데리야끼 소스의 품질향상개발에 관한 연구

김미경 ( Mee Kyung Kim ),김경묘 ( Kyoung Myo Kim ),이상희 ( Sang Hee Lee ),이양봉 ( Yang Bong Lee ) 한국호텔리조트학회(구 한국호텔리조트카지노산학학회) 2010 호텔리조트연구 Vol.9 No.1

인간의 건강 향상을 위한 기능성 천연소재 연구 : 운향과 과실류 발효추출물의 항산화 및 항균 비교 분석

김미경(Kim, Mee kyoung) K교육연구학회 2021 사회과학리뷰 Vol.6 No.3

본 연구에서는 운향과 과실류(유자, 자몽, 레몬, 밀감, 오렌지, 탱자)의 식품 및 화장품 기능성 소재로서의 적용 가능성을 확인하고자 6종을 혼합하여 발효한 후 에탄올로 추출한 추출물의 naringin, hesperidin의 함량, 항산화능 및 항균력을 비교 분석하였다. 그 결과 버섯발효 에탄올 추출물(FME)이 naringin 220.36 μg/mL, hesperidin 1254.67 μg/mL로 가장 높은 함량을 나타내었다. 항산화 효과는 DPPH 라디컬 소거능과 ABTS 라디컬 소거능에서 에탄올 추출물(MRE)와 버섯발효 에탄올 추출물(FME)이 자연발효 및 젖산발효 에탄올 추출물(FSE, FME)에 비해 다소 높은 소거능을 나타내었고 antioxidant protection factor에서는 버섯발효 에탄올 추출물(FME)가 다른 추출물에 비해 소거능이 높게 나타났다. 피부 상재균에 대한 항균활성은 젖산발효 에탄올 추출물(FLE)이 S. epidermidis(16.9~22.3 mm)와 P. acnes(8.5~10.4 mm) 균에서 항균력을 나타내었고 버섯발효 에탄올 추출물(FME)은 S. epidermidis(12.0~16.1 mm), E. coli(9.5~13.3 mm) 및 P. acnes(9.0~13.1 mm) 균에서 항균활성을 나타내었다. 이상의 결과로 보아 버섯발효 에탄올 추출물(FME)은 피부 미용 식품 및 기능성 화장품의 소재로서의 활용이 가능할 것으로 사료된다. This study evaluated hesperidine and naringin contents, antioxidant and antimicrobial activities of the extracts of fermented Rutaceae fruits(citron, grapefruit, lemon, mandarin orange, orange, trifoliate) in order to confirm the applicability as food and cosmetic functional materials. The samples used in th experiment were ethanol extract from mixed Rutaceae fruits (MRE), ethanol extract of mixed Rutaceae fruits fermented with sugar (FSE), ethanol extract of mixed Rutaceae fruits fermented with lactic acid bacteria (FLE) and ethanol extract of mixed Rutaceae fruits fermented with mushroom mycelium (FME). The content of narigin and hesperidin was highest in FME. In DPPH radical scavenging activity and ABTS radical scavenging activity, MRE and FME showed higher scavenging activity than FSE and FME. In the antioxidant protection factor, FME was higher than that of other extracts. In antibacterial activity against skin flora, FLE showed antibacterial activity against S. epidermidis and P. acnes, and FME showed antibacterial activity against S. epidermidis, E. coli and P. acnes. Therefore, it is considered that the ethanol extract of mixed Rutaceae fruits fermented with mushroom mycelium can be used as a natural material for cosmetic and food.

청소년기에 발생하여 하부 생식기 폐색과 양측 난관 농양을 초래한 심한 소음순 유착

김미경 ( Mi Kyoung Kim ),김수현 ( Soo Hyun Kim ),차선희 ( Sun Hee Cha ),이미화 ( Mee Hwa Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10

Labial adhesions are extremely rare in adolescent and adult populations, because the etiology of this entity commonly relates to chronic vulvar inflammation or irritation, and is basically associated with low estrogen status. Although a few cases reported urinary retention resulting from severe labial adhesions, there is no report of labial adhesion that precipitates upper genital tract infection in prepubertal and postpubertal females. We present a rare case of severe labial adhesion and consequential lower genital tract obstruction that allegedly causing bilateral pyosalpinx in a 14-year-old adolescent girl who decisively denied sexual experience. The patient was successfully treated with surgical lysis of adhesion and administration of antibiotics.

