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( Suqin Shen ),( Jie Zuo ),( Huan Feng ),( Meirong Bai ),( Chenji Wang ),( Youheng Wei ),( Yanhong Li ),( Yichen Le ),( Jiaxue Wu ),( Yanhua Wu ),( Long Yu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.6
T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. [BMB Reports 2016; 49(6): 325-330]
Jiang Wei,Ni Guosong,Zuo Pingping,Qu Shijie,Li Yunmei,Niu Hongxian,Shen Wenzhong 한국탄소학회 2019 Carbon Letters Vol.29 No.5
Isotropic pitch-based carbon fiber was successfully prepared from tetrahydrofuran-soluble fraction of coal tar pitch co-carbonization with petrolatum by air-blowing. The effects of reaction temperature and time, amount of petrolatum added on the composition and spinning properties of resultant pitches were investigated. It indicated that petrolatum could effectively improve the softening point, aromaticity, hydrogen content and molecular weight of the resultant pitches by promoting cross-linking and dehydrogenation polymerization reactions at low air-blowing temperature. Moreover, more aliphatic and naphthenic structures had been introduced into resultant pitches as addition of petrolatum and also inhibited the generation of quinoline-insoluble particles. The obtained green fibers were facile to be stabilized and carbonized and the resultant carbon fibers showed fully isotropic and finer, uniform diameter with smooth surface and higher tensile strength of up to 0.92 GPa. It provided a facile chemical modification method for isotropic pitch-based carbon fiber production.
Wei Jiang,Guosong Ni,Pingping Zuo,Shijie Qu,Yunmei Li,Hongxian Niu,Wenzhong Shen 한국탄소학회 2019 Carbon Letters Vol.29 No.5
Isotropic pitch-based carbon fiber was successfully prepared from tetrahydrofuran-soluble fraction of coal tar pitch cocarbonization with petrolatum by air-blowing. The effects of reaction temperature and time, amount of petrolatum added on the composition and spinning properties of resultant pitches were investigated. It indicated that petrolatum could effectively improve the softening point, aromaticity, hydrogen content and molecular weight of the resultant pitches by promoting cross-linking and dehydrogenation polymerization reactions at low air-blowing temperature. Moreover, more aliphatic and naphthenic structures had been introduced into resultant pitches as addition of petrolatum and also inhibited the generation of quinoline-insoluble particles. The obtained green fibers were facile to be stabilized and carbonized and the resultant carbon fibers showed fully isotropic and finer, uniform diameter with smooth surface and higher tensile strength of up to 0.92 GPa. It provided a facile chemical modification method for isotropic pitch-based carbon fiber production.