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Dexamethasone이 황체용해에 미치는 영향에 관한 면역조직화학적 연구
박선희,고영복,이윤이,노흥태,김원식,Park, Sun-Hee,Ko, Young-Bok,Rhee, Yun-Ee,Noh, Heung-Tae,Kim, Won-Sik 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.1
목 적: Glucocorticoid가 황체용해에 미치는 효과의 기전의 일부를 면역 조직학적 연구를 통해 알아보고자 하였다. 연구방법: 8주령의 Rat 암컷 30마리 대조군, 덱사메타손 0.1 mg 투여군 및 덱사메타손 1mg 투여군의 3군으로 나누어 황체용해의 차이와 대식세포의 침투여부를 비교하기 위하여 광학현미경을 이용하여 계수하였다. 결 과: TUNEL 면역염색 결과 덱사메타손 0.1 mg 투여군과 1 mg 투여군 모두에서 대조군에 비해 황체용해의 비율이 현저히 감소하였고, ED1 면역염색 결과 덱사메타손 1 mg 투여군에서 대식세포의 황체 내 침투가 현저히 억제된 것으로 나타났다. ED1 면역염색 결과 덱사메타손 1 mg 투여군에서 대식세포의 면역반응성이 대조군에 비해 감소되어 나타났다. 결 론: 덱사메타손은 직접 황체세포에 작용하여 세포자멸사를 억제한다. 또한 대량 투여했을 때는 대식세포의 황체 내 침투를 억제하거나 황체 내에 이미 존재하는 대식세포의 활성화를 억제함으로써 황체용해를 억제한다. Objective: This study was attempted to look at the effect of dexamethasone on the luteolysis of corpus luteum in rats by immunohistochemical study. Methods: Counting with an optical microscope was conducted to make a comparison on difference in luteolysis and penetration of macrophage into three groups: control group of 30 female rats at 8 weeks of age, dexamethasone 0.1 mg administered group, and dexamethasone 1mg administered group. Results: As a result of TUNEL immunostaining, the percentage of luteolysis was significantly reduced in both dexamethasone 0.1 mg administered group and 1 mg administered group, and after ED1 immunostaining, macrophage invasion was reduced in dexamethasone 1 mg administered group. As a consequence of ED1 immunostaining, the immune response of macrophage was much decreased in dexamethasone 1 mg administered group than control group. Conclusion: Dexamethasone works on luteal cell, so it can suppress apoptosis. It can suppress luteolysis by suppression macrophage invasion into corpus luteum or suppress macrophage activation in corpus luteum.
이경은 ( Kyung Eun Lee ),고영복 ( Young Bok Ko ),노흥태 ( Heung Tae Noh ),서광선 ( Kwang Sun Suh ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
목적: 유방암 환자에서 수술 후 재발 및 전이 방지를 위해 사용되고 있는 타목시펜이 자궁내막에 미치는 영향을 알아보기 위하여 연구를 시행하였다. 방법: 유방암 수술 후 타목시펜 치료를 받는 폐경된 유방암 환자 664명 중 부인과에 진료 의뢰된 55명을 대상으로 부인과적 진찰, 자궁내막초음파검사, 자궁내막조직검사 및 면역조직화학 염색을 시행하였다. 결과: 타목시펜 치료를 받은 유방암 환자에서 자궁내막의 양성 병리소견 중 가장 많은 조직학적 유형은 자궁내막 용종이었다. 초음파로 측정한 자궁내막의 두께가 10 mm을 초과할 때 자궁내막 용종과 자궁내막암이 유의하게 증가하였다. 타목시펜으로 치료받은 환자에서 발생한 자궁내막 용종과 대조군을 ER, PR, Ki-67에 대한 면역조직화학염색의 시행 결과 ER의 염색점수는 타목시펜을 복용한 군의 용종의 선에서 낮은 값을 보이고 기질에서의 PR값은 높았으며 Ki-67은 높은 점수를 보였다. 결론: 타목시펜으로 치료받은 유방암 환자는 정기적인 부인과 검진이 필요할 것으로 보인다. 또한 투여기간이 길어질수록, 초음파 검사상 자궁내막의 두께가 10 mm가 넘을 경우, 그리고 환자가 질출혈의 증상이 있는 경우는 자궁내막암을 포함한 자궁내막의 병변의 발생 가능성이 있으므로 반드시 자궁내막의 병리에 대한 검사를 시행하여야 할 것이다. 또한 타목시펜을 복용한 환자에서 자궁내막 용종의 발생이 많은 것은 타목시펜이 용종의 호르몬 수용체 및 세포증식에 영향을 미치기 때문이라고 보인다. Objective: Tamoxifen is a nonsteroidal hormone that functions as a selective estrogen-receptor (ER) modulator in breast tissue. It is the first- choice drug for the postoperative treatment of ER-positive breast cancer patients. However, tamoxifen, if administered for a prolonged duration, has estrogen-like effects on the uterus, leading to an increased risk for the development of endometrial diseases such as endometrial hyperplasia, endometrial polyp, and endometrial cancer. This study was designed to