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폐암 치험 73례: Alveolar cell carcinoma 를 중심으로
손광현,이남수,고일향,Sohn, Kwang-Hyun,Lee, Nam-Soo,Ko, Il-Hyang 대한흉부심장혈관외과학회 1979 Journal of Chest Surgery (J Chest Surg) Vol.12 No.4
During the period of 4 years from August 1975 to August 1979 one hundred and forty seven cases of lung cancer were seen at Paik Foundation Hospital in Seoul, Korea. Among these 147 cases, 104 patients had primary carcinoma of the lung and the remainder was metastatic carcinoma to the lung. Among these 104 primary carcinoma patients, 73 cases were proven histologically as primary carcinoma of the lung. There were three cases of alveolar cell carcinoma [Table 1 ]. This clinical observation is based on those 73 cases including three case reports of the alveolar cell carcinoma. 1. Peak incidence was observed in the 5th decade of life. Male to female ratio was 2 to 1 [Fig. 1]. 2. Pathological classifications were as follows: epidermoid carcinoma, 24 cases [32.9%]; undifferentiated carcinoma, 20 cases [27.4%]; adenocarcinoma, 15 cases [20.5%]; bronchioloalveolar carcinoma [5.5%] and positive cytology, 10 cases [13.7%] [Fig. 2]. 3. Evidence of inoperability was observed in 55 patients [75% of the 73 cases] [Table 3]. 4. Among those 73 cases, operability was evaluated in 18 patients or 25%. One patient refused operation and 17 patients [23.6%] were explored. In 11 [15%] out of 17 patients, thoracotomies were performed. Six cases were pneumonectomies and 5 cases were lobectomies or bilobectomies [Fig. 3]. 5. First case of alveolar cell carcinoma was a 46 year-old housewife complaining of cough and hemoptysis for one year. The plain chest X-ray and bronchogram showed characteristic pictures as Figures 4 and 5. A pneumonectomy was carried out. Histologically, a beautiful alveolar carcinoma consisted of the characteristic tall columnar epithelial cells, which were lining the alveolar spaces as seen in Figures 6, 7, 8, and 20. 6. In the second case of 41 year old male, predominant clinical feature was single, well defined mass in the right lower lobe [Fig. 10 and 11] on chest X-ray. Bilobectomized specimen showed fragile, soft and hard tissue containing mucoid secretions and focal yellowish necrosis with pigmentation on cut surface [Fig. 12]. Slides showed tumor cells lined up along the alveolar septa with papillary projections [Fig. 13 and 14]. 7. Third case of alveolar cell carcinoma was a 50-year-old housewife with hemoptysis. An outstanding clinical picture was a round to lobulated mass in the right upper lobe [Fig. 16]. She is living now, 2 years and 1 month post-operatively, but has arrived at terminal stage with military nodular disseminations to the contralateral lung [Fig. 19].
갑상선의 여포상 종양과 결절성 갑상선 종대에 대한 세침 흡인 세포학적 연구
유진예,조혜제,고일향,Yoo, Jin-Ye,Cho, Hye-Jae,Ko, Il-Hyang 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1
There is a lot of difficulty in the diagnosis of follicular lesions of the thyroid by fine needle aspiration cytology(FNAC). The main purpose of this report is offering more guidance regarding the cytologic appearance to distinguish follicular neoplasm from nodular golfer and laying stress on the presence of mixed group. The histologic and cytologic findings of 23 follicular neoplasms and 13 nodular (adenomatous) getters were reviewed. Histologic specimens were classified into the microfollicular(MIF), mixed(MIX), and nodular getter(NG) groups. The comparison of histologic patterns with histologic diagnosis revealed that all the lesions with predominantly microfollicular, trabecular, or solid pattern were follicular carcinoma and all the lesions with predominantly macrofollicular pattern were nodular goiter. The distinguishing cytologic features for the MIF group were irregular cell arrangement in cell groups(100%, p=0.00001), absence of atrophic follicular cells(100%, p=0.0007), abundant microfollicles(100%, 0=0.002), pleomorphic nuclei(100%, p=0.002), not predominant syncytial smear pattern(100%, p=0.002), heterochromatin(100%, p=0.032), absence of macrofollicles(100%, p=0.038), scant colloid(100%, 0=0.04), clear back-ground(83%, p=0.00006), and uniform sized follicles(83%, p=0.014). And regular cell arrangement(honeycomb appearance) in cell groups(85%, p=0.0000), atrophic change of follicular cells(69%, p=0.0002), syncytial smear pattern(54%, p=0.000), monomorphic nuclei(85%, p=0.008), and hemorrhagic background(100%, p=0.027) were characteristic features of the NG group. Seventeen out of 36 cases(47%) were the MIX group composed of combined cytologic features of the MIF and NG groups. Therefore the frequent presence of the MIX group is considered to be main cause of the difficulty in the diagnosis of follicular lesions by FNAC. The mixed morphologic feature may support the hypothesis of a biologic 'continuum' between nodular goiter and follicular neoplasm of thyroid gland.
