쿠싱 중후군 환자에서 미세단백뇨의 빈도 및 수술의 효과

고정민(Jung Min Koh),정윤이(Yun Ey Chung),박중열(Joong Yeol Park),송영기(Yung Kee Shong),홍성관(Sung Kwan Hong),이기업(Ki Up Lee),김기수(Ghi Su Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.2

N/A Objectives: Microalbuminuria predicts cardiovascular mortality in patients with non-insulin-dependent diabetses mellitus (NIDDM). Microalbuminuria is frequently associated with high blood pressure, dyslipidemia, insulin resistance and central obesity, and has been suggested to be a feature of metabolic syndrome (syndrome X). Metabolic syndrome is also present in Cushings syndrome, which is characterized by primary hypercortisolism as well as profound visceral obesity. Considering common features of Cushings syndrome and metabolic syndrome, microalbuminuria could be a feature of Cushings syndrome. Methods ' We studied urinary albumin excretion (UAE) in 13 patients with Cushings syndrome, UAE was reexamined after the correction of hypencortisolemia in the patients with microalbuminuria or overt proteinuria. Kidney biopsy was performed in 3 patients with microalbuminuria. Hesults: Eight out of 13 patients (61.5 %) had microalbuminuria. Kidney biopsy revealed apparently normal glomerular structures without evidence of diabetic or hypertensive nephropathy. Patients underwent successful removal of pituitary or adrenal tumors and were reevaluated 2 months after surgery. TJAE declined profoundly in all of the patients with initial microalbuminuria. . Conclusion - Our results demonstrate that more than 60% of patients with Cushings syndrome have microalbuminuria. This rate far exceeds the rate in NIDDM patients and hypertensive patients. Microalbuminuria nearly completely reversed after successful treatment of hypercortisolism.

부신우연종의 진료지침: 대한내분비학회 진료지침제정위원회

이정민 ( Jung-min Lee ),김미경 ( Mee Kyoung Kim ),고승현 ( Seung-hyun Ko ),고정민 ( Jung-min Koh ),김보연 ( Bo-yeon Kim ),김상완 ( Sang-wan Kim ),김수경 ( Soo-kyung Kim ),김혜진 ( Hae-jin Kim ),류옥현 ( Ohk-hyun Ryu ),박주리 ( Jur 대한내과학회 2017 대한내과학회지 Vol.92 No.1

An adrenal incidentaloma is an adrenal mass found in an imaging examination performed for reasons unrelated to suspected adrenal disease. The prevalence of adrenal incidentaloma increases with age; there is no gender difference, but it is often accompanied by obesity, diabetes mellitus, or hypertension. The detection of adrenal incidentaloma is expected to rise with the rapid development of imaging technology and increasing frequency of imaging studies. The Korean Endocrine Society is promoting appropriate practice guidelines to meet the rising incidence of adrenal incidentaloma, in cooperation with the Korean Adrenal Gland and Endocrine Hypertension Study Group. In this paper, we discuss important core issues for treating adrenal incidentaloma, along with the most important factors for healthcare providers who treat and manage affected patients. Initially, we identified 47 recommendations using the Delphi technique, after evaluating core propositions. We reduced these to the 20 most critical recommendations. (Korean J Med 2017;92:4-16)

보문 : 백제복식문화 연구 (제1보)

채금석 ( Keum Seok Chae ),고정민 ( Jung Min Koh ) 韓國衣類學會 2009 한국의류학회지 Vol.33 No.9

연구논문 : 한국 전문대학과 미국 지역사회대학의 직업교육에 관한 비교 연구

안현순 ( Hyun Soon Ahn ),고정민 ( Jung Min Koh ),윤병철 ( Byeong Cheol Yoon ) 한국미용학회 2007 한국미용학회지 Vol.13 No.3

This study focuses on drawing success factors of Korean traditional folk play, The purpose of this essay is to study of the vocational education between Korean Junior Colleges and American Community Colleges in the viewpoint of comparative education and to explore its educational implications for the education of Korean Junior Colleges. And also this study explores the alternative how Korean Junior Colleges will be the center of vocational education. We examine the developmental process, the purpose of vocational education, educational feature of Korean Junior Colleges. Especially, we examine the developmental process Dept. of Skin & Beauty of Korean Junior Colleges in social and economic point. And then we explore the developmental process of American Community Colleges in the viewpoint of comparative education. American Community Colleges have a lot of good ideas and policies. They have some implications for the education of Korean Junior Colleges: First, They develope various incoming students sources. Second, They make a place as life-long education institutes. Third, They closely communicate with community through different educational programs.