investigate the effects of tamoxifen treatment on endometrium in breast cancer patients. Methods: Fifty-five tamoxifen-treated breast cancer patients visited an outpatient gynecology clinic. We analyzed the endometrial pathology with consideration to the duration of tamoxifen treatment the patient symptoms and the endometrial thickness, as measured by transvaginal ultrasonography. Endometrial polypectomy was performed to obtained polyps from women presenting with abnormal bleeding (17 polyps from postmenopausal women who had not been treated with tamoxifen and 14 from women who had been treated with this drug). To investigate the effects of tamoxifen treatment on the endometrial polyps, we performed immunohistochemical staining for ER, the progesterone receptor (PR), and Ki67 on the polyps obtained from both groups of women. Results: In 29 (52.7%) of 55 tamoxifen-treated breast cancer patients, the endometrium was more than 10 mm thick, and in 19 (65.5%) of these patients, the abnormalities noted comprised 11 endometrial polyps, 5 endometrial carcinomas, 2 submucosal myomas, and 1 endometrial hyperplasia. The incidence of endometrial proliferation was significantly higher in patients who had been treated with tamoxifen for less than 1 year (P=0.037) than in those who had been treated for more than 1 year. Although the endometrial carcinomas, submucosal myomas, and endometrial hyperplasia were found in the patients who had been treated for more than 1 year, this result was not statistically significantwhen compared with the other group. As compared to the endometrial polyps obtained from women who had not received tamoxifen treatment, those obtained from patients who had received the treatment exhibited significantly lower levels of ER expression (P=0.000) in the glands and increased levels of PR (P=0.031) and Ki-67 expression (P=0.000) in the stroma. Conclusions: During tamoxifen treatment for breast cancer, the endometrial pathology should be investigated if transvaginal ultrasonography reveals the tissue to be more than 10 mm thick. Although tamoxifen has significant effects on the expression of hormone receptors, the mechanism underlying the development of endometrial polyps does not appear to be mediated by the ER.
임신 37주에 COX-2 억제제 복용 후 발생한 동맥관 조기수축을 동반한 태아 심부전
이민아 ( Min A Lee ),고영복 ( Young Bok Ko ),이윤이 ( Yun Ee Rhee ),장미영 ( Mee Young Chang ),길홍량 ( Hong Ryang Kil ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
We report a case of premature constriction of the fetal ductus arteriosus following maternal ingestion of a cyclooxygenase-2 (COX-2) inhibitor at 37 weeks` gestation. Fetal sonography at 38+2 weeks` gestation revealed tricuspid regurgitation, absent transpulmonary valve flow, right heart enlargement, and pericardial effusion. An immediate delivery resulted in a good postnatal outcome with dramatic improvement in the clinical and echocardiographic findings. Maternal exposure to Non-steroidal anti-inflammatory drugs (NSAIDs), especially late in gestation, can cause premature constriction of the ductus arteriosus, heart failure, and fetal death. Therefore, the use of NSAIDs late in gestation should be considered in limited cases with close fetal heart monitoring.
