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- 저자 : 강경아 ( Kyoungah Kang ) (검색결과 3 건)
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6-Hydroxydopamine로 유도된 In Vitro 파킨슨병 모델에서 토란추출물의 Brain Resilience에 미치는 영향
조혜영(Cho Hyeyoung),강경아(Kang Kyoungah) 한국기초간호학회 2020 Journal of korean biological nursing science Vol.22 No.4
Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce a neuroinflammatory reaction and the in vitro Parkinson’s disease model, SH-SY5Y cells were stimulated with lipopolysaccharide (LPS) and 6-OHDA, respectively. After that, cells were treated with at various concentrations (1, 5, and 10 mg/mL) of taro extract. Then nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), interleukin (IL)-6, synaptophysin (SYP) and growth associated protein (GAP)-43 messenger ribonucleic acid (mRNA) expression level were measured. Results: Taro extract significantly suppressed LPS-induced NO production. Meanwhile, iNOS and IL-6 mRNA expression decreased in a dose-dependent manner. In addition, taro increased the mRNA expression of SYP and GAP-43 mRNA. Conclusion: These findings indicate that taro played an important role in brain resilience by inhibiting neuronal cell death and promoting neurite outgrowth, synaptogenesis, and neural plasticity. The results of this study suggest that taro may contribute to the prevention of neurodegenerative disease and become a new and safe therapeutic strategy for Parkinson’s disease.
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정맥주사 투여 시 대상자가 인지하는 통증, 우울 및 불안과의 관계
김희정(Kim Heejeong),정승교(Chaung Seung Kyo),김경희(Kim Kyunghee),강경아(Kang Kyoungah) 기본간호학회 2007 기본간호학회지 Vol.14 No.3
Purpose: The purpose of this study was to identify factors that have an influence on the pain which patients recognize when receiving an intravenous injection. Method: Participants were 111 patients who were admitting to C University Hospital. The collected data were analyzed using the SPSS 11.0 program. Results: For the participants, factors related to administration of medication were the following: Phlebitis scale, who administers the Ⅳ injection, failure to complete the Ⅳ injection, explaination of the Ⅳ injection and rate of injection. Level of pain, depression and anxiety in the participants was as follows: Pain (4.86±2.09), depression (35.76±9.91), anxiety (32.34±8.87). There were positive correlations between pain and depression (r=.437, p<.000), between pain and anxiety (r=.478, p<.000), and between depression and anxiety (r=.544, p<.000). Conclusion: Such findings provide new insights into the dynamic relationships between depression, anxiety and pain which patients recognize when having an intravenous injection. Further studies should be conducted to establish the causal relation between depression, anxiety and pain and to determine appropriate nursing interventions.
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문지영 ( Jiyoung Moon ),김주호 ( Juho Kim ),현진원 ( Jinwon Hyun ),강경아 ( Kyoungah Kang ),고재숙 ( Jeasook Koh ),서영경 ( Youngkyoung Seo ),백지훈 ( Jihwoon Baek ),박덕훈 ( Deokhoon Park ),이종성 ( Jongsung Lee ),정은선 ( Eunsun 대한화장품학회 2006 대한화장품학회지 Vol.32 No.3
본 연구에서는 제주도에서 자생하는 37 종의 식물추출물에 대한 미백 및 항산화 효능을 조사하였다. 미백 효능은 in vitro tyrosinase 저해활성과 B16-F1 세포를 이용한 멜라닌 합성 저해효과를 조사하여 확인하였고, 항산화 효능은 DPPH (1,1-diphenyl-2-picrylhydrazyl)를 이용한 전자공여능 측정방법과 DCF-DA (dichlorofluorescin diacetate)를 이용한 V79-4 폐 섬유아세포에서 활성 산소종 소거작용 능력을 조사하여 측정하였다. 세포실험 조건에서 식물추출물들의 투여농도에 따른 세포독성 정도를 조사하기 위하여 MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay를 수행하였다. 미백 효능조사 실험에서 우수한 결과를 나타내었던 8종의 식물 추출물들은 토끼를 이용한 국소 독성 시험 및 인체 피부 자극 임상 시험에 적용하여 안전성을 조사하였다. 연구결과에서 높은 미백과 항산화 효능을 동시에 나타내었던 비수리(Lespedeza cuneata), 제주광나무(Ligustrum lucidum (stem)), 산뽕나무(Morus bombycis (stem)), 꿀풀(Prunella vulgaris var. lilacina)의 식물추출물들은 화장품 원료화에 매우 유리한 조건을 갖고 있음을 확인하였다. In this study, we investigated the whitening and anti-oxidant activity of 37 Jeju island native plants. The active ingredients of the plants were prepared by methanol extraction. Whitening activity of plant extracts was examined from the inhibitory effect of tyrosinase and the inhibition of melanin synthesis of the B16-F1 cell line. Their anti-oxidant activity was measured by electron donating ability of DPPH (1,1-diphenyl-2-picrylhydrazyl) and ROS (reactive oxygen species) scavenging activity in V79-4 lung fibroblast cells using DCF-DA (dichlorofluorescin diacetate). Cytotoxicity of the extracts on cell s based experiments was investigated by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay. Also, the toxicity test using a rabbit and the human skin patch test were carried out for examining the safety of the extracts which showed the high whitening activity. It is interesting that the extracts of Lespedeza cuneata, Ligustrum lucidum (stem), Morus bombycis (stem) and Prunella vulgaris var. lilacina showed both potent whitening and anti-oxidant activities.
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