논평 : 비알코올성 지방간질환의 중증도 평가를 위한 바이오마커

김미경 ( Mee Kyoung Kim ) 대한비만학회 2013 The Korean journal of obesity Vol.22 No.2

특집 -비만 : 비만의 행동중재와 약물치료

김미경 ( Mee Kyoung Kim ) 대한내과학회 2013 대한내과학회지 Vol.84 No.5

Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. The U.S. Preventive Service Task Force (USPSTF) recommends screening all adults for obesity. Clinicians should offer or refer patients with a body mass index of 30 kg/m2 or higher to intensive, multicomponent behavioral interventions. Behavioral interventions can lead to a moderate weight loss and improvement in blood sugar and other risk factors for cardiovascular disease. Behavioral interventions decreased the incidence of diabetes diagnosis by about 50% over 2 to 3 years. Orlistat, phentermine, diethylpropion, phendimetrazine, mazindol have been approved as anti-obesity drugs by Korea Food and Drug Administration. The U.S. Food and Drug Administration approved lorcaserin and phentermine plus topiramate combination for treatment of obesity in 2012. (Korean J Med 2013; 84:624-628)

여러 장기를 침범한 이차성 혈색소침착증 1예

김미경 ( Mee Kyoung Kim ),임동준 ( Dong Jun Lim ),백기현 ( Ki Hyun Baek ),송기호 ( Ki Ho Song ),강무일 ( Moo Il Kang ),이광우 ( Kwang Woo Lee ),이종욱 ( Jong Wook Lee ) 대한내과학회 2008 대한내과학회지 Vol.75 No.6

불가피하게 반복적인 수혈을 받는 환자에서 수혈과 관련하여 이차성 혈색소 침착증이 발생할 수 있는데, 본 저자들은 재생불량성 빈혈로 10년간 약 400pints의 수혈을 받은 환자에서 피부 색소 침착, 저성선자극호르몬에 의한 성선기능저하, 당뇨병, 간기능 장애, 확장성 심근병증에 의한 울혈성심부전 등 여러 가지 심각한 합병증을 동반한 이차성 혈색소 침착증 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of transfusion-associated hemochromatosis in a 38-year-old female who had severe aplastic anemia. She had undergone conservative treatment consisting of multiple transfusions because she had no suitable HLA-matched bone marrow donor. She had received 400 units of red blood cells (RBCs) over 10 years. The transferrin saturation and serum ferritin were increased to 88.4% and 29,905 ng/mL, respectively. Abdominal computed tomography (CT) showed increased densities in the liver and myocardium, suggesting iron deposits in those organs. In general, transfusional iron overload results in primarily reticuloendothelial iron accumulation, which is considered to be less harmful than parenchymal iron accumulation. Nevertheless, our patient had many striking complications associated with hemochromatosis, such as skin pigmentation, hypogonadotropin hypogonadism, insulin-requiring diabetes mellitus, impaired liver function, and left ventricular dysfunction. (Korean J Med 75:709-713, 2008)

임상화보 : 거대 뇌하수체 낭종으로 나타난 프로락틴종

김미경 ( Mee Kyoung Kim ),신주영 ( Joo Young Shin ),임동준 ( Dong Jun Lim ),백기현 ( Ki Hyun Baek ),강무일 ( Moo Il Kang ),이광우 ( Kwang Woo Lee ) 대한내과학회 2006 대한내과학회지 Vol.71 No.6

연구논문 : 돼지감자분말 첨가가 쌀 스펀지케이크의 품질 특성과 항산화능에 미치는 효과

김미경 ( Mee Kyoung Kim ),이은주 ( Eun Ju Lee ),김경희 ( Kyung Hee Kim ) 한국식생활문화학회 2014 韓國食生活文化學會誌 Vol.29 No.2

