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강정민 ( Jeong Min Kang ),김은지 ( Eun Jee Kim ),구본경 ( Bon Kyoung Koo ),송운흥 ( Woon Heung Song ) 대한임상병리사협회 1999 임상혈액검사학회 발표자료집 Vol.5 No.1
The fibrinolytic system is responsible for maintenance of vascular patency via a complex series of molecular interactions that result in the proteolytic degradation of fibrin. Tissue-type plasminogen activator(tPA) is specific serine protease that activate the proenzyme plasminogen, by cleavage of a single Arg-Val peptide bond, to the broad-specificity enzyme plasmin. The most important endogenous inhibitor of tPA is endothelial cell plasminogen activator inhibitor type 1(PAI-l). Interaction of tPA with PAI-1 rapidly leds to the formation of a 1:1 inactive highly stable tPA-PAI-1 complex. Plasma tPA and PAI-1 level were assessed using ELISA method in 385 patients including 183 patients with cardiovascular disease. Thirty four (8.8%) of 385 patients revealed abnormal results in tPA or PAI-1. Among cardiovascular disease patients. 72 of 183 (39.4%) showed abnormal tPA or PAI-1 level.