한국 남사당패(男寺堂牌)와 일본 가부키(歌舞伎) 비교 연구

안현순 ( Hyun Soon Ahn ),고정민 ( Jung Min Koh ) 한국미용학회 2007 한국미용학회지 Vol.13 No.1

에도(江戶)시대 여성의 화장법과 두발양식 고찰

안현순 ( An Hyun Soon ),고정민 ( Koh Jung Min ) 한국디자인트렌드학회 2010 한국디자인포럼 Vol.29 No.-

일본 에도(江戶)시대 전반의 미의식은 사비(さび), 와비(わび), 가루미(かるみ), 시오리로 대표되는데 이는 외적인 아름다움과 동시에 내면의 아름다움을 추구하는 것으로 아담하고 한적한 미와 품위를 중시하였다. 이러한 미의식은 화장을 통해 여성들의 화장법과 두발양식에도 적용되었는데, 특히 화장술은 문화의 내부 원인으로 변화하는 경우도 있지만, 복수의 문화가 서로 교차할 때, 이문화의 미의식에 영향을 받아, 미추의 기준이나 화장법이 변화하는 현상도 드물지 않았음을 알 수 있었다. 에도시대 화장법은 화장하는 개인의 특성을 부각시키는 방향으로 진행되었는데 순서는 크게 씻기, 면도, 손발톱정리, 머리 묶기, 백분 바르기, 흑치물들이기로 이루어졌다. 특히 흑치물들이기는 고대 아시아 여러 국가에서 이루어진 것으로 그 당시 독특한 미의 기준이 국가 간 교류를 통해 후대에도 이어졌음을 추측할 수 있다. 에도시대는 일본의 전통적 두발양식이 결정된 시기로 그 의미가 있으며, 각자 취향에 따라서 그 경향을 선택하고, 또한 다양한 양식과 특수한 형태를 고안해 내어 이를 다시 통일된 공동의 양식으로 유행되었다. The general aesthetic consciousness of the Edo period of Japan is represented by Sabi, Wabi, Garumi and Siori, which sought for inner as well as outer beauty with a focus one legant and quiet beauty and grace. Such consciousness of beauty also applied to women`s beautycare and hairstyle through make up, and as far as beauty care concerned, it changed, on one hand, due to the inner cause of culture, but on the other hand, in not a few cases, the crossing of multiple different cultures also affected and changed the standard of beauty or beauty care. The beauty care in the Edo period proceeded in the direction of embossing the characteristics of the person who applied cosmetics with the generalorder of wash, shaving, finger and foot nailcare, tying one`s hairback, powdering one`s face, and dyeing black. Especially, dyeing black, which had been popular in many ancient Asian countries, allows us to surmise that in thosedays, auniquestandard of beauty was set through international exchange. The Edo period has significance as a time in which Japan`s traditional hairstyle was fixed. As such, each one selected the trend according to her taste thinking up diverse styles and special shapes, which was then made popular as aunified, commonstyle.

