간아세포종 환아의 임상적 특성과 예후

김민영,김대연,안효섭,김종재,김인원,정성은,이성철,박귀원,김우기,Kim, Min-Young,Kim, Dae-Yeon,Ahn, Hyo-Seep,Kim, Chong-Jai,Kim, In-One,Jung, Sung-Eun,Lee, Seong-Cheol,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 1997 소아외과 Vol.3 No.2

Hepatoblastoma is a rare pediatric malignancy which frequently presents at an advanced un resectable stage. With the neoadjuvant chemotherapy, improved resectability and survival have been reported. Twenty children with biopsy proven hepatoblastoma were treated during the period between January 1987 and June 1995. Median age at diagnosis was 13 months(2 months to 7 year and 10 months), and 13 were male. Histologic profile was 13 epithelial(5 fetal, 4 mixed, 1 embryonal, 3 undetermined), and 5 mixed mesenchymal and epithelial and 2 of undetermined type. Chemotherapy effectively reduced the tumor volume($p$=0.008), and was able to convert 7 out of 9 initially unresectable cases(78%) to resectable ones. Twelve radical and 2 palliative operations were done with or without adjuvant chemotherapy. The Median follow up period was 33 months and the median survival was 26 months. The group with curative resection had a 61.1% 5 year survival rate, but none of palliative resection group survived more than 13 months($p$=0.0001). In univariate analysis for prognostic factors revealed, large tumor size at diagnosis and abscence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Histological pure fetal type did not mean a better prognosis. Even with a recent neoadjuvant chemotherapy, the strategy should be focused on the radical resection as early as possible.

품종별 유색미 및 현미 추출물의 항산화 활성 및 지방축적 억제 효과

김민영,박혜영,이유영,이병원,김미향,이진영,이종희,강문석,구본철,김현주,Kim, Min Young,Park, Hye Young,Lee, Yu-Young,Lee, Byong Won,Kim, Mi Hyang,Lee, Jin Young,Lee, Jong Hee,Kang, Moon-Suk,Koo, Bon Cheol,Kim, Hyun-Joo 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.2

The purpose of this study was to investigate antioxidant characteristics and anti-adipogenic effects of colored rice and brown rice extracts in 3T3-L1 adipocyte depending on cultivar (Josaengheugchal, Heugjinmi, Hongjinju, Geongganghongmi, Seolgaeng, Milyang 320, Sindongjin, Baegjinju). Colored rice and brown rice was extracted with 100% ethanol, followed by the analysis of polyphenol, flavonoid, anthocyanin, antioxidant, and anti-adipogenic activity. Total polyphenol and flavonoid content ranged from 6.86~314.08 mg GAE/g and 1.47~56.88 mg CE/g the highest total polyphenol and flavonoid content was observed in Heugjinmi cultivar. Anthocyanin composition was analyzed by HPLC, cyanidin-3-gluoside and peonidin-3-glucoside was found in black rice including Josaengheugchal and Heugjinmi. Also, the ABTS and DPPH radical scavenging activity of colored rice cultivars was higher than that of brown rice cultivars, the highest ABTS radical scavenging activity also was observed in Heugjinmi (128.20 mg TE/g). The anti-adipogenic effects of colored rice and brown rice extracts on differentiation of 3T3-L1 preadipocytes evaluated that extracts of Heugjinmi cultivar significantly reduced intracellular lipid accumulation. These results provide valuable information for the use of Korean colored rice cultivar as a functional food materials relative to anti-obesity.

품종별 땅콩 종피 추출물의 효소저해활성 및 암세포주 증식억제 효과

김민영,김현주,이유영,김미향,이진영,이병규,이병원,Kim, Min Young,Kim, Hyun-Joo,Lee, Yu-Young,Kim, Mi Hyang,Lee, Jin Young,Lee, Byoungkyu,Lee, Byong Won 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.5

