18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

엠보싱 알루미늄 판재의 기계적특성과 스프링백 평가 (제1보)

김영석(Kim, Young-Suk),조준행(Cho, Jun-Haeng),Van-Cuong Do,신동우(Do, Van-Cuong) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.2

엠보싱된 알루미늄 판재는 표면적이 증가하여 방열효과가 뛰어나고 가공경화에 의해 굽힘강성이 증가하여 자동차 열차단기에 널리 사용된다. 하지만 판재의 특성상 주름발생률이 높아 프레스 성형에 많은 제약이 따른다. 본 연구에서는 3차원 구조 알루미늄 판재의 프레스 성형성 평가를 위한 기초연구로 3차원 구조 엠보싱 콘 형상 판재의 기계적특성을 평가 하고 굽힘실험을 통해 프레스 가공 후 발생하는 스프링백을 정량적으로 평가하였다. 엠보싱 판재는 패턴의 방향에 따라 인장특성이 상이하다. 특히 평행 엠보싱 시편의 경우 항복응력이 감소하며 대각 엠보싱 시편의 경우 항복응력이 증가하게 되고 영률의 감소가 크게 나타난다. 그 결과 굽힘 성형가공 후에 스프링 백에 영향을 미친다. Embossed aluminum sheets were been used in heat insulation purpose for automative exhaust parts because of increasing their surface areas and stiffness reinforcement. However, there are many restrictions because of high rate of wrinkle occurrence on press working. We have performed the tensile and bending tests for embossed sheets to clarity its mechanical properties and springback characteristics. Embossed aluminum sheets showed a different flow stress after plastic yielding due to flattening the embossed cone shape. Above all, yield stress of parallel embossed specimen decreases while its diagonal one increases and the decrease of young’s modulus in the embossed sheets contributes to the increase of springback amount.

양파(Allium cepa L.) 추출물이 Tyrosinase 유전자 발현에 미치는 효과

조남철,윤연희,이혜진,손현정,김양경,최근희,나명석,조영권,이황희,진종언 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.3

Melanin 생성에 관여하는 tyrosinase 유전자의 발현을 억제하는 물질을 탐색하고자 tyrosinase promoter를 지닌 Bl6 mouse melanoma cell해 앙파 methanol 추출물을 처리한 바 양파 methanol 추풀물은 10.0㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml의 농도에서 대조군에 비해서 약 15%, 23% 57%의 억제효과를 나타냈으며 세포생존율은 1.0 ㎍/ml, 10.0 ㎍/ml, I00.0 ㎍/ml, 1.0㎎/ml의 농도에서 약 126 %, 92%. 85%, 64%로서 세포독성이 낮게 나타났다. Ethyl acetate, butyl alcohol, 그리고 물 용매 분획물은 tyrosinase 유전자의 발현물 억제하는 효과가 없었지만 methylene chloride 용해 분획물은 10.0 ㎍/ml과 100.0 ㎍/ml의 농도에서 약 37%와 35%의 발현율을 나타냄으로서 대조군에 비해 크게 억제하였다. Onion(Allium cepa L,) extract by methanol repressed the expression of tyrosinase gene of B16 mouse melanoma cell containing tyrosinase promoter. 10.0 ㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml of the extract repressed expression of tyrosinase gene about 15%, 23%, and 57%, respectively, compared with control. In the MTT assay, the same extract exhibited low cytotoxicity at 1.0 ㎍/ml, 10.0 ㎍/ml, 100.0 ㎍/ml, and 1.0 ㎎/ml, respectively. The fractions of ethyl acetate, butyl alcohol, and water did not showed the repressive effect on the expression of tyrosinase gene, but the fraction of methylene chloride repressed highly at 10.0 ㎍/ml and 100.0 ㎍/ml.