This study was conducted to evaluate the quality characteristics and antioxidant activities of rice flour sponge cakes containing 0, 20, 30, 40, and 50% Helianthus tuberosus powder (HTP). As HTP content of sponge cake increased, the pH of sponge cake batter significantly decreased, whereas specific gravity significantly increased (p<0.05). Meanwhile, volume and symmetry indices of sponge cake were inversely proportional to HTP amount. Further, with higher HTP content in sponge cake, L and b values of crumbs significantly decreased (p<0.05), whereas a value significantly increased (p<0.05). L, a, and b values of crust significantly increased with higher HTP content. For texture characteristics, hardness, cohesiveness, gumminess, and chewiness of sponge cake significantly increased (p<0.05),whereas cohesiveness did not significantly change. In the sensory evaluation test, rice sponge cake prepared with 10% HTP showed the highest sensory scores in terms of color, flavor, taste, softness properties, and overall preference. The levels of total polyphenol compounds and DPPH radical scavenging activities of rice sponge cakes significantly increased with higher HTP contents (p<0.05). The results of this study suggest that rice sponge cake containing 10% HTP is the most appropriate for quality characteristics and sensory evaluation. This study also provides a way to increase the quality, texture characteristics, and organoleptic properties of sponge cake while reducing HTP content to less than 10% in order to satisfy consumer tastes.

부신우연종의 진료지침: 대한내분비학회 진료지침제정위원회

이정민 ( Jung-min Lee ),김미경 ( Mee Kyoung Kim ),고승현 ( Seung-hyun Ko ),고정민 ( Jung-min Koh ),김보연 ( Bo-yeon Kim ),김상완 ( Sang-wan Kim ),김수경 ( Soo-kyung Kim ),김혜진 ( Hae-jin Kim ),류옥현 ( Ohk-hyun Ryu ),박주리 ( Jur 대한내과학회 2017 대한내과학회지 Vol.92 No.1

An adrenal incidentaloma is an adrenal mass found in an imaging examination performed for reasons unrelated to suspected adrenal disease. The prevalence of adrenal incidentaloma increases with age; there is no gender difference, but it is often accompanied by obesity, diabetes mellitus, or hypertension. The detection of adrenal incidentaloma is expected to rise with the rapid development of imaging technology and increasing frequency of imaging studies. The Korean Endocrine Society is promoting appropriate practice guidelines to meet the rising incidence of adrenal incidentaloma, in cooperation with the Korean Adrenal Gland and Endocrine Hypertension Study Group. In this paper, we discuss important core issues for treating adrenal incidentaloma, along with the most important factors for healthcare providers who treat and manage affected patients. Initially, we identified 47 recommendations using the Delphi technique, after evaluating core propositions. We reduced these to the 20 most critical recommendations. (Korean J Med 2017;92:4-16)

당뇨병환자의 우울증과 자가 관리

김수연 ( Su Yoen Kim ),이재호 ( Jae Ho Lee ),김하늘 ( Ha Neul Kim ),김동규 ( Dong Kyu Kim ),나영 ( Young Na ),김길선 ( Guil Sun Kim ),김미경 ( Mee Kyoung Kim ),백기현 ( Ki Hyun Baek ),강무일 ( Moo IL Kang ),이광우 ( Kwang Woo Lee 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.5

