백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

제장소 전노 dust로부터 $\alpha$-장분말 회수에 관한 연구(II) -전노 dust의 이용에 관한 연구-

김미성,김만,조명호,오재현,김태동,김성완,Kim, Mi-Sung,Kim, Mahn,Cho, Moung-Ho,Oh, Jae-Hyun,Kim, Tae-Dong,Kim, Sung-Wan The Korean Institute of Resources Recycling 1994 資源 리싸이클링 Vol.3 No.2

본 연구에서는 제철소 전로 dust를 사용하여 일차보고의 기초적인 철분말의 회수에 이어 semi pilot 장치의 혼식 사이클론(wet cyclone)을 사용해서 고순도의 철분말을 회소하여 분말합금용(용접봉용 포함) 원료, 철분법 페수처리용 등으로 그 용도를 개발하고자 하였으며, 이를 통하여 다음과 같은 결론을 얻었다. 1. 광양제철소 EC dust를 vibration mill로 2분 동안 마광한 다음 혼식 사이클론에 분급하여 얻어진 철분말(+200 mesh. underflow)를 다시 아트리터에서 5분 동안 마광한 후 분급실험을 하여 고순도으 철분말(Total Fe 99.76%)을 47.66% 회수할 수 있었다. 2. 전로 dust에서 회수한 철분말은 +65 mesh : 36.16%, 65/100 : 24.43%, 100/200 : 26.68%, 200/270 : 12.64%의 입도분포를 가지고 있었으며, 모두 ${\alpha}$-Fe러 flake형을 보이고 있었다. 3. 재항 CF dust와 광양 EC dust에서 회수한 철분말을 가지고 동이온 제거실험을 한 결과, 철분말에 의해서 동이온이 99%이상 제거됨을 알 수 있었다. 4. 전로 dust를 적당시간 마광하여 혼식 사이클론에 의해 +270mesh(underflow)와 -270 mesh(overflow)로 입도로 분급한 후, -270 mesh 의 입도(산화철)는 폐수처리용 원료로 사용하고, +270mesh 의 입도(철분말)는 분말합금용(용접봉용 포함) 원료로 사용하는 것이 바람직하다. In this study, the grinding and wet cyclone process of the dust for the effective separation of high purity iron powder and iron oxide were investigated. The results obtained in this study can be summarized as follows: 1. By applying the wet cyclone technique for the iron powder(+200 mesh) produced from EC dust of the Kwangyang 2nd steel making factory, the iron powder of high content more than 99.76% of Fe was obtained with 47.66% yield at grinding time of 5 minutes by attritor. 2. The particle size distribution of the iron powder recovered from converter dust is quite simillar with the iron powder of sweden Hoganas Co.(W40.24, W40.29, W40.37, W40.37OX). 3. By using iron powder, copper ions are all adsorbed and removed in any concentration ranges of copper sulfate solution(Cu:100, 200, 300, 600 ppm).

이팝나무 잎과 열매, 꽃 (Chionanthus retusus) 추출물의 항산화 효과

김미성,이은호,조영제,Kim, Mi-Sung,Lee, Eun-Ho,Cho, Young-Je 경북대학교 농업과학기술연구소 2015 慶北大農學誌 Vol.33 No.2

