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A군 연쇄구균 무증상 감염자에서 페니실린 투여 후 세균제거 효과에 대한 조사
정현주,김선주,Jung, Hyun-Ju,Kim, Seon-Ju 대한소아감염학회 1998 Pediatric Infection and Vaccine Vol.5 No.2
목 적 : A군 연쇄구균 무증상 감염자는 증상은 없지만 A군 연쇄구균이 분리되고 ASO(antistreptolysin O)치가 높은 사람으로서 이들은 류마티스열이나 사구체신염 등 후유증을 일으킬 수 있다. 저자들은 무증상 감염자를 대상으로 경구용 페니실린을 복용하게 하여 이들에서 페니실린 치료 효과를 조사하였다. 방 법 : 상기도 감염 증상이 없는 건강한 초등 학생들을 대상으로 인두배양과 ASO치를 정량적으로 측정하였다. A군 연쇄구균이 분리되고 ASO 치가 400IU/mL 이상인 아동 36명을 대상으로 하여 그 중 22명의 학생은 경구용 페니실린 제제(penicillin V, 500mg. 하루 2회)를 10일간 복용하게 하였고, 14명은 대조군으로 삼고 항생제를 복용하지 않았다. 한달 후 두 그둡 아동에서 동시에 인두배양을 시행하여 A군 연쇄구균 제거율을 비교하고 ASO치를 측정하여 농도 변화를 관찰하였다. 결 과 : 항생제를 복용한 그룹과 복용하지 않은 그음의 A군 연쇄구균 제거율은 각각 91%(20/22)와 50%(7/14)로서 항생제를 사용한 그룹에서 유의하게 높았다(P<0.05). 항생제를 사용한 그룹과 사용하지 않은 그룹에서 ASO치가 100IU/mL 이상 상승한 경우는 각각 22%(4/18)와 30%(3/10)이었고 200IU/mL이상 감소한 경우는 각각 44.4%(8/18)와 40%(4/10)로서 유의한 차이가 없었다. 결 론 : 무증상 감염자를 대상으로 페니실린을 투여했을 때 인두에서 균이 효과적으로 제거되어 페니실린 치료의 타당성을 확인하였다. 그러나 ASO치 감소는 두 그룹간에 유의한 차이가 없었는데, 이는 ASO의 반감기가 걸고 경구용 페니실린의 경우 순응도가 낮기 때문으로 사료된다. 항생제 치료에도 불구하고 ASO치가 상승한 것을 치료 실패로 판정할 때 22%의 치료 실패율을 보였다. Purpose : Asymptomatic infections with positive throat culture for group A beta-hemolytic streptococci(GABHS) and high antistreptolysin O(ASO) concentration may lead to sequelae such as rheumatic fever or acute poststreptococcal glomerulonephritis. Children with asymptomatic infections were treated with oral penicillin V to evaluate the effectiveness of penicillin treatment on the asymptomatic infections. Methods : Throat culture and ASO concentration analysis were performed against healthy elementary school children. Thirty-six children with positive throat culture for GABHS and ASO concentrations of 400 IU/mL or more were divided into two groups. Twenty-two children were treated with oral penicillin V for 10 days, and the others were not treated. Eradication rate of GABHS and the change of ASO concentration between the two groups were compared after one month later. Results : Eradication rates of GABHS between treated and untreated children were 91%(20/22) and 50%(7/14) respectively(P<0.05). Children showing elevation of ASO levels more than 100IU/mL were 22%(4/18) in the treated group and 30%(3/10) in the untreated group, while children showing a decrease of more than 200IU/mL in the ASO level were 44%(8/18) and 40%(4/10) respectively. Conclusion : We confirmed the validity of penicillin treatment, because when we treated the asymptomatic children with penicillin V, the GABHS was eradicated effectively. But there was no significant difference of decrease in the ASO levels between the two groups due to long half-life of ASO or poor compliance. Treatment failure was 22% in terms of elevated ASO levels after penicillin treatment.
