한국인 20세부터 24세까지 각막 두께와 안압의 분석

김덕훈,Douk Hoon Kim,Kishor Sapkota 한국임상보건과학회 2023 한국임상보건과학회지 Vol.11 No.1

Purpose: The aim of this study was to determine the distribution of the cornea thickness and intra ocular pressure Korean adult of 20 to 24 year old using the Pentacam and tonometer. Methods: The subjects of this study were 43 Korean adults with healthy eyes. Corneal thickness was measured with Pentacam device. The intra ocular pressure was measured with tonometer. Data was analyzed by means of the Pearson's correlation cofficient. P-values<0.001 were considered statistically significant. Results: Mean age of subjects was 20.41±0.86 years. The mean +/- intra ocular pressure of the right eye and left eye were 16.236±2.523mmHg and 16.971±1.992mmHg, respectively. The mean central corneal thickness of the right eye and left eye was 545.324±38.682㎛ and 547.442±33.778㎛, respectively. No significant difference in central corneal thickness was found between the right and left eyes. But, there was a statistically significant difference between central cornea thickness and peripheral cornea thickness around 4 mm of central cornea(p<0.001, Pearson's correlation). However there was no statistically significant difference between central cornea thickness and intra ocular pressure. Conclusion: The results of this study could be used as a clinical reference data for diagnosis and treatment of cornea in Korean adult.

20세부터 29세까지 한국인 성인 난시 분석

김덕훈,박상열,Kim, Douk-Hoon,Park, Sang-Youl 한국임상보건과학회 2021 한국임상보건과학회지 Vol.9 No.1

Purpose. To analysis of astigmatism in Korean adults from 20 to 29 years old. Methods. From January 2019 to February 2020, one hundred two subjects were performed in refraction test using the Auto-Refractometry. Results. In the type of astigmatism based on refractive error, the male's right eye was 4.26% simple myopic astigmatism and 95.74% complex myopic astigmatism, and the left eye was 2.22% simple myopic astigmatism and 97.78% complex myopic astigmatism. However, in the female's right eye, simple myopic astigmatism was 2.27%, complex myopic astigmatism was 97.73%, and left eye was simple myopic astigmatism was 2.17%, complex myopic astigmatism was 97.83%. The types of astigmatism in men and women similar to other. The mean refractive astigmatism values were -0.922±-0.798 diopter and -0.877±-0.707 diopter for male right and left eye, and -0.765±-0.599 diopter and -0.853±-0.586 diopter for female. On the other hand, the refraction values of the right and left eyes of men and women have statistical significance(p=0.000). The mean power comparative between refractive astigmatism and corneal astigmatism power were -0.186±-0.745 diopter, -1.091±-0.589 diopter in male and -1.140±-0.593 diopter, -1.140±-0.534 diopter in female. Therefore, the mean power values of the refractive astigmatism and corneal astigmatism of men and women were statistical significance(p=0.000). At the 0.75 diopter or more, which can have clinical symptoms of astigmatism power, males have 60.86% and 72.09% of the right and left eyes, and females have 47,64% and 60.10% of the right and left eyes. At 0.75 diopter or more, which can have clinical symptoms of corneal astigmatism power, males have 68.75% and 74% of the right and left eyes, and females have 86.50% and 82.35% of the right and left eyes. In the type of astigmatism axis, both men and women had a high frequency of the rule astigmatism. However, men had a high frequency of against-the-rule astigmatism and women showed a high frequency of oblique astigmatism. Conclusions. In this study, the complex myopic astigmatism and with-the rule astigmatism was the most common of all subjects. However, there was a statistical significance between right and left eyes of all subjects. The corneal astigmatism was higher refractive values in both males and females than refractive astigmatism. This study suggests that the analysis of the astigmatism can provide the useful diagnosis information for the correction of visual acuity.