The purpose of this study was to investigate the inhibitory effect of enzyme activity and anti-proliferation of human cancer cell lines (HCT 116, NCI-H460 and MCF-7) of peanut skin depending on cultivars (Arachis hypogaea L. cv. K-Ol, cv. Sinpalkwang, cv. Daan, cv. Heuksaeng) and extraction solvent. Peanut skin was extracted with 80% ethanol, 80% methanol, 80% acetone, and distilled water, followed by analysis of the enzyme inhibitory activity and anticancer activity. Methanol extract of Daan cultivar most effectively inhibited ${\alpha}$-gluosidase (65.08%, 0.025 mg/mL), tyrosinase (82.49%, 2 mg/mL) and ACE (73.61%, 10 mg/mL). The inhibitory effect of peanut skin extracts on colon cancer cell (HCT-116), lung cancer cell (NCI-H460) and breast cancer cell (MCF-7) growth were investigate using MTT assay. The highest anti-proliferation of cancer cell line of peanut skin extracts was observed in the methanol extract of Daan cultivar. The cell viability on HCT 116, NCI-H460 and MCF-7 cell lines of methanol extracts from peanut skin of Daan cultivar was 48.13%, 41.03%, and 36.02% at $200{\mu}g/mL$, respectively. These results suggest that peanut skin extracts may mediate physiological activity, and provide valuable information for the use of peanut byproduct as a functional food material.

전문간호사제도에 대한 의료인의 경험

김민영,전미경,최수정,김정혜,김희영,임초선,Kim, Min Young,Jeon, Mi-Kyeong,Choi, Su Jung,Kim, Jeong Hye,Kim, Heeyoung,Leem, Cho Sun 한국중환자간호학회 2021 중환자간호학회지 Vol.14 No.2

Purpose : The purpose of this study was to understand and describe the experiences of the advanced nurse practitioner (APN) system used by healthcare providers including APNs, doctors who worked with APNs, and APN master's course professors at a graduate school. Methods : Qualitative data were collected via snowball sampling. The participants were nine APNs, six doctors, and three professors. They were divided into three focus groups, each of which consisted of all three types of healthcare providers. Data were collected via interviews with the three focus groups conducted from September to October 2019. All interviews were audiotaped and transcribed verbatim. The transcribed data then underwent qualitative content analysis. Results : Based on the data, we extracted four themes and 14 categories. The themes were "Role and system of APNs started according to healthcare environment changes", "Optimal healthcare provider to ensure quality of care", "Confused role and system of APNs due to incomplete medical law", and "Tasks for the stable operation of the APN system." Conclusion : For quality treatment and safety of patients, a legal basis must be established for the APN system. For its stable operation, social consensus regarding legislation about APNs' scope of practice is required. Finally, a discussion is necessary about the integration of APNs' 13 fields.

Cracked Selenium을 이용한 CIGS 박막 셀렌화 공정에 관한 연구

김민영,김기림,김종완,손경태,이종관,임동건,Kim, Minyoung,Kim, Girim,Kim, Jongwan,Son, Kyeongtae,Lee, Jongkwan,Lim, Donggun 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.7

In this study, $Cu(In_{1-x},Ga_x)Se_2$ (CIGS) thin films were prepared on the Mo coated soda-lime glass by the DC magnetron sputtering and a subsequent selenization process. For the selenization process, selenization rapid thermal process(RTP) with cracker cell, which was helpful to smaller an atomic of Se, was adopted. To make CIGS layer, they were then annealed with the cracked Se. Based on this selenization method, we made several CIGS thin film and investigated the effects of In deposition time, and selenization time. Through x-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), and atomic force microscopy (AFM), it is found that the Mo/In/CuGa structure and the high sputtering power shows the dominant chalcopyrite structure and have a uniform distribution of the grain size. The CIGS films with the In deposition time of 5 min has the best structure due to the smooth surface. And CIGS films with the selenization time of 50 min show good crystalline growth without any voids.

탄소섬유 표면에서의 고분자 전착과 복합재료 물성 (1) - MVEMA 와 EMA 의 전착 -

김민영,김지홍,김원호,김부웅,황병선,최영선 ( Min Young Kim,Ji Hong Kim,Won Ho Kim,Boo Ung Kim,Byung Sun Hwang,Young Sun Choi ) 한국공업화학회 1998 공업화학 Vol.9 No.6

고분자유기응집제 (Polyacrylamide)를 활용한 농경지 사면 토양유실 저감 효과 분석

김민영,최용훈,이상봉,김현정,김승희,김영진,Kim, Minyoung,Choi, Yonghun,Lee, Sangbong,Kim, Hyunjeong,Kim, Seounghee,Kim, Youngjin 한국농공학회 2015 한국농공학회논문집 Vol.57 No.5

