미만성 침윤성 폐질환의 진단: HRCT와 단순흉부X선사진의 비교

김경아 ( Kyeong Ah Kim ),강은영 ( Eun Young Kang ),오유환 ( Yu Whan Oh ),김정숙 ( Jeung Sook Kim ),박재성 ( Jai Soung Park ),이경수 ( Kyung Soo Lee ),강경호 ( Kyung Ho Kang ),정규병 ( Kyoo Byung Chung ) 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.3

남일 돌연변이 후대계통 Namil(EMS)-bl10,bph1의 도열병 및 벼멸구 저항성에 대한 유전분석

조성우(Seong-Woo Cho),정지웅(Ji-Ung Jeung),신영섭(Young-Seop Shin),강경호(Kyung-Ho Kang),이상복(Sang-Bok Lee),김보경(Bo-Kyeong Kim) 한국육종학회 2014 한국육종학회지 Vol.46 No.3

Rice is a source of food supply as the staple food. The narrow genetic diversity of Korean Japonica cultivars is prone to be susceptible to abiotic and biotic stresses such as rice blast, bacterial blight, and brown planthopper (BPH). The best approach for prevention of the breeding and extermination of disease and insect pest would be the development of rice cultivars harboring multiple disease and insect pest resistance genes. National Institute of Crop Science (NICS) in Korea developed a mutant line, Namil(EMS)-bl10,bph1, by using ethyl-methane-sulfonate (EMS) as the chemical mutagen on the wild type, Namil. The mutant line exhibits strong resistance levels against rice blast and brown planthopper. To localize favorable mutated allele types, two mapping populations were constructed by using F2 progenies derives crosses between Namil(EMS)-bl10,bph1 andMilyang23 and Namil (wild type) and Milyang23. Each F2 progenies were evaluated in terms of DNA marker genotype as well as agronomic traits measured, and for rice blast and BPH resistance, virulent blast isolate 94-254 and Korean biotype of BPH were used to screen F2:3 seedlings to conduct association analysis between marker genotype and evaluated phenotype of progeny lines. Through comparisons on major loci between two mapping populations, the putative major loci for rice blast resistance (RM1337, R2=54.4%) and BPH (RM0277, R2=55.1%) were primarily localized on chromosome 12.

벼 생태형별 아프리카인의 쌀 외관품질 및 밥맛 선호도 평가

이점식 ( Jeom Sig Lee ),이정희 ( Jeong Heui Lee ),윤미라 ( Mi Ra Yoon ),곽지은 ( Jieun Kwak ),천아름 ( Areum Chun ),강경호 ( Kyung Ho Kang ),정지웅 ( Ji Ung Jeung ),전재범 ( Jaebuhm Chun ),김보경 ( Bo Kyeong Kim ) 한국국제농업개발학회 2014 韓國國際農業開發學會誌 Vol.26 No.3

The objective of this study was to evaluate grain appearance and cooked rice taste preferred by Africans for the rice ecotype of one Japonica variety, one Indica variety, and two varieties of Tongil type as compared with Korean’s preference. The preferred grain appearance by Africans who have participated as panelists was in the order of grain length, aroma, and shape, while Korean preferred rice quality in the order of appearance(head rice) and grain length. Africans preferred imported Indica rice from Thailand the most, while Korean preferred Japonica Haimi the most. Overall, African preferred aromatic rice with long grain, while Korean preferred short grain rice with high head rice ratio. In the evaluation of cooked rice taste, there was no significant statistical difference between varieties preferred by Africans. Whereas, Koreans showed clear preference in the order of Haiami > Dasan 1 = Hanareum > Indica rice. The preference analysis results of cooked rice taste subjected to Japonica and Indica which showed clear preference by Koreans revealed that Africans from Cameroon, DR Congo, and Tanzania preferred Haimai. Meanwhile, the Africans from Uganda, Mali, and Nigeria preferred imported Indica rice from Thailand. The Africans from Kenya, Malawi, Ghana, and Sudan showed similar preference among Japonica and Indica varieties. The study results indicated that Africans had different preference of cooked rice taste for eco-type rice varieties by different nations. It is regarded that additional research would be conducted to evaluate cooked rice taste by the appropriate numbers of panelists from various field and by the various rice varieties including rice variety preferred by different African countries.

