증례 : 방사성 동위원소 정맥조영술로 진단한 심부정맥혈전증 2 예 ( Cases Report : Two Cases of Deep Vein Thrombosis Detected by Radionulide Venography )

고은미(Eun Mi Koh),김경진(Kyung Jin Kim),김시영(Si Young Kim),조경삼(Kyung Sam Cho),김광원(Kwang Won Kim),최병길(Young Kil Choi),윤엽(Yup Yoon) 경희대학교 경희의료원 1989 慶熙醫學 Vol.5 No.3

연구논문 : 현미 로스팅(Roasting)이 선식의 입자 크기와 물 결합력 및 점도에 미치는 영향

고은미 ( Eun Mi Koh ),문세훈 ( Sae Hun Mun ),서정희 ( Jeong Hee Surh ) 한국식품조리과학회(구 한국조리과학회) 2014 한국식품조리과학회지 Vol.30 No.5

The effect of roasting on particle size distribution, water-holding capacity, and viscosity of sunsik was investigated in this study using non-roasted one as control. Roasting increased the size of particles in sunsik, in particular, particles larger than 1 μm in diameter, indicating that roasted sunsik is likely to sediment faster, thereby decreasing the time to maintain dispersibility when mixing with water. Roasting also increased the water-holding capacity of sunsik, indicating that polymerization occurred greater than a pyrolysis during roasting, leading to increased viscosity in roasted sunsik. These results indicate that the roasting affected the dispersibility and viscosity of sunsik by increasing particle size and water-holding capacity, respectively.

한국인의 비만형 인슐린비의존성 당뇨병 발생기전에 있어서 β₃아드레날린 수용체 유전자 다형성의 의의

고은미(Eun Mi Koh),안규정(Kyu Jeung Ahn),김경아(Kyoung Ah Kim),김연선(Yeun Sun Kim),정재훈(Jae Hoon Choung),민용기(Young Ki Min),이명식(Myung Shik Lee),이문규(Moon Kyu Lee),김종원(Joung Won Kim),김광원(Kwang Won Kim),김성운(Sung Woon 대한내과학회 1997 대한내과학회지 Vol.53 No.6

N/A Objectives : The β₃adrenergic receptor(β₃-AR) may play an important role in the regulation of energy expenditure and lipolysis. A mutation of the β₃- AR gene(Trp64Arg) has been reported to be associated with early onset of non-insulin dependent diabetes mellitus(NIDDM), obesity and syndrome X which are related with insulin resistance. It is well known that Korean NIDDM patients, in contrast to Caucasians, are mainly non-obese and have experienced severe weight loss during the course of disease. We studied the frequency of the mutation in Korean NIDDM patients and non-diabetics control and evaluated the clinical characteristics of Korean obese NIDDM patients. We investigated the frequency of the mutation in NIDDM patients and clinical characteristics of the patients with the mutation in order to elucidate the significance of the mutation in the pathogenesis of NIDDM in Koreans. Methods: We studied 401 NIDDM patients and 99 controls. The NIDDM patients were divided into two groups, non-obese group and obese group, according to their body mass index at diagnosis of the disease. The Trp64Arg mutation was detected by the PCR/RFLP method using restriction enzyme Mva I. Results: The Trp64Arg allele frequency(16M) of NIDDM did not differ from that(16%) of controls. Although the mutant allele frequency was not different between non-obese and obese group both in NIDDM patients and controls, the frequency of patient with the mutant allele was significantly higher in obese NIDDM patients than in non-obese NIDDM patients(38.5% vs. 26.9%, P=0.04). However, no significant differences were found in clinical and laboratory findings between the NIDDM patients with the mutant allele and those without the mutant allele. Conclusion: These data suggest that β³-AR mutation might be associated with Korean obese NIDDM, and other factors might also be associated with the development of obesity and insulin resistance in NIDDM patients.