본 연구는 이팝나무 잎과 열매, 꽃 추출물에서 항산화 활성을 통한 기능성 식품에 대해 탐색하고자 하였다. 이팝나무 꽃 추출물에서 phenolics 함량은 물과 90% ethanol 추출물에서 각각 20.8, 32.2 mg/g을 나타내었다. 이팝나무 잎, 열매, 꽃을 $100{\mu}g/mL$로 농도를 조절하여 DPPH free radical 소거 활성을 측정한 결과, 물과 ethanol 추출물 모두 70% 이상의 높은 소거 활성을 나타내었다. ABTS radical decolorization는 $100{\mu}g/mL$ phenolic 농도에서도 모두 약 80% 이상의 항산화 활성을 나타내었다. Antioxidant protection factor는 $50{\mu}g/mL$ phenolic 농도에서 이팝나무 잎의 물과 ethanol 추출물은 각각 2.27, 1.70 PF로 가장 높게 측정되었다. TBARs를 측정한 결과, 이팝나무 잎, 열매, 꽃 추출물의 $200{\mu}g/mL$ phenolic 농도에서 물과 ethanol 추출물 모두 70% 이상의 항산화 활성을 나타내었다. 이팝나무 잎 추출물의 항산화활성은 TBARs를 제외한 모든 실험에서 대조구로 사용한 BHT보다 높은 항산화 활성을 나타내었다. 따라서 이팝나무 잎, 열매, 꽃 추출물은 수용성, 지용성 물질에 대한 높은 항산화능을 나타내었고, 이 결과로 이팝나무 잎과 열매, 꽃 추출물은 항산화 효과와 기능성 식품 소재로서 활용 가능성을 기대할 수 있었다. The aim of this research was to investigate the anti-oxidantive activities of extracts from Chionanthus retusus leaves, fruits and flower. The content of phenolics were 20.8 mg/g in water extracts and 32.2 mg/g in 90% ethanol extracts from flower. The DPPH free radical scavenging activity of extracts from Chionanthus retusus was above 70% at phenolic concentration $100{\mu}g/mL$. The ABTS radical decolorization activities of water and ethanol extracts were both above 80% at $100{\mu}g/mL$ phenolic concentration, respectively. The antioxidant protection factor(PF) of water and 80% ethanol extracts from leaves was the highest as 2.27 PF and 1.70 PF at $50{\mu}g/mL$ phenolic concentration. The TBARs inhibition rate of the Chionanthus retusus extracts, was above 70% at $200{\mu}g/mL$ phenolic concentration. The anti-oxidantive activities of extracts from leaves were shown more active than BHT as a positive control except TBARs. These results confirmed that the extracts from Chionanthus retusus leaves, fruits and flower was shown the high anti-oxidant activity. The results can be expected isolated phenolic compounds from Chionanthus retusus to use as functional beauty food resource.

