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침자극(鍼刺戟)이 심허증(心虛證) 환자(患者)의 심자도(心磁圖) 변화(變化)에 미치는 영향(影響)
권순범,김이화,장소영,김현중,이은용,성현제,허영,최선미,박영배,Kwon, Soon-Beom,Kim, Ee-Hwa,Chang, So-Young,Kim, Hyun-Joong,Lee, Eun-Yong,Sung, Hyun-Jae,Huh, Young,Choi, Sun-Mi,Park, Young-Bae 대한침구의학회 2005 대한침구의학회지 Vol.21 No.6
Objectives : The aim of this study is to investigate the effect of acupuncture stimulation on the relationship of change in magnetocardiography (MCG). Methods : For this purpose, 30 heart deficiency volunteers were acupunctured at Shinmun (HA7) and Naegwan (PC6) acupoint. Then, we measured and observed the change of frequency parameters in MCG. Results : In the mean frequency, during and after acupuncture treated groups of PC6 were decreased the activity of $f\;_{mean-max}$ compared to the control group. In the median frequency, during the acupuncture treated group of PC6 was decreased the activity of $f\;_{median-max}$ compared to the control group. Conclusion : These results suggested that acupuncture stimulation plays an important role to the activities of MCG.
CFD를 이용한 AVD설치에 따른 흡입수조 내의 유동특성
권순범(Sun-Beom Kwon),박영규(Young-Kyu Park),왕운해(Yun-Hai Wang),최윤환(Yoon-Hwan Choi),이연원(Yeon-Won Lee) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
A Pump-sump system is used to supply water at thermal power or nuclear power plants for cooling. Recently, the size of pump-sump system has been reduced to cut down on construction costs. This leads to change in the design on intake location or the structure around the pump bell. In cases of improper design, undesirable vortices (free-surface and submerged vortices) or swirl occur at the vicinity of the pump column due to non-uniformity of the approach flow. This occurrence of vortex or swirl can create local pressure drop from which appears air-entrained water at the suction, leading to significant loss in the efficiency of the pumps or induce noise and vibrations. In order to restrain the submerged vortices, an Anti submerged-Vortex Device (AVD) is considered. In this study, Computational Fluid Dynamics (CFD) techniques are used to study the influence of various types of AVD on the submerged vortex and to validate the characteristics of the flow around the pump bell.
시간 분해 직렬 펨토초 결정학을 위한 3차원 프린팅 기반의 초고속 믹싱 및 인젝팅 시스템
지인서 ( Inseo Ji ),강전웅 ( Jeon-woong Kang ),김태영 ( Taeyung Kim ),강민서 ( Min Seo Kang ),권순범 ( Sun Beom Kwon ),홍지우 ( Jiwoo Hong ) 한국화학공학회 2022 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.60 No.2
매우 짧은 펄스 폭의 X선 자유전자 레이저(XFEL)를 이용한 시간 분해능 연속 펨토초 결정학(time-resolved serial femtosecond crystallography, TR-SFX)기법에서 반응 물질과 생체분자 결정 샘플간의 혼합률(mixing rate)과 결정 샘플과 X선 레이저 간의 충돌률(hit rate)은 생체분자의 시분해 구조 변화에 대한 정확한 이미지 획득 및 효율적인 샘플 소비와 같은 TR-SFX의 분석 성능을 결정짓는 핵심인자이다. 본 연구에서는 극초단 내 일어나는 생체분자의 시분해 구조 변화 해석을 위해 초고속 믹싱 기능을 가짐과 동시에 공압 기반의 주문형 액적 젯팅이 가능한 두 가지 다른 방식의 샘플 전달시스템을 고안하였다. 한 방식은 이중 노즐을 통해 토출된 액적의 고속 충돌에 유발된 관성 믹싱을 기반으로 하고 있으며, 다른 방식은 마이크로믹서가 내장된 공압 젯팅을 기반으로 하고 있다. 먼저, 이중 노즐을 통해 토출된 액적의 충돌에 대한 동적 거동 및 액적 내부 관성 유동에 대한 믹싱에 대한 실험 및 수치해석적 연구를 수행하였다. 다음으로 마이크로믹서가 내장된 공압 젯팅 시스템의 성능을 유사한 방법을 통해 평가하였다. 본 연구에서 개발한 샘플 전달시스템은 질환을 유발하는 특정 단백질들의 기작을 규명하거나, 항체 의약품과 신약 후보 물질 탐색하는 데 있어 필수적인 3차원 생체 분자 구조분석 연구에 매우 유용하게 활용될 수 있을 것이다. Time-resolved serial femtosecond crystallography (TR-SFX) is a powerful technique for determining temporal variations in the structural properties of biomacromolecules on ultra-short time scales without causing structure damage by employing femtosecond X-ray laser pulses generated by an X-ray free electron laser (XFEL). The mixing rate of reactants and biomolecule samples, as well as the hit rate between crystal samples and x-ray pulses, are critical factors determining TR-SFX performance, such as accurate image acquisition and efficient sample consumption. We here develop two distinct sample delivery systems that enable ultra-fast mixing and on-demand droplet injecting via pneumatic application with a square pulse signal. The first strategy relies on inertial mixing, which is caused by the high-speed collision and subsequent coalescence of droplets ejected through a double nozzle, while the second relies on on-demand pneumatic jetting embedded with a 3D-printed micromixer. First, the colliding behaviors of the droplets ejected through the double nozzle, as well as the inertial mixing within the coalesced droplets, are investigated experimentally and numerically. The mixing performance of the pneumatic jetting system with an integrated micromixer is then evaluated by using similar approaches. The sample delivery system devised in this work is very valuable for three-dimensional biomolecular structure analysis, which is critical for elucidating the mechanisms by which certain proteins cause disease, as well as searching for antibody drugs and new drug candidates.