비내시경적 누낭비강문합술에서 비강내공의 모양에 따른 수술 성공률

권영아,김호창,하명숙,김성주,장재우,Young A Kwon,MD,Ho Chang Kim,MD,Myung Sook Ha,MD,Sung Joo Kim,MD,PhD,Jae Woo Jang,MD,PhD 대한안과학회 2009 대한안과학회지 Vol.50 No.1

Purpose: To evaluate the success rates according to the shape of rhinostomy after endonasal dacryocystorhinostomy. Methods: We analyzed 131 patients (188 cases) who had undergone endonasal dacryocystorhinostomy with a minimum follow-up of 6 months. After surgery, all cases were classified into flat, alcove, concave, or concealed concave types according to Jane’s rhinostomy classification. Patency to irrigation and improved symptoms were considered indicative of a successful outcome. Results: There were 81 flat type patients (125 cases), 31 alcove type patients (42 cases), 19 concave type patients (21 cases), and no cases were classified as concealed concave type. The success rates were 75.2%, 85.7%, 81.0% respectively, and the most common cause of failure was the formation of granulation within the ostium. The success rates did not significantly vary according to the shape of rhinostomy (p=0.144). Conclusions: The success rates after endonasal dacryocystorhinostomy of flat, alcove, and concave types in turn were 75.2%, 85.7%, and 81.0%.

마이봄샘 기능이상을 동반한 안구건조증 환자에서 온열마사지치료기기의 임상적 유용성

김대우,권영아,송상률,김병엽,정재림,Dai Woo Kim,MD,Young A Kwon,MD,Sang Wroul Song,MD,Byoung Yeop Kim,MD,Jae Lim Chung,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.9

Purpose: To evaluate the clinical usefulness of KCL 990<sup>® for the treatment of dry eye with meibomian gland dysfunction (MGD). Methods: Patients (n = 54 eyes, 27 subjects) diagnosed with dry eye with MGD were recruited for a prospective, one-month clinical trial. Patients received a twice-a-day 15-minute treatment using the KCL 990?. Effectiveness parameters included patient symptom scores using the Ocular Surface Disease Index (OSDI) questionnaires, tear osmolarity measured with TearLab<sup>® (TearLab Corporation, San Diego, CA, USA), classical tear break-up time (TBUT), and objective TBUT value using an Optical Quality Analysis System (OQAS<sup>®, Visiometrics, Castelldefels, Spain). Data are presented for pre-treatment (baseline) and at 1 week and 1 month post-treatment. An objective TBUT value was estimated in each eye when the optical scattering index (OSI) started to increase consistently, and data were obtained at pretreatment (baseline) and at 1 month post-treatment. Results: The symptom scores on OSDI questionnaires, tear osmolarity, and tear break-up time improved significantly from baseline to one week (p < 0.05). This improvement was maintained with no significant regression at 1 month (p < 0.05). The objective TBUT value decreased significantly at 1 month (p < 0.05). Conclusions: KCL 990<sup>® contributed to improve not only signs and symptoms of dry eye with MGD, but also the function of the tear film and ocular surface.

두 가지 저함수율 비이온계 실리콘 하이드로겔 치료용 콘택트렌즈에 따른 굴절교정레이저각막절제술 후 통증의 비교

고경민(Kyung Min Koh),한상윤(Sang Youn Han),권영아(Young A Kwon),송상률(Sang Wroul Song),김병엽(Byoung Yeop Kim),김용란(Yong Ran Kim),손용호(Yong Ho Sohn),정재림(Jae Lim Chung) 대한검안학회 2015 Annals of optometry and contact lens Vol.14 No.2

Purpose: To compare of the pain after photorefractive keratectomy (PRK) according to two kinds of silicone hydrogel contact lenses. Methods: 92 eyes of 46 patients who underwent PRK surgery were prospectively investigated. Each patient was randomly assigned senofilcon A in one eye and lotrafilcon B in the other eye. Pain score (0-10) was assessed at postoperative day 0, 1, 2, 3 and 4 using visual analogue scale. Results: The pain scores (mean ± SD) of senofilcon A and lotrafilcon B were 1.6 ± 1.4, 2.2 ± 1.5 on postoperative day (POD) #0 (p = 0.0029), 2.9 ± 1.5, 3.7 ± 1.5 on POD # 1 (p = 0.009), 2.1 ± 1.2, 2.2 ± 1.4 on POD #2 (p = 0.6208), 0.5 ± 0.7, 0.7 ± 0.8 on POD #3 (p = 0.8375), and 0.1 ± 0.3, 0.1 ± 0.3 on POD #4 (p = 0.1332) respectively. Conclusions: Senofilcon A contributed to reduce postoperative pain effectively in patients undergoing PRK due to lens design, material and moisture-rich properties.