ez NANOsence II RGP 콘택트렌즈의 시력과 각막에 미치는 임상적 연구

김덕훈,배한용,한명교,Kim, Douk-Hoon,Bae, Han-Young,Han, Mung-Gyo 한국안광학회 2007 한국안광학회지 Vol.12 No.4

본 연구는 ez NANOsence II RGP 콘택트렌즈를 사용하여 굴절이상 눈의 피검자에 대한 시력과 각막에 미치는 임상적 검증을 하였다. 피검자는 성인 121명(남성 29인, 여성 92명; 연령은 17세와 43세 사이, 평균 22.86세)을 대상으로 실시하였다. 피검자는 콘택트렌즈 착용 전의 증상을 포함하는 문진을 실시하였고, 또한 콘택트렌즈 착용전후의 눈에 대한 자각과 타각증상 변화도 검진하였다. 시력측정은 콘택트렌즈를 착용하여 원거리에서 실시하였고, 굴절검사는 타각적 방법(Topcon KR-8100, Japan)으로 나안 상태에서 실시하였다. 입체시 검사는 Titmus fly(Stereo Optical Co., U.S.A)와 TNO(Tech, The Netherlands)로서 콘택트렌즈 착용 후 근거리에서 시행하였고, 대비감도 진단은 콘택트렌즈 착용 후 대비감도 챠드(pelli-Robertson, USA)로 1m 거리에서 실시하였다. 각막 지형도검사는 콘택트렌즈 착용 후 나안상태에서 ORB scan(Bausch Lomb, U.S.A.)을 사용하였다. 콘택트렌즈의 표면미세구조는 SEM(JSM-5800, Japan)을 이용해서 관찰하였고, 콘택트렌즈의 화학 성분은 EDS 프로그램을 사용해서 분석하였다. 연구 결과는 다음과 같다. 1. 렌즈의 착용 기간이 길수록 피검자는 대게 개선된 시각기능을 획득했다. 2. 렌즈 착용에 따른 눈의 부작용은 거의 없었다. 3. 피검자의 렌즈 사용은 잘하고 있다. 4. 렌즈 착용기간이 길수록 각막의 굴절 값은 약간 감소하고, 곡률반경은 약간 증가하며, 각막난시는 감소(P<0.01)하고, 각막의 중앙부 두께도 감소하였다. 5. 렌즈 사용 기간이 길수록, 입체시와 대비감도는 더욱 정상 값을 가졌다. 6. 각막지형도 분석에서 대부분 피검자들은 착용기간의 차이에도 비슷한 형태를 나타내었다. 7. 새로운 렌즈와 사용한 콘택트렌즈의 표면미세구조는 미세 형태에서 비슷한 상태이다. 8. 새로운 렌즈와 사용된 콘택트렌즈의 화학적 구성 성분은 거의 같았다. 결론적으로 본 연구는 새로운 것과 사용된 콘택트렌즈의 표면 미세구조와 화학적 구성성분이 유사함을 확인하였다. 또한 렌즈의 장기 착용에도 피검자의 시기능은 개선되고, 눈의 부작용은 적게 나타났으며, 각막난시 값은 감소되었다. 본 검사는 콘택트렌즈 착용자의 시각기능은 콘택트렌즈의 성분과 미세구조가 시각 기능에 관련이 있다고 여겨진다. 본 연구에서 저자들은 ez NANOsence II RGP 콘택트렌즈는 굴절 이상 눈의 교정시력에 좋은 효과가 있다고 추측된다. The purpose of this study was to perform a clinical test using ez NANOsence II RGP contact lenses for the effects of visual acuity and cornea on subjects with abnormal refraction status. One hundred twenty one adults (twenty nine males, ninety two females, range = 17 to 43, mean = 22.86) were recorded. The subject's history including, the symptoms from previous lens wear, were studied. The subjects were observed, both pre and post lens wear, for any symptoms and signs of change of the eye. The Visual acuity and the binocular status were tested at the far distance using the contact lens. The refraction test was performed on the naked eye using the objective method (Topcon KR-8100, Japan). The Stereopsis test was performed at the near distance after contact lens wear by the Titmus fly (Stereo Optical Co., U.S.A) and TNO (TECH, The netherlands). The contrast sensitivity diagnosis was performed at 1m distance after contact lens wear by the contrast sensitivity chart (pelli-Robertson, USA). The corneal topography was analyzed on the naked eye after lens wear by ORB scan (Bausch Lomb, U.S.A.). The ultra structure of surface on the contact lens was observed using SEM (JMS-5800, Japan). The chemical component's of the contact lens was analyzed by EDS program. The results of this study were as follows: 1. The longer of contact lens wear period, The subjects have acquired the most improved visual function. 2. Subjects had experienced few side effects wearing the contact lenses. 3. The lenses were easy to use by the subjects. 4. The longer of contact lens wear period, the power of cornea had more decrease. but the base curve of cornea had more increase and corneal astigmatism was decrease (p<0.01). Also, the thickness of corneal center was few decrease. 5. Longer periods of using the contact lens showed stereopsis and contrast sensitivity at more normal values. 6 The corneal topographical after lens wear showed most subjects with similar morphology for different wear periods. 7. The surface ultrastructure of the new and used contact lens was the similar fine shape. 8. The chemical component's of in the new and used contact appeared to have similar results. In conclusion, this study showed that the surface ultrastructure and chemical component's of the new and used contact lens are similar. In addition, the subjects had improved the quality of vision and few experienced any side effects during long periods of contact lens wear. Also they have decrease of corneal astigmatism during the long period of lens wear. Our test has showed that the chemical composition and fine structure of contact lens have related to the visual function on contact lens wearer. In this paper, we suggested that ez NANOsence II RGP contact lenses had a moderate effect for correcting vision of abnormal refraction eye.

