Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

Streptococcus faecalis var. liquefaciens 의 Plasmid 와 변이주 형질의 연관성

姜國熙,李命基,金榮勳,李春花,朴淵姬 成均館大學校 科學技術硏究所 1986 論文集 Vol.37 No.2

Lac^- and Prt^- variants were selected from Str. faecalis var. liquefaciens SKD-1007 by acrifiavin treatment. Prt^- Lac^- variant was obtained from Prt^- vaiant by mitomycin C treatment. The plasmid of variants showed same pattern with parent strain. Plasmid cured variants(SKR1, SKR2, SKR3) were obtained from parent treated by novobiocin. SKR3 variant which lost pSK6 plasmid(2.1 Mdal) was sensitive to lincomycin and erythromycin. The results implied that pSK6 plasmid of test strain was associated with antibiotic resistance (L.M, EM).

개의 대퇴골간에서 발생한 유합부전의 1례

강은경,조성환,류시윤,손화영 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Fracture healing is a complex physiological process that involves the coordinated participation of several cell types. Unlike other tissues that heal by the formation of poorly organized scar, in fracture healing the original tissue, bone, is regenerated and the properties of the preexisting tissue largely are restored. Fracture healing generally proceeds in an orderly fashion when appropriate biological and mechanical component are present. Many complications may occur with repair and subsequent healing of fracture, including osteomyelitis, implant loosening, and fracture instability. All of these complications may result in delayed union, nonunion or malunion of the fracture. A 1-year-old male, Collie sustained a closed, transverse femoral fracture in a mortor vehicle accident. His initial treatment with open reduction and bone plating was failed. A second surgery was done to remove the plate and perform corrective osteotomy, and bone grafting. Histopathological observation of the bone fragment from fracture end was carried.

단음절 합성단위음을 사용한 시간영역에서의 한국어 연속음 규칙합성에 관한 연구

강찬희,안영화 江南大學校産學技術硏究所 2004 산학기술연구소논문집 Vol.- No.18

본 논문은 시간영역에서의 한국어 연속음 규칙합성에 관한 실험적 연구결과이다. 특히, 단음절 단위음을 사용하여 연속음을 합성할 경우 음절간의 피치 불연속성으로 인한 자연성 및 음질이 저하되는 현상을 개선하고자 하였다. 이를 위하여 자연음으로부터 추출한 구문 단위의 피치 패턴을 보간법으로 생성시켜 합성하는 방법을 제안하였다. 중심주파수가 80, 118, 140, 170, 200Hz인 5가지 유형의 피치 패턴을 2음절어 및 3음절어에 각각 부여하여 합성시킨 합성음에 대한 MOS평가를 수행한 결과를 제시하였다. 실험결과, 제안한 시간영역에서의 합성방식에 의한 합성음의 음질은 명료하고 자연스러웠으며, 간단한 문장단위의 연속음 합성이 가능하였다. 운율요소의 제어결과는 지속시간(장단)과 악센트(강약)와 피치주기(억양) 및 에너지 패턴의 제어도 시간영역에서 가능하였다.

일 도시 고등학생의 음주동기와 음주문제

강혜영,신경은,장현지,나영화,조은희 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : The purpose of this study was to investigate drinking motives and the drinking-related problems of Korean high school students at a city in Jeonbuk province. Methods : There were 657 students from two academic and two vocational high schools at J city in Jeonbuk province. The sample was collected using a stratified sampling method and the data was collected from June 30th to July 16th 2003. The study instrument used to examine drinking motive was a 20.item summated scale (Cronbach's α = .95) and for drinking-related problems was an 18 item summated scale (Cronbach's α = .91). The data was analyzed using SPSS/PC+ by percentage, χ2.test, t-test and correlations. Results : 1. Drinking experience: Among the high school students, 74.3% of them had drinking episodes. Female students started drinking later (χ2 = 12.857, p = .002) and had more drinking friends (χ2 = 7.785, p = .020) than males. Vocational school students drank more frequently (χ2 = 32.138, p = .001), had more heavy drinking episodes (χ2 = 40.370, p = .001). 2. Drinking motives & Drinking-related problems: The mean score of drinking motives was 31.2 ± 11.12 out of 80 and that of drinking-related problems was 21.8 ± 5.85 out of 72 points. Neither score were stronger was significantly different according to gender and grade. On the other hand, both drinking motives (t = .4.077, p = .001) and drinking-related problems (t = .3.423, p = .001) were stronger in vocational school students than in academic school students. The correlation between drinking-related characteristics and problems were weak (from r = .286 to r = .520) but the correlation within the subcategories of drinking motives was high such as between enhancement and coping (r = .822) and enhancement and social motives (r = .822). Conclusion : The majority of Korean high school students start to drink during their junior high school days. Drinking motives and drinking-related problems were not serious but the drinking motives and the drinking-related problems are stronger among vocational school students. As a result, school-based health education and counseling programs should focus on solving drinking motives than on drinking-related problems.