온라인 연관관계 분석의 장바구니 기준에 대한 연구

김미성,김남규,Kim, Mi-Sung,Kim, Nam-Gyu 한국CRM학회 2011 CRM연구 Vol.4 No.2

There is a large difference between purchasing patterns in an online shopping mall and in an offline market. This difference may be caused mainly by the difference in accessibility of online and offline markets. It means that an interval between the initial purchasing decision and its realization appears to be relatively short in an online shopping mall, because a customer can make an order immediately. Because of the short interval between a purchasing decision and its realization, an online shopping mall transaction usually contains fewer items than that of an offline market. In an offline market, customers usually keep some items in mind and buy them all at once a few days after deciding to buy them, instead of buying each item individually and immediately. On the contrary, more than 70% of online shopping mall transactions contain only one item. This statistic implies that traditional data mining techniques cannot be directly applied to online market analysis, because hardly any association rules can survive with an acceptable level of Support because of too many Null Transactions. Most market basket analyses on online shopping mall transactions, therefore, have been performed by expanding the co-occurrence criteria of traditional association rule mining. While the traditional co-occurrence criteria defines items purchased in one transaction as concurrently purchased items, the expanded co-occurrence criteria regards items purchased by a customer during some predefined period (e.g., a day) as concurrently purchased items. In studies using expanded co-occurrence criteria, however, the criteria has been defined arbitrarily by researchers without any theoretical grounds or agreement. The lack of clear grounds of adopting a certain co-occurrence criteria degrades the reliability of the analytical results. Moreover, it is hard to derive new meaningful findings by combining the outcomes of previous individual studies. In this paper, we attempt to compare expanded co-occurrence criteria and propose a guideline for selecting an appropriate one. First of all, we compare the accuracy of association rules discovered according to various co-occurrence criteria. By doing this experiment we expect that we can provide a guideline for selecting appropriate co-occurrence criteria that corresponds to the purpose of the analysis. Additionally, we will perform similar experiments with several groups of customers that are segmented by each customer's average duration between orders. By this experiment, we attempt to discover the relationship between the optimal co-occurrence criteria and the customer's average duration between orders. Finally, by a series of experiments, we expect that we can provide basic guidelines for developing customized recommendation systems. 오프라인 쇼핑몰에 비해 온라인 쇼핑몰은 빠르게 접근이 가능하기 때문에 처음 구매의사를 생성하고 실제 구매가 이루어지기까지의 기간이 오프라인 쇼핑몰에 비해 매우 짧게 나타난다. 즉 오프라인 쇼핑몰의 경우 구매 희망물건을 바로 구매하기 보다는 몇 개의 물건들을 모두 모아서 구매하는 행태가 일반적이다. 하지만, 인터넷 쇼핑몰의 경우 단 하나의 물품만을 포함하고 있는 주문이 전체 주문의 절반이상을 차지한다. 이러한 차이는 온라인 쇼핑몰 거래데이터의 분석을 위해서는 데이터 마이닝 분석에서 사용되어 온 장바구니의 정의에 대한 확장이 필요함을 의미한다. 하지만 현재까지 온라인 데이터를 대상으로 한 장바구니 분석 연구는, 장바구니의 기준 즉 동시구매의 기준에 대한 명확한 근거나 합의 없이 연구자의 선택에 따라 서로 다른 기준으로 수행되어왔다. 따라서 본 연구에서는 온라인 쇼핑몰 분석에 적용되는 동시에 구매되는 물건들에 대한 기준을 고찰해보고 연구모형을 마련하고자 한다.

한국 성인 남녀 대사증후군 집단의 영양소 섭취와 식사의 질 및 hs-CRP와 관련성 - 국민건강영양조사(2015년) 자료를 활용하여 -

김미성,김병숙,이종신,오경재,한성희,Kim, Mi Sung,Kim, Byung Sook,Lee, Jong Sin,Oh, Gyung Jae,Han, Soung Hee 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.3

Metabolic syndrome is a risk factor for cardiovascular and type 2 diabetes. This study was conducted to examine the relevance between nutrition intake, meal quality, and high-sensitivity C-reactive protein in Koreans with metabolic syndrome. The 2,536 subjects, aged 19~64, who participated in 2015 National Nutrition Survey were included in this study. The 24-hour recall method was employed to analyze nutrition intake and dietary quality. Subjects were grouped into either the non-metabolic syndrome group (n=1,938) or the metabolic syndrome group (n=598). Total males and females were divided into 3 groups according to the high-sensitivity C-reactive protein (hs-CRP) level to study its relationship to metabolic syndrome and its components, including odds ratio (OR) and confidence interval (CI). Results showed the homeostasis model assessment of insulin resistance (HOMA-IR) value was higher in the metabolic syndrome group (3.37) than non-metabolic syndrome group (1.57) (p<0.001). In the Index of Nutrition Quality, males in the non-metabolic syndrome group showed higher niacin (p<0.05) than males in metabolic syndrome group. Females in the non-metabolic syndrome group had higher vitamin $B_1$ (p<0.01), vitamin $B_2$ (p<0.001), niacin (p<0.05), calcium (p<0.001), and phosphate (p<0.01). Female in the high hs-CRP group showed high OR in blood glucose component (OR 2.488, 95% CI: 1.269~4.879) and metabolic syndrome risk (OR 2.856, 95% CI: 1.292~6.314). Females in the middle hs-CRP group had high triglycerides component (OR 2.956, 95% CI: 1.920~4.551), compared to the low hs-CRP group. The study showed females with higher hs-CRP had a higher risk of metabolic syndrome.