한국노인여성의 검열과 안구돌출의 상관관계

김덕훈,Kim, Douk-Hoon 한국임상보건과학회 2015 한국임상보건과학회지 Vol.3 No.3

Purpose: This study was to investigate the relationship between the palpebral fissure and the exophthalmos in an elder women population in Korea subjects with normal eye status. Methods. From November 2014 to July 2015, The author analyzed the morphological values in 81 Korean elder women population. The clinical test was performed using the Hertel exophthalometer and verner califer. Analysis of data were described using the spss 20 and Pearson's test. Results. The mean age of the 81 subjects (162 eyes) was (73.938+/8.585)mm. The mean value of palpebral fissure was (5.673+/-2.065)mm in width and (24.179+/-4.409)mm in height. The mean value of exophthalmos was (5.537+/-2.151)mm. There were a significant relationship(P>0.01) in the mean size between the width and height in palpebral fissure. Also, there were a significant relationship(P>0.01) in the mean size between the palpebral fissure width and exophthalmos. Also, there were a significant relationship(P>0.01) in the mean size between the palpebral height width and exophthalmos. However, there were not significant relationship(P>0.01) in the mean size between the palpebral fissure width and exophthalmos in right eye. On the other hand, The relationship between right eye and left eye of the palpebral fissure and exophthalmos was similar results. Conclusions. In this study, these results suggested that the palpebral fissure and exophthalmos was a significant relationship in the mean value of morphologic characters in Korean elder women population.

