Domain Adaptation 방법을 이용한 기계학습 기반의 미세먼지 농도 예측

강태천(Tae-Cheon Kang),강행봉(Hang-Bong Kang) 한국멀티미디어학회 2017 멀티미디어학회논문지 Vol.20 No.8

한국재래산양 코눈물관계통의 해부학적 및 방사선학적 연구

서강문,강태천,이흥식,이인세,남치주,Seo, Kang-moon,Kang, Tae-cheon,Lee, Heungshik S,Lee, In-se,Nam, Tchi-chou 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.1

This study was carried out to identify the gross anatomical and radiographic characteristics of the nasolacrimal system of the Korean native goat. The results were as follows : The nasolacrimal system are composed of two lacrimal ducts, two lacrimal, canaliculus, one lacrimal sac and one nasolacrimal duct. The nasolacrimal duct was divided into proximal, middle and distal portion. The nasolacrimal duct took a straight course to be paralleled with nasal bones and opened close to the nostril on the medial surface of the alar fold. The diameter of lacrimal punctum, the length of eyelid margin to lacrimal punctum, the length of canaliculus and the diameter of lacrimal sac were 0.82~0.90mm, 1.06~1.54mm, 5.65~6.30mm and 1.77~2.06mm, respectively. The length of proximal, middle and distal nasolacrimal duct were 36.84~40.00mm, 23.53~24.31mm and 14.55~14.73mm, respectively. The diameter of the orifice of nasolacrimal duct, the length of lateral margin of nostril to orifice of nasolacrimal duct and the length of dorsum to orifice of nasolacrimal duct were 1.29~1.33mm, 12.97~12.53mm and 15.24~16.11mm. The skull index of Korean native goat was not significantly different from the length of nasolacrimal duct.

한국재래산양 혀에 관한 형태학적 연구

이흥식,이인세,강태천,Lee, Heungshik S.,Lee, In-se,Kang, Tae-cheon 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.2

This studies were carried out to identify the characteristics of the tongue of Korean native goat(Capra hircus) by macroscopy, microscopy and scanning microscopy. Korean native goat had torus linguae, median lingual sulcus, lingual fossa and ventral median fissure but did not have glossoepiglottic fold and terminal sulcus in the tongue. The whole length of tongue was $11.51{\pm}0.76cm$. The length of tongue apex, tongue body, tongue root and the torus linguae were $2.62{\pm}0.28$, $7.39{\pm}0.27$, $1.56{\pm}0.26$ and $6.37{\pm}0.29cm$, respectively. The width of tongue apex, torus linguae and tongue root were $3.41{\pm}0.24$, $3.74{\pm}0.29$ and $3.68{\pm}0.11$, respectively. The thickness of tongue apex was $1.60{\pm}0.10$, and the height of torus linguae was $1.52{\pm}0.15cm$. Filiform papillae were present at the tongue apex and the tongue body rostral to torus linguae. Fungiform papillae were scattered from tongue apex to rostral portion of torus linguae, being in abundance at the tongue apex. Vallate papillae were showed at the lateral portion of torus linguae, while lentiform papillae were present at its central portion. Conical papillae were located between vallate and lentiform papillae. The numbers of filiform, fungiform, conical, vallate and lentiform papillae were $46,980{\pm}1070.98$, $446.8{\pm}36.97$, $818.4{\pm}43.99$, $34.8{\pm}2.77$, and $255.6{\pm}39.30$, respectively. The average numbers of taste bud were $8.3{\pm}2.04$ in a fungiform papilla and $247.3{\pm}37.44$ in a vallate papilla. The filiform papilla had secondary and tertiary papillae. The height of filiform papilla was about $150{\mu}m$ and the diameter was $100{\mu}m$. The diameters of fungiform papillae were 350 to $550{\mu}m$. The long and short diameters of maximum-sized lentiform papilla were 4000 and $3000{\mu}m$, respectively, while those of minimum-sized papilla were 700 and $600{\mu}m$, respectively. The height of conical papillae was 450 to $600{\mu}m$ and diameter was 250 to $450{\mu}m$. The vallate papilla was round or oval in shape and its diameter was 500 to $850{\mu}m$. It had well-developed papillary groove around itself. The modified conical papillae were not observed in the tongue of Korean native goat.