가토안의 Cathepsin D의 정제 및 분자량 측정

趙瑛淑,石貴德 대구효성 가톨릭대학교 1994 연구논문집 Vol.48 No.1

Cathepsin D was purified from rabbit eyes homogeneously. The homogeneity of the preparation was determined by SDS-polyacrylamide gel electrophoresis and densitometer trace. The isolation scheme involved an homogenization, acid treatment, ammonium sulfate fraction, and sephadex G-200 chromatography. The end product represent about a 61. 3-fold purification, and a 26.1% recovery. The apparent molecular weight was estimated to be 63,000 by electrophoresis in polyacrylamid gel containing sodium dodecyl sulfate according to the method of Weber and Osborn.

Culex pipiens pallens 모기의 난황단백질 합성에 대한 Hormone의 영향

조정래,박영민,강석희 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.2

Culex pipiens pallens모기의 난황단백질 합성에 대한 brain hormone과 β-ecdysone의 영향에 대하여 조사하였다. 흡혈하지 않은 모기에게 β-ecdysone을 주사하였을 때 주사 후 12시간에 최대의 vitellogenin 합성을 나타내었다. 흡혈 후 decapitation 이나 ligation된 모기중 maturing ovary를 가진 모기의 vitellogenin 합성율은 decapitation이나 ligation이 지연될수록 증가하였다. 흡혈 후 decapitation이나 ligation된 모기중 maturing ovary를 가진 모기의 vitellin level은 decapitation이나 ligation이 지연될 수록 증가하였다. 이 결과는 C. pipiens 모기의 난황단백질 합성은 brain hormone과 β-ecdysone이 조절할 가능성을 제시해 주고 있다. Injection of β-ecdysone into unfed Culex pipiens pallens(Diptera: Culicidae) females stimulated incorporation of ^3H-leucine into proteins by the fat body in vitro. The rate of incorporation began to rise by 6 hours and reached at a maximum at 12 hours after ecdysone injection. Blood fed decapitated females produced maturing and arrested ovaries. The fat bodies of females with arrested ovaries failed to synthesize proteins, while fat bodies from females with maturing ovaries produced vitellogenin even when the females were decapitated within few minutes after a blood meal. The yolk deposition into the ovaries for females with maturing ovaries was not affected by decapitation.

타액에 오염된 상아질에 대한 콤포머의 접합양상

조영곤,김병태,이석종 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.4

In this study, adaptation of compomer to saliva contaminated dentin was evaluated with scanning electron microscope(SEM) and confocal laser scanning microscope(CLSM). For the SEM study, the occulusal surfaces of thirty two molar teeth were grounded to exposure dentin surfaces. The specimen were randomly assigned to control and three experimental groups with four samples in each group. In control group, Dyract and F-2000 compomer were bonded on the specimens according to the manufactures' direction. Experimental groups were subdivided into three groups. They were contaminated with saliva on dentin surfaces ; Experimental group 1 : Saliva was dried with compressed air. Experimental group 2 : Saliva was rinsed with air-water spray and dried, Experimental group 3 : After polymerization of an adhesive, they were contaminated with saliva, and then saliva was rinsed with air-water spray and dried. Dyract and F-2000 compomer were bonded on saliva-treated dentin surfaces. The interfaces between dentin and compomer were observed with SEM. For the CLSM study, Class V cavities were prepared in buccal and ligual surfacess of thirty two molars. The specimens were divided into control and experimental groups. Class V cavities in experimental group were contaminated with saliva and those surfaces in each experimental groups received the same treatments as for the SEM study. Cavities were applied Prime & Bond 2.1 and F-2000 compomer primer/adhesive that were mixed with fluorescein, and then were filled with Dyract and F-2000 compomer. Specimens were embedded in transparent acrylic resin and sectioned buccolingually with diamond wheel saw, and then mounted on cover slide for CLSM study. The interface between cavity and compomer was observed by fluoresence imaging with a CLSM. The results were as follows : 1.In SEM exammination of Dyract group, control group, experimental group 2, 3 showed close adaptation to dentin and hybrid layer of 3~4㎛ diameter. Interfacial gap between compomer and dentin in experimental group 1 was wider than in control group. 2.In SEM exammination of F-2000 group, adaptation to dentin of control group was closer than Dytact control group, but hybrid-like layer was not observed. Interfacial gap between compomer and dentin in experimental group 1 was wider than in Dyract experimental group 1. 3.In dissolution specimens of Dyract and F-2000 group, resin tags penetrated through dentinal tubules in control group and experimental group 1 and 3, but the penetration of resin tag was irregular and partial in experimental group 1. 4.In CLSM exammination of Dyract and F-2000 group, adhesive patterns of control and experimental groups showed same as in SEM. This result suggests the treatment methods, rinsing & drying, repeating all adhesive procedures, will produce good effect on adaptation of compomer to dentin if the dentin surface or polymerized adhesive is contaminated by saliva.

