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- 저자 : 구진숙 ( Jinsuk Koo ) (검색결과 2 건)
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對金飮子가 알코올 투여로 유발된 흰쥐의 간 지방 병증과 면역억제의 예방에 미치는 영향
김정자(Jeongja Kim),서부일(Buil Seo),최홍식(Hongsik Choi),김승모(Seongmo Kim),우창훈(Changhoon Woo),구진숙(Jinsuk Koo),박규열(Gyuryeol Park) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.2
Objective : The present study has been undertaken to investigate the preventive effects of Daekumeumja on fatty degeneration of liver and immunosuppression induced by alcohol in rats. Method : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Daekumeumja(DK) extract was administrated for the same period. We measured the serum component in rat's blood, weight of internal organs, liver triglyceride contents, histomorphometry and histopathological observation of internal organs. Results : 1. In the change measurement of serum components, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of AST, ALT, albumin, ALP and triglyceride in comparison with those of the alcohol control group. 2. In the change measurement of internal organ's weight, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of relative body weights of liver, thymus and spleen in comparison with those of the alcohol control group. 3. DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of hepatic triglyceride contents in comparison with those of the alcohol control group. 4. In histomorphometrical changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of numbers of hepatocytes occupied by over 10 % lipid droplets, percentages of regions occupied by lipid droplets and mean diameters of hepatocytes in comparison with those of the alcohol control group. In histomorphometrical changes of thymus, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of lobular thickness and cortex thickness in comparison with those of the alcohol control group. In histomorphometrical changes of spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of splenic thicknesses, numbers of white pulps and mean diameters of white pulps in comparison with those of the alcohol control group. 5. In histopathological changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of severe fatty changes in comparison with those of the alcohol control group. In histopathological changes of thymus and spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of atrophic changes in comparison with those of the alcohol control group. Conclusions : Reviewing these experimental results, it appears that Daekumeumja have pharmaceutical preventive efficacy on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
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작약 및 포제작약의 최종당화산물 억제를 통한 피부 주름 개선 효과
김수지 ( Suji Kim ),이아름 ( Ahreum Lee ),김수현 ( Soohyun Kim ),김경조 ( Kyeongjo Kim ),권오준 ( Ojun Kwon ),최준영 ( Joonyoung Choi ),구진숙 ( Jinsuk Koo ),노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.4
Objectives:Collagen decrease of Skin appears through various path ways. One of causes may be the Advanced glycation endproducts (AGEs) that combine formation of glucose and protein. The aim of this study was to explore the prevent wrinkle formation of Paeoniae radix (PR) and heated Paeoniae radix (HPR) via AGEs path way. Methods:AGEs formation inhibitory activities of PR and HPR measured using bovine serum albumin, glucose, and fructose. To evaluate the protective effects of PR and HPR in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rat were distributed into four groups. Normal rats (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 ㎎/㎏ PR(PR), AGEs-induced rats treated with 100 ㎎/㎏ HPR (HPR). To induce AGEs, streptozotocin (50 ㎎/㎏) was administered intraperitoneally and after 3 days administrated 100mM methyl glyoxal for 3 weeks. Results:The oral administration of HPR inhibited AGEs in skin tissues compared with PR. The increased reactive oxygen species (ROS) levels in the serum were diminished by HPR treatment. The analyses of kidney and skin tissues proteins indicated that HPR treatment effectively reduced AGEs related protein levels as compared to that by PR treatment. Also, HPR decreased anti-oxidant related protein levels in skin tissues such as catalase, glutathione peroxidase. Moreover, it inhibited the reduction of COL1A2 by decreasing MMP-1. Conclusion:Based on these results, it was suggested that PR and HPR could have Improving effects on wrinkle formation. These evidences provide useful information for the development wrinkle formation treated agent.
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