Expression of neutralizing epitope of porcine epidemic diarrhea virus in the chloroplasts of tobacco

Eun-Mi Koh(고은미),Bang-Geul Kim(김방글),So-Chon Han(한소천),Tae-Jin Kang(강태진),Moon-Sik Yang(양문식) 한국생물공학회 2004 한국생물공학회 학술대회 Vol.2004 No.10

애니메이션 자막 활용방법이 초등 영어 학습자의 듣기 능력에 미치는 영향

고은미 ( Koh Eun Mi ),홍선호 ( Hong Sun Ho ) 서울교육대학교 초등교육연구소 2018 한국초등교육 Vol.29 No.3

국제 사회에서 영어의사소통능력에 대한 요구는 갈수록 증가하고 있으며 이에 따라 2015 영어과 개정교육과정에서는 학생들의 영어의사소통능력 강화해야 한다고 강조하고 있다. 여러 학자들에 의하면 의사소통능력을 기르기 위해서는 언어의 4가지 기능 중 먼저 ‘듣기’에 집중하는 것이 필요하다. 그러나 우리나라는 영어를 배우는 학습자들이 실생활에서 영어를 듣고 사용할 기회가 거의 없는 EFL 환경이기에 제한된 시간에 제한된 장소에서만 영어 학습이 주로 이루어지고 있는 실정이다. 따라서 본 연구에서는 애니메이션 영화를 활용한 영어수업에서 영어자막의 유무와 자막의 제시 순서에 따라 초등 영어 학습자들의 영어 듣기 능력 및 정의적 영역에 미치는 영향에 대해 분석해보고 영상 시청수업에서 자막의 효과적인 활용방안에 대해 살펴보고자 하였다. 연구 결과, 초등학교 5학년 학습자를 대상으로 한 애니메이션 영상을 활용한 수업에서 무자막 영상보다 영어자막을 함께 제시하는 것이 학생들의 듣기 능력과 정의적 영역에 더 긍정적인 영향을 주었다. 자막을 제시하는 순서에 있어서는 평균 수준의 영어 학습자들에게는 처음에는 자막이 없는 영상을 제시하고 후반에 자막을 함께 제시하는 방법이 더 효과적인 것으로 나타났다. 영상에 문자언어가 함께 노출될 때 학생들의 영어에 대한 자신감과 흥미도도 증가하였다. 따라서 본 연구는 5학년 학습자들을 대상으로 한 애니메이션 영상 활용 수업에서 음성언어와 문자언어를 함께 노출하는 것이 학습자들의 듣기 능력 향상에 더 효과적이며 이때 문자 언어인 영어자막을 영상의 후반에 제공하는 것이 보통 수준의 초등 영어 학습자들의 영어 듣기 능력 향상에 도움이 될 수 있다는 지도 방향을 제시할 수 있다. 후속 연구로 문자언어(자막)의 읽기 능력과 듣기 능력 사이의 관계 분석, 학년 군에 따른 자막을 활용방법에 대한 연구가 필요할 것으로 보인다. The purpose of this study is to analyze the effects of using English subtitles, and the timing they are provided, during animation-based instruction on L2 learners’ listening comprehension and learning attitude. This study also examines subtitle utilization methods to facilitate learning among students. It was conducted on 79 fifth grade students in an elementary school. Students were divided into groups in which the subtitles were given or not, and were given 24 units in the experiment class. Results of the study are as follows. First, it was more effective to use English subtitles during animation-based instruction for L2 learners. Furthermore, analysis comparing students of different level, using English subtitles with the mid and low-level groups was especially effective. Secondly, it was most effective to first provide students with no subtitles and then adding subtitles towards the end of the animation. Regarding the prior knowledge about the animation and the timing of the subtitles being provided, it was proved that showing less exposed animation and giving subtitles towards the end of the animation was the best method to exploit subtitles in animation-based instruction. Third, using English subtitles during animation-based instruction fostered both students’interest and confidence towards learning English. Although animation-based instruction was effective regardless of subtitles, the effects of the animation were amplified when students were provided with English subtitles while watching the animation. Also, regarding the effects of different timings of the subtitles being given, the experiment demonstrated meaningful improvements of the students’interest, confidence, and participation for all timings, but it was noticeable that providing subtitles from the beginning was more effective to increase students’interest and at the end to encourage participation.

폐경기 후 여성에 대한 여성 호르몬 대체요법시 순응도에 미치는 인자에 관한 연구

고은미(Eun Mi Koh),백승규(Seung Kyu Paek),이경희(Kyung Hee Lee),박만철(Man Chul Park),이용우(Yong Woo Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10

