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세침흡인검사 후 호흡곤란을 동반한 일측성 갑상선 혈종 2례
고윤우(Yoon Woo Koh),권계원(Kye Won Kwon),변장열(Jang Yul Byun) 대한두경부종양학회 2007 대한두경부 종양학회지 Vol.23 No.1
Fine needle aspiration biopsy(FNAB) has been used for many decades in the diagnosis of benign and mal-ignant tumors of thyroid gland. Complications of thyroid fine-needle aspiration biopsy(FNAB) are extremely rare. Hematoma formation is the most commonly encountered complication. However, massive intrathyroid uni-lateral hemorrhage and hematoma formation inducing upper airway distress rarely occurs. Here, we report two cases diagnosed as having hematoma that caused upper airway distress after FNAB for thyroid nodule.
고윤우(Yoon Woo Koh),이종대(Jong Dae Lee),변장열(Jang Yul Byun),이재용(Jae Yong Lee) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2
Neuroendocrine carcinomas are rare neoplasms of the hypopharynx. Neuroendocrine neoplasms are divided into four main types : carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. The diagnosis is primarily based on light microscopy and should be confirmed by immunohistochemical investigation. Small cell neuroendocrine carcinoma of the hypopharynx is extremely uncommon tumor and surgical results for this tumor have been disappointing. Chemotherapy and radiotherapy currently appear the most effective forms of therapy. We report our case of small cell neuroendocrine carcinoma of the hypopharynx with the brief review of literatures.
침샘관암에서 PD-L1의 발현율 분석과 종양 표지자로서의 효용성에 대한 고찰
이용주,고윤우,윤선옥,류향주,김혜련,신향애,Lee, Yong Ju,Koh, Yoon Woo,Yoon, Sun Och,Ryu, Hyang Joo,Kim, Hye Ryun,Shin, Hyang Ae 대한두경부종양학회 2019 대한두경부 종양학회지 Vol.35 No.1
Background/Objectives: Despite multiple approaches of treatments for salivary duct carcinoma, there has been a need for more successful treatment methods because of its poor prognosis. Treatment options like immunotherapy using new technologies have been attempted. Based on recent study results indicating that targeting programmed death receptors are effective in treating various cancers, this study aimed to identify the frequency of PD-L1 expression and its impact on survival rate in salivary duct carcinoma. Materials & Methods: We studied 33 patients with salivary gland cancer who were available for histologic specimens. We examined the expression of PD-L1 in the tissues and analyzed the association with the survival rate and the association with various clinical parameters. Results: According to this study and review of similar studies, we discovered that the expression of PD-L1 in salivary duct carcinoma was lower than other types of cancers. The impact of PD-L1 on survival rate also showed inconsistency in salivary duct carcinoma. Conclusion: Immunotherapy by PD-1/PD-L1 checkpoint blockade in salivary duct carcinoma needs further evaluation for clinical application.
이승원,김재욱,고윤우,이준호,Lee, Seung-Won,Kim, Jae-Wook,Koh, Yoon-Woo,Lee, Jun-Ho 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.1
OPD based laryngeal procedures offers a new avenue to the modern laryngologist, incorporating new technology in the office setting. With the development of flexible fiberoptic endoscopes, compact video system, and short acting anesthetics and sedatives allow these procedures. The success or failure of procedures are depend on excellent topical anesthesia. An inadequately anesthetized patient is apt to be uncomfortable, anxious and hyperresponsive and therefore unlikely to tolerate the procedure. On the other hand, a patient who is well informed, reassured, and thoroughly anesthetized can complete procedures. Therefore, optimal anesthesia is obligatory for excellent surgical results. The phonosurgeon should choose the anesthetic and sedative agents based on duration of action, time of onset of action, and any medical contraindications that the patient may have. And should be familiar with the properties and interaction of the agents used, as well as the signs of toxicity.
안면신경을 보존하며 이하선과 경부청소술 시료를 일괴로 절제하는 방법
최은창(Eun Chang Choi),고윤우(Yoon Woo Koh),최재진(Jae Jin Choi),정상호(Sang Ho Chung),홍현준(Hyun Jun Hong),문인석(In Suk Moon) 대한두경부종양학회 2000 대한두경부 종양학회지 Vol.16 No.2
Parotidectomy, combined with neck dissection, is not rare situation in case of parotid malignancy. It is common to accomplish the parotidectomy and neck dissection separately. But there are numerous lymph nodes surrounding the marginal mandibular branch of facial nerve and facial artery and vein. And so, Mono-bloc dissection of the parotid gland and neck specimen is neccessary to completely resect these lymph nodes with preserving the marginal mandibular branch of facial nerve. We are reporting three cases of mono-bloc dissection of the parotid gland and neck specimen.