문학,문화 : 중국(中國) 청(淸) 왕조시대(王朝時代)와 일본(日本) 강호시대(江戶時代)의 미의식(美意識)에 따른 화장문화(化粧文化) 비교 연구

안현순 ( Hyun Soon Ahn ),고정민 ( Jung Min Koh ) 경희대학교 비교문화연구소 2012 비교문화연구 Vol.27 No.-

China and Japan are geographically close and the two countries had shared the Chinese Character Culture and the thoughts of Confucianism, Buddhism and Taoism since the ancient age. They also actively exchanged culture in various areas. Some cultural exchanges had been caused by surrounding environment and culture had been introduced to other country in a natural way; while some cultural exchanges had been forcibly introduced through artificial process. It is believed that such cultural phenomenon must have had impact on the make-up cultures of the two countries and it was assumed that there must have been commons and differences in the make-up cultures of the two countries. This study explored the historical background of the Ching dynasty of China and the Edo Age in Japan, which are in the same time frame, and studied the aesthetic consciousness of the two countries at the time. Then the make-up style of ladies in the two countries had been studied to find out how their aesthetic consciousnesses had been expressed in the make-ups of the two countries. Then the commons and differences in make-up skills between the two countries had been identified. According to the study results, the main stream of aesthetics during the Ching dynasty in China can be classified into Confucianism aesthetics and Taoism aesthetics. On the other hand, the main stream of aesthetics during the Edo Age in Japan can be classified into "mitate(見立)", "ikki(いき)" and "garumi(かるみ). The skin care in the make-up culture of Ching dynasty in China was based on "rouge (연脂, yanzhi)" and "powder(粉, fen)". The Ching ladies loved the make-up style using rouge. It had been same both in the high society and common people. The eyebrow care was delicate and curved so that the feminine beauty with elegant spirit could be emphasized. The lips had been expressed to be smaller and the ladies tried to express elegance and reliability, rather than frail and tender feminine image. The skin care in the make-up culture of Edo Age in Japan focused on even applying of white powder so that the face would look soft. The eyebrow make-up was a very important part of the make-up. The shapes of eyebrow had been advanced in various styles and there had been eyebrow make-up styles such as "crescent-shaped brow (三日月), "crane style brow (鶴眉) and "Tang style brow (唐眉). The lips had been applied of thick red color, imitating the make-up skill of the ladies in the entertainment business. The lips make-up skill expressing the lips in two colors had been quite popular. Among the make-up skills during the Edo Age in Japan, the "black teeth (齒黑)" can be said as the most unique make-up style of Edo Age.

부갑상샘절제술 이후 뼈스캔에서 발적 현상을 나타낸 갈색종

신광호 ( Kwang Ho Shin ),박설훈 ( Seol Hoon Park ),백소라 ( So Ra Baek ),채선영 ( Sun Young Chae ),고정민 ( Jung Min Koh ),김재승 ( Jae Seung Kim ),문대혁 ( Dae Hyuk Moon ),류진숙 ( Jin Sook Ryu ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5

Brown tumor is the benign bone lesion consists of woven bone and fibrous tissue without matrix, which develop due to chronic excessive osteoclastic activity such as hyperparathyroidism. Usually they appear with normal uptake or occasionally focally increased uptake on bone scan. We present a case with brown tumor shown more increased uptake and more number of lesions on bone scan after parathyroidectomy, and lesser increased uptake on serial bone scans without any other treatment through several months. This finding is thought to be similar to `flare phenomenon` which is occasionally seen after treatment of metastatic bone lesions of malignant cancer, and may represent curative process of brown tumor with rapid normal bone formation. (Nucl Med Mol Imaging 2009;43(5):495-498)

