혈관내 카테터 및 수액요법과 관련된 감염

최강원,송영욱 대한감염학회 1987 감염 Vol.19 No.3

진균성 부비동염의 임상적 고찰

이승원,김장욱,박영진,송태현,이병돈,장혁순 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The fungal sinusitis is relatively rare and mainly develops in immunocompromised hosts, but is sporadically appears in the immunocompetent patients, where its incidence tends to be increasing. Because the clinical features of this disease are similar to those of chronic suppurative sinusitis, this entity may be overlooked. We analysed thirteen fungal sinusitis from January 1997 through December 1999 based on clinical features, laboratory characteristics and operative findings. The results are as follows. 1)Fungal sinusitis occurred 3.3 times as frequently in female patients as in male patients and the peak age groups are 4th and 5th decades. 2) The time intervals between the onset of symptoms and the first hospital visit were as follows: 5 cases within 3 months, 1 case between 4 and 6 months, 3 cases between 7 and 12 months, and 4 cases over 1 year. 3) The chief complaints were nasal obstruction, postnasal drip, rhinorrhea, cheek pain, headache, ocular pain, sneezing. 4) The characteristic computerized tomographic findings were hyperattenuated lesions in the maxillary sinus and in the nasal cavity near the natural ostium. 5) The most common pathogen was Aspergillus(92.3%) 6) We performed Caldwell-Luc's operation only in 4 cases, Caldwell-Luc's operation with intranasal ethmoidectomy in 3 cases, Caldwell-Luc's operation with endoscopic sinus surgery in 3 cases and endoscopic sinus sugery only in 3 cases. 7) Most of the gross specimens revealed a fungus ball containing a black-brown necrotic debris or caseous material.

Behçet's disease and genes within the major histocompatibility complex region.

Song, Yeong Wook,Kang, Eun Ha Springer-Verlag Tokyo 2012 Modern Rheumatology Vol.22 No.2

<P>The role of genetic background in the development of Behçet's disease (BD) is best reflected by the strong association between HLA-B*51 and BD that has been demonstrated across various ethnic groups. The contributions made by other HLA or non-HLA genes to disease susceptibility have been suggested by the results of a number of gene association studies, although the true associations between the genes located within the major histocompatibility complex (MHC) region and BD have often been doubted due to the possibility of linkage disequilibrium of those genes with HLA-B*51. The presence of a true susceptibility gene in the vicinity of HLA-B*51 has also been extensively investigated because of the limited evidence that directly relates HLA-B*51 to the pathogenesis of BD. However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51. In this review, we discuss BD-associated genes within the MHC region and their biological roles in the pathogenesis of BD.</P>

전신성홍반성낭창과 특발성혈소판감소성자반증 환자 혈청에서 항혈소판항체의 출현빈도 및 항원특이성에 관한 연구

송영욱(Yeong Wook Song),이제환(Je Hwan Lee),이윤재(Yoon Jae Lee),박선양(Seon Yang Park),최강원(Kang Won Choe),박명희(Myung Hee Park) 대한내과학회 1990 대한내과학회지 Vol.39 No.4

N/A There is a special relationship between systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP), both of which are autoimmune diseases. Some patients with thromhocytopenic purpura, labeled as idiopathic at the onset, later develop a classical course of SLE, suggesting that ITP may be an early manifestation of SLE. Furthermore, a thrombocytopenic purpura, indistinguishable from ITP, is a common feature of SLE. Recent studies by several laboratories show that some patients with ITP produce autoantibodies against the glycoprotein IIb/IIIa complex and glycoprotein lb. Since in most cases of SLE an increase of platelet-associated IgG has been observed, it was suggested that the destruction of platelets might be dependent on the coating of the platelets with specific antibodies or on the binding of the immune complexes. A better knowledge of the antigen recognized by the antibodies present in the patients with SLE might help to clarify the cause of the thrombocytopenia. In this study, serum antiplatelet antibody was detected using platelet suspension immunofluorescence test in SLE and ITP patients. The positive rate of serum antiplatelet antibody was 85% (17/20) in SLE, 66.7% (10/15) in ITP, 60% (3/5) in platelet alloimmunization, and 0% (0/13) in the normal group. Sera from patients of SLE and ITP were incubated with platelet fractions immobilized on nitrocellulose paper (Western blotting) to detect platelet antigen specificity using a 125I-goat anti-human IgG. Normal sera reacted with platelet fractions in the range of 190~200 KD, 142~152 KD, and 87~90 KD, Howerver, 11 of the 20 SLE sera (55%) and seven of the 15 ITP sera (46.7%), bound to one or more fractions with large variations in the number and molecular weights in the platelet fractions, did not react with normal sera. Binding was directed to the platelet fractions in the range of 162 KD, 117~123 KD, 60~69 KD, 53~55 KD, 40~45 KD, and 37~39 KD in the SLE group, along with 117~123 KD, 106 KD, and 60~69 KD in the ITP group. The antigenic determinants were located in the cytoplasmic fraction of the platelets. This observation surggests the presence of multiple antigenic binding site for platelet-specific immunoglobulin, as well as differences, of antigen specificity in SLE and ITP sera. This variation may reflect heterogeneous antibodies binding to diverse antigens, or homogeneous antibodies bound to a limited number of antigenic determinants shared by the discrete platelet molecules.