연구배경: 당뇨병환자들에서 우울증의 유병률이 높고 이는 환자들이 생활 개선 요법을 적절히 수행하는데 지장을 주어 혈당 조절을 악화시키거나 합병증의 발생을 증가시킬 수 있다. 본 연구에서는 두 가지 설문 조사를 통해 우리나라 당뇨병환자들의 우울증의 빈도 및 자가 관리 정도에 관해 조사하고자 하였다. 방법: 2008년 7월에서 2008년 12월 사이에 제2형 당뇨병 치료를 위해 성모병원 외래를 방문한 환자들을 대상으로 Harvard Department of Psychiatry/National Depression Screening Day Scale (HANDS)와 Summary of Diabetes Self-Care Activities (SDSCA)를 이용하여 이들의 우울증 여부와 식사 조절, 운동, 혈당 체크, 발 관리, 금연 등의 자가 관리 수행 정도를 조사하였다. 또한 당뇨병의 유병 기간, 만성 합병증, HbA1c, 총 콜레스테롤, 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤을 측정하였다. 위의 결과들을 토대로 당뇨병환자들의 우울증 빈도 및 우울증과 자가 관리, 우울증과 혈당 조절 정도와의 관계를 Two-tailed t tests, chi-square analysis, Pearson`s correlation coefficient 방법으로 조사하였다. 통계적 유의수준은 0.05 미만으로 정의하였다. 결과: 총 191명의 환자들이 설문 조사를 완료 하였고 이중 39명(20.4%)의 환자가 주요 우울 장애에 이환되어 있는 것으로 나타났다. 그러나 우울증이 있는 환자 39명 중 6명(15.3%)만이 이에 대해 전문가의 진단 또는 치료를 받은 기왕력이 있었다. 우울증이 없는 군과 있는 군 사이의 자가 관리 정도를 비교해 보았을 때 적절한 식사 요법과(평균점수: 18.54 vs 15.94, P=0.046) 자가 혈당 측정은(평균점수: 4.05 vs 2.69, P=0.047) 우울증이 있는 환자군에서 통계적으로 유의하게 그 수행 정도가 떨어졌다. 그러나 규칙적 운동, 매일의 발 관리, 금연 여부 등은 두 환자군 사이에 의미있는 차이를 나타내지 않았다. 당화혈색소, 총 콜레스테롤이나 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤 수치도 우울증이 있는 군과 없는 군 사이에 통계적으로 유의한 차이를 나타내지는 않았다. 결론: 당뇨병이 있는 환자들은 건강한 성인에 비해서 우울증이 동반되는 경우가 더 흔하며 이들 중 상당수가 적절히 진단되지 않고 있다. 우울증이 있는 당뇨병환자들은 식사 조절이나 혈당 체크와 같은 자가 관리의 수행 정도가 우울증이 없는 당뇨병환자에 비해 낮으며 따라서 당뇨병환자들의 우울증 동반 여부에 대해 적절히 진단하고 치료하는 것이 필요하다. Background: Depression is known to be a risk factor for type 2 diabetes mellitus. Conversely, diabetes is also a risk factor for depression, and patients with diabetes have nearly twice the risk of comorbid depression as the general population. Depression in patients with diabetes may cause poor clinical outcomes through lower adherence to self-care activities such as exercise, diet control, and glucose monitoring. Furthermore, diabetic patients with depression are more likely to suffer from microvascular or macrovascular complications. We explored the prevalence of major depressive disorder in Korean diabetic patients and its impact on self-care activities and glucose control. Methods: We surveyed depressive symptoms and self-care activities in 191 type 2 diabetic patients from the outpatient clinic of the St. Mary`s hospital. Two questionnaires were used for assessment, the Harvard Department of Psychiatry/National Depression Screening Day Scale (HANDS) and the Summary of Diabetes Self-Care Activities (SDSCA). Results: Of the 191 respondents who completed questionnaires, 39 (20.4%) patients were categorized as having major depressive disorder. Among the depressed patients, only six (15.3%) had been previously evaluated and managed for their psychiatric problems. The incidence of depression was significantly higher in female diabetic patients compared to patients without depression (74.4% vs. 45.4%, P<0.001). Patients with depression showed significantly poorer diet control (18.5 vs. 15.9, P=0.046) and less glucose monitoring (4.1 vs. 2.7, P=0.047). However, there were no differences in exercise, foot care, or smoking status between the two groups. Additionally, metabolic parameters such as HbA1C and lipid profile were not significantly different between the two groups. Conclusion: Many diabetic patients are suffering from depression and exhibit poorer self-care activities than patients without depression. Identifying and managing depressed diabetic patients may help improve their self-care activities. (Korean Diabetes J 33:432-438, 2009)