목적: 본 연구는 호르몬 대체요법의 여러 가지 방법 중, 자궁이 있는 경우 지속적 병합 투여 요법으로 치료한 환자 군과 자궁적출술후 에스트로젠 단독 투여 군에서 연령, 무월경 기간, 치료 동기, 치료 목적, 투여 요법, 부작용이 순응도에 어떠한 영향을 미치는지 알아 보기 위한 것이다. 연구 방법: 1994년 7월부터 1997년 8월까지 한림대학교 한강성심병원 폐경기 클리닉에서 호르몬 대체 요법을 시행받은 258명을 대상으로, 자궁이 있는 환자에게는 에스트로젠제제와 프로제스틴제제로 지속적 병합 투여하였으며, 자궁적출술을 시행받은 환자에게는 에스트로젠제제만을 단독 투여하였다. 순응도는 1년 이상 투약을 꾸준히 받은 경우에는 양호군에 포함시켰고, 치료를 중단하였거나 불완전하게 받은 경우에는 불량군에 포함시켰다. 결과: 전체적으로 약 40%의 환자에서 양호한 순응도를 보였고, 본원에서 자궁적출술후 호르몬 대체요법을 권유받은 환자군과 자궁적출술후 Premarin을 단독 투여한 군에서 양호한 순응도를 보였던 환자의 비율은 각각 64.7%와 58.4%로 다른 투약 동기군이나 지속적 병합요법투여군보다 의미있게 높았다. 무월경 기간, 치료 목적, 지속적 병합 투여시 부작용 유무 등은 순응도에 영향을 미치지는 못하였으며, 투약시의 환자 연령도 통계학적으로 의미있는 영향을 미치지는 못하였지만 젊은 환자일수록 높은 순응도를 보이는 경향이 있었다. 결론: 호르몬 대체요법으로 얻을 수 있는 여러 가지 이점 중에서 골다공증 예방과 심혈관계 질환의 위험을 감소시키는 효과를 얻기 위해서는 호르몬 대체요법을 장기간 투여하는 것이 필요하고, 이를 해결하기 위해서는 치료자와 환자 양측에 대한 교육, 환자 개개인에 따른 차별화된 처방 및 호르몬 제재들의 표준화 등이 필요하다. Objectives: The purpose of this study is to evaluate effects of patients' age, amenorrhea duration, motivation, purpose, regimen, side effects on compliance to hormone replacement therapy(HRT) Methods: Compliance to HRT was assessed in 258 postmenopausal women who began HRT in the Menopause Clinic of Hangang Sacred Heart Hospital, Hallym university. One hundred sixty nine women who had intact uterus received continuous combined therapy with 0.625 mg of conjugated equine estrogen (CEE) and 100 mg of micronized progesterone. Eighty nine women who were hysterectomized received only 0.625 mg of CEE. Results: A total of 103 women (39.9%) reported that they continued HRT at least for one year. Continuation of HRT was significantly more common among women who started HRT becuase of recommendation by gynecologist after hysterectomy in our department (p < 0.05). A greater percentage of women who received only CEE without uterus continued HRT than women who received continuous combined therapy (p < 0.05). Duration of amenorrhea, reasons for taking HRT and side effects such as irregular bleeding or breast tenderness were not related to the continuation of HRT. Conclusion: Education of menopausal women about the benefit/risk and side effects of HRT may be critical in improving compliance.

한국인의 나트륨 섭취 급원 음식 및 섭취 양상

연미영(Mi Yong Yon),이윤나(Yoon Na Lee),김도희(Do Hee Kim),이지연(Jee Yeon Lee),고은미(Eun Mi Koh),남은정(Eun Jeong Nam),신혜형(Hye Hyung Shin),강백원(Baeg Won Kang),김종욱(Jong Wook Kim),허석(Seok Heo),조해영(Hea Young Cho),김초일(C) 대한지역사회영양학회 2011 대한지역사회영양학회지 Vol.16 No.4

We attempted to define the sources of sodium intake for the Korean population at prepared dish level to provide a basis for developing sustainable nutrition policies and feasible programs for sodium intake reduction. Dietary intake data from 2008 and 2009 Korea National Health and Nutrition Examination Survey was used in the analysis for sodium intake sources. Sodium intake from individual dish consumed by each subject was calculated and used in delineating major sodium sources at dish and dish group level for sub-populations of different sex and age. Also, sodium intake was compared between eaters and non-eaters of some specific dish groups with considerable contribution to total sodium intake. The number of subjects included in the analysis was 18,022 and mean sodium intake was 4,600 mg/capita/day. Major sources of sodium intake at dish group level were in the following order: kimchi (1125 mg, 24.5%), noodles (572 mg, 12.4%), soups (488 mg, 10.6%), stews (399 mg, 8.7%), and cooked rice (284 mg, 6.2%). The magnitude of contribution to total sodium intake by soups and stews was different by age group. Sodium intake difference between eaters and non-eaters was much larger for kimchi group (2,343 mg for male, 1,452 mg for female) than for soups or stews. Interaction between consumption of aforementioned specific dish groups and age was highly significant (p < 0.0005) for both sexes. This study revealed an importance of having not only the control over sodium content of foods/dishes, but also the customized approach for different groups of population to accomplish an appreciable reduction in sodium intake. (Korean J Community Nutr 16(4) : 473~487, 2011)