혈관염을 포함한 류마티스 질환에서의 항호중구세포질 항체 양성율

송영욱 ( Yeong Wook Song ),백경란 ( Kyong Ran Peck ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.1

연구 배경: Anti-neutrophil cytoplasmic antibody(ANCA)는 호중구와 단핵구의 세포질내에 존재하는 단백질에 대한 자가항체로, 많은 전신성 괴사성 혈관염 환자들의 진단에 도움이 되는 지표로서 이용이 되고 있고. ANCA가 전신성 혈관염에 비교적 특이적인 항체이어서, 다른 면역학적인 검사와 함께 실시하면 전신성 혈관염과 류마티스 질환을 감별진단하는데 도움이 되는 것으로 알려져 있다. 저자들은 전신성 혈관염 중 우리 나라에 많은 베체트병 타카야수 동맥염에서의 ANCA 양성율과 그 외 여러 류마티스 질환에서의 ANCA 양성율에 대한 조사를 하고자 본 연구를 시행하였다. 방법: 서울대학교병원 내과 류마티스 크리닉에 다니는 활동성 류마티스 질환 및 혈관염성 질환 환자를 대상으로 간접면역형광법을 이용하여 혈청의 ANCA 양성률을 조사하였다. 대상 환자는 총 185명(여자 115명, 남자 70명)이었고, 질환 별로는 전신성홍반성낭창 41예, 류마티스양관절염 31예, 베체트병 50예, 그리고 타카야수 맥염 11예이었다. 그밖에 Henoch-Schonlein 자반증(HSP)과 베게너 육아종증 환자가 각각 1예씩 있었다. 결과: 전신성홍반성낭창 환자 41예 중에서는 2예가 P-ANCA 양성이었고, C-ANCA가 양성인 예는 없었으며, P-ANCA가 양성인 2예는 특별히 혈관염 증상 및 징후가 관찰되지는 않았다. 피부 근염 및 다발성근염 환자 22예 중에서 1예가 P-ANCA 양성이었고 역시 C-ANCA 양성을 보이는 환자는 없었다. 류마티스양관절염 환자 31예, 강직성척추염 환자 9예, 진행성전신경화중 환자 19예는 모두 ANCA 음성이었다. 베체트병, 환자 50예 중 P-ANCA 양성은 2예 있었고, C-ANCA 양성은 없었다. P-ANC가 양성인 2예는 모두 완전형(complete type)으로 구강궤양, 성기궤양, 포도막염 및 피부병변이 있었고, 이중 1예는 혈관염 병변으로 우측 대퇴정맥의 폐쇄소견이 있었다. 타카야수 동맥염 11예와 Henoch-Schonlein 자반증 1예에서 ANCA 양성을 보이는 예는 없었다. 베게너 육아종중 환자 1예는 전형적인 C-ANCA 양성을 보였다(Table 2). 이 환자는 치료 후 관해가 온 다음에는 C-ANCA가 음전되었다. 결론: 이상의 결과로 한국인에 많은 혈관염 및 류마티스질환의 ANCA 검사가 ANCA 양성 혈관염과 다른 류마티스질환을 감별하는데 도움이 될 것으로 사료되었다. Background: Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies that are specific for proteins in the cytoplasm of neutrophils and monocytes. In the 10 years since their discovery, ANCA have become widely used serological markers for various systemic necrotizing vasculitides, including Wegener`s granulomatosis, polyarteritis nodosa, crescentic glomerulonephritis, and Churg-Strauss syndrome. Rheumatic manifestations (such as arthralgia, myalgia, even frank arthritis) are observed frequently in the group of primary vasculitides. In the group of collagen vascular diseases and the various forms of chronic inflammatory arthritis, vasculitis may severely complicate the course of the disease. Since atypical vasculitic diseases are indistingushable from other rheumatic disorders in the initial period of disease, immunological studies must be performed. We conducted this study for obtaining the seroprevalence of ANCA in rheumatic disorders including vasculitides which are common in Korea. Method: ANCA was detected with indirect immunofluorescent microscopy of alcohol-fixed granulocytes. Results: Total 185 patients were enrolled in this study. There was no patient having C-ANCA except one patient with Wegener`s granulomatosis. Total 5 patients were positive for P-ANCA; 2 of 41 SLE patients, 1 of 22 dermatomyositis/polymyositis patients, 2 of 50 Behcet`s disease patients. All 11 patients with Takayasu`s arteritis were ANCAnegative. These results were similar to those of others. Conclusion: ANCA, as a adjunct to other autoantibodies, will be helpful for differential diagnosis of various vasculitides and rheumatic disorders.

