일부 소방공무원의 직무스트레스로 인한 사회심리적 건강, 피로도 및 수면영향 연구

김건형(Kun-Hyung Kim),김정원(Jung-Won Kim),김성훈(Sung-Hoon Kim) 대한직업환경의학회 2006 대한직업환경의학회지 Vol.18 No.3

원형질막 타기팅에 필요한 ApPDE4의 N-말단의 아미노산 서열 분석 및 발현에 의한 형태적 변화

김건형(Kun-Hyung Kim),전용우(Yong-Woo Jun),이진아(Jin-A Lee),장덕진(Deok-Jin Jang) 한국분석과학회 2013 분석과학 Vol.26 No.1

갱년 및 폐경 후 여성의 안면홍조에 대한 침 치료 다기관 임상연구: 수행보고 및 방법론적 교훈

김건형 ( Kun Hyung Kim ),김동일 ( Dong Il Kim ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),김형준 ( Hyung Jun Kim ),윤현민 ( Hyun Min Yoon ),정희정 ( Hee Jung Jung ),강경원 ( Kyung Won Kang ),이명수 ( Myeong Soo Lee ),최선 대한한방부인과학회 2010 大韓韓方婦人科學會誌 Vol.23 No.1

목포지역에서의 C형 간염 바이러스 항체의 양성율

김건형(Kun Hyung Kim),최요안(Yo An Choi),민귀환(Kwi Hwan Min),안기석(Ki Seok Ahn),박찬웅(Chan Woong Park),김지운(Ji Woon Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5

N/A Background: Hepatitis C virus has an important etiologic role in hepato-cellular carcinoma in HBsAg negative patients in Korea. Superinfection of hepatitis C virus is not infrequent and may modify the natural course of chronic HBV infection.This study was aimed to investigate the prevalence of anti-HCV among the general population in Mokpo, Korea. Methods: We evaluated the anti-HCV seropositivity from 1,299 persons who visited the Health Clinic Center, Anti-HCV was detected by enzyme immunoassay method. Results: Twenty three (1.77%) were positive for anti-HCV, and twenty (1.54%) persons were male. Male to female ratio was 6.7:1. The prevalence of anti-HCV among male subjects (1.54%) was higher than that of female subjects (0.237o). Among twenty three persons who had anti-HCV positivity, 14(61%) had normal values of serum AST and ALT and 8 (35%) had two fold elevated values of serum AST and ALT. Twenty three persons who had anti-HCV positivity were negative for HBsAg. But 14 (617c) persons were positive for IgG anti-HBc. Conclusions: Anti-HCV prevalence increased with age through the fifth decade of life. The prevalence of antibody to HCV in Mokpo, Korea was 1.77%. And it was predominant in ma]e. (Korean J Gastroenterol 1996;28:677 - 682)

70 세 이상 여성 고령 환자에서 관상동맥 중재술

김윤아(Yun Ah Kim),정명호(Myung Ho Jeong),주신배(Shin Bae Joo),최명자(Myung Ja Choi),김인수(In Soo Kim),김남호(Nam Ho Kim),김건형(Kun Hyung Kim),이승욱(Seung Uk Lee),조장현(Jang Hyun Cho),안영근(Young Keun Ahn),조상기(Sang Ki Cho),조정 대한내과학회 2001 대한내과학회지 Vol.60 No.5

N/A Background : Previous reports have mentioned the increased mortality of percutaneous coronary intervention (PCI) in elderly female patients compared with elderly male. The purpose of this study was to evaluate the clinical characteristics, coronary lesion, characteristics and differences of success rate of PCI between male and female elderly patients. Methods : Three hundred sixty six elderly patients (454 lesions), including 210 male (255 cases, 73.4±2.45 year-old) and 156 female (199 cases, 73.5±2.55 year-old) who underwent PCI at Chonnam National University Hospital between Jan '96 and Dec '98 (out of 3,030 patients during same period). We compared clinical characteristic, coronary artery lesion morphology, success and complication rates of PCI in elderly male and female patients. Result : Clinical diagnosis and risk factors for atherosclerosis were not different between two groups. Right coronary lesions were more common in female and left circumflex artery lesion less common in female patients. The success rate of balloon angioplasty was 93.2% (110/118) in male and 93.3% in (98/105) in female patients, and the success rates of stenting were 99.2% (136/137) in male and 100% (94/94) in female. Success rates of PCI were not different between two groups. Procedure-related mortality was one cardiac death (1/255, 0.39%) in male group only. Complications of elderly male were two occlusive dissection (OD: 2/255, 0.8%), three thrombotic occlusion (TO: 3/255, 1.2%) and two ventricular arrhythmia (VA) with shock (2/255, 0.8%). In 199 female patients, three OD (3/199, 1.5%), three TO (3/199, 1.5%) and two VA (2/199, 1.0%) developed. The complications rates were not different two groups. Conclusion : PCI in female patients older than 70 years can be performed with comparable success and complication rates to those of elderly male patients.(Korean J Med 60:456-462, 2001)