한국재래산양 혀에 분포하는 신경전달물질에 관한 면역조직화학적 연구

이흥식,이인세,강태천,Lee, Heungshik S.,Lee, In-se,Kang, Tae-cheon 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.2

This study was performed to identify the localization of several neuropeptides; calcitonin gene-related peptide(CGRP), substance P(SP), vasoactive intestinal polypeptide(VIP), neuropeptide Y(NPY), serotonin(5-HT) and neurotensin in the tongue of Korean native goat(Capra hircus) by immunohistochemical method. The results were summarized as follows: CGRP- and SP-immunoreactive fibers were observed as moderate immunoreactivity at the subepithelial plexus and subgemmal fibers in lamina propria of lingual papillae, but not seen in intragemmal, intergemmal, perigemmal fibers as well as in the supporting, basal and taste cells. Fibers around the acinus of the von Ebner's gland and blood vessels showed weak immunoreactivities against CGRP and SP. In the intrinsic ganglion cells, CGRP- and SP-immunoreactivities were not observed. The distribution patterns of VIP- and NPY-immunoreactive fibers were similar to CGRP-or SP-immunoreactive fibers, but their immunoreactivities were stronger than those of CGRP- or SP immunoreactive fibers. The immunoreactivities to VIP or NPY were seen in the intrinsic ganglion. Only a few serotonin immunoreactive fibers were seen in some filiform or fungiform papillae. Neurotensin immunoreactivity was not observed in the tongue of Korean native goat.

한국재래산양 뇌하수체의 성장자극세포 및 젖샘자극세포에 관한 면역조직화학적 연구

이인세,이흥식,강태천,서제훈,송승훈,남영삼,Lee, In-se,Lee, Heungshik S.,Kang, Tae-Cheon,Seo, Jehoon,Song, Seung-hoon,Nam, Young-Sam 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.3

The localizations and morphological characteristics of immunoreactive cells for prolactin(PRL) and growth hormone(GH) antisera were studied with double immunohistochemistry in the adenohypophysis of the Korean native goat. PRL immunoreactive cells(mammotropes) and GH immunoreactive cells(somatotropes) were present in the pars distalis and pars tuberalis, but not in the pars intermedia. A few cells were stained with both PRL and GH antisera (somatomammotropes). The possessional percentages of mammotropes, somatotropes and somatomammotropes were 37.0%, 32.6%, 1.0% in females and 35.6%, 32.6%, 1.1% in males, respectively. Mammotropes were oval or round in shape, and $10{\sim}20{\mu}m{\times}17{\sim}25{\mu}m$ in size. These cells were distributed throughout the pars distalis, but were more abundant on the dorsal part adjacent to the hypophyseal cavity and along the lateral and ventral peripheral regions. Somatotropes were elliptical, triangular or polygonal in shape, and $8{\sim}17{\mu}m{\times}17{\sim}18{\mu}m$ in size. The distribution pattern of somatotropes was similar to that of mammotropes. Some somatomammotropes were intercalated between clusters of mammotropes while the others were dispersed independently among the secretory cells.

한국재래산양 뇌하수체의 성샘자극세포에 관한 전자현미경적 연구

이인세,이흥식,강태천,원무호,Lee, In-se,Lee, Heungshik S.,Kang, Tae-cheon,Won, Moo-ho 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.4

Ultrastructures of hypophyseal gonadotropes were studied in the hypophysis of the Korean native goat by electron microscopic immunohistochemistry with antisera to follicle stimulating hormone(FSH) and luteinizing hormone(LH). 1. Gonadotropes in the adenohypophysis were observed in the pars distalis and the pars tuberalis, but not in the pars intermedia. 2. FSH cells were round or oval in shape, and contained two types of round secretory granules, i.e., small and large granules. Small secretory granules were electron-dense and 180-275nm in diameter. Large secretory granules were less electron-dense than small granules and 485-555nm in diameter. 3. LH cells were round or oval in shape and also contained two types of secretory granules, the size of which were smaller than that of FSH cells. Small secretory granules were electron-dense and 160-230nm in size. The size of large secretory granules were 315-415nm with moderate electron densities.