최은창(Eun Chang Choi),고윤우(Yoon Woo Koh),김철호(Chui Ho Kim),김동영(Dong Young Kim) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.1
It is well established that cervical lymph node metastasis is the base of clinical study on head and neck cancer. But few studies have been reported on lymph node metastasis of head and neck cancer in Korea. We consider it essential that studies on cervical lymph node metastases are conducted on pathologically proven database. Therefore, We must have database and consitent system for documentation and data collection of neck dissection specimen for prospective and retrospective study. Herein, We suggest several points from our experiences performing the proper data collection and documentation of neck dissection specimen.
구강암편평세포암에서 c-Met 발현여부에 따른 (-)-Epigallocatechin-3-Gallate의 세포사멸 및 종양침습억제효과의 변화분석
신유섭(Yoo Seob Shin),고윤우(Yoon Woo Koh),최은창(, Eun Chang Choi),강성운(Sung Un Kang),황혜숙(Hye Sook Hwang),추옥성(Oak-Sung Choo),이한빈(Han Bin Lee),김철호(Chul-Ho Kim) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.1
Hepatocyte growth factor(HGF) and c-Met play an important role in the control of tumor growth and inva-sion, and they are known to be good prognostic indicators of patient outcome. Epigallocatechin-3-gallate (EGCG) has been shown to have chemopreventive and therapeutic properties by modulating multiple signal pathways regarding the control of proliferation and invasion of cells. In this study, we evaluated the role of c-Met in EGCG-induced inhibition of invasion and apoptosis in an oral cancer cell line. In KB cells where c-Met was knocked down with siRNA, we performed invasion assay and FACS with Annexin V-FITC/PT staining. In addition, we checked the change of mitochondrial membrane potential(MMP) and the generation of reactive ox-ygen species(ROS). EGCG-induced inhibition of invasiveness was significantly decreased after the knock-down of c-Met. EGCG-induced apoptosis, MMP change and ROS generation was also reduced in c-Met knock-ed-down KB cells. These results suggest that c-Met is involved in EGCG-induced apoptosis and inhibition of invasiveness of oral cancer cell line.
기관-기관지 협착에서 내시경적 확장술 및 실리콘 스텐트의 유용성 : 예비보고
이경수,박동욱,김규훈,김재욱,고윤우,김도진,이승원,Lee, Kyong-Soo,Park, Dong-Wook,Kim, Kyu-Hun,Kim, Jae-Wook,Koh, Yoon-Woo,Kim, Do-Jin,Lee, Seung-Won 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.1
Objectives: Endoscopic airway dilatation and stenting has been developed to treat the airway stenosis without potential morbidities of open surgery. We report the clinical results of endoscopic airway dilatation with silicone stenting in patients with posttuberculous bronchial stenosis(PTBS) and with severe main tracheal stenosis who have poor general conditions Methods : A prospective observation study of five patients, who have undergone endoscopic airway dilatation and silicone stenting between Feb 2007 and Feb 2009. A total of twelve patients were treated with endoscopic airway dilatation, among them 5 patients were included in this study. three patients were treated with newly designed silicone stent (Natural stent: TNO Co., Seoul, South Korea) because of poor surgical conditions and longer stenotic segment Results: 3 patients were grade III PTBS, and the other 2 patients were grade IV post tracheotomy main tracheal stenosis. One patient of PTBS were treated with silicone stent following endoscopic dilatation because of longer stenotic segment. Two patients of main tracheal stenosis patients were treated with silicone stent because of tracheal lumen collapse. There was no severe postoperative complications except mild granulation tissue formations Conclusions : Endoscopic dilatation including silicone stenting could be a useful method for treating patients with PTBS, and for main tracheal stenosis patients with poor general surgical conditions
양성침샘질환 수술에서 Thunderbeat<sup>TM</sup>와 Harmonic scalpel<sup>®</sup>의 유용성에 대한 비교연구
이형신,김성원,이강대,오다솔,김주현,고윤우,최은창,Lee, Hyoung Shin,Kim, Sung Won,Lee, Kang Dae,Oh, Dasol,Kim, Ju Hyun,Koh, Yoon Woo,Choi, Eun Chang 대한두경부종양학회 2018 대한두경부 종양학회지 Vol.34 No.1
Background and Objectives: Thunderbeat (TB) and Harmonic scalpel (HS) have been applied to variable head and neck surgery, which are useful for both coagulation and cutting of tissues. However, there have been no comparative studies covering the usefulness of these energy devices in surgery for major salivary gland. In this study, we analyzed the surgical outcomes of two devices in surgery for parotidectomy and submandibular gland (SMG) resection. Materials and Methods: A retrospective chart review of 90 patients including two groups (HS group, n=45 versus TB group, n=45) of patients matched for their patient factors was conducted. Clinicopathologic factors of the patients and surgical outcomes such as the operation time, intraoperative bleeding, amount and duration of drain, hospital stay and complications were compared between two groups. Results: There were no significant difference between two groups regarding the clinicopathologic factors and short-term surgical outcomes. Conclusion: Thunderbeat and HS are both effective and safe for parotidectomy and SMG resection in variable benign disease of major salivary gland.