특집: 류마티스 관절염 진단과 치료의 최신지견 : 최근 조명된 류마티스 관절염의 병태 생리

송영욱 ( Yeong Wook Song ) 대한내과학회 2009 대한내과학회지 Vol.76 No.1

Rheumatoid arthritis is a chronic inflammatory disease that primarily affects joint synovium. Although its etiology has yet to be identified, the underlying mechanism of joint inflammation is understood as autoimmune process. The inflamed synovium is thickened due to synovial hyperplasia and infiltrating mononuclear cells such as T and B lymphocytes, macrophages, and plasma cells. Key inflammatory cytokines TNF-α and IL-1, as shown by the significant therapeutic effect of their blockade, are mainly secreted by macrophages whereas IL-17 is secreted by a newly recognized subset of T cells (Th17 cells) and induces TNF-α and IL-1 production by adjacent macrophages, synoviocytes, and chondrocytes. IL-17 has also been shown to induce RANKL from osteoblasts, thereby indicating that this cytokine plays as an upstream molecule that regulates inflammation and osteoclastogenesis. More importantly, IL-17 has been shown to convert acute inflammation into chronic inflammation and when combined with already important cytokines, more marked inflammation occurs. The role of B cells as antigen presenting cells are now being recognized based on the therapeutic effect of rituximab, a B cell inhibitor, in rheumatoid arthritis. Great attention has been turned to anti-citrullinated peptide antibodies because they form immune complex and contribute to inflammation by activating complement system. Recently, clinical trials showed therapeutic efficacy of tocilizumab, monoclonal antibody against IL-6 receptor, suggesting relevant involvement of IL-6 in disease process of rheumatoid arthritis. Thus, various cellular and molecular players seem to interact within rheumatoid synovium to perpetuate inflammation. Further studies are needed to explore the exact mechanisms of development and maintenance of inflammation in rheumatoid arthritis. (Korean J Med 76:1-6, 2009)

Increased Frequency of Antifilaggrin Antibody in Patients With Rheumatoid Arthritis

송영욱(Yeong Wook Song),이은봉(Eun Bong Lee),백한주(Han Joo Baek),정은숙(Eun Sook Chung),김현아(Hyun Ah Kim),김인규(In Gyu Kim),최경호(Kyung Ho Choi) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

관동맥연축의 진단을 위한 Ergonovine Echocardiography의 안전성 및 임상적 유용성

송재관,박성욱,강덕현,조구영,나득영,이내희,이철환,홍명기,김재중,박승정 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Homologous Series of Phenylquinoline-Carbazole MainLigand Based On Red-Emitting Iridium(III) Complexes for PhosphorescentOrganic Light-Emitting Diodes

Song, Myungkwan,Park, Jin Su,Gal, Yeong-Soon,Kang, Sunwoo,Lee, Jin Yong,Lee, Jae Wook,Jin, Sung-Ho American Chemical Society 2012 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.116 No.13

<P>New red-emitting phosphorescent Ir(III) complexes, bis[9-ethyl-2-(4-phenylquinolin-2-yl)-9<I>H</I>-carbazolato-N,C<SUP>2′</SUP>]iridium picolinate-<I>N</I>-oxide [(2-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O)] and bis[9-ethyl-3-(4-phenylquinolin-2-yl)-9<I>H</I>-carbazolato-N,C<SUP>2′</SUP>]iridium picolinate-<I>N</I>-oxide (3-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O), were synthesized,and their applications in phosphorescent organic light-emitting diodes(PhOLEDs) as well as their photophysical, electrochemical, and electroluminescent(EL) properties were investigated. To tune the performance of PhOLEDscontaining these substances, the 9-ethyl-2-(4-phenylquinolin-2-yl)-9<I>H</I>-carbazole (2-Et-CVz-PhQ) and 9-ethyl-3-(4-phenylquinolin-2-yl)-9<I>H</I>-carbazole (3-Et-CVz-PhQ) were prepared and used as mainligands for the synthesis of Ir(III) complexes. The solution processedred PhOLEDs with a configuration of ITO/PEDOT:PSS/TCTA/PVK or 3-Et-CVz-PhQ:TPD:OXD-7:Ircomplex/cathode were fabricated. The maximum EL emission peaks of(2-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O) and (3-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O) were observed at 689 and 609 nm, respectively. The PhOLEDswith (2-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O) and (3-Et-CVz-PhQ)<SUB>2</SUB>Ir(pic-N-O) exhibited respective maximum external quantumefficiencies of 4.32% and 8.74% along with CIE (Commission Internationalde l’Eclairage) coordinates of (0.68, 0.28) and (0.62, 0.37),respectively. Furthermore, by introducing a TCTA interlayer, the PhOLEDsshowed a slight efficiency roll off of 15% from a low current density(1 mA/cm<SUP>2</SUP>) to a high current density (30 mA/cm<SUP>2</SUP>). The electro-optical properties and the performance of PhOLEDs,prepared by using the two Ir(III) complexes, were probed through theuse of density functional theory (DFT) calculations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-13/jp2101094/production/images/medium/jp-2011-101094_0009.gif'></P>

이식유전자 마우스를 이용한 자가면역질환의 연구

宋永旭 대한의사협회 1996 대한의사협회지 Vol.39 No.1