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Etretinate로 치료한 소아에서의 호저피상 어린선
김명남(Myeung Nam Kim),전인기(In Gi Chun),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1
A 4-year-old boy have had widespread, multiple, dark brownish, verrucous ]papular plaques on the neck, left chest, right side of abdomen, back and penile skin since birth. Clinical features and light and electron microscopic findings were consistent with ichthyosis hystrix. The patient was successfully treated with systemic administration of etretinate and vitamin E.
아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic protein, IL-4 및 soluble E-selectin의 변화
김명남 ( Myeung Nam Kim ),신봉주 ( Bong Ju Shin ),탁우정 ( Woo Jung Tak ),노병인 ( Byung In Ro ),박애자 ( Ae Ja Park ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11
N/A Background : Since the management of atopic dermatitis often needs rolonged administration of medication, the laboratory index reflecting disease severity is necessary for optimal treatment for this disease. Objectives : The purpose of this study is to evaluate peripheral eosinophil counts, serum total IgE, eosinophilic cationic protein(ECP), IL-4 and soluble E-selectin as severity indices or disease marker. Method : A total of 21 patients with atopic dermatitis and 21 normal controls were evaluated for the symptoms and signs according to SCORAD index and measured for peripheral eosinophil counts, serum total IgE, ECP, IL-4 and soluble E-selectin. Results : Peripheral eosinophil counts, serum total IgE, ECP and soluble E-selectin levels of patients with atopic dermatitis were significantly increased compared with those of normal control(p<0.05). Moreover, serum ECP and soluble E-selectin correlated with SCORAD score. Serum IL-4 levels of patients with atopic dermatitis were slightly increased compared with those of normal control but not statistically significant(p>0.05). Conclusion : ECP and soluble E-selectin were good serum marker reflecting the severity of atopic dermatitis.
침습성 (侵襲性) 편평세포암 (扁平細胞癌) 으로 이행한 다발성 Bowen병
김명남(Myeung Nam Kim),전인기(In Gi Chun),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.5
Bowen's disease is an intraepidermal squarnous cell carcinoma referred to also as squamous cell carcimona in situ. Approximately two-thirds of Bowen's disease consist of solitary lesion while remaining show multiple lesions, We experienced a 68-year old male patient who had multiple erythematous pathes and plaques covered with scales and grayish crusts developing on the trunk and both lower extremities. At first, clinically we suspected psoriasis, seborrheic keratosis, eczema and mycosis fungoides, and finally histopathologic features revealed Bowen's disease showing transformation to invasive squamous cell carcinorna.
만성 피부점막 칸디다증 - 증례 보고 및 문헌적 고찰 -
김명남(Myeung Nam Kim),홍창권(Chang Kwun Hong),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.5
A 11-year-old girl with chronic mucocutaneous candidiasis(CMCC) has been observee since the age of 4 years. At first(November, 1978) there was a good response to treatment with amphotericin B intravenously of total 300 mg, but not to with oral administration of nystatin and local clotrirnazole cream. Since that time, she bas been admitted on different occasions for further evaluation and therapy because of recurrences. During the most recent hospitalization in October, 1985, she was suffered from herpes zoster in addition to CMCC. We treatecl her with analgesics and intravenous globulin for herpes zoster, and concomitantly with ketoconazole(200 mg/day) and 5-fluarocytosine for 20 days. At the end of this period, she was free of any clinical evidences of CMCC and herpes zoster.
배양된 정상 인체 각질형성세포에서 자외선 B 조사에 의한 아포프토시스와 p53의 발현
김명남(Myeung Nam Kim),서성준(Seong Jun Seo),홍창권(Chang Kwun Hong),노병인(Byung In Ro),노성욱(Sung Wook Ro),조성인(Sung In Cho) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.4
N/A Cutaneous absorption of ultraviolet B(UVB) in the skin occurs primarily in keratinocyte, causing DNA and protein damage. p53 tumor suppressor gene appeared in the epidermis after UVB irradiation, and the wild type has been known to be responsible for apoptosis and plays an important role in excluding abnormal cells with significant DNA damage. While p53 has been implicated in both DNA repair and apoptosis, it is unclear whether the p53 protein is involved in both of these processes within the same cell. Therefore, UVB-induced apoptosis and changes in p53 expression were studied in cultured normal human keratinocyte to determine that the cellular response to UVB induced DNA damage(DNA repair or apoptosis) correlated with p53 expression. The cultured normal human keratinocytes were irradiated with the doses of UVB(25-150 mJ/cm2) and incubated for various times(3, 6, 12, 24 hour) after radiation. At UVB doses of 100 and 150 mJ/cm2, acridine orange/ethidium bromide(Ao/Eb) staining-positive cells and TUNEL (TdT mediated dUTP-biotin nick end labeling) staining-positive cells increased significantly after 3 hours and 6 hours postirradiation respectively. Twelve hour postirradiation, staining-positive cells increased at each level of UVB-radiation exposure. These results suggest that there were significant influences of UVB doses and time course after irradiation to the number of Ao/Eb and TUNEL staining-positive cells. To determine whether all Ao/Eb and TUNEL-positive cells were actually undergoing apoptosis, cellular DNA was extracted from keratinocytes at 12 hours after UVB irradiation and seperated by electrophoresis on an 2.5% agarose gel to detect the internucleosomal DNA fragmentation(DNA ladder). 'DNA ladder' occurred at every dose of UVB 12 hour after irradiation, but did not appear early after irradiation, suggesting that whether Ao/Eb and TUNEL-positive cells observed early after irradiation were not undergoing apoptosis. Activation of p53 and the response to DNA damage is not observed universally, but is dependent on tissue specificity, species specificity and type of genotoxic damage. To correlate p53 level with UVB-induced apoptosis at the dose of 100mJ/cm2 UVB, p53 levels were determined by western blot analysis. The accumulation of p53 protein was apparent after 6 hours postirradiation, and UVB irradiation caused a dramatic increase in p53 levels at 12 and 24 hours. These results demonstrate that p53 is required for UVB-induced apoptosis in cultured normal human keratinocyte and p53 has a time-dependent effect in the initiation of apoptosis. In this study, the results indicated that a low dose(25mJ/cm2) of UVB irradiation could induce apoptosis in human keratinocyte in vitro and UVB exerts a time-dependent effect on inducing apoptosis. And the results also give support to increasing evidence that p53 may play a role in UVB-induced DNA damage and the induction of apoptosis in cultured normal human keratinocyte and that p53 is involved in the decision process which determines the fate of keratinocyte after UVB -induced DNA damage. (Korean J Dermatol 2000;38(4):481~489)