정현주,양창섭,정우진,Chung, Hyun-Ju,Yang, Chang-Seob,Jung, Woo-Jin 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.3
This paper describes design and construction results of the measurement system developed on the purpose of measuring properties of AC magnetic field sensors used in the weapon system. The system for measuring the properties of AC magnetic field sensors consist of 3-axis helmholtz coil, signal generator, signal amplifier, sensor data acquisition unit and AC magnetic field sensor property measurement & analysis equipment including the operating software. By using this system, we can measure various properties of AC magnetic field sensor such as sensitivity, linearity and dynamic response in the frequency from 1 Hz to 10 kHz. Finally we also verified its performance by measuring the property of a MAG 639, standard magnetic field sensor of bartington instruments, with the developed measurement system.
소아과 의원을 방문한 급성인두염 환자의 인후배양과 emm 유전자형을 이용한 A군 연쇄구균의 역학조사
정현주,이남용,권오영,맹국영,김선주,Jung, Hyun Ju,Lee, Nam Yong,Kwon, Oh-Young,Maeng, Kook Young,Kim, Sunjoo 대한소아감염학회 2003 Pediatric Infection and Vaccine Vol.10 No.2
목 적 : 소아과 의원을 방문한 인두염 환자에서 A군 연쇄구균 분리율을 살펴보고자 하였다. T 항원형과 emm 유전자형을 동정하여 역학적 특성을 살펴보고, 같은 지역의 보균자 결과와 비교하고자 하였다. 방 법 : 2001년 11월부터 2002년 5월까지 경남 진주시에 위치한 한 소아과 의원에서 인두염 환자 246명(남자 123명, 여자 123명)을 대상으로 인후배양을 시행하였다. 슬라이드 응집법으로 T 항원형을 결정하였고, emm 유전자 증폭 후 염기서열 분석을 시행하여 emm 유전자형을 동정하였다. 결 과 : 인두염 환자 246명 중 130명(52.8%)에서 베타용혈성 연쇄구균이 분리되었으며, 그 중 96.1%가 A군이었다. 연령별로는 4세에서 7세가 70.4%로 가장 많았다. T12가 35.2%로 가장 흔하였고, T non-typeable 30.4%, T28 14.4% 순이었다. emm12(28.5%)가 가장 많이 동정되었고, emm75(18.7%), emm22(13.0%), emm2(12.2%) 및 emm8(8.1%) 순이었다. 결 론 : A군 연쇄구균 인두염은 약 50%에서 분리될 정도로 흔하므로, 개인 소아과 의원에서 급성인두염 환자에 대해 항생제 처방 전에 인후배양이 필요할 것으로 사료된다. T항원 및 emm 유전자형은 급성 인두염 환자와 보균자에서 비슷한 분포를 보였다. Purpose : Group A streptococci(GAS) was isolated from the patients with acute pharyngitis. Epidemiological studies using T typing and emm genotyping was performed for GAS and compared with the results of the carriers. Methods : Throat cultures were taken from 246 children(123 boys, 123 girls) from November, 2001 to May, 2002 who visited a pediatrician's office located in Jinju, Gyeongnam province. T types were identified with slide agglutination and emm genotypes were identified with DNA sequencing after amplification of emm genes. Results : One hundred thirty(52.8%) out of 246 children yielded beta-hemolytic streptococci, of which 96.1% were group A. Children from 4 to 7 years old comprised 70.4% of the GAS positive group. T12 were the most common(35.2%) and T non-typeable strains were the next(30.4%). emm12 was most frequent(28.5%), and emm75(18.7%), emm22(13.0%), emm2(12.2%), and emm8(8.1%) were relatively common. Conclusion : Since GAS is so highly prevalent in acute pharyngitis, indeed being half of the population, good clinical practice dictates the systematic employment of throat culture for acute pharyngitis before prescribing antibiotics in a pediatric setting. The distribution of the T antigens and emm genes showed similar pattern between the acute pharyngitis and the carriers.
