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마우스 만성천식모델에서 경구면역관용 유도에 의한 알레르기 염증의 예방효과
김진숙 ( Jin Sook Kim ),이정미 ( Jung Mi Lee ),김승준 ( Seung Joon Kim ),이숙영 ( Sook Young Lee ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.5
담배 연기에 의한 Muc5ac 유전자 발현에 관여하는 세포 내 신호 전달 경로로서의 ERK1/2와 p38 MAPK
김용현 ( Yong Hyun Kim ),윤형규 ( Hyoung Kyu Yoon ),김치홍 ( Chi Hong Kim ),안중현 ( Joong Hyun Ahn ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),박성학 ( Sung Hak Par 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.6
수면다원검사를 시행한 환자들의 각성지수와 임상양상과의 관계
김성경 ( Sung Kyoung Kim ),이상학 ( Sang Haak Lee ),강현희 ( Hyeon Hui Kang ),강지영 ( Ji Young Kang ),김진우 ( Jin Woo Kim ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Par 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3
Background: Repeated arousals during sleep have been known to be associated with excessive daytime sleepiness and cardiovascular complications. We investigated the relationship between arousal indices and clinical parameters. Methods: We retrospectively reviewed medical records of 41 patients who performed polysomnography for a diagnosis of obstructive sleep apnea syndrome. We defined total arousal index (TAI) as the number of arousals per hour and respiratory arousal index (RAI) as the number of arousals associated with apnea or hypopnea per hour. Results: There were significant positive correlations between arousal indices and apnea-hypopnea index (AHI) (RAI vs. AHI, r=0.958, p<0.001; TAI vs. AHI, r=0.840, p<0.001). RAI and mean oxygen saturation showed a significant negative correlation with each other (r=-0.460, p=0.002). TAI revealed a significant positive correlation with mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP) (TAI vs. MSBP, r=0.389, p=0.014; TAI vs. MDBP, r=0.373, p=0.019). There was no significant correlation between arousal indices and parameters of sleepiness. RAI had a significant positive correlation with body mass index (BMI) and neck circumference (NC) (RAI vs. BMI, r=0.371, p=0.017; RAI vs. NC, r=0.444, p=0.004). When partial correlation analysis was performed to adjust for other variables, there was significant correlation between RAI and AHI (r=0.935, p<0.001). Conclusion: This study shows that respiratory arousal index could be a useful index reflecting of severity of obstructive sleep apnea syndrome. Arousal during sleep would be concerned in the development of cardiovascular complication of obstructive sleep apnea. And some anthropometric factors would contribute to the development of arousals during sleep. Further studies are needed to clarify any cause-effect relationship.
비소세포폐암과 염증성 폐질환에서 가래와 혈액 및 조직에서 p16(INK4a) Promoter 과메틸화
김정표 ( Jeong Pyo Kim ),김경미 ( Kyong Mee Kim ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ),안중현 ( Joong Hyun Ah 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.2
결핵 후유증과 진균덩이를 가진 객혈환자에서 발견된 기관 게실 1례
김진우 ( Jin Woo Kim ),송선화 ( Sun Wha Song ),최선욱 ( Son Ook Choi ),지병수 ( Byoung Soo Jie ),권순석 ( Soon Seog Kwan ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.4
We experienced a rare case of trachea diverticula combined with the sequela of tuberculosis and a fungus ball. The patient had complained of coughing and hemoptysis for a long time after experiencing tuberculosis. He was admitted due to hemoptysis and the aggravation of coughing. The CT scan showed a variable sized trachea diverticula combined with tuberculosis sequela and a fungus ball in the right lung fields. The diagnosis was made by bronchoscopy and a CT scan. After bronchial artery embolization and conservative treatment, the patient`s symptoms improved and the patient was discharged. (Tuberc Respir Dis 2006; 60: 469-472)