This study conducted a series of field experiments using soil conditioners, Polyacrylamide(PAM) and gypsum, to evaluate their effects in reducing sediment loss and surface runoff. In addition, the correction factors (K-alpha) for the erodibility factor (K) were determined to reflect the effects of PAM and PAM+gypsum in applying the USLE equation. Experimental erosion plots individually sized $10m^2$ (5 m long, 2 m wide and 1 m deep) have different slopes (10, 20 and 30%). Erosion plots were prepared for one control (C; no PAM and gypsum) and two treatments (P; PAM 20 kg/ha, PG; PAM 20 kg/ha+gypsum 3,000 kg/ha). The amounts of soil eroded and runoff were continuously monitored from July $1^{st}$ to Oct. $31^{st}$ in 2010 and compared to each other. The amount of sediment loss from a control plot was 399.2 ton/ha and the relative reduction of sediment loss were 11.4% and 33.4% for PAM-treated and PAM+gypsum treated plots, respectively. This study also determined the K-alpha factors in the USLE equation to account for the erosion control effectiveness of PAM and gypsum application. The K-alpha factors were calculated as 0.92 for PAM-treated plot and 0.69 for PAM+gypsum-treated plot. The findings of this study revealed that soil conditioners (PAM and gypsum) could play a significant role in controlling soil erosion. In addition, the modified USLE equation using the K-alpha could provide valuable information to make better decision on establishment of best management practice for soil erosion control in agriculture.

한국 전문간호사의 분야 체계화 관련 연구

김민영,최수정,전미경,김정혜,김희영,임초선,Kim, Min Young,Choi, Su Jung,Jeon, Mi-Kyeong,Kim, Jeong Hye,Kim, Heeyoung,Leem, Cho Sun 병원간호사회 2020 임상간호연구 Vol.26 No.2

Purpose: This study was conducted to provide basic data for the systematization of 13 areas related to Advanced Practice Nurses (APN). Methods: The three-phase study was conducted as follows. 1) review of APN system and curriculum, 2) Focus Group Interviews (FGI) with 9 APNs, 6 physicians, and 3 nursing professors on the APN system, 3) analysis of clinical practice of the 13 APN areas, and of the accreditation and certification system for APNs, medical board, and medical subspecialty board. Based on the above data, a systematic plan was drawn. Results: The 13 APN areas could be divided into 7 groups based on a review of the APN system and curriculum for the 13 areas. Analysis based on clinical practice showed that the 13 APN areas could be divided into 4 groups. Two themes and seven categories emerged in FGI. The two themes were 1) 13 APN areas that need to be discussed, 2) improving the curriculum for APN. Considering these themes from FGI and the system of the medical subspecialty board, results could be integrated into 2 groups - clinical area and non-clinical area. Conclusion: The 13 APN areas need to be integrated in order to activate the APN system. For that, further discussions on improvements and a standard curriculum according to legislation related to APN should be carried out.

탄소섬유 표면에의 고분자 전착과 복합재료 물성(I) - MVEMA와 EMA의 전착 -

김민영,김지홍,김원호,김부웅,황병선,최영선,Kim, Minyoung,Kim, Jihong,Kim, Wonho,Kim, Booung,Hwang, Byungsun,Choi, Youngsun 한국공업화학회 1998 공업화학 Vol.9 No.6