로터리킬른 반응로를 이용한 폐슬러지 활성탄의 제조와 세공구조 및 흡착특성

강화영,박상숙 順天大學校 1999 論文集 Vol.18 No.1

We have tried to wasted biological sludge as a starting material to produce a low-cost adsorbent alternative for activated carbon and for reuse of wasted materials. The carbonated sludge was chemically activated with phosphoric acid. To find out the optimum conditions for activated carbon, chemical activation was used with varying: carbonization time, activation agent, activation temperature and activation time. The activated products were characterized by measuring iodine adsorptivity, methylene blue adsorptivity, specific surface areas, yield, pore structure and SEM photograph. The products activated by phosphoric acid in a rotary kiln reactor operated around 700℃ had iodine adsorptivity, methylene blue adsorptivity, and specific surface area of 312.4mg/g, 32.2 mg/g, and 96.6㎡/g with yields of 84.1wt%, respectively.

팔체질침을 이용한 반월판 관절경부분절제술 환자의 치험례

강영화,김성욱,손인석,서정철,윤현민,장경전 동의대학교 한의학연구소 2001 동의한의연구 Vol.5 No.-

슬관절은 지속적인 압력을 받거나 충격때문에 동작범위의 한계에 이를 때 손상받기 쉽다. 반월판 파열 환자는 일상생활에 지장을 주는 동통, 정복되지 않는 잠김, locking이나 giving way가 자주 일어나는 경우, 지속적인 신전제한이 있을 때 수술의 적응증이 된다. 반월판 파열 환자의 재활에 있어서 관건은 대퇴사두근의 근력과 ROM의 회복이다. 팔체질침 시술후 반월판 부분절제술을 시행한 환자가 동통의 강도와 동통 재발의 감소, ROM의 개선, 전반적 상태면에서 체침이나 MPS 시술 때보다 더 나은 경과를 얻었다. Knee joints are apt to be injured when they are over the limit of ROM by continuous pressure or impact. The patient of meniscus tear has to be operated in case that he has the symptom of knee pain obstructive to daily life, unreducable locking, frequent locking or giving way, continuous extention limit. In the rehabilitation of the patient of meniscus tear, the key is the progress of musculi quadratus femori's power and ROM. After 8 constitutional acupucture therapies, partial menisectomy patient has the better process about decrease of pain intensity and relapsing pain frequence, development of ROM, general condition more than general acupucture or MPS medical treatment.

모 축전지 회사 근로자들의 연폭로 지표에 대한 경시적 관찰

강명식,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

Lead poisoning is still prevalent and one of important occupational disease in Korea. To prevent undue high lead burden and maintain good health condition of lead workers in lead using industries, periodic health examination and regular biological monitoring of lead workers are often required in addition to the fundamental improvement of their working condition. To evaluate the effect of comprehensive occupational health program with regular biological monitoring on the level of lead exposure of lead workers in lead using industries, 11 year database from 1983 to 1994 of one storage battery factory was reviewed. From 1983 to end of 1986 only periodic health examination was provided to the lead workers, but from 1987 comprehensive occupational health program with regular biological monitoring was provided to maintain better health condition of lead workers. Selected study variables for lead exposure were blood lead(PbB), zinc protoporphyrin in blood(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb), hematocrit(HCT). Information on sex, age and work duration was also reviewed. 5 years data from 1983 to 1987 and 3 years data from 1990, 1993 and 1994 were available for all lead exposure indices except ALAU which has only 5 years data from 1983 to 1997. The results of 11 years longitudinal observation of lead indices are all follows: 1. The mean value of ZPP of lead workers in 1983 was 148.7±73.1 ㎍/㎗(Male: 145.5±72.3, Female: 168.1±79.1), whereas that of ZPP of lead workers in 1994 was decreased to 64.3±32.7 ㎍/㎗(Male: 60.2±28.8, Female: 95.2±43.4). 2. The mean value of PbB of lead workers in 1983 was 56.4±18.8 ㎍/㎗(Male: 55.59±19.1, Female: 59.6±19.1), whereas that of PbB of lead workers in 1994 was dcreased to 35.4±11.9 ㎍/㎗(Male: 35.7±12.0, Female: 32.8±10.8). 3. The mean value of Hb of lead workers in 1983 was 14.1±1.4 g/㎗(Male: 14.4±1.1, Female: 11.7±0.8), whereas that of Hb of lead workers in 1994 was increased to 15.6±1.5 g/㎗(Male: 15.9±1.2, Female: 12.9±1.1). 4. Blood lead is most highly correlated with ZPP(r=0.522, male:0.54 and female:0.50) and also correlated with ALAU and work duration also. 5. The simple regression analysis of PbB and ZPP showed different coefficient of regression by the measurement year, but there was no difference of coefficient of regression between sex. The slope of equation of pooled data for 1983-1986 without comprehensive occupational health program was 2.16 and differed from that of pooled data for 1987-1994(1.25). This difference suggests that the unit effect of blood lead on ZPP was relatively smaller in later period of comprehensive occupational health program than carly period without comprehensive program. The slope change in the analysis of linear regression of PbB on ZPP in lead workers can be used to evaluate the possible effect of health intervention to prevent undue high lead absorption in lead using industries. 6. 11 years occupational health service in this storage battery factory brought out considerable improvement of health status of lead workers in terms of decrease of PbB and ZPP and increase of Hb and the improvement was more remarkable after the introduction of comprehensive occupational health program.

Electronic Structure Calculations of Silicon Using the Tight binding Method

강갑중,이근우,오영기,조화석 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

The local density of states of bulk Si is calculated by using the tight-binding method and the recursion method. The matrix elements of the Hamiltonian are obtained from the calculation using the exponentially decaying orbitals with an empirical pseudopotential Hamiltonian and the calculation using empirical tight-binding approaches.