脚筋力 및 몇몇 體力要因과 全身反應과의 相關關係에 關한 硏究

趙泳奭 全北大學校 師範大學 1980 사대논문집 Vol.6 No.-

The 47 students of sophomore in Jeonbug National University are selected as the subject of this study. This is aimed at presenting the factors to affect the whole body reaction time and making some data for reference in order to develop the reaction time. By means of while body reaction measuring device, the reaction time was measured, and from the measurements of leg strength, back strength, sargent jump. strength of abdominal muscle, the correlation was searched. The results of this study are as follows ; 1. The highest degree of correlation in all of the athletes, non-athlete, and girl students are shown between the whole body reaction time and the strength of abdominal muscle. 2. Leg strength, back strength, sargent jump are in little correlation with whole body reaction time. 3. The difference in whole body reaction time between athletes and non-athletes is not remarkable.

Alkali 감령처리된 Polyethylene Terepthalate Filament 직물에 나타난 흰얼룩의 원인분석

曺煥,李石榮,許萬宇,鄭元圭 嶺南大學校 工業技術硏究所 1983 연구보고 Vol.11 No.1

A study has been undertaken to know the reason why the white specks appear in the polyethylene terephthalate (PET) filament fabrics which were made alkali weight loss treatment in the dyeing and finishing factories of Taegu area. The results are as follows 1. Main component of the white spects in PET filament fabrics is CaCo₃. 2. The CaCO₃was extracted from the washing water and adhered to the PET filament fabrics during the dyeing and finishing process. 3. When PET filament fabrics were treated with hard water, the warp sizing agent did not dissolve to make specks on dyed fabrics. Then the insoluble sizing agent can not be got rid of by alkali treatment. 4. On account of using Na₂CO₃ in washing PET filament fabrics, white spects also can be appeared.

노인의 운동행위변화단계에 따른 변화과정, 의사결정평가, 자아효능감 및 주관적 건강지각

조영숙,이해정 성인간호학회 2003 성인간호학회지 Vol.15 No.2

The purpose of this study was to examine the differences of the process of change, decision making. Self-efficacy and perception of subjective health according to the stages of exercise behaviors suggested by transtheoretical medals among older adults. Method: The subjects consisted of 291 older adults. Trained research assistants interviewed the older adults using structured questionnaires. ANOVA analyses with post hoc test were used to examine the mean differences for each stage of exercise behavior using SPEE for windows. Result: The subjects were divided into five stages of exercise behavior: 24.4% pre-contemplation, 12.4% contemplation, 17.9% preparation, 12.4% action, 33.0% maintenance stage. There were significant differences in process of change, decision making, self-efficacy and exercise stage of change. ‘Self-liberation’ and ‘stimulus control’ were important strategies for intention of exercise, while ‘reinforcing management’ for the actual practice of exercise. ‘Self-liberation’ was an effective strategy to change older adults from pre-contemplation to preparation stage. Conclusion: For exercise intervention, older adults should be classified into groups according to their stages of exercise behaviors and provided effective individualized intervention depending on their stage.