사향(麝香) 및 사향(麝香) 배합(配合) 한약제제(韓藥製劑)의 구강(口腔) 투여(投與)가 백서(白鼠)의 기억(記憶) 및 뇌기능(腦機能) 활성(活性)에 미치는 영향
정현주,이유경,채중원,Chung, Hyun-Ju,Lee, Yu-Kyung,Chae, Jung-Won 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.1
Objectives This study was investigated to find how the orally administrated Moschus, herbal combination with Moschus, and herbal combination improves the rats' memory and rats' liver. These medications are generally known asthe memory improvement. Methods This study used the Sprague Dawley rats. They were divided into two groups - SD rats and orally administrated Saline(Control group). 0.473 mg/kg Moschus(HM-A), 153.9 mg/kg herbal composition without Moschus(HM-B), and 165.95 mg/kg herbal composition with Moschus combined(HM-C) Control, saline were orally administered. Each group was trained in the eight-arm radial maze task at the conditions of before oral administrated, and also right after third, sixth, and eighth by oral administration. Lastly, these animals were killed and were tested for brain tissue and serum AST/ALT level to measure how the medications were effected to the liver function. Results The result of radial eight-arm maze task test, the HM-B and HM-C groups showed significant decrease in mistakes from the fourth day of testing. Whereas, the HM-A group showed increasing in the error rate. HM-A and HM-C group of rats had significantly increased amount of acetylcholinesterase in the CA1 region of hippocampus, compared to the control group. Whereas, HM-B and HM-C group had increased level of ChAT compared to the control group. On the other hand, each experimental group did not show any significant difference to the level of serum AST/ALT and the weight ratio of the liver to the body. Conclusions This study provided evidences that the orally administered memory improvement herbal medication, and Moschus were effective to improve memory.
감사이야기나누기 활동이 유아의 감사성향, 공감능력, 행복감에 미치는 영향
정현주(Jung Hyeon-Ju),김현수(Kim Hyun-Soo) 한국아동심리치료학회 2018 한국아동심리치료학회지 Vol.13 No.3
With the advent of positive psychology, clinical attention has shifted from maladaptive/dysfunctional aspects of human psychology to people’s adaptive/functional aspects. Considering this paradigm shift, this study constructed story-sharing activities expressing themes of gratefulness that were suitable for preschoolers and examined effects of the activities on preschoolers’ grateful dispositions (Gratefulness), empathetic abilities (Empathy), and feelings of happiness (Happiness). For this purpose, the study recruited 5 year-old preschoolers from two kindergartens in Seoul: 23 preschoolers from the one kindergarten were placed in the experimental group and 24 preschoolers from the second kindergarten were placed in the control group. The experimental group was given 22-session grateful story-sharing activities for 11 weeks (twice a week, 20-25 minutes per session) and the control group was given the corresponding 22-session free play activities. To examine the efficacy of the treatment, levels of Gratefulness (Gratefulness awareness, Gratefulness expression, and Gratefulness total), Empathy (teacher-rated Empathy and preschooler-rated Empathy), and Happiness were measured at pre-, post-, and 1-month follow-up (FU) time points. FU measurements were made only for the experimental group. Two-way ANOVAs with group (experimental and control) and measurement point (pre and post) as independent variables revealed significant interaction effects for all six preschooler outcomes. Further analyses testing pre-post score differences in each group showed significant pre-post improvement in all six preschooler outcomes in the experimental group but not in the control group. Moreover, treatment gains were maintained at the 1-month FU in the experimental group. These findings suggest that grateful story-sharing activities can be of significant benefit to preschoolers’ grateful dispositions, abilities to empathize, and feelings of happiness.