한국재래산양 췌장의 insulin, glucagon, somatostatin 및 pancreatic polypeptide 분비세포에 관한 면역조직화학적 연구

이흥식,이인세,강태천,김진상,이성준,Lee, Heungshik S.,Lee, In-se,Kang, Tae-cheon,Kim, Jin-sang,Yi, Seong-joon 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.1

Pancreatic endocrine cells containing glucagon, insulin, somatostatin and pancreatic polypeptide were identified in the pancreas of the Korean native goat by using immunohistochemical method. Glucagon immunoreative cells were oval or fusiform in shape and located at the periphery of the pancreatic islets. Insulin immunoreactive cells were round or oval in shape and occupied throughout the pancreatic islets except the small area of the periphery. Somatostatin immunoreative cells were oval and elliptical, and mainly located at the periphery of the pancreatic islets. Some of these cells had a cytoplasmic process. Pancreatic polypeptide immunoreactive cells were elliptical or polyhedral and located at the periphery of the pancratic islets where two or more cells formed a cell cluster. The distribution rates of glucagon, insulin, somatostatin and pancreatic polypeptide immunoreactive cells were 24.4%, 44.3%, 13.2% and 18.1% respectively.

한국재래산양 췌장의 insulin, glucagon, somatostatin 및 pancreatic polypeptide 분비세포에 관한 전자현미경적 연구

이흥식,이인세,강태천,원무호,이성준,Lee, Heungshik S.,Lee, In-se,Kang, Tae-cheon,Won, Moo-ho,Yi, Seong-joon 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.1

Ultrastructures of pancreatic endocrine cells containing glucagon, insulin, somatosratin and pancreatic polypeptide were studied in the pancreas of the Korean native goat by immunohistochemical and elecron microscopy. Glucagon immunoreatctive cells were round or fusiform in shape and contained secretory granules of 200-260 nm in diameter. The secretory granules were high in electron density and had a halo between the limiting membrane and the central granule core. Insulin immunoreactive cells were round or oval in shape, and contained various sizes of secretory granules from 135 to 300 nm in diameter. The secretory granules were low or moderate electron density and had a variform halo. Somatostatin immunoreactive cells were elliptical or fusiform shape with cytoplasmic processes. They contained the secretory granules of 140-320 nm with moderate electron densities. Pancreatic polypeptide immunoreactive cells were elliptical or fusiform and contained small secretory granules with high electron densities. The secretory granules were 120-230 nm in diameter and the least in number.

한국재래산양 골성골반계측에 대한 해부학적 연구

이성준,이흥식,강태천,Yi, Seong-joon,Lee, Heungshik S,Kang, Tae-cheon 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.3

This study was carried out to observe the differences of bony pelvis between male and female Korean native goat by the pelvimetry. The results represented that the middle transverse diameter(1:1.35), ventral transverse diameter(1:1.12), transverse diameter of pelvic outlet(1:1.22), right oblique diameter(1:1.09), the width between ruber ischii(1:1.15) and width of pubis(1:1.11) were shown significant differences(p<0.01) between male and female Korean native goat.

Autometallography for Zinc Detection in the Central Nervous System

조승묵,김성준,박승국,강태천,원무호,Jo, Seung-Mook,Gorm, Danscher,Kim, Sung-Jun,Park, Seung-Kook,Kang, Tae-Cheon,Won, Moo-Ho Korean Society of Electron Microscopy 2000 Applied microscopy Vol.30 No.4

