치유 절제술을 받은 위암 환자에서의 3년 무병생존이 5년 전체생존을 대치할 수 있는가?

권성준,김형주,김미경,Kwon, Sung-Joon,Kim, Hyoung-Ju,Kim, Mi-Kyung 대한위암학회 2005 대한위암학회지 Vol.5 No.3

배경: 대부분의 악성종양에 있어 그 치료성적을 평가하는 가장 유용한 방법으로 가장 많이 사용되는 매개변수는 전체 5년 생존율이다. 그러나 근치적 절제술이 시행된 위암환자에 있어 재발의 대부분은 수술 후 3년 이내에 일어나므로 3년 무병 생존이 5년 전체 생존의 의미를 대치할 수 있는가를 알아보고자 한다. 대상 및 방법: 근치적 위절제술을 받고 추적이 가능한 656예에서 생존 함수로 산출한 각각의 생존확률을 이용한 단순 회귀분석에서 3년 무병 생존이 5년 전체 생존을 대치할 수 있는지를 파악하였다. 결과: 추적 기간동안 175예에서 재발이 확인되었고, 재발시기별 누적빈도는 수술 후 1년이 81예(46%), 3년이 156예(89%), 5년이 170예(97%)였다. 3년 무병 생존확률과 5년 전체 생존확률 사이의 회귀 분석결과 상관성은 r=0.87, 설명력은 $R^2=0.76$, 회귀 방정식은 5년 전체 생존확률=0.18+($0.80{\times}3$년 무병 생존확률)을 나타냈다. 복막파종, 혈행성 전이, 국소 재발의 경우 상관성과 설명력은 각각 $r=0.89\;(R^2=0.80),\;r=0.88\;(R^2=0.78),\;r=0.86\;(R^2=0.73)$으로 모두 높은 상관관계가 있음을 나타냈다. 결론: 위암환자의 근치적 위절제술 후 3년 무병 생존 확률은 5년 전체 생존확률에 대한 높은 상관성 및 설명력을 보였다. 위암의 치료성적을 평가하는 방법으로 5년 전체 생존 대신에 3년 무병 생존을 이용한다면 기간을 단축(2년)하여 평가하고 결론을 얻고 또한 보고할 수 있는 이득이 있겠다. Purpose: The 5-year survival rate is the most useful parameter for evaluating the effect of management on most malignant tumors. Recurrence after a curative resection for gastric cancer occurs mostly within 3 years of the operation, which caused us to evaluate whether a 3-year disease-free survival (3DFS) can be substituted for a 5-year overall survival (5OS). Materials and Methods: We reviewed the medical records of 656 consecutive patients who had undergone a curative resection for gastric cancer To assess whether 3DFS represents 5OS, we used a simple linear regression with survival probability calculated by using the survival function. Results: Recurrence was found in 175 cases during the follow-up periods. The accumulative frequencies of recurrence at postoperative 1 year, 3 years, and 5 years were 46% (81 cases), 89% (156 cases), and 97% (170 cases), respectively. The correlation coefficient (r) and the coefficient of determination $(r^2)$ between 3DFS and 5OS were 0.87 and 0.76, respectively, and the regression equation was $5OS=0.18+(0.80{\times}3DFS)$. The r and $R^2$ according to the type of recurrence were 0.89 and 0.80 in peritoneal seeding, 0.88 and 0.78 in hematogeneous metastasis, and 0.86 and 0.73 in local recurrence, respectively. The r (0.77) and $r^2$ (0.60) were relatively lower in low stages (stage I and II) compared to r (0.88) and $r^2(0.77)$ in high stages (stage III and IV). Conclusion: The 3DFS is an excellent predictor of 5OS. Therefore, if we use the former as the treatment evaluating method, 2-year time reduction in assessing and reporting treatment results is expected.