슬관절염에 대한 뜸 치료의 유효성 및 안전성 연구: 무작위 대조 예비 임상연구 프로토콜

이승훈 ( Seung Hoon Lee ),김건형 ( Kun Hyung Kim ),김태훈 ( Tae Hun Kim ),김정은 ( Jung Eun Kim ),김주희 ( Joo Hee Kim ),강경원 ( Kyung Won Kang ),정소영 ( So Young Jung ),김애란 ( Ae Ran Kim ),박효주 ( Hyo Ju Park ),신미숙 ( Mi S 경락경혈학회 2011 Korean Journal of Acupuncture Vol.28 No.4

Objectives: The purpose of this study is to evaluate the feasibility of massive clinical research and to make a basic analysis on the effectiveness and safety of moxibustion treatment on knee osteoarthritis compared to usual care. Methods and Results: This study is a protocol for a pilot randomized controlled trial. Forty participants are assigned to the moxibustion group (n=20) and usual care group (n=20). Participants assigned to the moxibustion group receive moxibustion treatment on the affected knee(s) at six standard acupuncture points (ST36, ST35, ST34, SP9, Ex-LE04 and SP10) three times per week for four weeks (total of 12 sessions). Participants in the usual care group don`t receive moxibustion treatment during the study period and follow-up are made on the 5th, 9th and 13th weeks after random allocation. Both groups are allowed to use any kind of treatment, including surgery, conventional medication, physical treatment, acupuncture, herbal medicine, over-the-counter drugs and other active treatments. Education material that explains knee osteoarthritis and current management options and self-exercise is provided for each group. The pain scale of the Korean Western Ontario and McMaster Universities Questionnaire (K-WOMAC) is the primary outcome measurement used in this study. Other subscales of the K-WOMAC, the Short-Form 36 Health Survey (SF-36), Beck Depression Inventory (BDI), Physical Function test, Patient Global Assessment, and Pain Numeric Rating Scale (NRS) are used as outcome variables to evaluate the effectiveness of acupuncture. Safety is assessed at every visit. Conclusions : The result of this trial will provide a basis for the effectiveness and safety of acupuncture treatment for knee osteoarthritis.

자살시도로 응급실에 내원한 환자의 자살 위험성과 양극성 장애 가능성의 연관성

허량,김건형,전진호,박영민,김영훈,이봉주,Huh, Lyang,Kim, Kun Hyung,Chun, Jin Ho,Park, Young Min,Kim, Young Hoon,Lee, Bong Ju 한국정신신체의학회 2015 정신신체의학 Vol.23 No.2

연구목적 본 연구는 자살 시도자를 대상으로 자살 생각의 심각성과 관련된 요인들을 찾아보고자 하였다. 방 법 일 대학병원 응급실에 자살 시도로 내원한 환자 중 50명을 대상으로 임상가가 면담, Columbia Suicide Severity Rating Scale(C-SSRS), Beck Depression Inventory(BDI), Korean Version of Mood Disorder Questionnaire(K-MDQ), Bipolar Spectrum Diagnostic Scale(BSDS)를 시행하였다. 결 과 자살 경향이 높은 고위험군은 C-SSRS의 자살 생각의 심각성 점수와 BDI 점수가 높았고(p<0.001), MDQ에서 양극성 장애 가능성의 양성으로 판정된 자는 자살생각의 심각성 점수가 높았다(p=0.033). 결 론 자살 시도자의 자살 생각의 심각성과 양극성 장애의 가능성은 서로 연관성이 있을 것으로 생각된다. Objectives : The aim of this study was to investigate the factors including possibility of bipolar disorder that are related to intensity of suicidal idea. Methods : The study subjects consisted of 50 patients who did suicidal attempt and treated at the Inje University Haeundae Paik Hospital Emergency Room. All participants underwent psychiatric interview and underwent Columbia Suicide Severity Rating Scale(C-SSRS), Beck Depression Inventory(BDI), Korean Version of Mood Disorder Questionnaire(MDQ) and Bipolar Spectrum Diagnostic Scale(BSDS) to evaluate patient's suicide attempt, severity of depression and possibility of bipolar disorder. Results : Compared to non-high risk group, suicide high risk group showed significantly higher BDI(p<0.001) and intensity of ideation(IOI) in C-SSRS(p<0.001). Also intensity of ideation(IOI) was correlated with Mood Disorder Questionnaire(MDQ) bipolarity positive(p=0.033). Conclusions : The present study indicated that possibility of bipolar disorder plays a significant role in suicide attempters. Assessment of suicide ideation severity and possibility of bipolar disorder should be considered when suicide attempters come to emergency room.