불임을 동반한 중증 자궁내막증 환자에서 수술 후 임신에 미치는 요인에 관한 연구
유헌종 ( Heon Jong Yoo ),고영복 ( Young Bok Ko ),박찬준 ( Chan Jun Park ),김도영 ( Do Young Kim ),양정보 ( Jung Bo Yang ),신관섭 ( Kwan Seop Shin ),현석환 ( Suk Hwan Hyun ),황순호 ( Soon Ho Hwang ),이기환 ( Ki Hwan Lee ),강길전 ( 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9
김보연 ( Bo Youn Kim ),양정보 ( Jung Bo Yang ),이민아 ( Min A Lee ),고영복 ( Young Bok Ko ),이기환 ( Ki Hwan Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.2
Vesicovaginal fistula (VVF) is one of the most serious surgical complication in gynecologic surgery. Surgical approach to repair this condition can be performed by transvaginal or transabdominal. However, laparoscopic repair of VVF may be an alternative surgical method. We present four cases of VVF treated with transperitoneal laparoscopic technique. Laparoscopic repair is a feasible, safe and efficacious minimally invasive approach for the management of VVF. We believe that this method provides excellent results and may result in lower morbidity, shorter hospital stay, and quicker recovery than the abdominal or transvaginal approaches.
α-Fe₂O₃ 미세입자의 크기분포에 관한 Mossbauer 분광학적 연구
이민용(Min Yong Lee),김시정(Sea Jung Kim),고영복(Young Bok Ko),서정철(Jung Chul Sur),이충섭(Choong-Sub Lee) 한국자기학회 1999 韓國磁氣學會誌 Vol.9 No.1
α-Fe₂O₃ was accomplished by chemical method as low temperature as possible and the crystallographic and magnetic properties have been studied by Mossbauer spectroscopy and X-ray diffraction. The sample heated at 150 ℃ is found to have a Corundums symmetry with the hexagonal lattice constant a=8.26±0.05Å, c=8.75±0.05Å. The Mossbauer spectra between the 4.2K and the room temperature show that the α-Fe₂O₃ crystalized with a single phase and fine sizes. The particle size distribution has the Gaussian distribution center at 98Å and the half width of 32Å.
양정보 ( Jung Bo Yang ),강병헌 ( Byung Hun Kang ),고영복 ( Young Bok Ko ),박찬준 ( Chan Joon Park ),유헌종 ( Heon Jong Yoo ),이윤이 ( Yun Ee Lee ),강길전 ( Kil Chun Kang ),노흥태 ( Heung Tae Noh ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
목적 : 임신전, 임신중의 인구학적, 임상적 특성을 통해 전자간증을 예측할 수 있는 요소를 결정하였다. 연구 방법 : 1998년 1월에서 2002년 12월까지 충남대학교 산부인과에서 전자간증으로 진단되어 분만을 시행한 산모 279명을 환자군으로 하여 의무기록 분석을 통해 후향적 환자-대조군 연구를 시행하였다. 대조군으로는 2002년 1월에서 12월 사이에 본원에서 분만을 시행한 산모중 무작위 추출을 통해 364명을 선정하였다. 각각의 연구대상에서 나이, Objective : To assess several variables that are known as the risk factor of preeclampsia. Methods : We have studied with 279 pregnant women who were diagnosed with preeclampsia and went through delivery in Chungnam University from January, 1998 to Decemb
유화 Spinel Co0.95Fe0.05Cr₂S₄에서 Jahn - Teller Distortion에 의한 Mossbauer 공명 흡수선의 변화에 관한 연구
서정철(Jung Chul Sur),이민용(Min Yong Lee),고영복(Young Bok Ko) 한국자기학회 1997 韓國磁氣學會誌 Vol.7 No.5
Sulphur Spinel Co_(0.95)Fe_(0.05)Cr₂S₄ has been studied with Mossbauer Spectroscopy between 4.2 K and room temperature. The Fe²+ ion in a tetrahedral site is the Jahn-Teller active and the dynamic Jahn-Teller distorts below the magnetic ordering temperature. The distortion cause a quadrupole shift to appear which increases with decreasing temperature. The magnetic hyperfine field has a maximum at 100 K and then decreases with decreasing temperature. The magnitude of the interaction ratio R between the electric quadrupole and magnetic dipole interaction increases from 0 near the magnetic ordering temperature to 5.4 at 4.2 K. The optimum values of θ, the polar angle of the magnetic hyperfine field with respect to the principle axis of the electric field gradient (EFG) remains zero and the asymmetry of the EFG η is about 0.25. The simulations of Mossbauer spectra coincidence with the experimental results.