탄소섬유 복합재료의 층간전단 강도의 손상없이 충격강도를 향상시키기 위하여 반응성을 가진 유연한 고분자 물질 (MVEMA(poly(methyl vinyl ether-co-maleic anhydride)) 및 EMA (poly(ethylene-co-maleic anhydride)) 전착을 이용하여 탄소섬유와 에폭시 기지재료 사이에 계면상으로 도입하는 방법을 고려하였다. 따라서 계면상 물질의 MVEMA 및 EMA의 탄소섬유에의 전착수율에 대한 공정변수의 영향을 체계적으로 평가하였다. 염기성 수용액상에서 anhydride기를 가진 고분자의 전착 메카니즘은 -OH기의 공격에 의한 $RCOO^-$기의 생성에 기인함을 적외선 분광분석으로 확인하였다. 농도, 전류밀도, 반응시간의 증가에 따라 전착수율이 증가하였으며, 과도한 산소 버블의 발생은 전착된 고분자를 탈착시켜 수율을 감소시켰다. 흐르는 물에서 세척을 할 경우 탄소섬유와의 결합력이 없는 전착고분자는 쉽게 제거되어 0.5 wt% 정도의 전착 고분자만 잔류하였다. An interphase between carbon fiber and epoxy matrix was introduced to increase impact strength of carbon fiber reinforced composites (CFRC) without sacrificing the interlaminar shear strength. Flexible polymers, I. e., MVEMA (poly(methyl vinyl ether-co-maleic anhydride)) and EMA(poly(ethylene-co-maleic anhydride)), which have reactive functional groups were considered as interphase materials. Weight hain of MVEMA and EMA onto the surface of carbon fibers was evaluated by changing the parameters of electrodeposition process. Electrodeposition mechanism of polymers which have anhydride functional group was identified by IR spectroscopy, that is, the generation of $RCOO^-$ functional group by the attack of hydroxide anion in the basic solution was observed. The weight gain was increased by increasing concentration of polymers, current density, and electrodeposition time. However the excess generation of oxygen gas decreased the weight gain by removing the deposited polymers. Washing in the running water easily removed the deposited polymers which are on the fiber surface without bonding, as a results, only 0.5 wt% of deposited polymers are remained.

2001년 봄철 황사기간 중 서해안지역에서 관측한 대기 중 수은의 환경유동특성 연구

김민영,신재영,조석주,김준,이강웅,김기현,Kim, Min-Young,Shin, Jae-Young,Cho, Suk-Choo,Kim, Joon,Lee, Gang-Woong,Kim, Ki-Hyun 한국지구과학회 2001 한국지구과학회지 Vol.22 No.6

2001년 3월말 기간을 중심으로 강화도 하리지점에서 대기 중 수은의 토양-대기간 교환율의 측정을 시도하였다. 본 연구에서 수은의 농도구배를 측정하고 이를 미기상학적 인자와 결합하는 방식으로 수은의 플럭스값을 산축하였다. 본 연구의 결과에 따르면, 강화지역의 수은 농도는 일반적으로 도심환경에서 발견되는 수준보다는 현저하게 낮은 수준인 것을 확인할 수 있었다. 그러나 측정된 플럭스값은 200ng/m$^2$/h에 근접하여 일반적으로 청정한 환경에서 발견되는 수준을 훨씬 초과하는 것으로 나타났다. 연구기간 동안 관측된 주요 환경변수들의 분포경향을 비교해 보면, NOx와 PM등을 포함하는 대부분의 변수들은 배출시의 농도가 침적시의 농도에 비해 높게 나타났다. 반면 기상학적 요인들은 이러한 경향성이 고온 또는 저습도에서 뚜렷하게 확인되었다. 상관분석의 결과에 따르면, 배출시에 대부분의 오염인자들이 수은과 강한 양의 상관성을 보여주었지만, 침적시에는 그러한 경향이 역전되는 것으로 나타났다. 특히 흥미로운 사실은 침적시에 수은관련 변수들은 미세입자와 어느 정도 연계성을 띠는 것을 확인시켜 주었다. The soil-air exchange processes of Hg were investigated from the Hari area of Kang Hwa Island during the late March 2001. In the course of our study, we determined the concentration gradients of Hg and combined these gradient data with micrometeorological components to derive its fluxes. Results of our study indicate that the concentration levels of Hg in the study area are notably lower than those typically found in urbanized areas of Korea. However, the computed fluxes were seen to be significantly larger for relatively remote areas, reaching over 200 ng/m$^2$/hr. Comparison of environmental conditions shows that the concentrations of most pollutant species including NO$_X$ and PM were significantly higher during emission, while meteorological conditions were characterized by high temperature and low humidity. Results of correlation analysis also indicate that such pollutants as hydrocarbons, nitrogen oxides, and PM generally exhibit strong positive correlations with Hg-related parameters during emission events, while such relationships were reversed during dry deposition events. The results of our present study suggest the possibility that the concentrations and fluxes of total gaseous Hg observed during deposition events can be influenced by the processes that are also important for the fine, rather than coarse, size fraction of particles.