원발성 위 림프종

권성준,대한위암연구동우회 회원,Kwon, Sung-Joon 대한위암학회 2001 대한위암학회지 Vol.1 No.4

Purpose: The aim of the study was to obtain data on the anatomic and histologic distributions, the clinical features, and the treatment results for patients with primary gastric non-Hodgkin's lymphoma. Materials and Methods: One hundred thirty-two patients who were treated at 8 university hospitals and 2 general hospitals between January 1991 and December 2000 were enrolled to evaluate clinico-pathologic features. Results: The lower one-third of the stomach was the most frequent site ($42\%$), and the most frequent chief complaint was epigastric pain ($54\%$). Gastric resection was performed in 114 cases. Pathologic findings of preoperative endoscopic biopsy specimens from the 114 patients that underwent surgery were a gastric lymphoma in 94 cases ($82\%$), a carcinoma in 15 cases ($13\%$), an ulcer in 4 cases ($4\%$), and a gastrointestinal stromal tumor in 1 case ($1\%$). The stage distributions by Musshoff's criteria were 71 cases ($54\%$) of stage IE, 36 cases ($27\%$) of stage $II_{1}E$, 8 cases ($6\%$) of stage $II_{2}E$, 2 cases ($2\%$) of stage IIIE, and 15 cases ($11\%$) of stage IVE. Histologic gradings by the Working Formulation in were 31 cases ($23\%$) of low grade, 96 cases ($73\%$) of intermediate grade, and 5 cases ($4\%$) of high grade. Chemotherapy-related complications occurred in 25 cases ($22\%$) while operation-related complications occurred in 6 cases ($5\%$). Seventeen patients ($13\%$) only underwent surgery, 19 ($14\%$) had chemotherapy (CTx) and/or radiotherapy (RTx) only, and 96 patients ($73\%$) received surgery and CTx and/or RTx. No substantial differences in survival were found in relation to the different histologic grades and different treatments. The five-year survival was $85\%$ in stage I or II and $47\%$ in stage III or IV (P=0.0000). Conclusion: Pathologic stage appears to be the single most important prognostic indicator. Survival differences according to treatment modalities were not statistically significant. However, the low number of patients treated with various approaches over a long period precludes a firm conclusion.

위전절제술 시 식도측 절제연 암 침윤의 예후적 가치

권성준,Kwon, Sung-Joon 대한위암학회 2001 대한위암학회지 Vol.1 No.3

Purpose: A positive esophageal margin is encountered in a total gastrectomy not infrequently. The aim of this retrospective review was to evaluate whether a positive esophageal margin predisposes a patient to loco-regional recurrence and whether it has an independent impact on long-term survival. Materials and Methods: A retrospective review of 224 total gastrectomies for adenocarcinomas was undertaken. The Chisquare test was used to determine the statistical significance of differences, and the Kaplan-Meier method was used to calculate survival rates. Significant differences in the survival rates were assessed using the log-rank test, and independent prognostic significance was evaluated using the Cox regression method. Results: The prevalence of esophageal margin involvement was $3.6\%$ (8/224). Univariate analysis showed that advanced stage (stage III/IV), tumor size ($\geq$5 cm), tumor site (whole or upper one-third of the stomach), macroscopic type (Borrmann type 4), esophageal invasion, esophageal margin involvement, lymphatic invasion, and venous invasion affected survival. Multivariate analysis demonstrated that TNM stage, venous invasion, and esophageal margin involvement were the only significant factors influencing the prognosis. All patients with a positive esophageal margin died with metastasis before local recurrence became a problem. A macroscopic proximal distance of more than 6 cm of esophagus was needed to be free of tumors, excluding one exceptional case which involved 15 cm of esophagus. Conclusion: All of the patients with a positive proximal resection margin after a total gastrectomy had advanced disease with a poor prognosis, but they were not predisposed to anastomotic recurrence. Early detection and extended, but reasonable, surgical resection of curable lesions are mandatory to improve the prognosis.

바텀애시를 활용한 경량골재 제조 및 활용 기술

권성준,Kwon, Seung-Jun 한국건설순환자원학회 2012 한국건설순환자원학회지 Vol.7 No.1

에틸렌 글리콜법을 이용한 전기로 환원슬래그의 Free CaO 정량 평가에 관한 연구

권성준,임희섭,이한승,Kwon, Seung-Jun,Lim, Hee-Seob,Lee, Han-Seung 한국건축시공학회 2018 한국건축시공학회지 Vol.18 No.4