Hyun Ju Jung(정현주),Tae Hyun Kim(김태현),Jae Suk Woo(우재석) 한국생명과학회 2019 생명과학회지 Vol.29 No.12
본 연구에서는 사람의 제대정맥 내피세포에서 고농도 당에 의해 유도되는 세포사멸과 연관된 미토콘드리아의 기능적 지표 변화에 미치는 diazoxide의 효과를 관찰하였다. 고농도 당에 노출된 내피세포에서 세포사멸이 시간에 따라 증가하였고, caspase 3와 8, 9의 활성 증가가 동반되었다. Caspase 3와 9의 억제제들이 세포사멸을 감소시킨 반면 caspase 8의 억제제는 효과가 없었다. 고농도 당에 노출된 세포에서 미토콘드리아 막전위의 탈분극과 막투과도의 증가, 치토크롬 C (cytochrome C)의 유리가 동반됨을 관찰할 수 있었다. Diazoxide는 고농도 당에 의한 미토콘드리아 의존성 세포사멸 신호의 활성화를 억제하였다. Diazoxide의 이러한 효과들은 미토콘드리아막의 ATP-억제성 칼륨통로 차단제인 5-hydroxydecanoate에 의해 차단되었다. 이상의 결과들을 종합하면 diazoxide가 미토콘드리아막의 ATP-억제성 칼륨통로 개방을 통해 미토콘드리아 의존성 세포사멸 신호기작의 활성화를 차단하여 고농도 당에 의해 유도되는 세포사멸을 억제하는 것으로 사료된다. In the present study, we examined the effect of mitochondrial K<SUP>+</SUP> channel opener diazoxide on the mitochondria-dependent apoptotic signaling in endothelial cells exposed to high glucose (HG) media. Endothelial cells derived from human umbilical veins were exposed to HG media containing 30 mM glucose, and the degree of apoptotic cell death associated with activation of the mitochondria-dependent apoptotic signaling pathway was determined. Exposure to HG media was seen to enhance apoptotic cell death in a time-dependent manner. In these cells, activation of caspases 3, 8, and 9 was observed, and while caspase-3 and -9 inhibitors suppressed the HG-induced apoptotic cell death, a caspase-8 inhibitor did not. The HG-treated cells exhibited disruption of mitochondrial membrane potential, formation of permeability transition pores, and cytosolic release of cytochrome c. Subsequently, diazoxide was seen to attenuate the HG-induced apoptotic cell death; caspase-9 activation was suppressed but caspase 8 was not. Diazoxide also suppressed the depolarization of mitochondrial membrane potential, the formation of mitochondrial permeability transition pores, and the release of cytochrome c. These effects were significantly inhibited by 5-hydroxydecanoate, a selective blocker of ATP-sensitive K<SUP>+</SUP> channels (KATP). The present results demonstrate that diazoxide exhibits a beneficial effect to ameliorate HG-induced endothelial cell apoptosis. Opening the KATP could help preserve the functional integrity of mitochondria and provide an underlying mechanism to suppress HG-triggered apoptotic signaling.
정현주(Jung, Hyun-Ju) 부산경남사학회 2021 역사와 경계 Vol.118 No.-
가라국은 백제의 쇠락으로 힘의 공백이 생긴 호남 동부지역에 영향을 미쳤다. 가라국은 섬진강로를 통해 중국의 南齊에 사신을 보내어 책봉을 받을 수 있었다. 한편, ‘임나 4현’과 대사는 지금의 전라남도 동부지역과 경상남도 하동 지역으로 볼 수 있는데, 모두 오랜 세월 동안 독자적인 세력을 유지했던 세력이었다. 이들은 가라국의 대외 교섭을 지지하고 도우면서 성장할 수 있었다. 특히 대사의 경우, 가라국의 유일한 항구로 기능하게 되면서 ‘임나 4현’ 등 주변 지역을 통솔할 수 있는 위치에 설 수 있었다. 백제는 동성왕 시기를 거치면서 대내적인 안정을 이룰 수 있었다. 동성왕 이후 집권한 무령왕은 더 적극적인 대외 공략에 나서게 되는데 그것이 바로 섬진강 유역에 대한 공격이었다. 백제는 먼저 ‘임나 4현’ 지역을 공략하여 손쉽게 성공했다. 이후 백제는 기문을 지배하고 이어 대사를 공격하였으나 쉽게 얻지 못한다. 가라국은 백제의 위협으로 유일한 항구인 대사가 위험해지자 이미 ‘임나 4현’의 이탈로 세력이 줄어든 ‘대사국’을 해체하고 다사진으로 격하시켰다. 하지만, 529년을 기점으로 대사를 백제에 빼앗기고 만다. 섬진강 유역의 재지 수장층들은 백제의 영향력 아래에 든 후 백제의 지방 제도에 포함되어 사라져갔다. 가라국과 백제의 섬진강 유역 쟁탈은 오랜 세월 동안 독자적인 세력을 유지하였던 섬진강 유역 세력들을 와해시킨 대사건이었다. Gara-guk(加羅國) influenced the eastern part of Honam, where a power gap was created due to the decline of Baekje. Gara-guk was able to receive a reward from Nam-je(南齊) by sending an ambassador through the Seomjin River. Meanwhile, ‘Imna(任那) 4 prefectures(縣)’ and Daesa(帶沙) were the forces that maintained their own power for many years. They were able to grow up supporting and helping Gara"s foreign ministries. Especially in the case of Daesa, it served as the sole port of the country, and it was able to direct the surrounding area such as ‘Imna 4 Prefectures’. Baekje was able to achieve domestic stability through