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Giant Synovial Chondromatosis of the Knee Mimicking a Parosteal Osteosarcoma: A Case Report
강창호,박종훈,이대희,김철환,박정미,이원석,Kang, Chang-Ho,Park, Jong-Hoon,Lee, Dae-Hee,Kim, Chul-Hwan,Park, Jeong-Mi,Lee, Won-Seok The Korean Musculoskeletal Tumor Society 2010 대한골관절종양학회지 Vol.16 No.2
Synovial chondromatosis is a benign nodular cartilaginous proliferation arising in the synovium of joints. The radiolographic features of this condition are variable. Rarely, it would be confused with malignancy such as chondrosarcoma, osteosarcoma or synovial sarcoma. We report a case of primary synovial chondromatosis of the posterior aspect of the proximal tibia mimicking a parosteal osteoarcoma on the radiography, which showed a homogeneously radiopaque juxtacortical mass. However, subsequent computed tomography (CT) showed multiple intra-articular masses containing chondroid mineralization, suggesting synovial chondromatosis. 활액막성 연골종증은 관절 활액막으로부터 기원하는 증식성의 결절성 연골성 양성 종양이다. 영상의학적 소견은 다양하게 나타나는데 드물게 연골육종, 골육종 그리고 활액 육종과 같은 악성 종양과의 감별을 요하는 수가 있다. 저자들은 컴퓨터 단층 촬영에서는 관절 내 다 발성의 연골성 무기질침착이 뚜렷한 종괴로 인해 활액막성 연골종증을 예상할 수 있으나, 단순 방사선 소견 상 피질골에 근접하고 균질한 방사선비투과의 모습을 보여 방골성 골육종과 유사해 보이는 근위 경골의 후면에 발생한 원발성 활액막성 연골종증 1예를 보고한다.
강창호,오수지,소재성,Kang, Chang-Ho,Oh, Soo Ji,So, Jae-Seong 한국미생물학회 2013 미생물학회지 Vol.49 No.2
비브리오균은 해양 및 하구 환경에서 상재하는 균으로 그람 음성 간균, 호염성, 비포자형성의 특징을 가지고 있다. 질병과 관련된 균주로는 Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio cholera 등이 있다. 매년 어패류의 섭취 등을 통해 식중독 사고가 빈번하게 발생하고 있으며, 이에 본 연구에서는 서해안 6곳에서 패류를 채취하여 비브리오균의 분포도를 모니터링하고, 이들의 항생제 내성을 분석하였다. 총 120건의 패류를 TCBS 평판배지와 API 20E kit 기법으로 동정하였을 때 23.3%의 시료에서 비브리오균이 검출되었다. 이들 분리균주들의 항생제 내성을 16종의 항생제에 대해 분석한 결과 82.1%가 각각 vancomycin과 ampicillin에 대해 내성을 보였고, rifampin (71.4%)과 cephalothin (53.6%)에 대한 내성비율도 다른 항생제들에 비해 상대적으로 높은 것으로 나타났다. 분리균주들의 항생제 감수성은 chloramphenicol (92.9%), sulfamethoxazole/trimethoprim (92.9%)과 tetracycline (96.4%)에 대해 가장 높았다. 분리균주들의 약 71.4%가 vancomycin과 ampicillin을 포함하여 3개 이상의 항생제에 대해 다중내성을 보였다. Bacteria of genus Vibrio are Gram-negative, curved, halophilic, nonspore-forming bacteria, autochthonous inhabitans of the marine and estuarine environments. Some of the Vibrio species such as V. parahaemolyticus, V. vulnificus, and V. cholerae are associated with human disease. Each year many people have been suffering from food-borne disease caused by the ingestion of seafood. In this study, we have monitored antibiotic resistance of this microorganism in 6 coastal areas of West Sea by sampling shellfish monthly. Vibrio spp. were detected from 23.3% of 120 samples analyzed using TCBS agar plates as well as API 20E kit. Among 16 antibiotics tested, resistance to vancomycin and ampicillin was observed in 82.1% of the isolates, and Vibrio spp. resistant to rifampin (71.4%) and cephalothin (53.6%) were also high. Most of the isolates were sensitive to chloramphenicol (92.9%), sulfamethoxazole/trimethoprim (92.9%), and tetracycline (96.4%). About 71.4% of the isolates showed multiple drug resistance toward 3 antibiotics including vancomycin and ampicillin.
강창호 ( Chang-ho Kang ),조상영 ( Sang-young Cho ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.2
최근에 다기능 복합화되는 임베디드 시스템을 위한 가상화 연구가 활발하다. 본 논문에서는 L4 마이크로커널을 기반으로 한 실시간 운영체제 MicroC/OS-II 가상화를 위한 L4 환경에서의 전체 구성, 인터럽트 핸들링, 게스트 운영체제 초기화 과정의 설계에 대해 기술한다.
