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샤염화탄소 투여 쥐에서 아연이 간세포의 아포토시스와 TGF-ßl 분바에 미치는 영향
제갈승주 ( Seung Joo Jakal ),김은정 ( Eun Jung Kim ),최영자 ( Young Ja Choi ),곽효일 ( Hyo Il Kwak ),노종섭 ( Jong Sup Rho ),신용섭 ( Yong Sup Shin ),김진경 ( Jin Kyung Kim ) 대한임상검사과학회 2002 대한임상검사과학회지(KJCLS) Vol.34 No.2
Recently zinc has been known as a beneficial agent in the protection against hepatotoxicity and Its effect was supposed due to decreased hepatic cel1 apoptosis by the inhibition of endonuclease activity. Meanwhile, Transfonning growth factor-ßl (TGF-ßl) was considered an important regu1ator in the pathogenesis of early hepatic fibrosis. The aim of this study was to ascertain the effect of zinc on hepatic cell apoptosis and TGF-ß lsecretion in early hepatic fibrosis induced by carbon tetrachloride (CC4). Twenty male Wistar rats were divided into four groups: the control group, control + zinc treated group, CC14 treated group and CC4 +zinc treated group. All the rats were sacrified 8 days later for histological and biochemical assessments. The col1agen content in liver was measured after Masson’s trichrome staining, apoptosis was detected by terminal UDP-nick end labelling (TUNEL) staining and TGF-ßl was quantified by labelled streptavidin biotin (LSAB) immunostaining using a computerized image analysis system. TUNEL-positive cells (apoptotic cel1s) increased in rats with early hepatic fibrosis and oral zinc administration decreased the number of apoptotic cells in the CC14-treated rats. The zinc-mediated decrease of apoptosis in the liver was related to an increase of TGF-ßl positive cel1s and col1agen content. However, AST, ALT levels and the number of fatty changed hepatic cel1s as an index of hepatic cell damage increased in rats with early hepatic fibrosis and two indices decreased by zinc administration. These results suggest that apoptosis may be involved, together with necrosis, in the early hepatic fibrogenesis and was closely related to the increase of TGF-ß 1 secretion and collagen content. Therefore, zinc could play an important role in the inhibition of early hepatic fibrosis induced by CC4
폐의 소세포암종에서 Synaptophysin, Neuron-SpecificEnolase, Chromogranin A, Neurofilarnent 항체들의 감수성에 대한연구
노종섭 ( Jong Sup Roh ),왕성수 ( Sung Su Wang ),이정아 ( Chung A Lee ),곽효일 ( Hyo Il Kwak ),윤기중 ( Ki Jung Yun ) 대한임상검사과학회 1998 대한임상검사과학회지(KJCLS) Vol.30 No.3
A variety of benign and malignant tumors may arise in the lung, but the bronchogenic carcinoma is majority. Among the brochogenic carcinomas, small cell carcinoma is a histologically distinctive type, and it is higly malignant and chemosensitive To evaluate of sensitivity of neuroendocrine markers such as synaptophysin, neuron-specific enolase(NSE), chrorrogranin A and neurofilament antibodies, we studied the small cell carcinoma of lung on the 32 paraffin embedded tissues. The sensitivities of synaptophysin, NSE, chrorrogranin A and neurofilarrent were ``irl.5%, 31.30/0, 25%, and l000~ respectively, Above result indicates that neurofilament and synaptophysin antibodies are good for diagnosis of small cell carcinoma of the lung.
자궁경부의 편평상피내병소와 편평상피세포암종에서의 비만세포에 관한 연구
제갈승주 ( Seung Joo Jekal ),차현희 ( Hyun Hee Cha ),최영자 ( Young Ja Choi ),노종섭 ( Jong Sup Roh ),곽효일 ( Hyo Il Kwak ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
Mast cells have recently been found to be well correlated with the inhibition of invasiveness and metastasis in various cancer. This work aimed to investigate the number of mast cells and ratio of mast cell granulation in squamous intraepithelial lesions and squamous cell carcinoma of the cervix. Cervical biopsy specimens were divided into low grade squamous intraepithelial lesion(n=20), high grade squamous intraepithelial lesion(n=75) and squamous cell carcinoma(n=40) by The Bethesda System. The sections were cut from routinely formalin- f1xed and paraffin-embedded tissues and stained with 0.5% toluidine blue(pHO.5)-nuc1ear fast red. The mast cells were quantif1cated the numbers per square millimeter using a computerized image analysis system. Mean number of mast cells was signif1cantly higher in high grade squamous intraepithelial lesion than in low grade squamous intraepithelial lesion and signif1cantly lower in squamous cell carcinoma than in high grade squamous intraepithelial lesion(p<0.01). The percent of mast cell ganulation also was significantly higher in high grade squamous intraepithelial lesion than in low grade squamous intraepithelial lesion and significantly lower in squamous cell carcinoma than in high grade intraepithelial lesion (p<0.01). These results suggested that mast cell number and percent of mast cell granulation were to be correlated to the development from precancerous lesion to cervical cancerous lesion and may be useful as markers of cervical squamous cell carcinoma.
한원철,곽효일,이경근,윤기중 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.1
Pilomatrixoma is a benign skin appendage tumor with differentiation toward hair cells, particularly hair cortex cells. Histologically, two types of basophilic and shadow cells compose the islands. The basophilic cells are round or elongated with deeply basophilic nuclei and scanty cytoplasm. Cytologically, this case showed clusters of tightly arranged basaloid cells with a uniform appearance, scanty cytoplasm and round hyperchromatic nuclei. And it may cause when attempting to establish a differential diagnosis with other neoplasms. We report the aspiration cytology findings of a case of pilomatrixoma.
하태규,권상철,김흥곤,곽효일,문형배 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.1
Cervical cancer is the most common gynecologic malignancy and leading cause of death in Korean women. Although the precise etiology of cervical cancer is unknown, epidemiologic studies suggest that venereally transmitted infectious agents could play an important role in the etiology of cervical cancer. Recently, human papillomavirus(HPV) has been reported to be associated with neoplastic change. Cervical cytology is limited by its false negativity and this may be supplemented by other adjunctive test such as HPV test. It is therefore important to explore the use of HPV DNA detection as a primary or supplementary screening method and to determine whether HPV typing can be used as a predictor of a lesions clinical behavior. This study used the data gained from 145 women who diagnosed cervical neoplasia at the department of Obstetric and Gynecology in Wonkwang University Hospital from August in 1996 to July in 1998. The results were as follows : 1. HPV DNA was detected in 104 cases of 145 patients (71.7%). 2. In cytological diagnosis, HPV DNA was detected in normal (53.5%), ASCUS (85.7%), LGSIL (94.1 %), HGSIL (74.6%) and invasive cervical cancer (80.0%). 3. In pathological diagnosis, HPV DNA was detected in chronic cervicitis (50.0%), CIN Ⅰ (52.9%), CIN Ⅱ (68.8%), CIN Ⅲ (81.3%) and invasive cervical cancer (68.8 %). According to these results, HPV DNA detection by Hybrid Capture System may be a useful method in supplement the pitfalls of cervical cytology. To be clinically significant HPV test as a screening tool, the more population will be necessary for further study from now on.