녹내장 수술 후 안축장의 변화

배숭환,권영아,김황기,손용호,Soong Hwan Bae,Young A Kwon,Hwang Ki Kim,Yong Ho Sohn 대한안과학회 2006 대한안과학회지 Vol.47 No.11

Purpose: This study examines the changes in axial length after trabeculectomy and Ahmed glaucoma valve implantation surgery. Methods: In the forty three eyes of the 42 patients who had the uncontrolled glaucoma, 22 eyes of 21 patients having trabeculectomy and 21 eyes of 21 patients having Ahmed glaucoma valve implantation from October 2004 to September 2005 at Kim`s Eye Hospital were analyzed prospectively. These patients had IOP and axial length measurements preoperatively, at 1 week, 1 month, and 3 months after surgery and refractive power measurements preoperatively, at 3 months after surgery. Axial length was measured by IOL Master?. Results: There was a statistically significant reduction in IOP after 3 months of 26.6±11.2 mmHg overall, 22.4±8.4 mmHg following trabeculectomy, and 30.9±12.3 mmHg after Ahmed glaucoma valve implatation (p<0.001). There was a statistically significant reduction in axial length after 3 months of -0.24±0.10 mm overall, -0.21±0.1 mm after trabeculectomy and -0.28±0.1 mm after Ahmed glaucoma valve implantation. Conclusions: There was a statistically significant decrease in axial length after both trabeculectomy and Ahmed glaucoma valve implantation. We must consider the influence of axial length change on refraction in planning combined glaucoma and cataract surgery or future IOL implantation.

수평각막직경을 포함한 전안부 계측에 있어서 슬릿광주사 각막형태검사기와 저간섭성 반사계의 비교

이택관,박지현,강효정,권영아,송상률,김병엽,정재림.Taek Kwan Rhee. MD. Ji Hyun Park. MD. Hyo Jeong Kang. MD. Young A Kwon. MD.Sang Wroul Song. MD. Byoung Yeop Kim. MD. Jae Lim Chung. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.5

Purpose: To compare the results of anterior segment biometry including white-to-white (WTW) between scanning-slit topography (ORBscan IIz<sup>®, Bausch & Lomb), optical low-coherence reflectometry (OLCR) biometry (Lenstar<sup>®, Haag-Streit), and Castroviejo calipers. Methods: Measurements on 72 eyes of 36 patients that underwent refractive surgery were measured using ORBscan<sup>®, Lenstar<sup>®, and calipers and compared. Ocular biometry parameters used in this study included the WTW, central corneal thickness, anterior chamber depth (ACD), keratometry, and pupil size. Results: The WTW measurements using ORBscan<sup>® and calipers (11.57 ± 0.35 mm and 11.58 ± 0.34 mm, respectively) were statistically similar. However, the measurement using Lenstar<sup>® (12.05 ± 0.40 mm) was significantly greater than with the other methods (<em>p</em> < 0.001). Central corneal thickness and keratometry measurements using ORBscan<sup>® were greater than when using Lenstar<sup>® (<em>p</em> = 0.01 for both). ACD and pupil size measurement using Lenstar<sup>® were greater than when using ORBscan<sup>® (<em>p</em> < 0.001 for both). Conclusions: Because WTW and ACD measurements using Lenstar<sup>® were greater than when using ORBscan<sup>® and calipers, unexpected high-vaulting may be observed due to the selection of a larger-sized posterior chamber phakic intraocular lens. Therefore, the differences in measurements obtained when using these methods should be considered. J Korean Ophthalmol Soc 2014;55(5):656-661

알코올 및 고콜레스테롤 식이로 유도된 흰쥐의 지방간에서 지방산 결합단백질의 역할 및 특성

김혜경(Kim Hye Kyung),권영아(Kwon Young A),노숙령(Rho Sook Ryoung),함영태(Hahm Young Tae) 韓國營養學會 1999 Journal of Nutrition and Health Vol.32 No.6

