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직장암 치료로 Oxaliplatin 항암화학 요법 후 문맥압 항진증으로 진단된
허준 ( Jun Heo ),신근영 ( Keun Young Shin ),권용환 ( Yong Hwan Kwon ),박수영 ( Soo Young Park ),정민규 ( Min Kyu Jung ),조창민 ( Chang Min Cho ),탁원영 ( Won Young Tak ),권영오 ( Young Oh Kweon ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4
We report herein a case of 35-years-old woman in whom portal hypertension (esophageal varix and splenomegaly) developed after 12 cycles of oxaliplatin based adjuvant chemotherapy for rectal cancer. She was transferred for the evaluation of etiology of new-onset portal hypertension. The esophageal varix and splenomegaly were absent before the oxaliplatin based adjuvant chemotherapy. Thorough history taking and serological exam revealed no evidence of chronic liver disease. Liver biopsy was done and there was no cirrhotic nodule formation. Instead, perivenular fibrosis was noted. Considering new development of esophageal varices and splenomegaly after 12 cycles of oxaliplatin-based adjuvant chemotherapy, we could conclude that portal hypertension in this patient were due to sinusoidal injury by oxaliplatin. Finally, we recommend regular follow-up with endoscopy and radiologic examination for checking the development of varices and for screening of varices and splenomegaly in patients with colo-rectal cancer who receive oxaliplatin-based chemotherapy. (Korean J Gastroenterol 2011;57:253-257)