Uncoupling Protein 3의 골격근 세포내 과발현이 OLETF 백서 및 배양된 골격근 세포에서 포도당대사에 미치는 영향

한정희,박혜선,고정민,김하영,강호경,이인규,박중열,홍성관,이재담,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:Uncoupling protein(UCP)는 미토콘드리아의 내막에 위치하는 단백질로 세포내의 과다한 에너지를 열로 발산시키는 기능을 가진다. 최근 동물의 갈색지방조직에만 존재하는 UCP와 유사성을 가진 아형들(UCP2,3)이 사람에게도 존재함이 알려져 큰 관심을 끌도 있는데 이중 UCP3는 그 발현이 골격근세포와 갈색지방조직에만 국한된다. 본 연구에서는 UCP3가 체내 인슐린 감수성을 결정하는데 가장 중요한 조직인 골격근에 국한되어 발현되는 점에 착안하여 UCP3를 골격근세포에 과발현시켰을 때 포도당 대사에 어떠한 영향이 나타나는 지를 조사하였다. 방법:25주령의 8마리의 OLETF 백서를 대상으로 하여 4마리는 골격근에 adenovirus 2mL(1×10¹²pfu/mL)를 주사하여 대조군으로 하였고 4마리는 골격근에 재조합법으로 제작된 adenovirus­UCP3 2mL(1×10¹²pfu/mL)를 주사하였다(UCP3 과발현군). UCP3를 투여한 백서에서 먹이섭취가 증가하는 경향이 있어 그 전날 대조군이 먹은 야의 먹이만큼 투여하였다. 골격근에 adenovirus를 주사한 10일 후에 euglycemic hyperinsulinemic clamp를 시행하였다. Adenovirus­UCP를 C2C12 골격근 세포에 transfection시켜 UCP3를 C2C12 골격근 세포에 transfection시켜 UPS3­C2C12를 만들고 C2C12 골격근 세포와 UPS3­C2C12 골격근 세포에서 포도당 수송 및 당원합성을 측정하였다. 결과:UCP3 과발현 OLETF에서 체중이 감소하는 경향을 보였고 인슐린 감수성이 증가하였다. C2C12세포에서 기저상태 포도당 수송은 1.28±0.17μmol/L/min였고 100nM 인슐린으로 2시간 처리한 후 2.67±0.20 μmol/L/min로 증가하였다. UCP3­C2C12 세포에서는 기저상태 포도당 수송이 3.98±0.13μmol/L/min로 증가되었고 인슐린 처리 후 5.74±0.44μmol/L/min로 증가하였다. 인슐린을 처리한 UCP3­C2C12 세포에 P13K 억제제인 wortmannin을 첨가하였을 때 포도당 수송활성이 3.81±0.20μmol/L/min로 감소하였다. 기저상태 당원합성은 C2C12 세포에서 0.25±0.01μmol/L/min였고 인슐린 처리 후 0.45±0.01μmol/L/min로 증가하였다. UCP3­C2C12 세포에서는 기저상태 당원합성이 0.62±0.01μmol/L/min였고 인슐린 처리 후 1.26±454μmol/L/min로 증가하였다. UCP3­C2C12세포에 wortmannin을 첨가하였을 때 당원합성율이 0.80±0.04μmol/L/min로 감소하였다. 결론:UCP3 과발현이 OLETF 백서에서 인슐린 감수성을 증가시켰고 골격근세포에서 포도당 수송 및 당원합성을 증가시켰다. wortmannin을 첨가하였을 때 포도당 수송 및 당원합성이 감소함으로 보아 이 과정이 인슐린 신호전달체계인 P13K에 일부 의존함을 알 수 있었다. Background : UC P3 is a mitochondrial membrane protein expressed selectively in the skeletal muscle and brown adipose tissue. Since the skeletal muscle is the main organ determining insulin sensitivity in the body, it was hypothesized that UCP3 overexpression in skeletal muscle cells would improve glucose metabolism. Methods : An adenovirus-UCP3 was produced by a recombinant DNA method. OLETF rats were divided into 2 groups. Four rats were injected with the adenovirus-UCP3 (UCP3 group) and others were injected with the adenovirus(control group) in the skeletal muscle. The UCP3 group was provided with the same quantity of food as that consumed by the control group on the previous day. Insulin sensitivity was evaluated by the euglycemic hyperinsulinemic clamp method. In a separate experiment, glucose transport and glycogen synthesis we evaluated in C2C212 cells transfected with ether an adenovirus or the adenovirus-UCP3. Results : The insulin sensitivity improved significantly and the body weight decreased in the UCP3 group. The glucose transport and glycogen synthesis were higher in the UCP3-C2C12 skeletal muscle cells at the basal state. After insulin treatment, glucose transport and glycogen synthesis were also higher in the UCP3-C2C12 cells but the increments were reduced after treatment with wortmannin, a PI3K inhibitor. Conclusion : Insulin sensitivity was higher in the UCP3-overexpressed OLETF rats in the in vivo study. UCP3 transfection also increased glucose transport and glycogen synthesis in the cultured skeletal muscle cells by a PI3K dependent mechanism(J Kor Diabetes Asso 25 :460~468, 2001).

네일 디자인의 표현기법과 작품제작에 관한 연구

정해량,고정민,안현순 한국패션뷰티학회 2008 한국패션뷰티학회지 Vol.6 No.1

This study focused on the expression technique and work manufacturing of nail design. Any woman that wants to be pretty is interested in nail design which is considered as a means to express beauty, intelligence and sensuality. These days, nail design carries heavy weight in completion of total fashion coordination. Good dress, elegant hair style, bright make-up and well-trimmed nails are requirements of modern women. These days, the range of nail design is more expanding and its importance is getting bigger. To maintain and establish such developmental flow properly, we have to break our stereotyped view on nails and accept it in open view. And we have to actively participate in development of new products and technologies and perform academic research on nail design. For the purpose, we have to consider further studies which contribute to understanding exact meaning of nails and necessity and importance of nails.