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SFX 자바스크립트 엔진 적시 컴파일 오버헤드 감소를 위한 context threading 기법 적용
권진우(Jin-Woo Kwon),오형석(Hyeon-Seok Oh),문소묵(Soo-Mook Moon) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.2A
적시 컴파일 방식은 실시간으로 머신 코드를 생성하여 생성한 머신 코드로 프로그램을 동작시키기 때문에 인터프리터 방식에 비해 수행 속도가 빠르다. 그러나 적시 컴파일 과정이 런타임에 일어나기 때문에 컴파일 오버헤드가 발생하게 된다. 본 논문은 이를 개선하기 위해 context threading 기법을 적시 컴파일에 적용한다. 실험 결과 기존 적시 컴파일 방식에 비해 런타임 성능은 나빠졌으나 적시 컴파일 오버헤드에 있어서는 25%의 감소를 보였다.
최진아(Jin A Choi),권진우(Jin Woo Kwon),지동현(Donghyun Jee) 대한안과학회 2018 대한안과학회지 Vol.59 No.9
목적: 녹내장의 추적관찰 주기와 녹내장의 진행 정도의 정량적 관계에 기초한 비용효용분석을 시행하고자 하였다. 대상과 방법: Markov 모델을 구축하여 초기 녹내장을 가지고 있는 40세 이상의 한국인 남녀를 가상의 코호트로 설정하였다. 녹내장 치료 관련 비용을 사회적인 관점에서 파악하였으며, 효용은 녹내장 상태에 따른 질보정수명을 산출하였다. 녹내장 건강상태는 5단계로 나누었다(초기, 중기, 후기, 단안실명, 양안실명). 녹내장 상태의 전이는 경도에서 중등도로 한 방향으로만 전이하는 것으로 하였고, 각 한 주기의 길이는 1년으로 설정하였다. 비용효용의 점진적 증가비율을 계산하여 추적관찰 주기에 따른 비용효용을 비교하였다. 민감도 분석을 시행하여 본 연구에서 사용한 변수의 불확실성이 어떻게 결과에 영향을 주는지를 파악하였다. 결과: 3개월 추적관찰의 점진적 비용효용비는 6개월의 추적관찰 대비 질보정수명당 28,244,398원이며, 6개월 추적관찰의 점진적 비용효용비는 12개월 추적관찰 대비 질보정수명당 13,615,443원으로 나타났다. 3개월 대비 6개월 주기 추적관찰의 진행확률이 약 10% 이상 증가하고, 3개월 대비 12개월 추적관찰의 진행확률이 약 15% 이상 증가하는 경우에는 3개월 주기 추적관찰이 비용효과적인 것으로 나타났다. 반면, 3개월 대비 6개월 추적관찰의 진행확률의 증가폭이 10% 미만이고, 3개월 대비 12개월 추적관찰의 진행확률이 15% 이상 증가할 경우 6개월 추적관찰이 비용효과적인 것으로 나타났다. 3개월 대비 6개월 추적관찰 전략의 진행확률 증가폭이 10% 를 넘고, 3개월 대비 12개월 추적관찰의 진행확률 증가폭이 15% 미만이면 12개월 추적관찰이 비용효과적인 것으로 나타났다. 결론: 본 연구에서 녹내장의 진행확률에 따라 비용효과적인 추적관찰의 전략이 다르며, 3개월 또는 6개월의 추적관찰 전략이 비용효 과적이며 우리나라의 의료보건체계에서 받아들일 수 있는 정도인 것으로 나타났다. <대한안과학회지 2018;59(9):842-847> Purpose: To evaluate the cost-utility based on the quantitative relationship between glaucoma follow-up and glaucoma progression. Methods: The Markov model was constructed and analyzed to determine the cost-effectiveness of primary open-angle glaucoma. The Markov model set up a virtual cohort of Korean over 40 years of age with early glaucoma. The costs associated with glaucoma treatment were assessed from a social point of view, and the utility was calculated using the quality adjusted life years according to the glaucoma states. Glaucoma health status was divided into 5 stages (early, middle, late, unilateral, bilateral blindness). The transition probability was set in one direction from mild to severe, and the length of each cycle was set at one year. The incremental cost effectiveness ratio (ICER) was calculated and compared with each other different follow-up periods. Sensitivity analysis was conducted to determine how the uncertainty of the variables used in this study affected the outcome. Results: ICER of 3-month follow-up was 28,244,398 won/quality adjusted life years (QALY) compared 6-month follow-up, and ICER of 6-month follow-up was 13,615,443 won/QALY compared to 12-month follow-up. If the probability of progression of glaucoma in 6-months follow-up observations increases by more than 10% over 3-month periodic follow-up and the progression probability of 12-month follow-up increases by more than 15% follow-up compared to 3-months follow-up, 3-months follow-up was found to be a cost-effective strategy. On the other hand, 6-month follow-up was found to be cost-effective if probability of progression of 6-month follow-up was less than 10% increase of 3-month follow-up and 15% increase of 6-months follow-up. Conclusions: Cost-effective follow-up strategies differed according to the probability of progression of glaucoma, and 3-month or 6-month follow-up strategies were cost-effective and acceptable in Korea s health care system. J Korean Ophthalmol Soc 2018;59(9):842-847