김홍용(Hong Yong Kim),고일향(Il Hyang Ko),이진호(Jin Ho Lee),김관엽(Kwan Yop Kim),류종철(Jong Cheol Ryu),차순주(Soon Joo Cha),신원창(Won Chang Shin),박태준(Tae Joon Park),최원충(Won chung Choi) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Carcinoid tumors which arise from enterochromaffin cells are usually found in the appendix, ileun, bronchus and rectum. Carcinoid tumors of the biliary tract are exceedingly rare and pre-operative diagnosis is very difficult. We report a case of carcinoid tumor of the gallbladder in a 43-year-old man presenting jaundice and right upper quadrant abdominal pain as a chief complaint. A tumor of the neck of gallbladder was demonstrated with ultrasonography, computed tomography, endoscopic retrograde cholangiopan-creatography, and percutaneous cholangiography and was confirmed as carcinoid tumor at operation.
서울 백병원서의 절제위암의 (切除胃癌) 발생 연령에 관한 연구 : 중촌의 (中村) 공식으로 조사함
석동수(Dong soo Suk),고일향(Il Hyang Ko) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A A total of 329 cases of gastric cancer from the Seoul Paik Hospital (1974-1987) were anlyzed with the Nakamuras formula to estimate its starting age. (1) Average age at the time of diagnosis 50.9 years old (male 51.1, female 50.7). This figure is 7 years younger and 14 years younger than those of Japanese and Americans, respectively. The differences can be speculated to be the same on the age differences of the cancer clcvcloprnent. Among these three countries. Generally, stronger the carcinogen, the age will become younger. (2) The estimated starting age of stomach cacner shows the highest in 40s age group, 30.7%, followed by 30s (26.1%), and 50s (20.4%). From 31 to 60 years, the figure is 77.2%. Average starting age is 42.5 years in both sex. (3) Interval between the starting age and the diagnosis (latent period) is 8.4 years in average (male 8.6, female 8.2). For the 41 EGC out of 329 stomach cancer, this latent period is 4 years. Therefore, the above 8.4 years will become ever closer to 4 years as early gastric cancer will he detected more in Korea in the future. (4) In coniparison with the age of EGC of Japan (1,300 cases), there are strikingly high percentages in the lower age groups is while low percentages in the upper age groups in Korea. This finding will indicate that Korean environment (traditional food) may cause the cancer more strongly than that of Japan.
림상검체(臨床檢體)에 따른 항산균(抗酸菌) 양성솔(陽性率)에 대(對)한 고찰(考察)
김영권 ( Young Kwon Kim ),박영희 ( Young Hee Park ),신태수 ( Tae Soo Sin ),고일향 ( Il Hyang Ko ) 대한임상검사과학회 1985 대한임상검사과학회지(KJCLS) Vol.17 No.1
Author practised total 14,993 cases of AFB stain for five years from Jan. 1, 1979 to Dec. 31, 1983 at clinical laboratory of seoul Paik Hospital, Inje medical col1ege. Author obtained 1,474 cases of AFB positive among a total 14,993 clinical specimens. Author have studied (1) Numbers of AFB stain from various specimen sources (2) AFB positive rate by different specimen sources (3) Age and sex distribution of AFB positive patients The results are summarized as fol1ows 1. Numbers of specimen sources requested for AFB stain are; sputum 12,498 cases (83.7%), urine 1,051 cases (7.0%), CSF 457 cases (3.0%) etc. among total 14, 993 cases 2. AFB positive rste is 9.9% (1, 474/14, 993 cases) AFB positive rate in different spesimen sources are; pus 12.8%, sputum 11.1%, stool 4.0%, urine 3.6%, others 3.4% respectively. 3. AFB positivity in sexes are 61.19 in male, 38.96 in female 4. Age distribution of AFB positivity are; 25~29 age groups 2.10, 30~34 age groups 0.82, 20~24 age groups 1.93%.