견관절의 임상적 평가도구에 관한 고찰

양동훈,김건형,김행범,최양식,박영배,Yang, Dong-Hoon,Kim, Kun-Hyung,Kim, Haeng-Beom,Choi, Yang-Sik,Park, Young-Bae 대한침구의학회 2007 대한침구의학회지 Vol.24 No.6

Objectives : A number of instruments have been developed to measure the quality of life in patients with various shoulder disorders. Much progress has been made in this area, and currently an appropriate instrument exists for each shoulder state. The purpose of this study is to review the instruments that are currently in use for assessing the shoulder joint. Methods : A literature research was performed to choose appropriate scales for assessment of function and the disability of the shoulder. Theoretically based scales were selected for review. Therefore, 11 scales were reviewed. The status of scales involved in shoulder treatment of acupuncture throughout several countries was evaluated. Results : 11 scales: The American shoulder and elbow surgeons evaluation form(ASES), Constant Shoulder Score, The disabilities of the arm, shoulder and hand(DASH), Shoulder Disability Questionnaire (SDQ), The Shoulder Pain And Disability index(SPADI), The simple shoulder test(SST), Oxford Shoulder Questionnaire(OSQ), The Rotator Cuff quality-of-life Measure(RC-QoL), Western Ontario Shoulder Instability Index(WOSI), Western Ontario Osteoarthritis of the Shoulder Index(WOOS), Western Ontario Rotator Cuff Index(WORC), wereevaluated. Each measurement has its own composition and characteristics. Their validity, reliability, responsiveness and practical characteristics were already evaluated. We found 3 domestic and 10 overseas papers about shoulder treatments using acupuncture assessed with shoulder scales. Conclusions : In clinical research, the selection of the measurement scale should take account of the condition of disease, the patient's traits and the characteristics of the research. Moreover, appropriate scales, which havevalidity, reliability, responsiveness and practical characteristics, are needed to enhance the quality of research.

부산 지역 임산부의 모체혈, 제대혈, 모유에서 PFOA, PFOS의 농도

서춘희,이채관,김건형,손병철,이종태,Suh, Chun-Hui,Lee, Chae-Kwan,Kim, Kun-Hyung,Son, Byung-Chul,Lee, Jong-Tae 한국환경보건학회 2012 한국환경보건학회지 Vol.38 No.1

Objectives: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are man-made, persistent global pollutants widely diffused throughout the environment. They have been even found in the cord blood and breast milk of humans. Furthermore evidence of developmental toxicity in animals exists. To assess the distribution of maternal and fetal exposure to PFOS and PFOA, we analyzed paired maternal blood, cord blood and breast milk samples. Methods: Maternal blood, cord blood and breast milk were collected from 150 volunteers from the general population (aged 20-40, mean $30.5{\pm}2.9$) of the city of Busan in 2009-2010. The samples were extracted using the weak anion exchange and solid-phase extraction methods and quantified by high-performance liquid chromatograph (HPLC, Agilent 1200 Series) coupled with an Triple Quad LC-MS/MS system (Agilent 6410). Results: Median PFOA and PFOS concentrations in maternal blood were 2.18 and 3.32 ng/ml, in cord blood were 0.83 and 0.58 ng/ml, and in breast milk were 0.13 and 0.11 ng/ml, respectively. PFOS and PFOA concentrations were significantly correlated among matrices (Spearson's ${\rho}=0.226$, p = 0.05 for maternal blood; ${\rho}=0.736$, p < 0.01 for cord blood; ${\rho}=0.493$ p < 0.01 for breast milk). The ratio of cord blood/maternal blood was 0.39 for PFOA and 0.19 for PFOS. The ratio of breast milk/maternal blood was 0.07 for PFOA and 0.06 for PFOS. Conclusions: Our findings suggest that PFOA and PFOS exposure through the placenta was more prominent than through breast milk among Korean neonates born in Busan. The transfer efficiency of maternal blood to breast milk was similar between PFOA and PFOS, but that of maternal blood to cord blood was higher in PFOA than PFOS.

