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      • KCI등재

        족삼리, 양릉천, 현종과 협척혈이 척수 압좌 손상 모델의 신경 재생에 미치는 영향

        양미성 ( Mi Sung Yang ),기영범 ( M Sung Yang ),강대희 ( Young Bum Kee ),신미숙 ( Mi Suk Shin ),김선종 ( Sun Jong Kim ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.4

        Objectives : The purpose of this study was to investigate the effects of ST36, GB34 and GB39, Hyeopcheok points, electrical acupuncture and acupuncture on nerve regeneration and neuromuscular synaptic reorganization in rat model of spinal cord injury(SCI). Methods : The subjects were divided into 5 groups; control group with no treatment after inducing SCI, experimental group Ⅰ taken with acupuncture of Hyeopcheok points after inducing SCI, experimental group Ⅱ taken with acupuncture of ST36, GB34 and GB39 after inducing SCI, experimental group Ⅲ taken with electrical acupuncture of Hyeopcheok points after inducing SCI and experimental group Ⅳ taken with electrical acupuncture of ST36, GB34 and GB39 after inducing SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, histological and immunological changes. Rats were tested at modified Tarlov test at the 1st day, Basso, Beattle, Bresnahan locomotor rating scale(BBB scale) at the 3rd, 7th, 14th and 21 days. Results : 1. Experimental group Ⅳ were improved compared with control group, experimental group Ⅰ, Ⅱ, Ⅲ in the motor behavior test(BBB scale). 2. BDNF(brain-derived neurotrophin factor) expression degree in the SCI tissue of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. 3. Muscular atrophy in gastrocnemius were restored only in experimental group Ⅳ. 4. NT-3(neurotrophin-3) expression degree in the SCI inducing rats of all the experimenral groups were increased compared with control group. Especially, those of experimental group Ⅳ was more effective. Conclusions : It can be suggested that electrical acupuncture of ST36, GB34 and GB39 may improve motor behavior, histological and immunological findings in SCI-induced rats compared with acupuncture of ST36, GB34 and GB39, acupuncture or electrical acupuncture of Hyeopcheok points.

      • KCI등재

        마황(麻黃)과 석고(石膏) 혼합물이 지방전구세포 분화와 흰쥐의 비만에 미치는 영향

        기영범 ( Young Bum Kee ),김대훈 ( Dae Hun Kim ),양미성 ( Mi Sung Yang ),강대희 ( Dae Hee Kang ),김선종 ( Sun Jong Kim ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.3

        Objectives This study was designed to evaluate the effects of Ephedra Sinica and Fibrosum Gypsum extract on obesity by using 3T3-L1 cells and high fat diet rats. Methods In vitro, Ephedra Sinica and Fibrosum Gypsum extract (50, 100, 200, 500 μg/ ml) were added in 3T3-L1 cells. Cytotoxicity was measured by MTT assasy. Adipocyte differentiation was measured by Oil Red O staining, GPDH activity and C/EBPα protein expression. In vivo, Sprague-Dawley rats were divided into 5 groups : Normal diet group (Normal group), taken high fat diet and no treatment group (Control group), taken high fat diet and orally administered Ephedra Sinica and Fibrosum Gypsum extract daily (Group I: 50 mg/kg, Group II: 100 mg/kg, Group III : 200 mg/kg, oral). For 6 weeks of administration, body weight and the amount of food intake were measured once a week. After administration, blood analysis (AST, ALT, T-Bilirubin, BUN, RBC, Hb, HCT), serum lipid level (triglyceride, Total cholesterol, HDL, LDL), serum leptin level, epididymal adipose tissue weight and histological finding of liver were estimated. Results In vitro, The cytotoxicity was not significant. 3T3-L1 cell’s differentiation was significantly decreased in Oil Red O staining, GPDH activity and C/EBPα protein expression. In vivo, Body weight and the amount of food intake, AST, ALT, Total cholesterol, TG, LDL, serum leptin, epididymal adipose tissue weight showed significant decrease in group I, group II and group III. There were no significant difference in T-bilirubin, BUN, RBC, Hb and HCT between all groups. HDL showed significant increase in group I, group II and group III. In histological finding of liver tissue, there were decreased adiposity and cytopathic effect in group I, group II and group III. Conclusions It is suggested that Ephedra Sinica and Fibrosum Gypsum extract can be used in the treatment of obesity. (J Korean Med Rehab 2014;24(3):11-27)

      • KCI등재

        요추 추간판 탈출증의 한의학적 치료와 슬링운동 병행 치료 효과

        양미성 ( Mi Sung Yang ),강대희 ( Dae Hee Kang ),기영범 ( Young Bum Ki ),박수곤 ( Su Gon Park ),조희근 ( Hee Geun Cho ),최진봉 ( Jin Bong Choi ),설재욱 ( Jae Uk Sul ),김선종 ( Sun Jong Kim ) 경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.4

        Objectives: Herniated lumbar intervertebral disc is common reason causing back pain. Lumbar stabilization exercise prevent back pain recurrence by strengthening lumbar muscles. Sling Exercise Therapy(SET) is a system for spinal muscle stabilization and strengthening using fixed string and mobile band. The purpose of this study is to investigate and measure the effectiveness of SET and oriental medicine for Herniated lumbar intervertebral disc. Methods: The subjects for this study are 40 patients suffering from Herniated lumbar intervertebral disc in our clinic. They were measured and compared by Visual Analogue Scale(VAS), 4 grades of recovery degree and sex, age, period of disease, disc herniation type, times of exercise. Results: In the above index, the score(VAS, 4 grades of recovery degree) improved after treatments. But they make no difference between sex, age, period of disease, disc herniation type and times of exercise. Conclusions: These results suggest that SET may be used for Herniated lumbar intervertebral disc for pain management and muscle strengthening as an essential treatment regardless of sex, age, period of disease and disc herniation type.

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