한국 성인 여성 집단에서 검열과 안구돌출의 상관관계

김덕훈,Kim, Douk-Hoon,Waidyarathna, Kumuda 한국임상보건과학회 2014 한국임상보건과학회지 Vol.2 No.1

Purpose. This study was to investigate the relationship between the palpebral fissure size and the exophthalmos in a population of Korean adult women subjects with normal eye status. Methods. From November 2012 to September 2013, The authors analyzed the morphological values in 73 Korean adults population. The test was performed using the Hertel exophthalmometer and verner califer. Analysis of subjects data were recorded using the spss version 20.0 a statistical program (IBM Co, Armonk, NY USA). Results. The average age of the 73 subjects (146 eyes) was (21.219+/-0.261)mm. the average value of palpebral fissure was (25.110+/-1.646)mm in width and (8.096+/-1.464)mm in height. The average value of exophthalmos was (15.002+/-1.922)mm. There was a significant relationship(P>0.05) in the average size between the width and height in palpebral fissure. Also, there was a significant relationship(P>0.05) in the average size between the palpebral fissure width and exophthalmos. On the other hand, there was a significant relationship(P>0.01) in the average size of palpebral fissure height and exophthalmos. Conclusions: In this study, these results suggested that the palpebral fissure and exophthalmos had a significant relationship in the average value of size in Korean adult women population.

수컷생쥐의 Leydig Cell 미세구조에 대한 Chlorambucil의 영향

김덕훈,박원학,Kim, Douk-Hoon,Park, Won-Hak 한국현미경학회 1988 Applied microscopy Vol.18 No.2

The purpose of this study was to investigate the effect of chlorambucil on the mouse Leydig cell by electron microscopy. Chlorambucil suspended in the 0.5N sodium bicarbonate(pH 8.0) was injected I.P.(intraperitoneal) at a dosage of level 20mg/kg for 1 weeks, 3 weeks and 5 weeks, respectively. The results obtained from this experiment are as follows: 1. One week after the administration of chlorambucil, there was an increase in heterochromatin, swelling and cristae disruption in some mitochondria, mild vacuolation between cells and the occurrence of membrane bound inclusions in some nuclei. 2. After 3 weeks, smooth endoplasmic reticulum dilations, cytoplasmic vacuolation, mitochondrial swelling, inner mitochondrial cristae disruption, membranous whorls, and intranuclear inclusions were observed in the treated cells. 3. After 5 weeks of treatment, most mitochondria were swollen and their membranes were severely disrupted. Further, smooth endoplasmic reticulum dilations and vacuolation of the cytoplasm were apparent in the treated Leydig cells. In addition numerous membranous whorls and intranuclear inclusion bodies were present. The nuclei displayed invaginatons of the nuclear membrane and large clumps of heterochromatin. From these results it is concluded the longer the duration of chlorambucil administration, the greater the degeneration of the nucleus and cytoplasmic organelles.

7세부터 9세 사이의 한국인 어린이의 굴절 이상

김덕훈,Kim, Douk-Hoon,Alberto, Mercedita O. 한국임상보건과학회 2014 한국임상보건과학회지 Vol.2 No.3

Purpose. To analysis the refractive error in 7-9 year-old Korea children. Methods. From July 2013 to June 2014, two hundred eighty two subjects were performed in refraction test using the Auto-Refractometry. Results. The refractive error by spherical equivalent among all subjects was myopia 47.58%, emmetropia 42.35%, astigmatism 32.33%, and hyperopia 8.76%. Myopia was more common in female than males although the difference was not statically significant. The axis of astigmatism was with the rule in 65%, against the rule in 31.5%, and oblique in 3.5% There was a statistical significance between 7 year and 9 year of male in the spherical equivalent power(p=0.010). Also there was a statistical significance between 7 years and 9 years of female in the spherical equivalent power(p=0.036). However, there was not a statistical significance between male and female in spherical equivalent power(p>0.5). Conclusions. In this study, myopia was the most common refractive error. On the other hand, The prevalence of the axis of astigmatism was the with- the- rule. The spherical equivalent of refractive error was similar results between male and female. However The refractive error was different style with aging. these data suggested that the analysis of the refractive error at young children can provide the information of useful diagnosis for the correction of visual acuity.