병합임신 1례

정의석(Ue Suk Joung),고은미(Eun Mi Koh),김성주(Sung Ju Kim),이경희(Kyung Hee Lee),박만철(Man Chul Park),이용우(Yong Woo Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12

Heterotopic pregnancy occurs when there are coexisiting intrauterine and ectopic pregnances. It occure, more often, due to assisted reproductive technology such as IVF-ET, GIFT and increased pelvic inflammatory diseases. We present a case of heterotopic pregnancy confirmed by surgical removal of ruptured left ovarian pregnancy and sonographic finding of the intrauterine pregnancy following natural conception.

한국인 류마티스 관절염 환자에 대한 에토리콕시브 90 mg 안전성 및 유효성

성윤경 ( Yoon Kyoung Sung ),고은미 ( Eun Mi Koh ),박원 ( Won Park ),이수곤 ( So Kon Lee ),이지수 ( Ji Soo Lee ),김철준 ( Chul Joon Kim ),박영주 ( Young Joo Park ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.4

Objective: To assess the efficacy and the safety of etoricoxib 90 mg daily administered to Korean patients for the treatment of rheumatoid arthritis over a 12-week period. Methods: Eighty-nine patients diagnosed with rheumatoid arthritis were administered Etoricoxib 90 mg for 12 weeks. Tender Joint Count (total 68 joints), Swollen Joint Count (total 66 joints), Patient Global Assessment of Disease Activity, and Investigator Global Assessment of Disease Activity were assessed as primary endpoints. Patient Global Assessment of Pain, Health Assessment of Questionnaire (HAQ: disability scales), Patient Global Assessment of Response to Therapy, Investigator Global Assessment of Response to Therapy, and Duration of Morning Stiffness were assessed as secondary endpoints. Those endpoints were assessed at week 2, 4, 8, and 12. Safety was evaluated by physical examination, serum chemistry, blood count, urinalysis, and occurrence of adverse events. Results: Etoricoxib 90 mg showed significant effects compared to baseline, thus the result indicated etoricoxib was clinically effective. Etoricoxib 90 mg showed significant improvement in all efficacy endpoints (primary endpoints and secondary endpoints). Treatment effects for etoricoxib 90 mg were approximately a 7.3 (95% CI 5.8 8.9, P<0.0001) joint reduction in the number of tender joints, 4.8 (95% CI 3.6 6.0, P<0.0001) joint reduction in the number of swollen joints, a 15.4 (95% Cl 12.1 18.7, p<0.0001) mm improvement in the patient global assessment (100 mm VAS) and 1.3 (95% Cl 1.1 1.6, p<0.0001) unit improvement in the investigator global assessment (0 to 4 Likert scale). Treatment effects were observed at the earliest time point of measurement and were maintained over time during the 12-week period. Drug-related clinical adverse events were reported by 22 (24.7%) of 89 safety evaluable subjects. Eight patients discontinued the drug due to clinical adverse events. Frequency of drug-related laboratory abnormalities was low with 2 (2.2%). Nobody discontinued due to laboratory abnormalities. Conclusion: (1) Etoricoxib 90 mg once daily was clinically effective for the treatment of rheumatoid arthritis in Korea patients. (2) Etoricoxib 90 mg once daily administered to patients with rheumatoid arthritis was generally safe and well tolerated.

Meigs’Syndrome

장선민(Sun Min Chang),고은미(Eun Mi Koh),김성주(Sung Ju Kim),이경희(Kyung Hee Lee),박만철(Man Chul Park),이용우(Yong Woo Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

Meigs' syndrome is characterized by the pleural effusion and ascites in patients with solid benign ovarian tumors and the resolution of the effusions after resection of the tumor. The tumor secretes a large amount fluid, possibly aggravated by lymphatics and venous obstruction of its pedicle by the relatively large tumor. Meigs' syndrome can resemble a metastatic pelvic carcinoma on its presentation, but the progression is more favorable when the syndrome is associated with a benign ovarian tumor. A case of ovarian fibroma associated with ascites and pleural effusion is presented with the brief review of literatures.