Blast furnace slag has been actively used as a substitute for cement in the construction field with high value-added through resource recycling research. However, most of the slag cannot find a clear recycling purpose. This is because some slags contain unstable materials and are used for road-use asphalt and embankment, which are low value-added materials. Electric arc furnace reduction slag(ERS) has been reported to contain a large amount of unstable free CaO due to deoxidation and component adjustment. In this study, free CaO of ERS which is generated in Korean steelmakers is quantitatively evaluated by using ethylene glycol method. As a result of free CaO quantitative evaluation of ERS, it was confirmed that there is a big difference according to the location of each field. In addition, ERS generally existed in powder form as undifferentiated characteristics, but it was confirmed that free CaO content was different due to hydration product in aggregate form due to water treatment. In addition, free CaO is an amorphous material and its crystallization characteristics are different due to the influence of temperature when it is cooled. ERS requires a long-term aging period as it contains a lot of free CaO. 본 논문은 한국 철강 생산업체에서 발생되고 있는 ERS의 free CaO를Ethylene glycol법을 이용하여 정량 평가하였다. ERS 생산업체 2곳을 선정하여 ERS의 물리적 특성 및 화학성분 분석을 비교하였으며, Ethylene glycol법을 이용하여 생산업체별, 입경 차이(size), 야적 위치(IN, OUT), 에이징 기간(1day, 7days, 14days, 21days, 28days)에 따른 분류로 free CaO 정량 평가를 진행하였다. 본 연구의 실험결과 ERS의 생산업체별 화학 성분이 일부 차이를 나타내고 있었으며, 야적 위치별, 입경, 에이징 기간에 따른 free CaO의 함량 차이가 나타남을 확인하였다. 이는 free CaO가 비정질 물질로서 에이징 기간이 증가하여도 결정화 되지 못한 것으로 사료된다.

A Study on the Operation and Function Improvement for apparel warehouse Using Fuzzy-AHP

권성준,차영두,여기태,Kwon, Sung-Joon,Cha, Young-Doo,Yeo, Gi-Tae The Society of Digital Policy and Management 2017 디지털융복합연구 Vol.15 No.9

국가 간 다양한 상품 무역에서 파생되는 물류업무를 처리하기 위해 세계 물류시장은 성장하고 있는 추세이다. 특히 의류물류는 매년 처리량이 증가하고 있으며, 세계 산업 중 손꼽히는 매출 기록을 나타내고 있다. 현재 의류품목은 고가의 제품으로 성장하였으며, 정교하고 알맞은 물류서비스가 요청되고 있다. 본 논문은 3PL 서비스를 제공하는 회사들이 앞으로 성장하고 있는 의류시장에 대한 서비스 및 오퍼레이션에 대응할 수 있도록 효과적인 운영방안을 제시하는 것에 연구목적이 있다. Fuzzy AHP방법을 사용하여 의류창고 운영에 대한 중요요인의 가중치를 산출하였다. 분석결과, 1위로는 인력교육(0.17) 2위로는 화재관리(0.169), 3위로 입출고 관리(0.142)로 나타났으며, 4위와 5위는 각각 Warehouse management system 및 바코드 시스템으로 확인되었다. 즉 '의류' 특성을 정확히 이해하고 이를 바탕으로 인력교육, 화재관리 그리고 입출고관리를 수행해야하며, 이를 통하여 의류물류 서비스의 질을 제고할 수 있다. Given the expansion of globalization and international trade, the number of apparel consumers is growing every year, making it difficult to estimate the amount of handling needed from the logistics industry. To determine which management factors are important and which ones require improvement, fuzzy AHP was used. Using this method, the factors were ranked in the final analysis as follows: The first and most important factor was training employees (0.17), while the second was fire hazard management (0.169); the third-highest factor was inbound and outbound goods (0.142), and the fourth was the warehouse management system. Barcode management was ranked fifth. By these results, we were able to analyze the processes of clothing warehouses, noting that although the factors appear independent, they are actually connected while proceeding with full management control. Moreover, because of the special characteristics of garments, employee management is crucial. Due to the vulnerability of these goods to fire hazards, this factor must be well managed.

제4기 위암 환자 중 장기 생존 예의 검토

권성준,Kwon, Sung-Joon 대한위암학회 2002 대한위암학회지 Vol.2 No.3

Purpose: The prognosis of stage IV gastric cancer is very grave. However, some of these patients survive long periods after surgery. This study was undertaken to investigate various clinico-pathological profiles related to the prognosis for these long-term survivors. Materials and Methods: One hundred fifty-five patients with stage IV gastric cancer who underwent a gastric resection from 1992 to 1997 at Hanyang University Hospital were evaluated. Thirty-three patients who survived more than 5 years after surgery were designated as long-term survivors (LTS); on the other hand, one hundred twenty-two patients who died within 5 years after surgery were named as short-term survivors (STS). Results: The rate of the patients with T4, preoperative serum level of CA19-9 greater than 37 U/g protein, and peritoneal dissemination was lower for the LTS than in for the STS (P=0.002, P=0.045, and P=0.0000, respectively). Tumors were smaller (7.3 cm vs. 8.9 cm, P=0.030) and metastatic lymph node were fewer (19.7 vs. 28.8, P=0.019) for the LTS than for the STS. Curative surgery ($\76\%\;vs.\;\46\%$, P=0.002) and a subtotal gastrectomy ($\76\%\;vs.\;46\%$, P=0.026) were performed more frequently for the LTS than for the STS. From a univariate survival analysis, depth of invasion, distant metastasis, extent of gastric resection, postoperative chemotherapy, and curability were statistically significant factors. From a multivariate survival analysis, curability, depth of invasion, and extent of gastric resection were independent prognostic factors. Conclusions: If feasible, we have to exert our efforts to achieve curative surgery although the tumor is considered to be a stage IV gastric cancer. Thereafter, multi-modality treatments including chemotherapy can be considered to improve the prognosis.