전북지역 성인 1인가구와 다인가구의 건강행태 비교

김미성(Mi Sung Kim),김병숙(Byung Sook Kim) 한국생활과학회 2018 한국생활과학회 학술대회 Vol.2018 No.5

한국과 스웨덴의 여성고용과 남녀고용평등정책 비교

김미성(Mi-Sung Kim),전겨옥(Kyung Ock Chun),문경희(Kyoung-hee Moon) 숙명여자대학교 아시아여성연구원 2007 아시아여성연구 Vol.46 No.2

본 연구는 한국과 스웨덴의 남녀고용평등 정책에 대한 비교이다. 본 연구는 여성고용은 시장적 요인만이 아닌 국가의 정책적 요인과도 연관이 있음을 전제로 하며, 한국과 스웨덴의 사례를 통해 이를 밝히고자 한다. 한국과 스웨덴의 남녀고용평등 정책에 대한 비교는 이 정책이 성별 노동분업을 재조직하는데 어느 정도나 기여하였는가를 기준으로 한다. 그리고 이 정책이 노동시장 안의 비대칭적인 성별 구조를 허물기 위하여 구체적으로 어떤 조치를 취하고 있으며, 그 결과는 어떠한가를 분석한다. 한국의 남녀고용평등 정책은 자유주의 모델로 볼 수 있다. 초기 이 정책은 ‘성별 노동분업 재조직’보다는 여성에 대한 차별금지를 위한 성격이 강하였다. 최근의 ‘자녀양육의 부분적 사회분담화’와 ‘적극적 조치’ 등을 통해 성별 노동분업을 재조직하고 노동시장 안에서의 성별 직종분리의 문제를 해소하기 위한 노력이 시작되었다. 그러나 문제는 이 정책으로 혜택을 받을 수 있는 대상이 너무 협소하다는 접이다. 한국의 경우, 저숙련보다는 고숙련 여성들이 남녀고용평등법의 수혜를 더 쉽게 받을 수 있다. 대다수의 여성들은 비정규직과 같은 불안정 노동에 종사하고 있다. 결과적으로 한국의 남녀고용평등 정책은 이 여성근로자들에게 실질적인 혜택을 주지 못하고 있다. 한국과 달리 스웨덴은 사민주의 모델을 따른다. 이 모델에서 최우선의 가치는 사회평등을 재조직하는 것이며, 이 사회평등에서 여성도 배제되지 않았다. 따라서 스웨덴의 남녀고용평등 정책은 처음부터 여성에 대한 차별 금지보다는 성별 노동분업을 재조직하기 위한 목적으로 시작되었다. 덕분에 스웨덴에서 여성고용율은 매우 높으며, 다른 국가들에 비하여 여성들의 임금도 높은 편이다. 그러나 스웨덴의 남녀고용평등 정책은 성보다는 계급의 평등을 더 강조하고 있다. 이로 인해 여성노동의 파트타임화나 노동시장의 성별 분절화와 같은 문제들은 해결되지 못하고 있다. This paper is about the comparative analysis of the equal employment policies in Korea and Sweden. Assuming that women's employment is affected by not only the market but also the state, this paper looks into the roles of each state in promoting gender equality in employment. The major focus of the comparative analysis is to see how much each state's policies have contributed to the elimination of the gender division of labor in employment. This study also examines specific measures taken by each state in order to get the asymmetric gender relations balanced and the effects of them on women's employment. Liberalism is an important ideological basis for the equal employment policies in Korea. The early policies had a stronger emphasis on prevention of discrimination against women than elimination of the gendered division of labor. However, in recent years, the state has made efforts to eliminate the gender division of labor and occupational segregation by gender by adapting the new child care policies and affirmative actions. The policies were created to reduce women's child care burden and provide women with more employment opportunities. Nevertheless, the state has achieved limited success with the policies because they are applied to only a small number of women, mainly women with professional jobs. In the meantime, Sweden's equal employment policies are based on the social democratic model, which highly values equality among all society members. Hence, the central focus of the policies has always been the elimination of the gender division of labor, the most important cause of gender inequality. The policies has effectively increased women's workforce participation and has reduced the wage gap between men and women. However, it is noted that the equal employment policies in Sweden have more emphasis on class equality than gender equality. Lacking gender sensitive approaches in the policies, the occupational segregation by gender still remains strong in the workplace.