한국 어린이의 연령에 따른 굴절이상 분석

김덕훈,김대년,Kim, Douk-Hoon,Kim, Dae-Nyoun 한국임상보건과학회 2014 한국임상보건과학회지 Vol.2 No.4

Purpose. to describe the prevalence of refractive error according to aging in young children in South Korea. Methods : From July 2013 to June 2014, five hundred subjects( 250 male subjects, 250 female subjects; aged between 7 and 12 years) were performed in refraction test using the Auto-Refraction. Myopia, hyperopia, astigmatism, and anisometropia were defined as spherical equivalent(SE)${\leq}-0.50$ diopters, SE ${\geq}+2.00$ D, cylinder error ${\geq}0.75$ D and SE difference${\geq}1.00$ D between binocular eyes, respectively. Results. The refractive error by spherical equivalent among all subjects was myopia 80.41%, astigmatism 44.89%, emmetropia 18.27%, anisometropia 16.92%, and hyperopia 1.32%. The prevalence of myopia increased with age. but hyperopia was decrease. Myopia and astigmatism were much more common in male than females although the difference was not statically significant. Emmetropia and hyperopia were much more common in female than males although the difference was not statically significant. The prevalence of spherical equivalent was much common from -1.00 diopter to 0.99 diopter. On the other hand, the prevalence of myopia was much more than hyperopia. There was a statistical significance between 9 year and 10 year of female in the spherical equivalent power(p>0.05). In all another group of age, there was not a statistical significance as aging in spherical equivalent power(p>0.5). However, there was a statistical significance between male and female as age in the spherical equivalent power(P>0.01). Conclusions: Myopia was the most common refractive error in Korea young children, while hyperopia was decreased after 7 years. There was a statistical significance as age between male and female at spherical equivalent power(P> 0.01). these results suggested that the analysis of the refractive error as age at young children can give the useful diagnosis data for the correction of visual function.

Pentacam을 이용한 한국 청소년 집단에서 각막의 중심두께와 전방깊이 분석

김덕훈,배한용,Kim, Douk-Hoon,Bae, Han-Yong 한국임상보건과학회 2013 한국임상보건과학회지 Vol.1 No.2

Purpose. This study was to investigate the analysis of the central corneal thickness and anterior chamber depth of eyes in Korean Young Population using the Pentacam topography. Methods. The subjects consisted of 126 eyes from normal cornea of Korean aged 7-12($8.857{\pm}1.501$) years during 2009. The thinnest location, pachy apex, and pupil central region of the cornea thickness was measured using the Pentacam pachymetry. The anterior chamber depth of normal corneas was measured with Pentacam. Results. The thinnest location of corneal thickness was $547.413{\pm}37.893$um. The pachy apex of cornea thickness was $552.103{\pm}36.016$um. Also, the pupil center of corneal thickness was measured $552.143{\pm}36.418$um. On the other hand, the mean thickness in the central cornea was a statically significant relationship(t-test, p=0.0002) between pachy apex and thinnest zone. Also the mean thickness of the central cornea was a statically significant correlation(pearson p=0.0001) among the pupil center, pachy apex and thinnest zone. The anterior chamber depth was $3.137{\pm}0.308$mm. The mean depth in the anterior chamber of cornea was a statically relationship(t-test, p>0.05) between OD and OS. Conclusions. The results of this clinical study suggested that the analysis of the central corneal thickness and anterior chamber depth using Pentacam in Korean young population can provide the useful morphological information in diagnosis of cornea for the contact lens fitting and corneal refraction surgery.

원추각막의 각막지형도 분석

김덕훈,Kim, Douk-Hoon 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.3

The analysis of cornea morphology using corneal topographers is a clinical practice for the diagnosis of keratoconus in contact lens fitting. The recently technique has developed with the possibility of achieving a great number of measuring points of both anterior and posterior corneal surfaces in cornea. Also these data are used to extract a series of topographic valuation indices that permit to offer the most exact clinical diagnosis of keratoconus in contact lens fitting. This study describes the technologies in which current corneal topographers are based on the morphological characteristics that the keratoconus status observe on corneal surface. Therefore, this paper can provide that the analysis of corneal topographers applied for the diagnosis of keratoconus in contact lens fitting.