Zinc는 인체 내에 철$(Fe^{2+})$다음으로 많은 trace element로서 200여개 효소의 기능에 필수적일 뿐만 아니라 신경계통내에서는 신경조절물질로 작용한다. 뿐만 아니라 허혈, 간질 및 퇴행성 뇌질환의 주요 병리기전에도 관여되어 있다. 그러나 대부분의 Zinc는 단백질에 결합되어 (bound form)신경세포의 세포질 및 핵질내에 존재하고, 10% 이하의 Zinc는 이온상태(free form, $Zn^{2+}$)로 신경종말 (Zinc enriched terminal)에 있는데 , 후자만이 조직화학법으로 가시화된다. 최근까지 새로 개발된 조직화학법으로 Zinc enriched(ZEN)neurons의 분포에 관한 연구가 각광받고 있으나, 국내에서는 이에 대한 연구가 전무한 실정이다. 이에 본 연구자는 고전적인 조직화학법의 기본 원리를 소개하고, 렛드 중추신경계통내 Zinc의 분포를 광학 및 전자현미경으로 관찰하고자 하였다. 본 연구에서 사용된 실험동물은 Wistar 계통의 랫드(10주령)와 BALB/c 마우스이며, 마취제로는 Pentobarbital(50mg/kg)을 이용하였다. 생체 뇌조직내 이온상태의 $Zinc(Zn^{2+})$를 침전시키기 위하여 selenium(10mg/kg, i.p.)을 처리하였고, 1시간 후 3% Glutaraldehyde액으로 관류고정하여 동물을 희생시켰다. 뇌와 척수를 꺼내어 sucrose에 가라앉을때 까지 담가두었다가 Dry Ice를 이용하여 얼리고, Freezing microtome위에서 $30{\mu}m$두께의 절편을 작성하였다. 조직절편내 $Zn^{2+}$을 동정하기 위한 조직화학법으로는 autometallography (AMG) (Danscher, 1985)를 이용하였다. 광학현미경하에서 밝혀진 Zinc의 분포는 해마복합체를 비롯한 종뇌의 여러부위에 고농도로 분포하였고, 척수에는 중간정도, 그리고 소뇌 및 뇌간에는 매우 낮은 농도로 분포하였다. 전자현미경에서 관찰된 AMG염색과립(silver grains)은 신경종말에 있는 연접소포에 국한되었으며, 이러한 ZEN terminals은 주위 여러 신경세포의 돌기(dendrites)및 세포체 (soma)에 특이한 연접을 이루고 있었다. 즉 후각망울을 포함한 종뇌에서는 주로 비대칭연접 (asymmetrical synapses)이 관찰되었던 반면에, 척수에서는 대칭연접(symmetrical synapses)을 이루고 있었다. 이상의 결과를 종합하면, 신경종말내 연접소포에 Zinc를 함유하고 있는 소위 ZEN terminals은 중추신경계통에 광범위하게 분포하고 있으며 또한 신경부위에 따라 다양한 분포와 미세구조의 차이를 보였다. 이러한 사실은 중추신경계통내에서 Zinc가 영위하는 신경생물학적 기능이 신경부위에 따라 다양할 것임을 시사한다. Zinc is one of the most abundant oligoelements in the living cell. It appears tightly bound to some metalloproteins and nucleic acids, loosely bound to some metallothioneins or even as free ion. Small amounts of zinc ions (in the nanomolar range) regulate a plentitude of enzymatic proteins, receptors and transcription factors, thus rolls need accurate homeostasis of zinc ions. Zinc is an essential catalytic or structural element of many proteins, and a signaling messenger that is released by neural activity at many central excitatory synapses. Growing evidences suggest that zinc may also be a key mediator and modulator of the neuronal death associated with transient global ischemia and sustained seizures, as well as perhaps other neurological disease stoles. Some neurons have developed mechanisms to accumulate zinc in specific membrane compartment ('vesicular zinc') which can be evidenced using histochemical techniques. Substances giving a bright colour or emitting fluorescence when in contact with divalent metal ions are currently used to detect them inside cells; their use leads to the so called 'direct' methods. The fixation and precipitation of metal ions as insoluble salt precipitates, their maintenance along the histological process and, finally, their demonstration after autometallographic development are essential steps for other methods, the so called 'indirect methods'. This study is a short report on the autometallograhical approaches for zinc detection in the central nervous system (CNS) by means of a modified selenium method.