흰쥐 결장운동에서 5-Hydroxytryptamine4 (5-HT4) Receptor Partial Agonist (Tegaserod)의 작용기전

김미성 ( Mi Sung Kim ),고병성 ( Byeong Seong Ko ),오석진 ( Seok Jin Oh ),한정호 ( Joung Ho Han ),전원중 ( Won Joong Jeon ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ) 대한소화기기능성질환·운동학회 2008 Journal of Neurogastroenterology and Motility (JNM Vol.14 No.1

목적 : 5-Hydroxytrypatmine4 (5-HT4) 수용체의 부분적 촉진제인 테가세로드(Tegaserod, Tega)는 연동반사를 자극하고 개의 소장 및 대장의 운동성과 통과를 촉진하는 것으로 알려져 있다. 본 연구는 흰쥐에서 혈류와 장내 신경이 온전히 유지된 채 결장을 분리한 실험모델을 사용하여 Tega가 결장운동에 미치는 영향 및 작용기전에 대해 알아보고자 하였다. 방법 : 상장간막 동맥을 포함하여 분리한 흰쥐 결장에서 Tega 10, 70, 140과 1400 pM을 단계적으로 동맥에 투여하여 근위부와 원위부 결장내압을 측정하였다. 운동성은 각 농도별 운동지수를 계산하여 기저치의 운동지수에 대한 %변화인 수축반응으로 표시하였다. 이후 억제 유무를 알아보기 위하여 근위부와 원위부에 각각 140 pM의 Tega 를 투여하였을 때와 비교하였고 phentolamine, propranolol, hexamethonium, atropine (ATR)과 tetrodotoxin (TTX)를 각각 전처치 후 Tega를 함께 관류시켜 운동성 변화를 측정하였다. 결과 : Tega를 10, 70, 140, 1400 pM의 다양한 농도로 각각 주입하였을 때 근위부 결장에서 수축반응은 각각 40±20.17, 101±92.43, 122±120.57, 101±89.05%, 원위부 결장에서 수축반응은 각각 20±22.05, 73±41.47, 93±75.45, 73±54.91%로 근위부 및 원위부 결장 모두 기저기의 결장운동과 비교시 유의하게 증가하였다(p<0.05). 근위부와 원위부를 비교하였을 때 근위부에서 원위부보다 운동지수의 증가가 더 강력하였다. 또한 특히 원위부에서는 10 pM에서 140 pM까지 농도-의존적인 운동지수의 증가가 관찰되었다. (p<0.05). Tega에 의한 결장운동 증가효과는 ATR에 의해 억제 되었으나 TTX, propranolol, phentolamine과 hexamethonium의 전처치 후에는 억제되지 않았다. 결론 : Tega는 근위부 및 원위부 결장 운동을 증가시켰으며 이러한 작용은 TTX-민감성 신경전도와 관련 없이 직접 국소적 콜린동작성 무스카린 수용체를 통해 작용할 것으로 판단된다. Backgrounds/Aim: A 5-Hydroxytrypatmine4 (5-HT4) partial agonist, Tegaserod (Tega), stimulated the peristaltic reflex in vitro and increases canine intestinal and colonic motility and transit. The objectives of this study were to investigate the action mechanism of Tega on colonic motility using a vascularly perfused rat colon. Methods: Thirty three Sprague-Dawley rat colons with attached superior mesenteric arteries (SMA) were isolated. Tega was administered to SMA and the intraluminal pressures were monitored in the proximal and distal colon of them. Phentolamine, propranolol, hexamethonium, atropine (ATR) or tetrodotoxin (TTX), 140 of pM Tega administered and the pressures were monitored. Results: Contractile responses were increased significantly by Tega at concentrations of 10, 70, 140 and 1400 pM in the proximal colon (40±20.17, 101±92.43, 122±120.57 and 101±89.05%, respectively) and in the distal colon (20±22.05, 73±41.47, 93±75.45 and 73±54.91%, respectively)(p<0.05). In particular, the stimulating effects of Tega on colonic motility were more potent in the proximal colon than in the distal colon. In addition the motility of the distal colon was increased by Tega in a concentration-dependent manner at concentrations of 10, 70 and 140 pM (P<0.05). The effect of Tega was inhibited by ATR but not by other drugs in the proximal and distal colon. Conclusions: Tega increased colonic motility in vascularly perfused rat colon. The activation of the muscarinic receptor rather than by TTX-senstive nerve conduction might be responsible for the excitatory effect of Tega on colonic motility in rats.

