증상과 자살 사고의 관계에서 주관적 행복감은 매개효과가 있는 것으로 나타났다. 본 연구의 결과로 갱년기 남성의 주관적 행복감을 향상시키는 것이 자살 사고를 예방하는데 도움이 될 수 있음을 확인하였다. 따라서 연구자는 본 연구 결과를 토대로 추후 갱년기 남성의 자살 사고를 예방하는 간호중재 방안을 마련하여 그 효과를 확인해 볼 것을 제언한다. This study was to investigate the mediating effect of subjective happiness on the effect of andropause symptoms on suicidal Ideation in married middle-aged men. Final Participants were 199 married middle-aged men with andropause symptoms. Andropause symptoms, suicidal ideation, and subjective happiness of middle-aged men showed significant correlations. The mediating effect of subjective happiness on the relationship between andropause symptoms and suicidal ideation was verified. The findings revealed that an improving subjective happiness of men with andropause symptoms can be helpful for the prevention of suicidal ideation. Therefore, the researchers suggest that future researchers develop nursing interventions for the prevention of suicide ideation of men with andropause symptoms based on the results of the study, and evaluate its' effects.
전광(癲狂) 유사 증상을 나타낸 화병(火病) 환자 치험 1례
양동호 ( Dong Ho Yang ),김보라미 ( Bo Ra Mi Kim ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3
Hwa-byung is said as a Korean folk syndrome in DSM-Ⅳ,and that is translated into ``Anger syndrome``. In Oriental Medicine, Hwa-Byung is related with clonic emotional-stress, and include symptoms having the character of ``fire``.In this case, the patient had symptoms similar with schizophreniform disorder. We treated the patient with Sihoukan-tang, Ssanghwa-tang and Ziunkoron. And her condition was improved through these oriental medical treatment.
일부 국내 어린이 음료의 우치 법랑질 침식력과 침식 위험 요소 평가
김보라 ( Bo Ra Kim ),민지현 ( Ji Hyun Min ),권호근 ( Ho Keun Kwon ),김백일 ( Baek Il Kim ) 대한예방치과·구강보건학회 2013 大韓口腔保健學會誌 Vol.37 No.3
본 연구는 pH 순환 모형을 적용하여 국내에서 시판되는 어린이 음료 8종류의 우치 법랑질 침식 정도를 콜라 및 오렌지 주스와 비교하고, 법랑질 침식 정도에 유의미한 영향을 미치는 음료의 위험 요인을 조사한 결과 다음과 같은 결론을 얻었다. 1. 국내에서 시판되는 8종류의 어린이 음료는 모두 콜라보다 침식 정도가 약하였다. 그러나 아이키커, 자연은 슬기, 쿠우, 카프리썬, 초롱이 5가지 어린이 음료는 오렌지 주스보다는 침식 정도가 컸고, 코알코알 코알라와 내친구 뽀로로는 유사한 정도의 침식정도를 보였던 반면 튼튼 짱구만이 거의 침식되지 않은 정도로 오렌지 주스보다 유의하게 침식력이 약하였다. 2. 법랑질 침식 정도에 유의미한 영향을 미치는 산성 음료의 화학적 요인은 pH와 칼슘 함량이었다. Objectives: The aims of this in vitro study were (1) to assess the erosive potential of several children`s beverages in comparison to cola and orange juice, by using an in vitro pH-cycling model, and (2) to investigate the factors related to dental erosion caused by the beverages. Methods: Eight different children`s beverages (Chorongi, Capri-sun, Grateful nature wisdom, I-kicker, Koal-koal koala, My friend pororo, Qoo, and Strong zzanggu), Cola, and an orange juice, which are available in the Korean market, were used. To characterize each test beverage, the pH, titratable acidity to pH 7.0, concentration of calcium and phosphorus, and degree of saturation with respect to hydroxyapatite (DSHAP) were analyzed. Erosive potential of the test beverages was assessed by the depth of enamel loss observed in specimens subjected to pH cycling for 8 days. This cycle consisted of exposure to each beverage for 20 min, thrice daily, and to a remineralizing solution every day. The correlation between the depth of the enamel loss and the chemical properties of the beverages was assessed by Spearman`s rank correlation coefficients and multiple linear regression tests (P<0.05). Results: The depth of enamel loss caused by the beverages was found to vary from 0.11 to 105.47 ㎛. Enamel loss with all the children`s beverages tested was lesser compared to that with Cola (P<0.05) but was similar or greater than that with orange juice, except in one beverage. The pH, concentration of calcium, and DSHAP were significantly correlated with the depth of enamel loss (P=-0.842, P=-0.796, and P=-0.867, respectively; P<0.01). Multiple regression analysis showed that pH and concentration of calcium were impact variables for the erosive potential of test beverages (P<0.05). Conclusions: The children`s beverages tested had lower erosive potential than Coca Cola, but five (I-kiker, Grateful nature wisdom, Qoo, Capri-sun, and Chorongi) of them had higher erosive potential than orange juice. Moreover, among the chemical properties of beverages, significant factors affecting enamel loss were pH value and concentration of calcium.
김보라 ( Bo Ra Kim ),이현진 ( Hyun Jin Lee ) 대한통합의학회 2014 대한통합의학회지 Vol.2 No.3
Purpose : The purpose of this study was to grasp the general status and trend of the driving rehabilitation research focusing on interested topics, study subjects, therapeutic approaches, study designs, etc. Methods : It targeted 18 papers published in the RISS (Research Information Service System) from 2000 to 2014, and performed a descriptive statistical analysis by classifying these papers to topics, study subjects, study forms, study designs, study fields, and researchers. Results : As a result of the analysis, for the study form in the driving rehabilitation field, the rate of experimental papers was 61.1%, the highest. Major study subjects turned out to be occupational therapists, the disabled, and the aged, in order. For the study quality and design, the rate of survey and non randomized-single experimental study, which correspond to stage IV, was the highest, and the general study quality was found to be low. For the study field, the rates of the roles and recognition of occupational therapists, evaluation on driving ability of the disabled, and institutional improvement and future measures were the highest, each of which being 16.7%. Conclusion : Through this study, major study subjects and study quality in the driving rehabilitation field could be grasped, and it could be found that for development of the driving rehabilitation field, higher quality researches on more various study subjects would be needed in the future.
광주와 서울의 교통 시설물의 설치 현황과 가이드라인 반영 분석 - 국제 행사장 지역 중심으로 -
김보라(Kim, Bo - Ra), 문정민(Moon, Jeong - Min) 조선대학교 조형미술연구소 2011 조형미술논문집 Vol.11 No.1
As street space is composed of many facilities, behaviors of users should be carefully considered. Most of the past urban facilities were confusing, focusing on economic and functional aspects, but present urban space has actively been engaged to express urban elements considering aesthetic design. At this point when guidelines on public facility installation and standard design have been announced by each local government, it is necessary to evaluate present public facilities.Therefore, this study analysed whether present public facilities which were installed through the past deliberation are suitable for standard guidelines and present public facilities reflect guidelines properly and the results are presented as follows: First, facilities in Gwanju and Jeonnam which have been reorganized based on organized and systematic guidelines have similar shapes, colors and textures, which seems that the degree recommended standards are reflected is low. Second, it is suggested that present guidelines need specific recommendations considering structures, shapes and characteristics of streets targeting hierarchical goals and integrated strategies of public facilities and space. Third, partial replacement and revision of the recommended installation guidelines of each local government are needed for reorganization of public space. Keywords : 교통시설물, 국제행사장, 가이드라인