위암 수술 시 절제연 암침윤의 임상적 의미

권성준,Kwon, Sung-Joon 대한위암학회 2001 대한위암학회지 Vol.1 No.1

Purpose: Despite knowledge of the adverse effects of resection-line disease, surgeons continue to perform inadequate resections. This demonstrates the need for a more aggressive approach to assessment of resection margins at operation. Materials and Methods: Seven hundred fifteen gastric cancer patients who were operated on at our hospital from 1992 to 1998 were included in this analysis. Various clinicopathological factors, including resection-line involvement, were ascertained from the surgical and histopathological records. Results: Of the 715 evaluable patients, 27 patients ($3.8\%$) had involvement of one or both resection lines; in 10 patients the proximal resection line only, in 16 the distal resection line only, and 1 both resection lines were involved. Presence of resection-line involvement was significantly associated with T3 and T4 stage, N (+) stage, M (+) stage, type of operation (total gastrectomy), tumor location (entire stomach), size$\geq$11 cm), and gross type of tumor (Borrmann 4 type). When performing a distal subtotal gastrectomy, no involvement was found when the cranial and caudal distances between the lesion and the line of transection was equal to or greater than 2 cm and 3 cm, respectively, for early cancer and 7 cm and 3 cm, respectively, for advanced cancer. When performing a total gastrectomy for upper 1/3 or middle 1/3 gastric cancer, no involvement was found when the cranial distances between the lesion and the line of transection were equal to or greater than 3 cm and 4 cm, respectively, without distinction of the presence of serosal invasion. Conclusions: The difference in survival between positive and negative margin patients is limited to the group of patients with curative surgery. An important principle of treatment is that the entire tumor must be removed with a 3 cm distal margin and a 2- to 7 cm margin depending on the location and the depth of wall invasion of the tumor, to provide histologically negative margins.

