http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
고성규(Seong-Kyu Ko),한세진(Se-Jin Han),김경욱(Kyung-Wook Kim) 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.5
Chromosome 18q alteration plays a key role in colorectal tumorigenesis, and loss of heterozygosity at 18q is associated with a poor prognosis in colon cancer. DCC(Deleted in Colorectal Cancer) is a putative tumor- suppressor gene at 18q21 that encodes a transmembrane protein with structural similarity to neural cell adhesion molecule that is involved in both epithelial and neuronal cell differentiation. DCC is implicated in regulation of cell growth, survival and proliferation. Thus, tumor progression in squamous cell carcinoma, stomach cancer, colorectal cancer correlates with downregulation of DCC expression. The mechanism for DCC suppression is associated with hypermethylation of the DCC gene promoter region. Hence, the goal of this study is to identify the promoter methylation responsible for the down-regulation of DCC expression in oral squamous cell carcinoma. 12 of tissue specimens for the study are excised and gathered from 12 patients who are diagnosed as SCC in department of OMS, dental hospital, dankook university. To find expression of DCC in each tissue samples, immunohistochemical staining, RT-PCR gene analysis and methylation specific PCR are processed. The results are as follows. 1. In the DCC gene RT-PCR analysis, 5(41.6%) of 12 specimens of oral squamous cell carcinoma did not expressed DCC gene. 2. In the promoter methylation specific PCR analysis, 5(41.6%) of 12 specimens showed promoter methylation of DCC gene. 3. In the immunohistochemical staining of poor differentiated and invasive oral squamous cell carcinoma, loss of DCC expression was observed. These findings suggest that methylation of the DCC gene may play a role in loss of gene expression in invasive oral squamous cell carcinoma.
스네이크 패턴을 가진 대면적 판형 열교환기의 전열성능에 관한 연구
김정규(Jung-Kyu Kim),박재홍(Jae-Hong Park),조성열(Sung-Youl Cho),양명국(Myeong-Kuk Yang),허인은(In-Eun Hur),고성규(Seong-Kyu Ko),임혁(Hyug-Lim),현용익(Yong-Ik Hyun) 한국유체기계학회 2009 유체기계 연구개발 발표회 논문집 Vol.2009 No.-
In view of space saving, the design of more compact heat exchangers is important. Also, to meet the demands for saving energy and resources today, manufacturers have tried to enhance efficiency and reduce the size and weight of heat exchangers. Over the past decades, there have been tremendous advancements in the manufacturing technology of high efficiency heat exchangers. This has allowed the use of high performance(high heat transfer coefficient and low pressure drop) heat exchangers. Consequently, the use of high performance heat exchanger becomes popular in the design of heat exchangers. When compared with the well-established shell and tube heat exchangers, the plate heat exchanger shows a lot of advantages like high NTU values, compactness, low cost, multi duties and reduced fouling etc. For the higher performance in plate heat exchanger, the snake pattern in the heat transfer plate has been developed instead of the conventional herringbone pattern. The performance of the plate heat exchanger with snake pattern was evaluated by test, and provided in this paper.
알레르기 비염의 한의학적 분류를 위한 진단 평가지와 한의사 변증의 일치도 평가
이규진,김희택,장보형,최인화,고성규,Lee, Kyu-Jin,Kim, Hee-Taek,Jang, Bo-Hyeong,Choi, In-Hwa,Ko, Seong-Gyu 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.1
Objective : This study aimed to assessment for concordance rate in pattern analysis between pattern diagnosis of KiFDA on allergic rhinitis in 2008 and doctor of Korean medicine. Methods : Data were obtained from 35 patients with allergic rhinitis(AR). They were asked to perform the questionnaires and had been interviewed by specialist of Korean Medicine. For correlation analysis, we used Cohen's Kappa. Results : The pattern diagnosis was done only 15 patients(42.9%). Correlation between pattern diagnosis of questionnaires and specialist showed 0.2105 in Kappa and 0.1993 in weighed Kappa. Conclusions : The result may provide the basis of modification in Pattern Diagnosis of KiFDA on allergic rhinitis in 2008.
탁리소독음(托裏消毒飮) 합(合) 황련해독탕(黃連解毒湯)의 아토피피부염에 대한 실험적 연구
원영호,황충연,임규상,김종한,고성규,이부균,이동효,김남권,Weon, Young-Ho,Hwang, Chung-Yeon,Lim, Kyu-Sang,Kim, Jong-Han,Ko, Seong-Gyu,Lee, Boo-Kyun,Lee, Dong-Hyo,Kim, Nam-Kwen 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.1
Objective : This Experimental study was done to investigate the Effect of Taklisodok-um and Hwangryunhaedok-tang(TH) on Atopic Dermatitis. Methods : We assessed effects of TH on the IgE, IL-4, IL-5, IL-6, IgM, IgG1, IFN-${\gamma}$ in vivo, on the IL-4, IL-5, CCR3 in the skin tissues of ear and dorsum with NC/Nga mice. And we assessed effects of TH on the COX-2, IL-$1{\beta}$, TNF-${\alpha}$, IL-6 with RAW 264.7 cell. Results and Conclusion : 1. IgE, IL-4, IL-5, IL-6, IgM, IgGl levels in the serum of TH treated NC/Nga mouse group were decreased compared to the untreated control mice. IFN-r showed a increase in the experimental group compared to the untreated control group. The spleen weight of TH treated NC/Nga mice was decreased compared to the untreated control group. 2. mRNA expression levels of IL-4, IL-5 and CCR3 in the skin tissues of TH treated NC/Nga mice were decreased, and expression levels of IL-6 in the skin tissues of TH treated NC/Nga mice were decreased compared to the untreated control group. IFN-${\gamma}$ mRNA expression levels were increased compared to the untreated control group. 3. Judged from that IL-$1{\beta}$, TNF-${\alpha}$, IL-6 express of gene, effect of inflammatory Cytokines revelation were decreased compared to the untreated control group. 4. Depend on the strength of TH, inflammatory RAW 264.7 in the serum of TH were inhibited compared to the untreated control serum that leaded a COX-2 activity model. 5. Histological observation of the ear and skin tissues showed that the extents of inflammation and infiltrated immune cells in the epidermis and dermis of TH treated NC/Nga mice were highly reduced compared to the untreated control group.
