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류강선,이완주,구현옥,이회선,이강노,김선여,Ryu, Kang-Sun,Lee, Won-Chu,Ku, Hyun-Ok,Lee, Hoi-Seon,Lee, Kang-Ro,Kim, Sun-Yeou 한국생약학회 1999 생약학회지 Vol.30 No.2
The hypoglycemic effect of mulberry leaves using alloxan-induced diabetic mice was investigated. The hypoglycemic effect of mulberry leaves was significantly affected with anaerobic incubation up to for 6 hrs. The body weight of mice treated with 20% anaerobic conditioned mulberry leaves was higher than that in the control group. Mulberry leaves which were treated with anaerobic condition significantly decreased blood glucose level in alloxan-induced type I diabetes mice. Furthermore, glucose tolerance was significantly recovered by feeding mulberry leaves anaerobically treated. Pathological analysis revealed that the disappearance of insulin-secreting beta-cells in the islets of Langerhans from the alloxan induced diabetic mice was strongly inhibited in the mulberry leaves feeding group. The content of 1-deoxynojirimycin increased up to 5% in detached mulberry leaves incubated under nitrogen gas for 6 hrs. Nevertheless, it is not clear whether the synthesis of 1-deoxynojirimycin is increased or the degradation of it is decreased. Overall, results obtained from this study indicate that the hypoglycemic effect was increased by the mulberry leaves with anaerobic treatment.
Deoxynivalenol에 의한 생체독성 스크리닝 및 중독증 진단지표 확립
김은주(Eun-Joo Kim),정상희(Sang-Hee Jeong),구현옥(Hyun-Ok Ku),강환구(Hwan-Goo Kang),조준형(Joon-Hyoung Cho) 한국독성학회 2007 Toxicological Research Vol.23 No.2
Deoxynivalenol (DON) is a common foodborne mycotoxin and occurs predominantly in grains such as wheat, barley, oats, etc. DON induces systemic health problems such as loss of appetite, emesis and diarrhea in both human and farm animals. Reliable diagnostic parameters for DON intoxication are needed to prevent deep health impact. In order to establish useful diagnostic parameters, we investigated clinical signs, hematological values, serum biochemical values, gross-, histo- and toxico-pathological findings in B6C3F1 male mice after oral administration of DON (0.83, 2.5 and 7.5 ㎎/㎏) for 8 days. Body weight gain was significantly decreased at the highest dose of DON. Anorexia, ataxia, fur crudness and lack of vigor were observed at the highest dose DON group. In hematological values, the numbers of WBC and platelets and hemoglobin content were reduced with decreased neutrophil and monocytes by 7.5 ㎎/㎏ DON. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were prolonged in a dose-dependent manner and the content of fibrinogen was elevated at high dose of DON. Of serum biochemical values, total protein, globulin, BUN, cholesterol and testosterone were reduced but total bilirubin and albumin/globulin ratio increased. The enzyme activity of alkaline phosphatase was decreased while that of alanine aminotransferase was elevated. Relative organ weights of thymus, seminal vesicle/prostate and testes were dose-dependently reduced but those of liver and left adrenal gland increased with dose dependency. As for pathological findings, atrophy of thymus, seminal vesicle/prostate and testes and submucosal edema and ulceration in stomach and depletion of lymphocytes in thymus cortex were observed. In conclusion, these clinical, hematological, blood biochemical and patholgical parameters obtained in the present studies can be used for diagnosis of DON-mycotoxicosis, especially, low WBC, platelets, protein, BUN and testosterone and delayed prothrombin time can be available as for reliable diagnostic parameters.
단보 : 국내 분리 Enterococci중 박테리오신에 대한 phenotype과 genotype의 특징 조사
황인영 ( In Yeong Hwang ),남향미 ( Hyang Mi Nam ),임숙경 ( Suk Kyung Lim ),구현옥 ( Hyun Ok Ku ),박최규 ( Choi Kyu Park ),정석찬 ( Suk Chan Jung ) 한국수의공중보건학회 2010 예방수의학회지 Vol.34 No.4
One hundred one enterococcal isolates from feces of livestock animals in Korea were screened for the presence of bacteriocins. Sixteen of 41 (39%) E. faecalis and 4 of 56 (7.1%) E. faecium isolates showed antimicrobial activity against at least one indicator strain. Only 4 of 20 the enterococcal isolates showing antimicrobial activity possessed at least one bacteriocin gene. While entA and entB were detected in three isolates as a pair of genotype, entQ, bac31, and AS-48 were not found in the enterococcal isolates. In almost all isolates, a correlation between genotype and phenotype of these determinants was not always observed.
조준형,정상희,구현옥,모인필,윤효인 한국수의공중보건학회 1994 예방수의학회지 Vol.18 No.3