망막중심정맥폐쇄에 동반된 황반부종에서 유리체강내 덱사메타손삽입물 치료의 1년 효과

김태훈(Tae Hoon Kim),윤창기(Chang Ki Yoon),이지은(Ji Eun Lee),이주은(Joo Eun Lee),정인영(In Young Chung),사공민(Min Sa gong),김건형(Kun Hyung Kim),김현웅(Hyun Woong Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.12

목적: 망막중심정맥폐쇄에 동반된 황반부종에서 유리체강내 덱사메타손삽입물의 1년 효과를 알아보고자 하였다. 대상과 방법: 망막중심정맥폐쇄에 동반된 황반부종으로 유리체강내 덱사메타손삽입물 주입술을 1년 동안 2회 이상 시행 받은 22명(22안)의 의무기록을 조사하여, 최대교정시력, 중심황반두께 및 안압의 1년간 변화를 분석하였다. 백내장 발생, 안압 상승 등의 이상반응여부도 확인하였다. 결과: 전체 환자의 평균연령은 64.3 ± 9.5세이며, 남성이 10명이었다. 주입술 시행 횟수는 평균 2.4 ± 0.6회였으며, 첫 주입술과 두 번째 주입술 사이의 간격은 22.0 ± 6.4주였다. 평균시력(logMAR)은 시술 후 8개월까지는 유의하게 좋아졌으나 1년째에는 0.72 ± 0.62로 시술 전 0.82 ± 0.50과 비교하여 유의하게 호전되지는 않았다(p=0.638). 중심황반두께의 경우 1년에 걸쳐 전 구간에서 유의하게 감소하였다(p<0.05). 위험군별 다변량 분석을 시행하였을 때, 유리체강내 덱사메타손의 농도가 유지되는 구간에서 시력이 유의하게 더 호전되었고, 중심황반두께 역시 유의하게 더 감소하였다. 또한 고혈압군과 허혈성 망막중심정맥폐쇄군에서 중심황반두께가 유의하게 더 감소하였다(p=0.006, p=0.032). 경과관찰기간 동안 6명(27.3%)의 환자가 22 mmHg 이상으로 안압이 증가하였고 3명(13.6%)에서는 백내장 진행이 있었다. 결론: 유리체강내 덱사메타손삽입물 주입술은 망막중심정맥폐쇄에서 심각한 부작용 없이 시력의 안정과 황반부종을 감소시키는 효과를 보였다. Purpose: In the present study, 1-year outcome of intravitreal dexamethasone implant in macular edema secondary to central retinal vein occlusion (CRVO) was evaluated. Methods: The medical records of 22 patients (22 eyes) with macular edema secondary to CRVO were reviewed retrospectively. All patients were treated with intravitreal dexamethasone implant more than twice a year and followed up at least for 1 year from the first dexamethasone implant injection. The best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) were measured every 2 months after the first injection. Adverse effects, including cataract formation and elevation of IOP, were analyzed. Results: The mean patient age was 64.3 ± 9.5 years and 10 patients (45.5%) were male. The average number of injections was 2.4 ± 0.6 and the interval between the first and second injection was 22.0 ± 6.4 weeks. The mean BCVA (log MAR) was 0.82 ± 0.50 and 0.72 ± 0.62 at baseline and after 1 year, respectively. Vision was significantly improved for 8 months after the first injection (p < 0.05). However, vision was not different from baseline after 1 year. The CMT was significantly decreased compared to baseline (p < 0.001). Subgroup analysis revealed that BCVA was improved and CMT decreased significantly when intravitreal dexamethasone concentration was presumed sufficient. Moreover, CMT decreased significantly in hypertensive and ischemic groups compared with normotensive and non-ischemic groups, respectively (p < 0.001). Elevated IOP was observed in 6 eyes (27.3%), but all 6 eyes became normal after topical agent was applied. Cataract formation was observed in 3 eyes (13.6%). Conclusions: Intravitreal dexamethasone implant resulted in visual acuity stabilization and macular edema reduction in patients having macular edema secondary to CRVO without significant adverse events.