우리나라 일차 진료의사의 만성폐쇄성폐질환(COPD) 진료실태조사

박명재 ( Myung Jae Park ),최천웅 ( Cheon Woong Choi ),김승준 ( Seung Joon Kim ),김영균 ( Young Kyoon Kim ),이승룡 ( Sung Yong Lee ),강경호 ( Kyung Ho Kang ),신경철 ( Kyeong Cheol Shin ),이관호 ( Kwan Ho Lee ),이진화 ( Jin Hwa L 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: COPD는 전세계적으로 유병률, 이환율 및 사망률이 급격히 증가하는 질환으로 환자의 삶의 질을 호전 시키고 사회, 경제적인 질병부담을 줄이기 위해 경증 COPD 환자를 조기에 진단하여 적절히 치료하는데 일차진료의사의 역할이 중요하다. 근거중심을 바탕으로 개발된 GOLD와 같은 COPD 진료지침은 이 목적을 위해 유용하나 우리나라의 진료실태가 반영되지 않은 문제점이 있다. 근거중심을 바탕으로 우리나라 진료실정이 반영된 진료지침을 개발하기 위해 우리나라 일차진료의사들의 진료 실태를 조사하여 보고한다. 방법: 진료실태는 웹을 기반으로 COPD의 진단, 치료, 위험인자, 교육, 진료지침에 대한 25개의 설문을 포함 제작하였고 총 217명의 일차진료의사가 설문조사에 동의하고 참여하였다. 참여자의 의사경력은 평균 17.7년이며 76.5%가 내과를 전공하였고 지역적으로는 63.6%가 서울, 경기지역에서 진료를 하고 있었다. 결과: 비교적 높은 비율(61.8%)로 폐기능검사기를 보유하고 있지만 실제 진료 시 활용도는 낮은(35.8%) 편임을 알 수 있었다. 안정 시, 급성악화 시 COPD의 치료에서 경구제제의 처방빈도가 흡입제제에 비해서 모두 높았다. COPD의 주요 위험인자인 흡연에 대해서는 흡연여부 확인율, 금연권유율 등이 90% 이상으로 높았으나 금연을 위한 처방에서 금연 성공률이 높은 니코친대체제와 부프로피온의 병용 처방률이 4.3%로 낮았다. COPD 진료지침에 대한 인지도는 56.7%였고 그대로 따르는 경우는 7.3%로 국내 진료실태를 반영한 진료지침의 개발이 요구되며 진료지침의 보급과 확산을 위해서는 진료지침책자를 포함한 인쇄자료의 보급이 효과적임을 알 수 있었다. 결론: 우리나라 일차진료의사들의 COPD 진료실태는 진단에서 폐기능검사의 보유율에 비해 사용률이 낮고 치료에서 흡입제에 비해 경구제제의 처방을 선호하는 경향을 보였다. GOLD 진료지침에 대한 인지도는 높으나 그대로 따르는 일차진료의사는 적으므로 이번 진료실태조사 결과를 바탕으로 근거중심이지만 국내실정을 반영한 COPD 진료지침의 개발 및 보급이 필요하리라 생각된다. Background: The incidence of chronic obstructive pulmonary disease (COPD) is increasing and the disease is becoming an important cause of morbidity and mortality worldwide. It is important to implement evidence-based guidelines by primary care physicians (PCPs) to establish qualified management of COPD patients. The aim of this survey is to investigate the pattern of COPD management among PCPs and to apply it to the development of Korean COPD guidelines. Methods: A web-based questionnaire was prepared that consisted of 25 questions on the pattern of COPD management. A total of 217 PCPs participated in the survey from June 2006 to May 2007. Results: Many PCPs (61.8%) possessed a spirometer, but the application rate was relatively low (35.8%) and more than half of the COPD patients (57%) did not receive a diagnosis based on spirometry. Administration of oral medication was preferred than the administration of inhaled medication for both stable COPD and acutely exacerbated COPD. More than 90% of the PCPs endorsed educational measures to quit smoking and vaccinate against influenza. It was noted that 56.7% of the PCPs were aware of the GOLD guidelines, but only 7.3% tended to fully implement the recommendations of the guidelines in daily practice. Conclusion: The results of the survey indicate that despite the high awareness rate of the current COPD guidelines, deficits exist among the PCPs with respect to the diagnosis and treatment of COPD. The results of this survey should be applied for the development of new COPD guidelines in order to decrease the discrepancy between the guidelines and the daily practice of the PCPs. (Tuberc Respir Dis 2008;64:109-124)

광범위한 폐정맥 폐쇄와 동반된 원발성 폐동맥 고혈압 1 예

김영훈,김혜경,강경호,진동규,오동주,박창규,심완주,박정의,서홍석,노영무,임도선 대한내과학회 1993 대한내과학회지 Vol.45 No.3

Primary pulmonary hypertension has been subdivided into several subsets, including plexogenic, theromoembolic, pulmonary veno-occlusive disease, and others. Pulmonary veno-occlusive disease (PVOD) is one of the least cause of clinical pulmonary hypertension, with approximately 100 patients reported in would medical literature, and no case reported in Korea. Here we report on a 35-year-old woman had primary pulmonary hypertension presenting with massive hemoptysis and secondary atelectasis. Her simple chest x-ray, C-T scan, pulmonary angiogram and cardiac catheterization findings were compatible with typical primary pulmonary hypertension, except elevated pulmonary capillary wedge pressure up to 26 mmHg. that was pathognomonic feature of pulmonary veno-occlusive disease subset of primary pulmonary hypertension. The laboratory findings were compatible with primary pulmonary hypertension and could rule out the secondary pulmonary hypertension and other cardiac diseases. Left lingular segment atelectasis due to massive hemoptysis clots was resolved by removal of large blood clots by bronchoscopy. Her pulmonary artery pressure was not response to the vasodilator trials including nifedipine and captopril. We report a case of PVOD with a review of the literature.

기관지천식의 중증도에 따른 안지오테신 전환효서 유전자 다형에 관한 연구

한선애,이신형,심재정,유세화,조재연,차대룡,이상엽,강세용,강경호,인광호 대한알레르기학회 1998 천식 및 알레르기 Vol.18 No.4

Background: The angiotensin-converting enzyme (ACE) has a major role in the degradation of bradykinin, tachykinin, substance P which are associated with bronchial hyperresponsiveness and inflammation. The other role of ACE is the genesis of angiotensin II which causes bronchial smooth muscle contraction. The deletion polymorphism of ACE gene(DDtype) may be related to the high serum level of ACE. Objective: We studied to evaluate an association between the insertion /deletion polymorphism of the ACE gene and asthma, and its severity. Materials and methods: Sixty asthmatic patients and 44 healthy controls were enrolled. Severity of asthma was classified by the guideline of NHLBI/WHO workshop. The ACE genotypes of all the subjects were determined by polymerase chain reaction. Results: The distribution of ACE genotypes were not significantly different between healthy controls and asthma group (p)0.05). In asthmatic patients, the genetic polymorphism was similar between different severity groups (p) 0.05). Conchcsion: It is suggested that I/D polymorphism of the ACE gene may not be associated with development of asthma. The severity of asthma may not be influenced by I/D polymorphism of the ACE gene.