성인에서 국소 장괴사를 동반한 Henoch-Schonlein Purpura 1예
김수진 ( Su Jin Kim ),박철희 ( Cheol Hee Park ),김소연 ( So Yeon Kim ),이인정 ( In Joung Lee ),박철민 ( Chul Min Park ),조창범 ( Chang Beom Cho ),권진우 ( Jin Woo Kwon ),박지원 ( Ji Won Park ),허경림 ( Kyung Rim Huh ),김경오 ( Kyo 대한장연구학회 2011 Intestinal Research Vol.9 No.2
Henoch-Schonlein purpura (HSP) is a vasculitis of the small vessels of the skin, joints, gastrointestinal tract, and kidneys characterized by immunoglobulin A deposits in the involved organs. HSP is typified by the classic tetrad of purpura, arthralgia, abdominal pain, and renal involvement. It is common in childhood, but may also occur in adults and can be accompanied by severe complications. Gastrointestinal symptoms occur in up to 85% of patients,and gastrointestinal involvement can manifest as severe problems including intussusception, obstruction, and perforation. The disease course is often self-limited, but severe manifestations occasionally require surgical intervention. We report the case of a 24-year-old man with HSP who presented with abdominal pain and vomiting. Computerized tomography revealed thickening of the ileal wall and multifocal disrupted prominent mucosal enhancement. These findings suggested hemorrhagic enteritis and mucosal necrosis. After treatment with high dose corticosteroids, the lesion improved and surgical intervention was avoided. Our experience suggests that corticosteroid therapy may help in controlling HSP with suspicious small bowel necrosis. (Intest Res 2011;9:148-152)
김수진 ( Su Jin Kim ),박철희 ( Cheol Hee Park ),김용민 ( Yong Min Kim ),김성열 ( Seong Yeol Kim ),천승연 ( Seung Yeon Chun ),권진우 ( Chin Woo Kwon ),박지원 ( Ji Won Park ),김경오 ( Kyoung Oh Kim ),백일현 ( Il Hyun Baek ),유교상 ( 대한장연구학회 2012 Intestinal Research Vol.10 No.2
Background/Aims: Intussusception is uncommon in adults compared with children. The present study aimed to review our experience of adult intussusceptions and discuss the preoperative diagnosis and management. Methods: A retrospective review was performed for 25 patients, at least 18 years old. These patients were diagnosed as intestinal intussusceptions at Hallym University Sacred Heart Hospital from January 1999 to October 2010. Results: There were 14 male and 11 female with a mean age of 55 years. The most common symptom was abdominal pain. The preoperative diagnostic rate was 92% because of the use of an abdominal computed tomography (CT) and an ultrasound. A total of 9 (36%) patients had enteroenteric intussusception, 8 had ileocolic, 1 had ileocecal and 7 patients had colocolic intussusception. A discrete pathologic process was present in 22 (88%) patients and the remaining 3 (12%) patients were idiopathic. There were 12 small bowel lesions and 10 colonic lesions. Neoplasms were the most common etiology of intussusceptions. Of the cases with a defined colonic cause, 8 (80%) were malignant. Overall, 12 (48%) patients underwent primary resection of the intussusception without prior reduction, 11 (44%) patients had reduction of their intussusception followed by resection. Conclusions: Adult colonic intussusception is usually associated with malignancy. All patients with obstruction of unknown cause or lead point on CT should consider surgical exploration. (Intest Res 2012;10:183-188)