유산균의 생존율 향상을 위한 동결건조보호제로서 호박분말의 효과
강창호(Chang-Ho Kang),김용경(YongGyeong Kim),한설화(Seul Hwa Han),김진성(Jin-Seong Kim),정율아(Yulah Jeong),백남수(Nam-Soo Paek) 한국생물공학회 2017 KSBB Journal Vol.32 No.4
Food-grade protective agents such as sucrose, skim milk, and pumpkin powder were studied for their ability to improve the viability of freeze-dried lactic acid bacteria, including Lactobacillus plantarum MG989, L. fermentum MG901, Streptococcus thermophilus MG5139, Lactococcus lactis MG534, Enterococcus faecium MG89-2, and Bifidobacterium animalis ssp. lactis MG741. The best results were obtained with 5% sucrose contained 10% skim milk and 2% pumpkin powder; approximately 43.1 to 86.6% cell viability was observed during the freeze-drying process. During accelerated storage of freeze-dried lactic acid bacteria, those survival rate decrease rapidly, reaching 9.8~35.2% in 1 month. As a result, the group (5% sucrose, 10% skim milk, and 2% pumpkin powder) showed the protective effect much higher by 639.5% than the control group (5% sucrose and 10% skim milk). These results suggested that pumpkin powder was good candidate as a potential cryoprotectant agent.
독활(Aralia cordata Thunb) 추출물의 Nitric Oxide Synthesis 저해효과
강창호(Chang-Ho Kang),구자룡(Ja-Ryong Koo),소재성(Jae-Seong So) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.5
Assessment was made of the effects of Aralia cordata Thunb (DH) on the cell proliferation, inducible nitric oxide synthase (iNOS) mRNA gene expression and nitric oxide (NO) production in RAW 264.7 macrophage cells. For the screening of anti-inflammatory activities, ethanolic extracts of 55 species of traditional herbal medicines were examined for inhibitory effects, and it was confirmed that DH possessed inhibitory effects on NO production. As a result, DH significantly decreased the production of NO and iNOS gene expression at a concentration of 250 μg/mL. The chloroformsoluble fractionates have the strongest No synthesis inhibitory effect. It is presumed that the inhibition of NO production in LPS-stimulated RAW 264.7 cells by DH components occurred via the modulation of iNOS and DH, and that the active compound from DH may be useful for therapeutic management of inflammatory-associate diseases.
강창호(Chang-Ho Kang),구자룡(Ja-Ryong Koo),조규섭(Guey Seob Cho),허태련(Tae-Ryeon Heo),소재성(Jae-Seong So) 한국생물공학회 2014 KSBB Journal Vol.29 No.2
Gang-Hwa Getbul eel is a well known well-being food in the Korean food industry. In this study it was undertaken to analyze crude compositions, minerals, and vitamins of Gang-Hwa Getbul eel. As a result of initial analysis, the ranges of moisture, crude protein, crude fat, and crude ash were 56.6±0.0, 17.3±0.4, 14.4±2.9, and 1.2±0.1%, respectively. Regarding mineral compositions, the concentration ranges of Ca, Fe, Mg, P, K and Na were 413.8±91.1, 0.8±0.1, 29.5±7.8, 361.9±118.4, 116.4±43.3, and 131.8±42.4 mg/100 g, respectively. Finally vitamin A was found being present at 2571.3±194.6 I.U/100 g.
딱지꽃 (Potentilla chinensis) 추출물의 항염증 효과
강창호(Chang-Ho Kang),한상현(Sang-Hyun Han),소재성(Jae-Seong So) 한국생물공학회 2013 KSBB Journal Vol.28 No.1
In this study, we investigated the anti-inflammation effect of Potentilla chinensis (PC) on Raw264.7 macrophage cells. Ethanol extract of PC decreased the production of nitric oxide (NO) in LPS-stimulated RAW264.7 cells. Ethanol extract was fractioned by n-hexane, chloroform, ethyl acetate, n-butanol, water and each fraction was tested for inhibitory effects on inflammation. Among the sequential solvent fractions, PC chloroform extracts (50, 100, 300, and 500 μg/mL) significantly suppressed LPS-stimulated production of NO. During the entire experimental period, 200 and 300 μg/mL of PC chloroform extracts had no cytotoxicity. LPSinduced NO and prostaglandin E2 (PGE2) production were inhibited by PC chloroform extracts up to 50% and 90% of these productions, respectively. PC chloroform extracts reduced the expression of iNOS and COX-2 gene. These results suggest that PC chloroform extracts exhibit strong effects of anti-inflammation and can be a potential candidate in the treatment of acute and chronic inflammatory diseases.
한국인 여성 및 식품 유래 유산균의 생리적 특성 및 지방분화 억제효과
강창호(Chang-Ho Kang),정율아(Yulah Jeong),한설화(Seul Hwa Han),김진성(Jin-Seong Kim),김용경(YongGyeong Kim),박혜민(Hye Min Park),최수임(Soo-Im Choi),백남수(Nam-Soo Paek) 한국생물공학회 2018 KSBB Journal Vol.33 No.3
Obesity is the most common health problem in developed countries and is considered a significant risk factor for many major human diseases. This study aimed to evaluate the inhibitory effect of lactic acid bacteria isolated from the human vagina and shellfish on adipocyte differentiation in 3T3-L1 preadipocytes. The activity of separated 221 strains on pancrease lipase was measured and 15 strains were first screened. The level of adipogenesis of these strains in the 3T3-L1 cells was measured by Oil Red O staining assay. Five strains including Lactobacillus plantarum (2 strains) and L. fermentum (3 strains) showed good adipocyte differentiation inhibitory activity. Also, the selected strains were resistant to bile acid up to 3% and their autoaggregation rates were as high as 50%. These Lactobacillus strains with probiotics potential may be useful for prevention or treatment of obesity, but further in vitro and in vivo studies on these strains are still required.