the period of Dongsung(東城王). King Muryong(武寧王), who ruled after Dongsung, was more aggressive in attacking the Seomjin River basin. Baekje first succeeded in easily reaching ‘Imna 4 Prefectures’. Baekje then dominated the Gimun and attacked the Daesa, but not easily. When the Daesa, the sole port, became dangerous, Gara dismantled the ‘Daesa-guk(帶沙國)’ and downgraded it to Dasa-chin(多沙津). However, from 529, Gara-guk lost Daesa to Baekje. The leaders of the Seomjin River basin were included in the local system of Baekje after the influence of Baekje. The struggle over the Seomjin River basin of Gara and Baekje was a great event that broke down the Seomjin River basin powers that had maintained their own power for many years.
루브릭을 활용한 자유탐구 지도가 초등학생의 자유탐구에 미치는 영향 및 인식 조사
정현주 ( Hyun Ju Jung ),임성만 ( Sung Man Lim ),천재순 ( Jae Sun Chun ) 한국초등과학교육학회 2013 초등과학교육 Vol.32 No.3
The purpose of this research is to find the effect of the lesson using open-inquiry report Lubric on openinquiry standard and science process skill; to find the change of cognition on open-inquiry for elementary school 5th grade students. Two classes (elementary school 5th grade) were selected which located in a small and medium-sized city for this research and they were separated as an experimental group and a comparative group. Open-inquiry lesson was done by referring teaching method which introduced through the curriculum. The procedure was understanding about open-inquiry, making open-inquiry subject, planning, and performing inquiry, mid-term, performing inquiry, making a report, presentation, and evaluation. Open-inquiry report Lubric which developed by Sook-Kyung Kim et al. (2010) was provided to the experimental group. Comparative group was instructed by using open-inquiry report which introduced to the elementary school 5th grade science text book. Interview paper was developed in order to check out the effect of the research by using a test paper of science process skill. The following could be found out through the research. After open-inquiry lesson, 10 open-inquiry reports(5 reports from experimental group, 5 reports from comparative group) have been drawn at random as samples from the total 62 sets (30 reports from experimental group, 32 reports from comparative group) and evaluated by a researcher and two elementary school teachers who have master degree. The reliability of the 3 scorers was 0.923 of mean correlation coefficient. And then the researcher evaluated all open-inquiry reports. The average score of open-inquiry report was 66.78 for experimental group, 54.27 for comparative group, respectively. And there was a significant difference at p<0.05 level as a result of the t-test. The experimental group rated high at p<0.05 level according to the analysis of post-science process skill test. According to the result of survey, both experimental group and comparative group had understood open-inquiry activity. It was especially rated high for experimental group on understanding scientific inquiry process, interest and satisfaction in open-inquiry and re-participation rate. By interviewing experimental group, it is recognized that the students utilized Lubric very well through the overall process. Finally, self-evaluation was done during open-inquiry activity and it was reported that the students gained more knowledge about science and changed to positive about science. As a result, the lesson using open-inquiry report Lubric was effective for students to improve writing skill of an open-inquiry report and science process skill and finally changed the cognition to positive about open-inquiry lesson.