표층 확장형 조기위암의 임상병리학적 특성

권성준,김형주,Kwon, Sung-Joon,Kim, Hyoung-Ju 대한위암학회 2005 대한위암학회지 Vol.5 No.4

목적: 표층 확대형 조기위암은 위벽 내로의 깊은 침윤은 없으면서 위의 표층부를 넓게 퍼져 나가는 성장형태가 특징이다. 이는 조기 위암 가운데 드문 형태로서 이들의 임상병리학적 특성은 아직 널리 알려져 있지 않다. 이에 이의 임상병리학적 특성을 규명 해 보고자 본 연구를 시행하였다. 대상 및 방법: 본원에서 위암으로 수술 받고 조기위암이 확인된 385예를 대상으로 하였다. 이들 가운데 종양의 최대 직경이 6 cm 이상이거나 종양의 면적이 $5{\times}5cm\;(25cm^2)$ 이상이었던 69명을 표층 확대형, 그 이하인 319명은 일반 형으로 정의하고 두 그룹 사이의 임상병리학적 특성을 비교 분석하였다. 결과: 표층 확대형의 경우 일반형에 비하여 림프절 전이, 미만형, 림프관 침윤이 의미 있게 많았다. 표층 확대형에서 림프절 전이 위치는 위 주위와 총간동맥 주위, 좌위동맥 주위에 국한되었다. 종양의 변연부와 절제선까지의 거리가 10 mm 이하이나 절제선 내 암침윤은 음성이었던 6예는 추적관찰 기간($4 {\sim}13$년)동안 재발 없이 생존 중이다. 단 변량 생존 분석에서 58세 이상의 연령, 위 상부1/3 위치 암, 림프절 전이 예, 점막하층 침윤 예 등이 의미 있는 불량예후인자였다. 다변량 생존분석에서는 연령 및 림프절 전이 여부만이 독립적인 예후관련 인자였다. 그러나 표층 확대형 여부는 의미 있는 예 후인자가 아니었다. 결론: 표층 확대형 조기 위암은 조직학적으로 특징적인 면모를 보이고 있으나 이의 치료 시 절제선 음성을 확인하며 위절제술을 시행하고 림프절은 $D1+{\beta}$범위에서 곽청하면 좋은 예후를 기대 할 수 있겠다. 수치는 체내 그렐린 생성량을 반영하지 못한다. 위는 그렐린 생성의 주요 장소이며 위 절제 범위에 따라 혈중 그렐린 농도에 유의한 차이가 없는 것으로 보아 위전절술 후 다른 장기에서 그렐린이 대상성으로 더욱 증가하였음을 알 수 있다. 그렐린의 생성에 영향을 미치는 다른 인자들에 대한 추가적인 연구가 필요할 것으로 생각한다.배 이상 강력한 미백활성을 나타낸 반면, $100{\mu}M$ 농도에서도 비교적 안전한 화합물로 확인되었으며, 작용기전은 MITF 단백질을 조절함으로 활성을 나타내는 것으로 확인되었다.이 바람직할 것으로 생각된다. 얻었으며 두 군 사이에 임상적 결과의 차이는 없었다.건측 보다 10도의 굴곡 제한이 있었다. 결론: 자가 슬괵 건을 이용한 전방 십자 재건술 시, 경골 부의 고정 시 슬관절의 굴곡 각도 따른 슬관절의 전방 안정성에 차이는 없었으나, 신전 위에서 고정하는 것이 과도한 이식 건의 장력으로 인한 슬관절 굴곡 구축을 예방하는데 도움이 될 것으로 사료된다.라 증가할 것으로 추정되었으며 이에 대한 연근 추출물 경구 투여가 간 조직을 보호할 수 있는지를 확인하기 위해 분리한 혈청으로부터 ALT 함량을 측정한 결과 대조군에 비하여 유의한 감소를 나타내었다. 또한 연근 추출물이 혈청 내 지질 과산화물의 생성을 억제할 수 있다면 질병의 예방과 치료에 효과적일 것으로 추정할 수 있으므로 그 생성량을 측정하여 보았으나 대조군과의 차이가 나타나지 않았다. 이상의 결과들을 종합하여 보면 스트레스가 부하된 5일 동안 연근(蓮根) 추출물을 함께 투여한 결과 혈청 corticosterone 함량을 유의하게 감소시켰고 뇌 조직내 noradrenaline 함량을 증가시키는 경향을 나타내어 스트레스 Purpose: Superficially spreading (SS) early gastric cancer (EGC) is characterized by wide horizontal extension without deep vertical invasion. It is a relatively rare form of EGC, and it's clinicopathological (C-P) characteristics are not evident. This study aimed to clarify their C-P characteristics. Materials and Methods: We defined SS EGC as invading less than the submucosal layer that measured more than 60 mm in diameter or wider than $5{\times}5cm \;(25cm^2)$ in width. The C-P characteristics and prognosis were compared between 69 patients with SS EGC and 319 patients with the common type EGC (EGC except SS type). Results: For SS EGC lymph node metastases, Lauren's diffuse type, lymphatic invasion were significantly higher than in common type EGC. In patients with SS EGC, all of the metastatic lymph nodes were anatomically distributed within the paragastric region, with fewer along the left gastric artery and common hepatic artery. In 6 cases of SS EGC with resection marqins less than 10 mm, there was no death during the follow-up period (4 to 13 years after operation) if margins were not involved. Age (>58 yrs), tumor site (upper 1/3), lymph node metastasis, submucosal invasion were statistically significant poor prognostic factor in univariate survival analysis. In multivariate survival analysis, age and lymph node metastasis were independent prognostic factors. However, tumor diameter or width was not a significant prognostic factor. Conclusion: Although SS EGC has histologically distinct properties, gastrectomy with free surgical margins and appropriate lymph node dissection $(D1+{\beta})$ could be a suitable treatment.

초기 및 임계 염화물량 변화에 따른 내구수명 변화

권성준 ( Kwon Seung-jun ),박선경 ( Park Sun-kyung ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.1

초기 염화물량 4 수준(0, 300, 700, 1,000 ppm), 임계 염화물량 2 수준(국내 및 일본 콘크리트 설계 기준), 고로슬래그 미분말 치환률 3 수준(0, 30, 50 %)을 고려하여 내구수명을 분석하였다. 초기 염화물이 증가함에 따라 내구수명은 감소하는 거동을 나타냈으나 우려할 정도는 아니며, 고로슬래그 미분말의 혼입 치환률을 증가시킬 경우 OPC 배합 대비 높은 내구수명이 확보되었다. 따라서 관련 조건의 적절한 배합으로 염화물 기준을 합리적인 수준으로 제정한다면 혼소재의 사용과 같은 자원의 선순환을 통해 탄소 저감에 높은 기여를 할 수 있다고 사료된다.