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천포창, 물집유사천포창 및 후천물집표피박리증 병변부 조직에서의 세포자멸사 발현에 관한 연구
오지구 ( Ji Goo Oh ),강주형 ( Joo Hyoung Kang ),황세진 ( Se Jin Hwang ),황규왕 ( Kyu Uang Whang ),이창우 ( Chang Woo Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.8
Background: Apoptosis, or programmed cell death, may participate with pathogenesis of intercellular detachment and loss of cell-matrix interaction. Autoimmune bullous dermatoses is an entity charaterized by bullous lesions of the skin and mucosa, and autoantibodies to the specific tissue components. Objective: The purpose of this study was to investigate the induction of apoptosis in the lesional skin of pemphigus vulgaris (PV), pemphigus foliaceus (PF), bullous pemphigoid (BP), and epidermolysis bullosa acquisita (EBA). Methods: Hoechst 33342 (bisbenzimide) staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was performed to determine the induction of apoptosis in the lesional skin of each disease. Results: In PV and PF, typical findings of apoptosis were observed in the lesional epidermis showing acantholysis. However, in BP and EBA, no apoptosis of the epidermis was observed. Conclusion: These results suggest that apoptosis is only associated with acantholysis of the epidermal keratinocytes, one of many components of pathogenesis in bullous disease, in patients with pemphigus. (Korean J Dermatol 2006;44(8):942~949)
임수진 ( Su-jin Lim ),임병란 ( Byung-Ran Lim ),이한샘 ( Han-saem Lee ),강주형 ( Joo-hyoung Kang ),안태웅 ( Tae-ung Ahn ),신현상 ( Hyun-sang Shin ) 한국물환경학회(구 한국수질보전학회) 2021 한국물환경학회지 Vol.37 No.4
This study investigated the pollution characteristics of the main pollution zone in the Hwangguji watershed and the influence of the tributary on the main stream. The characteristics of the main pollution zone, including, the water quality index (WQI), stream rating, load duration curve (LDC), delivery load density (DLD), and contribution of the tributary to the mainstream, were evaluated by time-series visual heatmap. The WQI of the mainstream of Hwangguji was lowered to the poor (IV) level from the inflow point of Suwon stream (SW) and the LDC excess rate in the T-P was higher than that of BOD<sub>5</sub>, especially for the wet season, suggesting that management of non-point source with T-P is preferred. The contribution (%) of the tributaries in the upstream section of Hwangguji watershed were BOD<sub>5</sub> 14.54%, TOC 15.67%, T-N 5.43%, and T-P 6.97%. In particular, the Suwon sewage treatment plant located in the mainstream showed a high contribution of BOD<sub>5</sub> (64.40%) and T-P (53.54%), respectively, due to the high discharge rate (6.019 ㎥/sec). Meanwhile, Sammi and Gal stream have a large impact on the mainstream with high DLD and poor WQI. Thus, both streams were considered as pollution hot spots. These results provide useful basic data for preparing more effective water quality improvement and management plans in the watershed.