지역사회 거주 노인 대상 노인영양지수(NQ-E)와 영양섭취 상태 조사 : 고창군 지역을 중심으로

김미성(Mi Sung Kim),김선경(Seon Kyung Kim),김순화(Soon Hwa Kim),이영훈(Young Hoon Lee),오경재(Gyung Jae Oh) 한국생활과학회 2018 한국생활과학회 학술대회 Vol.2018 No.11

19세기 전반 파리의 출판문화: 소설의 승리와 문학의 상업화

김미성 ( Kim Mi Sung ) 연세대학교 인문학연구원 2017 人文科學 Vol.109 No.-

The 19^th century was the golden age of print, and Paris was the epicenter. Those who had been pouring over the same few number of books over their lifetime found written form to be ever more accessible; and for the first time in history, books became an object of consumption for a single reading experience. What the public especially craved was fiction; and as Sainte-Beuve scoffed, the advent of newspaper novels in the 1830s propelled literature to enter the circuit of capitalist production and consumption to become an industry. Publishing houses played a significant role in the spread of novels. A mos noteworthy driver was the drop in book prices. The publisher Charpentier put forth a single volum novel in a small format of format in-18 at the price of 3,50 francs in 1838, making a mark in the falling prices and pulling down barriers for the larger readership. The earlier half of the 19^th century was a vibrant period with renowne players such as the still-present Imprimerie Royale established by cardinal Richelieu and old-standing publishing houses dating back to the 15^th century; co-existing with new publishers Didot armed with novel methods and equipment. This was also the time that the Parisian publishing landscape that continue to today start taking shape with the likes of Garnier and Hachette. It is also true, however, that publishing powerhouses of those days such as Charles Gosselin, Eugene Renduel, Urbain Canel, and Ladvocat have ceased to exist. The glut of published books, an import ban on French books by Spain, Portugal, and Italy, and the pirating by Belgium dealt blows to the French publishing scene. The publishers of the olden days were often small businesses, and the probability that a project would end up an inventory than a bestseller was high -as is the case today. This meant that publishers were constantly exposed to the risk of bankruptcy than safe sailing with a stable source of good income. In the financial crisis of the 19^th century in which excessive rise in credit dealings and debt were seen as culprits, the small publishers without strong capital means were vulnerable. The French publishing scene addresses these challenges by bettering the technology to continue lowering book prices, creating more quality paperbacks, offering educational materials or illustrations, installing book kiosques as railways opens on the back of a steady rise in the overall readership; to reach its heyday in the late 19^th century The century marked by maturing capitalism was indeed a remarkable period in the history of publishing as not only quality books become available through innovations in printers and paper production, but also as publishers become an industry it their own right by incorporating advertisement.