이선동,안상우,권영규,고성규,신상우,배종면,Lee, Sun-Dong,Ahn, Sang-Woo,Kwon, Young-Kyu,Ko, Seong-Gyu,Shin, Sang-Woo,Bae, Jong-Myun 대한예방한의학회 2005 대한예방한의학회지 Vol.9 No.1
Subjects in this study comprised of general public (907), high school students (772), individuals associated with Oriental medicine (660), and 60 majoring in western medicine, totalling 2,413 individuals. Survey was conducted on the necessity of establishing Oriental medicine school at the national university level and the following result were obtained: - 78.3% (1847 individuals) were in favor of establishing Oriental medicine school at the national university level. - For the validity of establishment, responders expressed opinions of standard and virtuous education, higher quality education, standardized practice, research on difficult to cure diseases, and obtaining competitiveness in the world market. - One to three schools were considered as an appropriate number of schools with less than 80 students per class, Class size may be adjusted from existing schools (52.5% favored decrease in size) and (46.3% favored increase in size). - Educational and research facilities must be accopanied with schools of Oriental medicine as well as clinical training facilities, herbal pharmaceutical research centers, and fundamental medical centers. - Many favored 6 year curriculum as the most appropriate system and the school of Oriental medicine should be established within the university. Based on the information gathered in this survey, we may recognize the limitations of Oriental medicine schools at the private institutional level and support the establishment of Oriental medicine schools at th national university level. This establishment may play as a steeping stone for advancement in education, standardization of research and treatment, and commercialization of Oriental medicine of benefit the general public.
안진향,윤영희,김규석,장보형,고성규,최인화,Ahn, Jin-Hyang,Yun, Young-Hee,Kim, Kyu-Seok,Jang, Bo-Hyeong,Ko, Seong-Gyu,Choi, In-Hwa 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.1
Objective : We performed a literature review for developing the clinical phenotype evaluation system of atopic dermatitis.Methods : We searched the papers that describe symptoms for atopic dermatitis through Oriental Medicine Advanced Searching Integrated System(OASIS) and Korean Studies Incategoryation Service System(KISS). We looked through all the papers and finally chose 47 papers that are suitable for inclusion. Then, we extracted symptoms from these papers and arranged them in order of frequency and validity through experts' conference.Results : We found 360 papers and chose 47 papers. We decided to include general information of patients, systemic and dermatologic symptoms in evaluation category of atopic dermatitis. Through experts' conference, it was decided that general information has age, sex and body type; Systemic symptoms have 9 items; Dermatologic symptoms have 15 items.Conclusion : To evaluate atopic dermatitis objectively, the standardization of diagnostic tool is needed. Therefore we developed a clinical phenotype evaluation system of atopic dermatitis.
컴퓨터 단층촬영(OMU CT)을 통해 진단 평가된 비부비동염 5례
이규진,윤영희,최인화,고성규,Lee, Kyu-Jin,Yoon, Young-Hee,Choi, In-Hwa,Ko, Seong-Gyu 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3
Objective : The purpose of this study is to report the effect of Korean medicine treatment on rhinosinusitis by showing OMU(ostiomeatal unit) CT(computed tomography). Methods : The clinical study was done on 5 cases of rhinosinusitis patients diagnosed by OMU CT. The patients were treated with herbal medicine and acupuncture. OMU CT was taken after treatment. Results & Conclusions : After treatment, 5 rhinosinusitis patients were improved in symptoms and remarkable resolutions of rhinosinusitis in OMU CT were observed. These results suggest that Korean medical therapy could be a safe and effective intervention in rhinosinusitis and we need to have more studies for objective evaluations of Korean medicine treatment.
변증 설문지 문항을 통해 살펴 본 알레르기 비염 환자의 특성
손재웅,이규진,장보형,장수빈,고성규,최인화,Son, Jae-Woong,Lee, Kyu-Jin,Jang, Bo-Hyeong,Jang, Soobin,Ko, Seong-Gyu,Choi, In-Hwa 대한예방한의학회 2014 대한예방한의학회지 Vol.18 No.3
Objective : We performed a clinical study to investigate pattern characteristics in persistent allergic rhinitis depending on Korean Medicine pattern questionnaire items as a pattern identification diagnostic tool. Method : 32 patients with persistent allergic rhinitis were asked to interview with doctor of Korean Medicine and perform the 4 pattern questionnaires(Cold-Heat Pattern, Phlegm Pattern, Yin Deficiency pattern, bloodstasis pattern). Then, we analyzed the response rate of each pattern questionnaires. Results : After diagnosis of Korean Medicine Doctor's pattern identification, 17 individual items have higher response rate, 7 of 17 items have a common tendency in allergic rhinitis. The other 8 of 10 items belong to Lung qi deficiency cold and Lung-spleen qi deficiency group, these have higher tendency of deficiency. In bloodstasis pattern questionnaires, we don't decide the tendency of patients with allergic rhinitis. Conclusion : The result may provide that we don't use Korean Medicine pattern questionnaires as a major tool in the pattern identification of allergic rhinitis. Continuous studies are needed to develop the standardized pattern identification diagnostic tool.