남한 상세 기후변화 시나리오를 이용한 아열대 기후대 및 극한기온사상의 변화에 대한 연구

박창용(Chang Yong Park),최영은(Young Eun Choi),권영아(Young A Kwon),권재일(Jae Il Kwon),이한수(Han Su Lee) 한국지역지리학회 2013 한국지역지리학회지 Vol.19 No.4

이 연구는 PRIDE 모델에 기반하여 산출된 1km×1km 공간 해상도의 RCP 4.5와 RCP 8.5 상세 기후변화 시나리오와 수정된 쾨펜-트레와다의 기후구분 기준을 이용하여 우리나라의 아열대 기후대와 극한기온지수의 변화와 전망을 분석하였다. 현재 일부 남부 해안에서 나타나는 아열대 기후대는 미래로 갈수록 서해안 및 동해안을 따라 북쪽으로 확장하며, 대도시 지역에서 나타날 것으로 전망되었다. 극한기온지수의 경우 미래로 갈수록 RCP 4.5와 RCP 8.5 두 시나리오 모두 우리나라 모든 곳에서 추위와 관련한 지수의 빈도는 감소하며, 더위와 관련된 지수의 빈도는 증가할 것으로 예측되었다. 특히 RCP 8.5 시나리오의 경우 2071~2100년에는 해발고도가 높은 일부 산지를 제외한 우리나라의 대부분 지역에서 일최고기온 33℃ 이상의 폭염이 30일 이상 발생할 것으로 전망되었다. 본 연구의 결과는 강화된 기후변화 대응 프로세스 구축에 중요한 기초자료로 활용될 수 있을 것이다. This study aims to examine spatially-detailed changes and projection of subtropical climate zones based on the modified Koppen-Trewartha`s climate classification and extreme temperature indices using 1km×1km high resolution RCP 4.5 and RCP 8.5 climate change scenarios based on PRIDE model over the Republic of Korea. Subtropical climate zones currently located along the southern coastal region. Future subtropical climate zones would be pushed northwards expanding to the western and the eastern coastal regions as well as some metropolitan areas. For both scenarios, the frequency of cold-related extreme temperatures projects to be reduced while the frequency of hot-related ones projects to be increased. Especially, hot days with 33℃ or higher temperature projects to occur more than 30 days over the most of regions except for some mountain areas with high altitudes during the period of 2070~2100. This study might provide essential information to make climate change adaptation processes be enhanced.

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

The Comparative Evaluation of Soil Removal

Schofield-Tomschin, Sherryl A.,Kadolph, Sara J.,Kwon, Young-Ah 한국의류학회 2003 한국의류학회지 Vol.27 No.12

본 연구의 목적은 기계에 의한 객관적 오염제거 평가와 육안에 의한 주관적 오염제거에 평가를 비교하기 위한 것이다. 본 연구를 위해 백색의 순면직물과 65%/35% 폴리에스테르/면 직물 시료에 9가지의 오염을 각각 처리한 오염포를 제작한 후, 세탁 실험을 하였다. 주관적 오염제거의 평가는 오염시키지 않은 포를 기준시료로 하여 오염포와 같은 조건으로 세탁한 후, 오염제거도를 AATCC Gray Scale for STaining으로 평가하였다. 세탁 후 오염제거도를 객관적으로 평가하기 위해서 각 시료의 K/S values, CIELAB, CMC, ASTM, E313 Whiteness Index(WI), ASTM E313 Yellowness Index, and CIE tristimulus values를 구하였고 세탁에 의한 control 시료의 반사율 변화에 대한 오염포의 반사율 변화를 비교한 오염제거울(PSR)을 구하였다. 육안에 의한 주관적 평가 결과와 기계에 의한 객관적 평가의 결과와의 관계를 파악하고자 상관분석을 실시하였다. 본 연구결과, 주관적 평가와 객관적 평가 사이에 유의적인 상관관계가 확인되었으며, 주관적 평가 결과 중 WI가 주관적 평가 결과와 가장 상관관계가 높았으며, PSR과 주관적 평가 결과와의 상관이 상대적으로 가장 낮은 것으로 나타났다. 따라서 백색포의 오염 판정이 필요한 산업체에서 현재 많이 사용하고 있는 PSR 보다는 WI나 다른 색차를 이용하여 객관적 오염 평가를 하는 것이 주관적인 오염평가 결과에 더 근접할 수 있음을 알 수 있었다.